Clinical case: idelalisib-induced immunoglobulin flare.

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Clinical case: idelalisib-induced immunoglobulin flare.

Immunopharmacol Immunotoxicol. 2017 Aug;39(4):251-252

Authors: Novak J, Havrda M, Gaherova L, Spicka J, Kozak T

Abstract
IgM flare is a transient, treatment-induced, increase of monoclonal IgM levels in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) patients. Until recently this phenomenon was observed in patients treated with Cladribine and Rituximab. Here we report a case of a heavily pretreated chronic lymphocytic leukemia patient with an atypically high immunoglobulin production who developed clinically significant immunoglobulin flare following Idelalisib treatment.

PMID: 28523957 [PubMed - indexed for MEDLINE]

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