Radiosensitivity enhancement of Fe3O4@Ag nanoparticles on human glioblastoma cells.

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Radiosensitivity enhancement of Fe3O4@Ag nanoparticles on human glioblastoma cells.

Artif Cells Nanomed Biotechnol. 2018 Apr 03;:1-10

Authors: Zhang X, Liu Z, Lou Z, Chen F, Chang S, Miao Y, Zhou Z, Hu X, Feng J, Ding Q, Liu P, Gu N, Zhang H

Abstract
Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of Fe3O4-OA, Ag and Fe3O4@Ag nanoparticles on U251 cells. The results show that Fe3O4@Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of Fe3O4@Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of Fe3O4@Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells.

PMID: 29609505 [PubMed - as supplied by publisher]

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