Systematic review on the efficacy and safety of immune checkpoint inhibition in renal cell carcinoma.

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Systematic review on the efficacy and safety of immune checkpoint inhibition in renal cell carcinoma.

Future Oncol. 2018 May 04;:

Authors: Lyu C, Li W, Liu S, Gao S, Zhang H, Hao L, Yu H, Wei W, Song J, Yang Y, Wang C, Zhang Z, Wang N

Abstract
To perform a systematic review of the relevant literature about clinical trials on efficacy and safety of immune checkpoint inhibition, whether it is used alone, in combination or with other targeted therapies in patients with advanced and metastatic renal cell carcinoma (RCC), two team members reviewed the abstracts and selected pertinent articles from the relevant databases. A narrative review of randomized controlled trials was performed and seven randomized controlled trials were identified in this systematic review. In treatment of RCC, nivolumab has superior efficacy and safety compared with second-line everolimus. Combination strategies, especially those combined with anti-VEGF agents presents better efficacy but worse outcomes in term of safety than monotherapy and conventional treatment and might guide treatment choice for patients with RCC.

PMID: 29726696 [PubMed - as supplied by publisher]

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