Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment

Immunodeficiency can be associated with acute lymphoblastic leukemia (ALL) in various ways. ALL can be a feature of various primary immunodeficiencies including, but not limited, to X-linked agammaglobulinemia, chromosomal breakage disorders such as ataxia telangiectasia, and GATA2 haploinsufficiency.1–4 ALL also can be secondary to an infection such as human immunodeficiency virus. A congenital leukemia such as ALL can lead to abnormal newborn screening results for severe combined immunodeficiency.

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