Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product. Graphical abstract [image: image] from #Medicine via ola Kala on Inoreader http:...περισσότερα »
1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Silvija Maračić, Tatjana Gazivoda Kraljević, Hana Čipčić Paljetak, Mihaela Perić, Mario Matijašić, Donatella Verbanac, Mario Cetina, Silvana Raić-Malić Versatile 1,2,3-triazole pharmacophore-based benzofused heterocycles containing halogen-substituted aromatic (9–17 and 25–28), 7-substituted coumarin (18–23 and 29–30) or penciclovir-like subunit (31a,b–38a) were designed and synthesized to evaluate their antibacterial activities against selected Gram-positive and Gram-negative bac... περισσότερα »
Discovery of bis-ary urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Jiaxin Cui, Mei Ding, Wei Deng, Yan Yin, Zhonghua Wang, Hong Zhou, Guofeng Sun, Yu Jiang, Yangbo Feng Lim kinase (Limk), a proline/serine-rich sequence, can regulate the polymerization of the actin filaments by phosphorylating, and it is found to be highly involved in various human diseases. In this paper, 47 reported Limk1 inhibitors with bis-ary urea scaffold were used to design potent and selective Limk inhibitors by computational approaches. Firstly, the structure-Limk1 activi... περισσότερα »
Synthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Matteo Fusari, Silvia Fallarini, Grazia Lombardi, Luigi Lay Zwitterionic polysaccharides (ZPS) behave like traditional T cell-dependent antigens, suggesting the design of new classes of vaccines alternative to currently used glycoconjugates and based on the artificial introduction of a zwitterionic charge motif onto the carbohydrate structure of pathogen antigens. Here we report the new synthesis and antigenic evaluation of di-/tri-saccharide fragments of Salmonella typhi Vi polysa...περισσότερα »
Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings
Background: The root of Angelica dahurica Bentham et Hooker (Umbelliferae) has been used as a traditional medicine for colds, headache, dizziness, toothache, supraorbital pain, nasal congestion, acne, ulcer, carbuncle, and rheumatism in China, Japan, and Korea. Interestingly, it has been used in the treatment of vascular diseases including hypertension. The aim of this study was to provide pharmacological evidence for the anti-hypertensive effect of A. dahurica by investigating the mechanism underlying its vasorelaxant effect. Methods: The vasorelaxant effects of a 70 % methanol e... περισσότερα »
Retrospective case-series of Paecilomyces lilacinus ocular mycoses in Queensland, Australia
Background: The purpose of this study was to report: (1) the varying presentation of Paecilomyces ocular infections arising in Queensland; (2) the significance of immunosuppression as a primary determinant of disease; (3) the outcomes of voriconazole use; and (4) the ongoing need for both surgical and medical management of this devastating fungal infection. Methods: A retrospective case series of 21 culture proven individuals participated in this series and were identified via a review of the pathology reporting system utilized in the Queensland public health system. All culture p... περισσότερα »
Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry
Background: Pasteurella multocida meningitis in an immunocompetent patient is rare and commonly occurs after animal bite. To our knowledge, only 48 cases have been reported in the literature since 1989. P. multocida meningitis is commonly linked to animal contagion. Here we report on a new case of P. multocida meningitis in an immunocompetent patient who is a dog owner without a dog bite. We used the matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry to investigate the clonal lineage between animal and human isolates.Case presentationIn our ca...περισσότερα »
Effect of consuming novel foods consisting high oleic canola oil, barley β-glucan, and DHA on cardiovascular disease risk in humans: the CONFIDENCE (Canola Oil and Fibre with DHA Enhanced) study – protocol for a randomized controlled trial
Background: Metabolic syndrome (MetS) has been identified as a major contributor to the development of cardiovascular disease (CVD). Current recommendations for dietary management of people with MetS involve quantitative and qualitative modifications of food intake, such as high consumption of vegetables, fruits, and whole grain foods. The results from our previous human trials revealed the potential of the dietary components high-oleic acid canola oil (HOCO)-docosahexaenoic acid (DHA) and high molecular weight barley β-glucan individually in managing CVD risk factors. Foods with ... περισσότερα »
Analysis of the Cochrane Review: Interventions for Improving Upper Limb Function after Stroke. Cochrane Database Syst Rev. 2014,11:CD010820.
