Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats.

Related Articles

Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats.

Arch Virol. 2018 Apr;163(4):1073-1077

Authors: Sumi R, Miyake A, Endo T, Ohsato Y, Ngo MH, Nishigaki K

Abstract
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.

PMID: 29353423 [PubMed - indexed for MEDLINE]

http://ift.tt/2mZGZPX