Evaluation of the effect of Pulsed Dye Laser on chronic Psoriatic plaque.

Evaluation of the effect of Pulsed Dye Laser on chronic Psoriatic plaque.

J Dermatolog Treat. 2018 Apr 18;:1-23

Authors: Elwan NM, Gheida SF, Hawwam SA, Ahmed AH

Abstract
Psoriasis is one of the most prevalent immune mediated skin diseases. Selective vascular destruction by pulsed dye laser is considered one of effective laser treatments.
OBJECTIVE: Evaluation of the therapeutic effect of pulsed dye laser in treatment of chronic psoriatic plaque lesions and changes in human beta defensin-2 expression in the psoriatic patients before and after treatment, with correlation to the clinical improvement.
METHODS: Twenty patients with psoriatic plaque on right side treated by laser and another plaque on left side similar in size and severity score as control receiving no treatment. Each patient received 3 to 4 sessions of pulsed dye laser 595 nm. Follow up was done for 3 months.
RESULTS: There was statistically significant difference between the two psoriatic plaques (untreated and treated) (A and B) (p = 0.004) .There was significant decrease in HBD-2 expression after treatment. No Recurrence during follow up period.
CONCLUSION: The pulsed dye laser is safe, effective and tolerable treatment for resistant stable localized plaque psoriasis with minimal side effects and prolonged recurrence period.

PMID: 29667472 [PubMed - as supplied by publisher]

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