Impairment of the upper limbs is quite frequent after stroke, making rehabilitation an essential step towards clinical recovery and patient empowerment. This review aimed to synthetize existing evidence regarding interventions for upper limb function improvement after Stroke and to assess which would bring some benefit. The Cochrane Database of Systematic Reviews, the Database of Reviews of Effects and PROSPERO databases were searched until June 2013 and 40 reviews have been included, covering 503 studies, 18 078 participants and 18 interventions, as well asdifferent doses and set... περισσότερα »
Hyperbaric Oxygen Therapy for the Treatment of Fournier’s Gangrene: A Review of 34 Cases
*Introduction:* Fournier's gangrene is a serious necrotizing infection that can be fatal if not promptly attended. Treatment for this condition consists of a combination of surgical debridement, antibiotherapy and supportive care. Hyperbaric oxygen therapy is used as an adjuvant for the optimization of infected tissue oxygenation and for its bactericidal and bacteriostatic effects. *Material and Methods:* The data presented in this study encompass a period of 25 years of clinical records of patients with Fournier's gangrene that had been treated at our center with hyperbaric oxygen... περισσότερα »
Alcohol and Youth in Portugal: An Intervention Through the Triangle Project
*Keywords:* Adolescent; Alcohol Drinking; Portugal. from #Medicine via ola Kala on Inoreader http://ift.tt/1HicEhl via IFTTT
Haemorrhagic Gingival Hypertrophy: A Striking Presentation of Acute Myelomonocytic Leukaemia
*Keywords:* Gingival Hypertrophy; Leukemia, Myelomonocytic, Acute. from #Medicine via ola Kala on Inoreader http://ift.tt/1Q12GrF via IFTTT
Pantothenate Kinase Associated Neurodegeneration in Two Brothers
*Keywords:* Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Siblings. from #Medicine via ola Kala on Inoreader http://ift.tt/1HicGFS via IFTTT
Takotsubo Cardiomyopathy: Cause of a Cardiogenic Shock
Takotsubo cardiomyopathy, of unknown etiology, is characterized by sudden and transient systolic dysfunction of the mid-apical segments of the left ventricle without significant coronary disease, and full normalization of segmental changes. More common in middle-aged women, it is cause of differential diagnosis with acute coronary syndrome. We present the case of a 59 year old woman admitted to the emergency room with sudden chest pain and dyspnea. At presentation: acute hypotensive pulmonary edema requiring aminergic support and invasive ventilation. Blood tests showed elevated n...περισσότερα »
Auto-Immune Pancreatitis: The Diagnostic Role of Imaging Studies
Auto-immune pancreatitis is an uncommon and underdiagnosed pathology. Its clinical picture is not specific and the diagnosis is therefore difficult. Imaging studies have a crucial role in the diagnostic process and also in the follow-up of treatment. With the objective of emphasizing the importance of imaging in the correct diagnosis of this pathology, the authors report the case of a patient with longterm unspecific abdominal complaints that was diagnosed as auto-immune pancreatitis after laboratorial and imaging investigation. Assuming this diagnosis it was instituted treatment ... περισσότερα »
Hypothyroidism Associated to TSH Hormone-Receptor Autoantibodies with Blocking Activity Assessed In Vitro
Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary c... περισσότερα »
Periarticular Corticosteroid Injection in the Therapeutic Approach of Musculoskeletal Disease in General Practice: A systematic Review
*Introduction:* Periarticular corticosteroid injection utilization by General Practitioners treating musculoskeletal disease in primary health care system is internationally acknowledged. This article aims at analyzing this evidence and contributing to the discussion of a potential development of the technique in Portugal. *Material and Methods:* Qualitative analysis of randomized control trials, cost-effectiveness studies, cross-sectional studies, retrospective cohort studies and observational studies, using PRISMA model. Data Sources: PubMed, Cochrane Library and Essential Evidence... περισσότερα »
Monoclonal Antibodies for Multiple Sclerosis Treatment
Since their introduction in medical therapy, in the last quarter of the 20th century, monoclonal antibodies have gained an increasing importance in the treatment of various diseases. Neurology has been one of the medical specialties benefiting of the therapeutic potential of these monoclonal antibodies and certain neurological conditions may now contain such drugs in their therapeutic algorithms. Multiple sclerosis is one of these diseases and, in addition to the monoclonal antibodies already licensed for clinical use, several others are in development for future utilization in th... περισσότερα »
Current Clinical Indications for Small Bowel Capsule Endoscopy
*Introduction:* Small bowel capsule endoscopy is currently the first line diagnostic examination for many diseases affecting the small bowel. This article aims to review and critically address the current indications of small bowel capsule endoscopy in clinical practice. *Material and Methods:* Bibliographic review of relevant and recent papers indexed in PubMed. *Results and Discussion:* Small bowel capsule endoscopy enables a non-invasive full-assessment of the small bowel mucosa, with high diagnostic yield even for subtle lesions. In patients with obscure gastrointestinal bleedi... περισσότερα »
Mediterranean Spotted Fever: Retrospective Review of Hospitalized Cases and Predictive Factors of Severe Disease
