Primary spinal cord melanoma: a case report and a systemic review of overall survival.

Primary spinal cord melanoma: a case report and a systemic review of overall survival.

World Neurosurg. 2018 Mar 31;:

Authors: Zhang M, Liu R, Xiang Y, Mao J, Li G, Ma R, Sun Z

Abstract
BACKGROUND: The incidence of primary spinal cord melanoma (PSCM) is very rare. Several case series and case reports have been published in the literature. However, the predictive factors of PSCM survival and management options are not discussed in detail.
METHODS: We present a case of PSCM; total resection was achieved and chemotherapy was given post-operatively. A comprehensive search was performed on PubMed's electronic database using the words "primary spinal cord melanoma". Survival rates with various gender, location, treatment and metastasis condition were collected from the published articles and analyzed.
RESULTS: 60 cases were eligible for the survival analysis. 53% were male and 47% were female. Patient sex did not influence Overall survival (OS). The most common location were thoracic. Patient sex and tumor location did not influence OS. The major presenting symptoms were weakness and paresthesia of the extremities. Metastasis or dissemination was noted in 45.16 % of 31 patients. In the Kaplan Meier survival analysis patient who had metastasis had the worst prognosis. Extent of resection was not related to mortality. Patients who received surgery and surgery with adjuvant therapy had a better median survival than those who had adjuvant therapy alone. Prognosis was the worst in those patient who underwent only adjuvant therapy without surgery (5 months).
CONCLUSIONS: Surgery is the first treatment of choice in treating PSCM. The goal of tumor resection is to reduce the symptoms. Adjuvant therapy after surgery had a beneficial effect to limit the metastasis.

PMID: 29614357 [PubMed - as supplied by publisher]

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