Content and construct validity, predictors and distribution of self-reported atopic dermatitis severity in US adults

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with variable lesional severity and extent, a broad symptom-burden, including itch, skin pain1, sleep2, 3 and mental health disturbance4, and negative impact on quality of life (QOL)5. Each of these domains differentially and cumulatively affects AD patients and contributes to overall AD severity. Many different scales exist that measure various aspects of AD severity6-13. However, there is no single patient-reported outcome (PRO) that fully captures all aspects of disease severity.

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