Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

Publication date: Available online 23 April 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Christopher J. Halbrook, Zeribe C. Nwosu, Costas A. Lyssiotis
Metabolic processes within cells are dynamically interconnected. If mitochondria become defective, cells must rewire their metabolism to survive. Here we highlight recent work by Gaude et al. that used a tunable model of mitochondrial dysfunction combined with metabolic tracing and in silico analyses to define these compensatory pathways.



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