Secondary antibody deficiencies
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό
Secondary antibody deficiencies.Dhalla, Fatima; Misbah, Siraj A., 2015-10-17 07:00:00 AM Purpose of review: Antibody deficiency can occur in the context of primary immune deficiency due to inherited genetic defects or secondary to a variety of causes. This review aims to summarize current data concerning the causes of secondary antibody deficiency and where possible evidence regarding the use of prophylactic replacement immunoglobulin. Recent findings: Advances in immune-mediated therapies ranging from monoclonal antibodies to novel B-cell-targeted therapeutics are responsible for an...περισσότερα »
Toll-like receptors as targets for allergen immunotherapy.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό
Toll-like receptors as targets for allergen immunotherapy.Aryan, Zahra; Rezaei, Nima, 2015-10-17 07:00:00 AM Purpose of review: Toll-like receptors (TLRs) are novel and promising targets for allergen immunotherapy. Bench studies suggest that TLR agonists reduce Th2 responses and ameliorate airway hyper-responsiveness. In addition, clinical trials are at initial phases to evaluate the safety and efficacy of TLR agonists for the allergen immunotherapy of patients with allergic rhinitis and asthma. Recent findings: To date, two allergy vaccine-containing TLR agonists have been investiga... περισσότερα »
Allergen immunotherapy: an update on protocols of administration
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό
Allergen immunotherapy: an update on protocols of administration.Larenas-Linnemann, Désirée, 2015-10-17 07:00:00 AM Purpose of review: Allergen immunotherapy (AIT) is still the only causal treatment for allergic rhinitis and asthma. However, conventional subcutaneous AIT administration schedules are time-consuming and safety issues still play a role; for sublingual AIT, the best efficacy is still investigated and for food allergy the best efficacy-safety balance is not yet completely discovered. Investigators have made progress in these fields lately. Recent findings: Since January 2...περισσότερα »
Common variable immunodeficiency (CVID) : Autoimmune and inflammatory
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
The autoimmune conundrum in common variable immunodeficiency disorders.van de Ven, Annick A.J.M.; Warnatz, Klaus, 2015-10-17 07:00:00 AM Purpose of review: Autoimmune and inflammatory manifestations are the biggest clinical challenge in the care of patients with common variable immunodeficiency (CVID). The increasing pathogenic knowledge and potential therapeutic implications require a new evaluation of the status quo. Recent findings: The conundrum of the simultaneous manifestation of primary immunodeficiency and autoimmune disease (AID) is increasingly elucidated by newly discovere...περισσότερα »
Patient selection for subcutaneous versus sublingual immunotherapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Patient selection for subcutaneous versus sublingual immunotherapy.Larenas-Linnemann, Désirée, 2015-10-17 07:00:00 AM Purpose of review: With the Food and Drug Administration's approval of sublingual allergen-specific immunotherapy (SL-AIT) tablets for grass and ragweed pollen, SL-AIT is progressively gathering importance not only in Europe, but also in the United States and other parts of the world. We reviewed issues related to the selection of patients for the sublingual or the subcutaneous route for allergic patients, based on what has been published since January 2014 on subcuta... περισσότερα »
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
The immunological and genetic basis of Bin Dhuban, Khalid; Piccirillo, Ciriaco A., 2015-10-17 07:00:00 AM Purpose of review: This article presents a comprehensive review of the immunodysregulation, polyendocrinopathy, enteropathy and X-linked (IPEX) syndrome, covering both the clinical and molecular aspects of the disease. Recent findings: The IPEX syndrome is a rare immunological disorder in humans caused by inheritable mutations in the FOXP3 gene, the master transcriptional regulator for the development and function of CD4+ regulatory T (Treg) cells. Forkhead box protein 3 (FOXP3+)... περισσότερα »
St Alphonsus, a saint for the Year of Mercy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
