Hypereosinophilic Syndrome in the Differential Diagnosis of Pulmonary Infiltrates with Eosinophilia

The finding of pulmonary eosinophilia elicits a broad differential diagnosis (Table 1).1–3 Attention to key differentiating histologic features combined with clinical and laboratory findings and pertinent radiologic findings are important for distinguishing among the most common entities in the differential diagnosis that include eosinophilic pneumonia, eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome), allergic bronchopulmonary aspergillosis (ABPA) or more generally allergic bronchopulmonary fungal disease (ABPFD) and isolated asthma.

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