Development of Mouse Model Systems of Germinal Center Lymphomas.

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Development of Mouse Model Systems of Germinal Center Lymphomas.

Methods Mol Biol. 2017;1623:233-242

Authors: Kabrani E, Sander S

Abstract
Germinal centers (GC) are the predominant origin of human B cell lymphomagenesis. Transgenic mice in which gene expression is altered specifically in GC B cells have broadened our knowledge about the mechanisms of malignant transformation. However, extensive resources are needed due to the genetic complexity of these mouse models. Thus, bone marrow (BM)-derived chimerism is an attractive approach to study GC B cell derived lymphomagenesis, as it allows for an efficient allocation of resources and reduces the number of animals used.

PMID: 28589360 [PubMed - indexed for MEDLINE]

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