Mupirocin resistance among Methicillin resistant Staphylococcus isolates in a tertiary health care center.

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Mupirocin resistance among Methicillin resistant Staphylococcus isolates in a tertiary health care center.

Infect Disord Drug Targets. 2018 Apr 30;:

Authors: Mittal S, Sayal P

Abstract
INTRODUCTION-Antibiotics have revolutionized medicine in many respects and countless lives have been saved, their discovery was a turning point in human history. Regrettably, the use of these wonder drugs has been accompanied by the rapid appearance of resistant strains. AIMS &OBJECTIVES-This study was carried out to with the aim to determine the rates of high-level and low-level mupirocin resistance in MRSA, to study the antimicrobial resistance pattern of mupirocin-resistant MRSA and mupirocin-sensitive MRSA. MATERIAL &METHOD- This study was conducted on 100 Staphylococcus isolates recovered from pus samples.Conventional disc diffusion tests were used for detection of mupirocin resistance (mupirocin 5 μg and 200μg for detecting the MuL and the MuH strains).Susceptibility pattern of following antimicrobial agents routinely used for gram positive agents were also tested. RESULTS-Outof 100 Staphylococcus isolates processed during the study period in the department of microbiology, 74 were S.aureus and 26 were CoNS.Among S.aureus43.4% were MRSA and 56.6% were MSSA, whereas among CoNS 42% were methicillin resistant and 58% were methicillin sensitive.We observed 6.75% of high level mupirocin resistance among S aureus and 19.23% among CoNS. CONCLUSION-We conclude that an increase in in-hospital mupirocin use is associated with a rapid increase in high-level resistance to mupirocin and resistance to other antibiotics in CoNS. This may have direct clinical consequences in the treatment of prosthetic infections and may, in the long term, increase the risk of high-level resistance to mupirocin in S. aureus.

PMID: 29714149 [PubMed - as supplied by publisher]

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