St Alphonsus, a saint for the Year of Mercy Timothy FiniganστοThe hermeneutic of continuity In just another act of generosity that marks the best of Catholic internet activity, somebody has scanned/transcribed the texts of three important spiritual books: - Meditations and Readings for Every Day of the Year selected from the writings of St Alphonsus Liguori - The Spiritual Combat by Father Dom Lorenzo Scupoli - True Devotion to the Blessed Virgin Mary by Saint Louis de Montfort The texts are available at the Religious Bookshelf. I am currently using the Meditations selected from St Al... περισσότερα »
Newborn screening for severe combined immune deficiency
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
(technical and political aspects). by Kobrynski, Lisa via Current Opinion in Allergy and Clinical Immunology - Published Ahead-of-Print Purpose of review: Newborn screening for severe combined immune deficiency (SCID) has been implemented in more than half of the states in the United States. Despite the success of these programs, numerous challenges remain for implementing newborn screening. The present review will focus on technical, programmatic, and political aspects pertinent to newborn screening for SCID. Recent findings: Recent data from newborn screening in 11 U.S. programs s...περισσότερα »
Oral immunotherapy in patients with cow's milk allergy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Clinical and laboratory 2-year outcome of Arnon Elizur, Michael Y Appel, Michael R Goldberg, Tamar Yichie, Michael B Levy, Liat Nachshon, Yitzhak Katz, 2015-10-21 09:47:40 AM Abstract Studies examining the long-term effect of oral immunotherapy in food-allergic patients are limited. We investigated cow's milk-allergic patients, >6 months after completion of oral immunotherapy (n=197). Questionnaires, skin-prick tests and basophil activation assays were performed. 180/195 (92.3%) patients contacted were consuming milk protein regularly. Half experienced adverse reactions, mostly mild.... περισσότερα »
IgE sensitization in house dust mite
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy by T. Batard, V. Baron-Bodo, A. Martelet, M. Le Mignon, P. Lemoine, K. Jain, S. Mariano, S. Horiot, H. Chabre, C. Harwanegg, C.A. Marquette, B.P. Corgier, W. T. Soh, P. Satitsuksanoa, A. Jacquet, F.T. Chew, E. Nony, P. Moingeon via Allergy Abstract Background Understanding patterns of IgE sensitization in *Dermatophagoides*-allergic patients living in various geographical areas is necessary to design a product suitable for worldwide allergen immunotherapy (AIT). Methods Using a ... περισσότερα »
Epstein-Barr virus (EBV)–induced lymphoproliferative disorders (LPDs)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
A Look Into the Evolution of Epstein-Barr Virus-Induced Lymphoproliferative Disorders: A Case StudyAmbrosio, M. R., Rocca, B. J., Ginori, A., Mourmouras, V., Amato, T., Vindigni, C., Lazzi, S., Leoncini, L., 2015-10-21 09:37:58 AM Objectives: Epstein-Barr virus (EBV)–induced lymphoproliferative disorders (LPDs) are lymphoid proliferations arising as a result of the loss of an effective EBV-specific cytotoxic T-cell response. LPDs may occur for primary or acquired impairment of the immune system, as well as in some persons without documented immunodeficiency. Methods: In this article,...περισσότερα »
Thyroid-Like Follicular Carcinoma of the Kidney
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
: One Case Report and Review of the LiteratureDawane, R., Grindstaff, A., Parwani, A. V., Brock, T., White, W. M., Nodit, L., 2015-10-21 09:37:58 AM Objectives: Thyroid-like follicular carcinoma of the kidney continues to confound the practicing pathologist with its close resemblance to the follicular variant of thyroid carcinoma, as well as other benign and malignant entities. Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistoc... περισσότερα »
High-sensitivity flow cytometric approach for systemic mastocytosis (SM)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
