miRNAs in Normal and Malignant Hematopoiesis.

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miRNAs in Normal and Malignant Hematopoiesis.

Int J Mol Sci. 2017 Jul 11;18(7):

Authors: Kotaki R, Koyama-Nasu R, Yamakawa N, Kotani A

Abstract
Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18-24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies.

PMID: 28696359 [PubMed - indexed for MEDLINE]

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