*Introduction:* Mediterranean spotted fever, an ancient zoonotic disease raising current issues. This study aims to reevaluate the disease clinical picture and to identify prognostic factors related to severe disease. *Material and Methods:* We evaluate cases admitted to a central hospital during 12-year period. The risk factors were determined by uni and multivariate analysis, comparing patients admitted in general infirmary versus intermediate/intensive care units or in case of death. *Results:* We reviewed 71 cases of Mediterranean spotted fever. The mean age was 63.3 ± 16.7 years ...περισσότερα »
Acute Ischemic Stroke on Cancer Patients, a Distinct Etiology? A Case-Control Study
*Introduction:* It is still unclear whether the etiology of ischemic stroke differs between cancer and non-cancer patients. Stroke and cancer share common modifiable risk factors but evidence suggests that cancer patients have specific conditions that increase the risk of stroke. Our goal was to compare the etiology of ischemic stroke in cancer and non-cancer patients. *Material and Methods:* Case-control study conducted in patients admitted to a stroke unit between January 2007 and December 2012. Cases had a concomitant diagnosis of cancer and acute ischemic stroke, controls of onl... περισσότερα »
Suicidal Behavior among Portuguese Psychiatry Trainees: Comparison with the European Situation
*Introduction:* The aim of this paper was to assess the prevalence of suicide ideation and attempts in Portuguese psychiatry trainees (adult and child and adolescence), and compare the data with the general population and other European countries. *Material and Methods:* A structured and anonymous questionnaire was sent by email to 159 portuguese trainees of adult psychiatry and child and adolescence psychiatry with questions about personal history of suicidal ideation and suicide attempts, as well as family history of suicide attempts and completed suicides. This is part of the BoSS... περισσότερα »
Neonatal Morbidity in Term Newborns Born by Elective Cesarean Section
*Introduction:* International guidelines suggest that non-urgent planned deliveries be scheduled at or after 39 weeks. Despite this recommendation elective cesarean often occurs before 39 weeks. Some research has demonstrated that elective cesarean before 39 weeks poses a greater risk to the infants than at or after 39 weeks. *Objective:* To evaluate neonatal morbidity in term newborns born by elective cesarean section. *Material and Methods:* Retrospective study of all term elective cesarean sections (scheduled and without labor) performed in level III maternity, in the last 11 year... περισσότερα »
Translation, Cultural Adaptation and Validation of the Power of Food Scale for Use by Adult Populations in Portugal
*Introduction:* The Power of Food Scale measures appetite for, rather than consumption of, palatable foods - a construct frequently designated as hedonic hunger. The purpose of this study was to examine the psychometric properties of a Portuguese version of the Power of Food Scale, namely reliability and construct validity. *Material and Methods:* Data was obtained from 1266 adult participants sampled from three different populations in Portugal: two nonclinical samples and one multi-center sample of severely obese candidates for weight-loss surgery. *Results:* We found that the fa... περισσότερα »
Quality of Recovery after Anesthesia: Validation of the Portuguese Version of the “Quality of Recovery 15” Questionnaire
*Background:* The "Quality of Recovery 15" questionnaire is used for the study of quality recovery after anesthesia. The aim of this study was to validate the Portuguese version of "Quality of Recovery 15" questionnaire. *Material and Methods:* After study approval by the institutional ethics committee, an observational and cohort prospective study was conducted on patients scheduled for elective surgery from June to August 2013. The "Quality of Recovery 15" questionnaire was translated in accordance with available guidelines. The "Quality of Recovery 15" Portuguese version was use... περισσότερα »
The Importance of Early Referral in Pediatric Acute Liver Failure
*Introduction:* Acute liver failure is a rare disorder associated to high morbidity and mortality despite survival improvement through liver transplantation. The importance of a multidisciplinary approach and early referral to a pediatric liver transplantation center were important conclusions of a national meeting in 2008, from which resulted an actuation consensus. *Objectives:* To characterize acute liver failure admissions in a Pediatric Intensive Care Unit of the portuguese pediatric liver transplantation center. To compare results before (A) and after (B) 2008. *Material and Met... περισσότερα »
Characterization and Evolution of Avoidable Admissions in Portugal: The Impact of Two Methodologic Approaches
*Introduction:* The aim of this study is to evaluate the health systems performance through the avoidable hospital admissions, once these have gained international relevance. We used two different methods to identify the admissions for Ambulatory Care Sensitive Conditions, describing the Portuguese reality and evolution. *Material and Methods:* Over 12 million hospitalizations were analyzed between 2000 and 2012 using the national hospital discharge databases. We used two different methodologies to identify the hospitalizations for Ambulatory Care Sensitive Conditions, determining th...περισσότερα »
Thirdhand Smoke: A Concept to Remember!