FLOCK Cluster Analysis of Mast Cell Event Clustering by High-Sensitivity Flow Cytometry Predicts Systemic MastocytosisDorfman, D. M., LaPlante, C. D., Pozdnyakova, O., Li, B., 2015-10-21 09:37:58 AM Objectives: In our high-sensitivity flow cytometric approach for systemic mastocytosis (SM), we identified mast cell event clustering as a new diagnostic criterion for the disease. Methods: To objectively characterize mast cell gated event distributions, we performed cluster analysis using FLOCK, a computational approach to identify cell subsets in multidimensional flow cytometry data in a... περισσότερα »
Primary cutaneous follicle center lymphoma (PCFCL)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Primary Cutaneous Follicle Center Lymphoma Associated With an Extracutaneous Dissemination: A Cytogenetic Finding of Potential Prognostic Value by Subramaniyam, S., Magro, C. M., Gogineni, S., Tam, W., Mathew, S. via American Journal of Clinical Pathology current issue Objectives:Cytogenetic studies on cutaneous lymphomas are rare, and very little is known about their prognostic value. We present a rare case of primary cutaneous follicle center lymphoma (PCFCL) with a complex translocation presenting with cutaneous and extracutaneous dissemination in the lymph node. Methods:Morpholog... περισσότερα »
Allergy
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 17 δευτερόλεπτα
- Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapyT. Batard, V. Baron-Bodo, A. Martelet, M. Le Mignon, P. Lemoine, K. Jain, S. Mariano, S. Horiot, H. Chabre, C. Harwanegg, C.A. Marquette, B.P. Corgier, W. T. Soh, P. Satitsuksanoa, A. Jacquet, F.T. Chew, E. Nony, P. Moingeon, 2015-10-21 09:47:40 AM Abstract Background Understanding patterns of IgE sensitization in *Dermatophagoides*-allergic patients living in various geographical areas is necessary to design a product suitable for worldwide ... περισσότερα »
Innovative Techniques General Reconstruction Aesthetic Plastic Surgery
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 25 δευτερόλεπτα
- Blepharoplasty Combined with Fat Grafting: A Treatment of Complications Following Polyacrylamide Hydrogel Injections in Tear Troughs2015-10-20 02:00:00 AM AbstractBackground Polyacrylamide hydrogel (PAAG) can cause serious complications during facial augmentation. Previous studies have reported complications following PAAG injections to correct tear troughs. Methods We report a rare case of tear trough deformity following PAAG injections. We developed a comprehensive treatment plan including transcutaneous blepharoplasty and fat grafting to address... περισσότερα »
American Journal of Clinical Pathology
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 27 δευτερόλεπτα
- Diagnostic EfficiencyJackson, B. R., 2015-10-21 09:37:58 AM Διαβάστε περισσότεραΑρχή - Advantages and Disadvantages of Technologies for HER2 Testing in Breast Cancer SpecimensFurrer, D., Sanschagrin, F., Jacob, S., Diorio, C., 2015-10-21 09:37:58 AM Objectives: Human epidermal growth factor receptor 2 (HER2) plays a central role as a prognostic and predictive marker in breast cancer specimens. Reliable HER2 evaluation is central to determine the eligibility of patients with breast cancer to targeted anti-HER2 therapies such as trastuzumab and lapat... περισσότερα »
Neurogastroenterology & Motility
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
- X-ray analysis of gastrointestinal motility in conscious mice. Effects of morphine and comparison with ratsR. Girón, I. Pérez-García, R. Abalo, 2015-10-21 08:26:08 AM Abstract Background Non-invasive methods to study gastrointestinal (GI) motility are of high interest, particularly in chronic studies. Amongst these, radiographic techniques after contrast intragastric administration may offer many advantages. In previous studies, we have successfully and reproducibly applied these techniques together with a semiquantitative analysis method to chara... περισσότερα »
Melanoma Research
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 51 δευτερόλεπτα
Melanoma Research - Published Ahead-of-Print - Robotic radiosurgery for the treatment of medium and large uveal melanoma.Eibl-Lindner, Kirsten; Fürweger, Christoph; Nentwich, Martin; Foerster, Paul; Wowra, Berndt; Schaller, Ulrich; Muacevic, Alexander, 2015-10-19 07:00:00 AM The aim of the study was to analyze the local efficacy and eye retention rate after frameless, image-guided robotic radiosurgery against uveal melanoma. A total of 217 patients, mostly with medium and large unilateral uveal melanomas (3% small, 62% medium, and 35% large) were treated. The ... περισσότερα »
