Genetic Vulnerability of GPCRs: A Call to Action

Publication date: April 2018
Source:Trends in Biochemical Sciences, Volume 43, Issue 4
Author(s): Stephen B. Liggett
G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The 'one-drug-fits-all' approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.



https://ift.tt/2utjCVN