Thrombospondin-1 triggers osteosarcoma cells metastasis and tumor angiogenesis.

Thrombospondin-1 triggers osteosarcoma cells metastasis and tumor angiogenesis.

Oncol Res. 2018 Mar 14;:

Authors: Jian YK, Zhu HY, Wu XL, Li B

Abstract
Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumoreffects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here, we demonstrated that thrombospondin 1 (TSP1) is a potent inhibitor of osteosarcoma cells MG-63 growth and metastasis. Moreover, we demonstrate up-regulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells. In angiogenesis assays, over-expression of TSP-1 inhibited MG-63 cells induced tube formation of human umbilical vein endothelial cells (HUVECs) and this effect required CD36. Finally, in xenografted tumors, we observed that TSP1 overexpression inhibited angiogenesis and tumor growth. These results provided the strong evidence for an important role of the TSP-1/CD36/vasculostatin signaling axis in mediating the anti-angiogenic activity of osteosarcoma.

PMID: 29540257 [PubMed - as supplied by publisher]

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