Robotic radiosurgery for the treatment of medium and large uveal melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Robotic radiosurgery for the treatment of medium and large uveal melanoma. by Eibl-Lindner, Kirsten; Fürweger, Christoph; Nentwich, Martin; Foerster, Paul; Wowra, Berndt; Schaller, Ulrich; Muacevic, Alexander via Melanoma Research - Published Ahead-of-Print The aim of the study was to analyze the local efficacy and eye retention rate after frameless, image-guided robotic radiosurgery against uveal melanoma. A total of 217 patients, mostly with medium and large unilateral uveal melanomas (3% small, 62% medium, and 35% large) were treated. The median age was 64 years (range 21-95 years)...περισσότερα »
Current Otorhinolaryngology Reports.Endoscopic Ear Surgery (D. Pothier, Section Editor)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
- Endoscopic Middle Ear Anatomy2015-10-20 02:00:00 AM Abstract The anatomy of the middle ear is very complex. The otologist must have a good knowledge of the structures comprising the tympanic cavity; a clear view of all the subsites of this region is essential to ensure the complete removal of all pathology. The development of endoscopic techniques to access the middle ear has offered the possibility to “look around corners” and explore hidden recesses the microscope cannot reach. Moreover, by leading to a better understanding of the different ventilation... περισσότερα »
Habitual daytime napping and prevalence of diabetes
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Sex difference in the association between habitual daytime napping and prevalence of diabetes: a population-based study via International journal of basic and clinical endocrinology AbstractOur objective was to evaluate the associations between habitual daytime napping and diabetes and whether it varies by sex, menopause, and sleep quality. We conducted a population-based cross-sectional study in 8621 eligible individuals aged 40 years or older. Information on daytime napping hours, night-time sleep duration, history of menstruation, and sleep quality was self-reported. Diabetes was d...περισσότερα »
Compensatory Mechanisms in Patients After a Partial or Total Glossectomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
due to Oral Cancer via Dysphagia AbstractExcision of a part or the whole of tongue due to oral cancer disturbs swallowing and speech. Lower airways aspiration of the swallowed bolus in patients after such oral structures excision is a symptom of major swallowing disorder and may be the cause of aspiration pneumonia. Restoration of oral nutrition is possible after exclusion or reduction of aspiration threat in the patients. Video fluoroscopic evaluation of the swallowing performed at the beginning of the swallowing rehabilitation in 95 patients after a total or partial glossectomy du... περισσότερα »
New Swallowing Evaluation Using Piezoelectricity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
in Normal Individuals via Dysphagia AbstractThis study aimed to elucidate the relationship between the piezoelectric waveform latency, hyoid bone movement, surface electromyogram (sEMG), and the pharyngeal transit time (PTT) during swallowing. Forty-one healthy subjects were divided into three age groups: younger (20–39 years, *n* = 8), middle-aged (40–59 years, *n* = 9), and older (60–79 years, *n* = 24). Motion analysis of the hyoid bone using videofluorography (VF), waveform analysis of the front neck using piezoelectric films, and sEMG of the suprahyoid muscle group were perform...περισσότερα »
Electromyography of Swallowing with Fine Wire Intramuscular Electrodes
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
in Healthy Human: Amplitude Difference of Selected Hyoid Muscles via Dysphagia AbstractFew studies have examined the intensity of muscle activity during swallowing in healthy humans. We examined selected hyoid muscles using fine wire intramuscular electromyography (EMG) during swallowing of four food consistencies. Thirteen healthy adults were studied using videofluorography and EMG of the anterior belly of digastric (ABD), geniohyoid (GH), sternohyoid (SH), and masseter (MA; surface electrodes) while ingesting thin liquid (three trials) and solid food of three consistencies (banana,...περισσότερα »
