IL-17 polarization of MAIT cells is derived from the activation of two different pathways.

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IL-17 polarization of MAIT cells is derived from the activation of two different pathways.

Eur J Immunol. 2017 11;47(11):2002-2003

Authors: Guggino G, Di Liberto D, Lo Pizzo M, Saieva L, Alessandro R, Dieli F, Triolo G, Ciccia F

Abstract
MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

PMID: 28815578 [PubMed - indexed for MEDLINE]

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