Laryngeal Dysfunction in Cough Hypersensitivity Syndrome: A cross sectional observational study.

Related Articles

Laryngeal Dysfunction in Cough Hypersensitivity Syndrome: A cross sectional observational study.

J Allergy Clin Immunol Pract. 2018 May 02;:

Authors: Vertigan AE, Kapela SM, Kearney EK, Gibson PG

Abstract
BACKGROUND: Chronic refractory cough(CRC), a phenotype of Cough Hypersensitivity Syndrome(CHS), is a disabling problem. Laryngeal dysfunction may be important in CC and CHS because laryngeal symptoms are common and CC, however the role of laryngeal dysfunction in CHS has not been systematically examined.
OBJECTIVE: To determine the nature of laryngeal dysfunction in patients with CC and compare with the related laryngeal conditions of Vocal Cord Dysfunction(VCD) and Muscle Tension Dysphonia(MTD).
METHOD: A cross-sectional analytic design was used. We recruited 69 participants including healthy controls and patients with CC, VCD and MTD who were referred for behavioural speech interventions. Participants underwent a comprehensive assessment of laryngeal function during breathing, phonation and swallowing.
RESULTS: Cough frequency was high in patients with CC(10.2coughs/hour) and VCD(16.5coughs/hour), but low in healthy controls(1.5) groups(p<0.001). Patients with CC, VCD, and MTD had impaired voice-related quality of life (vs controls p<0.05), and laryngeal hypersensitivity(vs controls p<0.05). Most voice assessment measures (3 out of 4) were significantly impaired in CC compared to controls and similar to VCD and MTD. Paradoxical vocal fold movement during respiration was present in 47% of patients with CC at rest, and in 67% after odour challenge. Mediolateral laryngeal constriction during phonation was present in 45% of the CC participants, 93% of VCD participants(p<0.001 vs CC) and 64% of MTD participants.
CONCLUSION: Laryngeal dysfunction is common in CC and CHS and may contribute to CHS mechanisms. Assessment and treatment of laryngeal dysfunction using speech pathology interventions is likely to be beneficial in CHS.

PMID: 29729441 [PubMed - as supplied by publisher]

https://ift.tt/2jIeftH