Prophylactic Percutaneous Gastrostomy Placement
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Usefulness of Prophylactic Percutaneous Gastrostomy Placement in Patients with Head and Neck Cancer Treated with Chemoradiotherapy via Dysphagia AbstractChemoradiotherapy (CRT) has evolved as the preferred organ preservation strategy in the treatment of locally advanced head and neck cancer (HNC). This approach increases malnutrition, and thus, establishing a direct enteral feeding route is essential. To evaluate the usefulness of prophylactic percutaneous endoscopic gastrostomy (PEG) in HNC patients receiving definitive CRT, we performed a prospective evaluation of HNC patients over...περισσότερα »
Lung : Intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC2015-10-05 02:00:00 AM AbstractAim The potential of intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT) is analyzed for two different concepts of fluorodeoxyglucose positron emission tomography (FDG PET)-based target volume delineation in* locally advanced non-small cell lung cancer (LA-NSCLC): involved-field radiotherapy (IF-RT) vs. elective nodal irradiation (ENI).* Methods Treatment planning was performed for 41 patients wit...περισσότερα »
HN-BCCs : Hedgehog pathway inhibitor in combination with radiation therapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Hedgehog pathway inhibitor in combination with radiation therapy for basal cell carcinomas of the head and neck2015-10-08 02:00:00 AM AbstractBackground Definitive radiotherapy and vismodegib, an oral inhibitor of the hedgehog pathway, are both established treatment options for locally advanced basal cell carcinomas (BCC). Both have shown good results in local tumor control; however, the effects concerning advanced tumors are often not of a lasting nature and to date no systematic data about the combination of the two modalities are available. Patients and methods We retrospectively a... περισσότερα »
Tomotherapy PET-guided dose escalation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Tomotherapy PET-guided dose escalation2015-10-09 02:00:00 AM AbstractAim The aim of this study was to investigate whether a safe escalation of the dose to the pleural cavity and PET/CT-positive areas in patients with unresectable malignant pleural mesothelioma (MPM) is possible using helical tomotherapy (HT). Material and methods We selected 12 patients with MPM. Three planning strategies were investigated. In the first strategy (standard treatment), treated comprised a prescribed median dose to the planning target volume (PTV) boost (PTV1) of 64.5 Gy (range: 56 Gy/28 fractions to 66 ...περισσότερα »
Sequential (SeqB) versus simultaneous integrated boost (SIB) radiotherapy plans delivered with volumetric modulated arc therapy (VMAT) for patients with locally advanced squamous cell cancer of the head and neck (HNSCC)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Comparative treatment planning study on sequential vs. simultaneous integrated boost in head and neck cancer patients2015-10-13 02:00:00 AM AbstractAim The purpose of this work was to compare sequential (SeqB) versus simultaneous integrated boost (SIB) radiotherapy plans delivered with volumetric modulated arc therapy (VMAT) for patients with locally advanced squamous cell cancer of the head and neck (HNSCC). Patients and methods SeqB and SIB plans using VMAT for 10 HNSCC patients given definitive chemoradiation were generated and analysed for differences in dose distribution, coverag... περισσότερα »
Dysphagia
Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
*Usefulness of Prophylactic Percutaneous Gastrostomy Placement in Patients with Head and Neck Cancer Treated with Chemoradiotherapy* *Chemoradiotherapy (CRT) has evolved as the preferred organ preservation strategy in the treatment of locally advanced head and neck cancer (HNC). This approach increases malnutrition, and thus, establishing a direct enteral feeding route is essential. To evaluate the usefulness of prophylactic percutaneous endoscopic gastrostomy (PEG) in HNC patients receiving definitive CRT, we performed a prospective evaluation of HNC patients over a 6-month period...περισσότερα »
