Receptor-interacting Protein Kinase 3 Controls Keratinocyte Activation in a Necroptosis-independent Manner and Promotes Psoriatic Dermatitis in Mice

RIPK3 in keratinocytes facilitates psoriatic inflammation by promoting cytokine and chemokine production, independent of the induction of necroptosis. Control of RIPK3 activation may be a novel therapeutic target for psoriasis.

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