*Keywords:* Tobacco Smoke Pollution; Smoking. from #Medicine via ola Kala on Inoreader http://ift.tt/1HicwOF via IFTTT
Prophylactic use of the Arabin cervical pessary in fetuses with severe congenital diaphragmatic hernia treated by fetoscopic endoluminal tracheal occlusion (FETO): preliminary experience
Abstract Objective To describe whether the prophylactic use of a cervical pessary decreases the rate of premature birth in congenital diaphragmatic hernia (CDH) fetuses treated with fetoscopic tracheal occlusion (FETO). Methods Consecutive series of all cases with CDH and FETO and a group of CDH without FETO. In a subgroup of the FETO group, a prophylactic cervical pessary was inserted the day following the procedure. Gestational age (GA) at birth was the primary outcome. Results 59 fetuses with FETO and 47 expectantly managed were included. The last 15 FETO had a cervical pess...περισσότερα »
Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors
Background: Neuroimaging features associated with vascular cognitive impairment have not been examined in sub-Saharan Africans. We determined magnetic resonance imaging (MRI) features associated with cognitive impairment in a sample of Nigerian stroke survivors. Methods: Stroke survivors underwent brain MRI with standardized assessment of brain volumes and visual rating of medial temporal lobe atrophy (MTA), and white matter hyperintensities (WMH) at 3 months post-stroke. Demographic, clinical and psychometric assessments of global cognitive function, executive function, mental sp...περισσότερα »
Pulsed Direct Current Electrospray: Enabling Systematic Analysis of Small Volume Sample by Boosting Sample Economy
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b02115 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1XG3pAX via IFTTT
Sensitive Trimodal Magnetic Resonance Imaging-Surface-Enhanced Resonance Raman Scattering-Fluorescence Detection of Cancer Cells with Stable Magneto-Plasmonic Nanoprobes
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b02419 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1XG3m8l via IFTTT
Enhancement of the Carbon Dots/K2S2O8 Chemiluminescence System Induced by Triethylamine
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b02562 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1XG3lRz via IFTTT
CIUSuite: A Quantitative Analysis Package for Collision Induced Unfolding Measurements of Gas-Phase Protein Ions
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03292 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1XG3k06 via IFTTT
Imaging of Proteins in Tissue Samples Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03389 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1PaIPWd via IFTTT
Modified-Atmospheric Pressure-Matrix Assisted Laser Desorption/Ionization Identification of Friction Modifier Additives Oleamide and Ethoxylated Tallow Amines on Varied Metal Target Materials and Tribologically Stressed Steel Surfaces
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b02793 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1PaIP8W via IFTTT
To Your Health: NLM update: Explaining health risks in drug advertising
[image: Listen to the NLM Director's Comments] Listen to the To Your Health: NLM update on Explaining health risks in drug advertising. The transcript is also available. The risks of U.S. Food and Drug Administration (FDA)-approved medications should be explained with the same dexterity as promoting its benefits by direct-to-consumer advertisers, suggests an interesting perspective recently published in The New England Journal of Medicine. from #Medicine via ola Kala on Inoreader http://ift.tt/1OegKyJ via IFTTT
To Your Health: NLM update: Ebola vaccine's initial success
[image: Listen to the NLM Director's Comments] Listen to the To Your Health: NLM update on Ebola vaccine's initial success. The transcript is also available. A vaccine to prevent Ebola was successful in an initial clinical trial within the West African nation of Guinea, reports a pioneering study and editorial recently published in The Lancet. from #Medicine via ola Kala on Inoreader http://ift.tt/1GCixuV via IFTTT
Tomosynthesis Imaging
This article reviews Tomosynthesis Imaging Imaging in Medical Diagnosis and Therapy. Editors: I. Reiser and S. Glick. Series Editor: William R. Hendee, , Boca Raton, FL, 2014. 257 pp. Price: $144.46. ISBN: 978143987870 (hardback). from #Medicine via ola Kala on Inoreader http://ift.tt/1kgWLlY via IFTTT