Strahlentherapie und Onkologie Journal of Radiation Oncology, Biology, Physics
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
- Undetected human papillomavirus DNA and uterine cervical carcinoma2015-10-20 02:00:00 AM AbstractBackground The time course of human papillomavirus (HPV) DNA clearance was studied in patients with carcinoma of the cervix during follow-up after primary radical radiotherapy (RT). This study investigated the relationship between timing of HPV clearance and RT effectiveness. Patients and methods A total of 71 consecutive patients who were treated for cervical cancer with primary radical radiotherapy and high-dose rate intracavitary brachytherapy with o... περισσότερα »
Neuro-Oncology
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Neuro-Oncology - Advance Access - Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor ConsortiumPoussaint, T. Y., Vajapeyam, S., Ricci, K. I., Panigrahy, A., Kocak, M., Kun, L. E., Boyett, J. M., Pollack, I. F., Fouladi, M., 2015-10-21 08:40:12 AM Background Diffuse intrinsic pontine glioma (DIPG) is associated with poor survival regardless of therapy. We used volumetric apparent diffusion coefficient (ADC) histogram metrics to determine associations with progr... περισσότερα »
Cephalalgia
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Cephalalgia -- Preview Articles - Corrigendum2015-10-21 08:14:16 AM Διαβάστε περισσότεραΑρχή - Percutaneous nerve field stimulation (PENS) of the occipital region as a possible predictor for occipital nerve stimulation (ONS) responsiveness in refractory headache disorders? A feasibility studyKinfe, T., Pintea, B., Roeske, S., Güresir, A., Güresir, E., Vatter, H., 2015-10-21 08:14:16 AM Background Occipital nerve stimulation (ONS) has been reported to diminish pain levels in intractable chronic headache syndromes of different origin. No ... περισσότερα »
Diffuse intrinsic pontine glioma (DIPG)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium by Poussaint, T. Y., Vajapeyam, S., Ricci, K. I., Panigrahy, A., Kocak, M., Kun, L. E., Boyett, J. M., Pollack, I. F., Fouladi, M. viaNeuro-Oncology - Advance Access BackgroundDiffuse intrinsic pontine glioma (DIPG) is associated with poor survival regardless of therapy. We used volumetric apparent diffusion coefficient (ADC) histogram metrics to determine associations with progression-free survival (PFS) and overall survival... περισσότερα »
Auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve (ABVN) on burn-induced gastric dysmotility
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in ratsH. Li, J. Yin, Z. Zhang, J. H. Winston, X.-Z. Shi, J. D. Z. Chen, 2015-10-21 08:26:08 AM Abstract Background Severe burn injury has been demonstrated to delay gastric emptying. The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced gastric dysmotility in rats. Methods Propranolol (*β*-adrenoceptor antagonist) was injected intraperiton... περισσότερα »
Chemical Senses
Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα
Chemical Senses - Advance Access - Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES)Rawal, S., Hoffman, H. J., Bainbridge, K. E., Huedo-Medina, T. B., Duffy, V. B., 2015-10-21 07:52:23 AM Chemosensory problems challenge health through diminished ability to detect warning odors, consume a healthy diet, and maintain quality of life. We examined the prevalence and associated risk factors of self-reported chemosensory alterations in 3603 community-dwelli... περισσότερα »
Mucoepidermoid carcinoma (MEC) : Hypomethylation of CLIC3 as a common alteration
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alterationZhiming Wang, Shizhang Ling, Eleni Rettig, Ryan Sobel, Marietta Tan, Elana J. Fertig, Michael Considine, Adel K. El-Naggar, Mariana Brait, Carole Fakhry, Patrick K. Ha, 2015-10-21 08:21:52 AM Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland malignancy in adults and children [1]. MECs arise more commonly in the parotid than the minor salivary glands, wherein the soft and hard palate are the main sites of involvement [2]. MEC is comprised of 3 m...περισσότερα »
Oral Oncology
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
