Blocking Bone Loss with l-BAIBA

Publication date: Available online 21 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Mark W. Hamrick, Meghan E. McGee-Lawrence
Osteocytes are cells nested within the mineralized bone matrix that play a key role in maintaining bone mass. New findings in Cell Reports show that β-aminoisobutyric acid (l-BAIBA), a metabolite secreted from muscle, promotes osteocyte survival under oxidative stress. This discovery reveals a novel mechanism linking muscle activity to skeletal health.



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