Novel quantitative analysis of autofluorescence images for oral cancer screening

Oral squamous cell carcinoma (OSCC) is the most common malignant disease of oral mucosae and is closely associated with betel quid chewing, chronic smoking and alcohol consumption [1,2]. OSCC is also the sixth most common cancer worldwide, with an average five year survival rate of approximately 60% [3]. The incidence and severity of OSCC are increasing worldwide, especially in Taiwan [4]. From 1981 to 2010, the standardized mortality rates increased from 2.5 to 8.1 per 100,000 persons [5]. Currently, there are no reliable or easy approaches for early detection except conventional oral examination and biopsy by physicians.

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