- A meta-analysis on selective versus comprehensive neck dissection in oral squamous cell carcinoma patients with clinically node-positive neckLizhong Liang, Tonghan Zhang, Qianying Kong, Jun Liang, Guiqing Liao, 2015-10-21 08:21:52 AM Cervical lymph node metastases has been well recognized as one of the most important prognostic factors for patients with oral squamous cell carcinoma (OSCC) [1,2]. Pathologically positive lymph node metastasis has occurred in about half of the OSCC patients at the time of diagnosis [3]. Studies have found that positive nodes in the ne... περισσότερα »
Relapsed Graves' Disease Patients Following Radioiodine or Prolonged Low Dose of Methimazole Treatment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Outcomes in by Danilo Villagelin via liebertpub1 Thyroid , Vol. 0, No. 0. Author information Danilo Villagelin,1,2 João H. Romaldini,1,3 Roberto B. Santos,1 Ana B.B.P. Milkos,3 and Laura S. Ward2 1Endocrinology and Metabolism, School of Medicine, Pontifical University Catholic of Campinas, Campinas, Brazil. 2Laboratory of Cancer Molecular Genetics, School of Medicine Sciences, University of Campinas (UNICAMP), Campinas, Brazil. 3Endocrinology, Hospital Servidor Público Estado de São Paulo, IAMSPE, São Paulo, Brazil. Address correspondence to: *Danilo Villagelin, MD* *Pontifícia Univer...περισσότερα »
Selective versus comprehensive neck dissection in OSCC patients with clinically node-positive neck
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A meta-analysis on by Lizhong Liang, Tonghan Zhang, Qianying Kong, Jun Liang, Guiqing Liao via Oral Oncology - Articles in Press Cervical lymph node metastases has been well recognized as one of the most important prognostic factors for patients with oral squamous cell carcinoma (OSCC) [1,2]. Pathologically positive lymph node metastasis has occurred in about half of the OSCC patients at the time of diagnosis [3]. Studies have found that positive nodes in the neck means survival rates decrease by 50% [4]. Moreover, recent studies showed that high lymph node density strongly indicate...περισσότερα »
Hypoxia triggers high-altitude headache with migraine features
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
: A prospective trialBroessner, G., Rohregger, J., Wille, M., Lackner, P., Ndayisaba, J.-P., Burtscher, M., 2015-10-21 08:14:16 AM Background Given the high prevalence and clinical impact of high-altitude headache (HAH), a better understanding of risk factors and headache characteristics may give new insights into the understanding of hypoxia being a trigger for HAH or even migraine attacks. Methods In this prospective trial, we simulated high altitude (4500 m) by controlled normobaric hypoxia (FiO2 = 12.6%) to investigate acute mountain sickness (AMS) and headache characteristics. Cl...περισσότερα »
Nurses improve migraine management in primary care
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Nurses improve migraine management in primary careVeenstra, P., Kollen, B. J., de Jong, G., Baarveld, F., van den Berg, J. P., 2015-10-21 08:14:16 AM Introduction Migraine is a common disorder with a high burden. Adequate treatment results in improvement of quality of life. Migraine patients are mainly treated by general practitioners (GPs), but there is still room for improvement. This study investigated whether primary care nurses could improve the treatment of migraine patients compared to usual care as provided by the GPs. Participants and methods We conducted a non-randomized con...περισσότερα »
Occipital nerve stimulation (ONS) responsiveness in refractory headache disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Percutaneous nerve field stimulation (PENS) of the occipital region as a possible predictor for occipital nerve stimulation (ONS) responsiveness in refractory headache disorders? A feasibility study by Kinfe, T., Pintea, B., Roeske, S., Güresir, A., Güresir, E., Vatter, H. via Cephalalgia -- Preview Articles BackgroundOccipital nerve stimulation (ONS) has been reported to diminish pain levels in intractable chronic headache syndromes of different origin. No reliable objective markers exist to predict ONS responsiveness. This study investigated the predictive value of occipital percu... περισσότερα »
Neglecting the soft triangle area might yield grim results in terms of cosmetic and functional aspects
