Systemic treatment in adult uterine sarcomas.

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Systemic treatment in adult uterine sarcomas.

Crit Rev Oncol Hematol. 2018 Feb;122:10-20

Authors: Desar IME, Ottevanger PB, Benson C, van der Graaf WTA

Abstract
Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.

PMID: 29458779 [PubMed - indexed for MEDLINE]

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