A Phase 2a Study of Toreforant, a Histamine H4 Receptor Antagonist, in Eosinophilic Asthma

Histamine appears to play a role in the pathophysiology of asthma. In patients with allergic asthma, there is an increase in histamine in bronchoalveolar lavage fluid that is negatively correlated with airway function.1-6 In addition, histamine levels rapidly increase in the plasma of antigen-challenged patients,7 and plasma histamine levels are lowered by effective management of asthma.8

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