Erratum: “Analytic variance estimates of Swank and Fano factors” [Med. Phys. 41, 072102 (5pp.) (2014)]
from #Medicine via ola Kala on Inoreader http://ift.tt/1OdVU2C via IFTTT
Erratum: “Modeling respiratory motion for reducing motion artifacts in 4D CT images” [Med. Phys. 40, 041716 (13pp.) (2013)]
from #Medicine via ola Kala on Inoreader http://ift.tt/1kgWL5A via IFTTT
Optimization of an on-board imaging system for extremely rapid radiation therapy
Purpose: Next-generation extremely rapid radiation therapy systems could mitigate the need for motion management, improve patient comfort during the treatment, and increase patient throughput for cost effectiveness. Such systems require an on-board imaging system that is competitively priced, fast, and of sufficiently high quality to allow good registration between the image taken on the day of treatment and the image taken the day of treatment planning. In this study, three different detectors for a custom on-board CT system were investigated to select the best design for integr... περισσότερα »
Image-derived and arterial blood sampled input functions for quantitative PET imaging of the angiotensin II subtype 1 receptor in the kidney
Purpose: The radioligand 11C-KR31173 has been introduced for positron emission tomography (PET) imaging of the angiotensin II subtype 1 receptor in the kidney in vivo. To study the biokinetics of 11C-KR31173 with a compartmental model, the input function is needed. Collection and analysis of arterial blood samples are the established approach to obtain the input function but they are not feasible in patients with renal diseases. The goal of this study was to develop a quantitative technique that can provide an accurate image-derived input function (ID-IF) to replace the conventio...περισσότερα »
A round-robin gamma stereotactic radiosurgery dosimetry interinstitution comparison of calibration protocols
Purpose: Absorbed dose calibration for gamma stereotactic radiosurgery is challenging due to the unique geometric conditions, dosimetry characteristics, and nonstandard field size of these devices. Members of the American Association of Physicists in Medicine (AAPM) Task Group 178 on Gamma Stereotactic Radiosurgery Dosimetry and Quality Assurance have participated in a round-robin exchange of calibrated measurement instrumentation and phantoms exploring two approved and two proposed calibration protocols or formalisms on ten gamma radiosurgery units. The objectives of this study ... περισσότερα »
A simple clot based assay for detection of procoagulant cell-derived microparticles
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print from #Medicine via ola Kala on Inoreader http://ift.tt/1NepYcU via IFTTT
Establishment of reference intervals of clinical chemistry analytes for adult population in Saudi Arabia: a study conducted as a part of the IFCC global study on reference values
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print from #Medicine via ola Kala on Inoreader http://ift.tt/1NepVxU via IFTTT
Incidence and determinants of neonatal morbidity after elective caesarean section at the national referral hospital in Kampala, Uganda
Background: Elective caesarean sections (ECS) have been implicated in increased risk of adverse neonatal outcomes. The primary objective was to assess the incidence and determinants of neonatal morbidity after elective caesarean section deliveries. The secondary objective was to describe the maternal morbidity associated with elective caesarean section. Methods: This was a prospective cohort study of women admitted for ECS, as well as their newborns, conducted at Mulago hospital from March 1, 2013 to February 28, 2014. These were followed from the time of the operation until 6 week...περισσότερα »
Proton pump inhibitor and voice therapy on reflux-related laryngeal disorders
*ORIGINAL ARTICLEYear *: 2015 | *Volume* : 43 | *Issue* : 4 | *Page* : 127--133 Effect of proton pump inhibitor and voice therapy on reflux-related laryngeal disorders *Hatem Ezzeldin1, Ahmed A Hasseba2* 1 Department of Otorhinolaryngology, Sohag University, Sohag, Egypt; Department of Phoniatrics, King Fahd Hospital Jeddah, Jeddah, Kingdom of Saudi Arabia, 2 Department of Otorhinolaryngology, El-Minia University, Minya, Egypt *Correspondence Address*: Hatem Ezzeldin (Phoniatrics), Department of Phoniatrics, King Fahd Hospital Jeddah, PO Box 8488, Jeddah 21196 *Objectives* The...περισσότερα »
