The severity of allergic reactions to insect stings ranges from mild, local reactions to systemic, life-threatening anaphylaxis.1, 2 Systemic reactions (SRs) to Hymenoptera stings can occur in 0.5-3.3% of adults in the US and 0.3-7.5% of adults in Europe.3, 4 In pediatric patients, the prevalence of SRs is lower, from 0.15-0.8%.5-8 In addition, in children, the majority of SRs from sting consist of exclusively cutaneous symptoms.9 Venom immunotherapy (VIT) is very effective in decreasing the SR risk after subsequent sting and is generally indicated in subjects with histories of SRs to Hymenoptera stings with extra-cutaneous symptoms.
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