Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice

Publication date: Available online 18 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Sang Hoon Lee, Pyung Sun Cho, Raquel Tonello, Han Kyu Lee, Jun Ho Jang, Gi Yeon Park, Sun Wook Hwang, Chul-Kyu Park, Sung Jun Jung, Temugin Berta

Teaser

Selective serotonin reuptake inhibitor (SSRI) antidepressants mediates pruritus via serotonin receptor 2B and transient receptor potential channel 4 expressed in mouse peripheral sensory neurons, revealing a previously unknown itch signaling pathway.


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