High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai.

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High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai.

J Med Virol. 2018 May 04;:

Authors: Ding L, Mo X, Zhang L, Zhou F, Zhu C, Wang Y, Cai C, Liu Y, Wei F, Cai Q

Abstract
Skin disorders vary greatly in symptoms and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlate of each HHV infection with different skin disorders remains obscure. To reveal the potential link of certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV-6A in inflammatory or neoplastic skin tissues is the most common (40.3%), followed by EBV (17.6%), KSHV (9.2%), HHV-6B (4.4%), HCMV (1.1%) and VZV (0.7%), albeit the co-infection of HHV-6A, EBV and KSHV presents to less extent and none of HSV-1, HSV-2 or HHV-7 detected. Moreover, HHV-6A infection is highly associated with nevocytic nevus and seborrheic dermatitis/keratosis diseases, which mainly occurs at head and neck or lower limb. Despite no significant difference among each HHV infection in different age group of skin patient tissues, the distribution of KSHV infection was exclusively and significantly higher (~3.7 fold) in the male skin patients. This article is protected by copyright. All rights reserved.

PMID: 29727474 [PubMed - as supplied by publisher]

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