Within-tester repeatability and between-tester reproducibility of skin test endpoint titration: A quality assurance study

Airway response to allergen depends on two independent factors: the degree of IgE sensitivity to the allergen and the level of lower airway response as quantified by histamine or methacholine challenge.1,2 The former can be assessed by skin prick titration (SPT) to determine the skin test endpoint (STE), which for research purposes is the smallest concentration of allergen that produces a skin wheal ≈ 2mm x 2mm (according to the standard operating procedure, SOP, for the AllerGen NCE Clinical Investigator Collaborative, CIC).

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