[Metastatic colorectal cancer: To stop or not to stop?]

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[Metastatic colorectal cancer: To stop or not to stop?]

Bull Cancer. 2018 Apr;105(4):408-414

Authors: Artru P, Bennouna J, Lievre A, Ducreux M, Lledo G

Abstract
The introduction of new regimens and targeted therapies has prolonged survival in metastatic colorectal cancer from 1 year during the fluoropyrimidines-only era to more than 30 months today. Avoiding the cumulative toxicity of oxaliplatin, but also the physical or psychological asthenia of prolonged chemotherapy, is currently a worthwhile management goal. Data from randomized controlled trials indicate that a formalized stop-and-go approach to the delivery of oxaliplatin does not compromise efficacy. This paper presents also a critical review of the randomized trials evaluating the place of bevacizumab and cetuximab as maintenance therapy. To conclude we recommend chemotherapy holidays only after 4 to 6 months of chemotherapy and only in the population of very good responders to the induction treatment.

PMID: 29477654 [PubMed - indexed for MEDLINE]

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