Intestinal dendritic cell licensing through TLR4 is required for oral tolerance in allergic contact dermatitis

The commensal flora and expression of TLR4 on hematopoietic cells are essential for oral tolerance and suppression of DNFB-induced contact hypersensitivity. TLR4 conditions the mobilization of tolerogenic intestinal CD103+CD11b+ DCs carrying the allergen to MLNs.

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