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The Soft Triangle: An Often Neglected Area in Rhinoplasty2015-10-01 02:00:00 AM AbstractBackground This study aims to focus on one of the lesser mentioned topics in discussions of aesthetic nose operations, the soft triangle. In addition to outlining the characteristics of the area, the various complications specific to the soft triangle are discussed along with methods and techniques utilized by the authors to avoid such complications. Methods One hundred twenty-seven of 841 (15 %) patients who were assessed both preoperatively and intraoperatively for the presence of an anatomical i... περισσότερα »
A simple and versatile protocol of chin microgenia aims to simplify the therapeutic indications for a predictable and a stable long-term aesthetic result
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Chin Microgenia: A Clinical Comparative Study2015-10-01 02:00:00 AM AbstractBackground The aesthetic relevance of the chin and its relatively simple correction through different approaches make genioplasty one of the most performed aesthetic procedures of the face. Sliding genioplasty is extremely rewarding, particularly when performed as an adjunction to rhinoplasty, rhytidectomy, or jaw surgery. In the scientific literature, many different surgical techniques are described, but the biological implications and the economical impact can shape the surgeon’s decision on which can be the...περισσότερα »
Salvia miltiorrhiza Enhances Survival Rate of Autologous Adipose Tissue Transplantation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Traditional Chinese Medicine: Salvia miltiorrhiza Enhances Survival Rate of Autologous Adipose Tissue Transplantation in Rabbit Model2015-10-07 02:00:00 AM [image: Salviamiltiorrhiza.jpg]Objective This study aimed to explore the influence of traditional Chinese medicines: *Salvia miltiorrhiza* on the survival of auto-transplantation of adipose tissue in a rabbit model. Methods Minced adipose tissue harvested from the scapular region was transplanted into the dorsum of the ears of New Zealand rabbits. The experimental groups were intra-peritoneally injected with *S. miltiorrhiza* for a... περισσότερα »
O.R.L. Journal for oto-rhino-laryngology and its borderlands
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
ORL - Application of the Mimic Valsalva Maneuver with the Help of a Saccule in Cerebrospinal Fluid Rhinorrhea Reconstruction Surgery2015-10-21 08:04:57 AM *Objective:* To explore the mimic Valsalva maneuver with the help of a saccule handled by an anesthesiologist in order to locate the leakage channel and repair the fistula during intranasal endoscopic reconstruction surgery of cerebrospinal fluid rhinorrhea. *Methods:* From 2012 to 2014, 8 patients were diagnosed with cerebrospinal fluid rhinorrhea by medical histories, physical and biochemical examinati... περισσότερα »
Cerebrospinal Fluid Rhinorrhea Reconstruction Surgery : Application of the Mimic Valsalva Maneuver with the Help of a Saccule
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Application of the Mimic Valsalva Maneuver with the Help of a Saccule in Cerebrospinal Fluid Rhinorrhea Reconstruction Surgery via O.R.L. Journal for oto-rhino-laryngology and its borderlands *Objective:* To explore the mimic Valsalva maneuver with the help of a saccule handled by an anesthesiologist in order to locate the leakage channel and repair the fistula during intranasal endoscopic reconstruction surgery of cerebrospinal fluid rhinorrhea. *Methods:* From 2012 to 2014, 8 patients were diagnosed with cerebrospinal fluid rhinorrhea by medical histories, physical and biochemical e... περισσότερα »
The factors affecting early wound complications after tympanoplasty for chronic otitis media
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
*Article in Press* Factors associated with prolonged duration of post-tympanoplasty local treatment in adult chronic otitis media patients: A retrospective observational study using a Japanese inpatient database *Received: July 17, 2015; Accepted: September 8, 2015; Published Online: October 08, 2015* *Sayaka Suzuki[image: correspondence][image: email], Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Tatsuya Yamasoba* *Auris Nasus Larynx* *DOI: http://dx.doi.org/10.1016/j.anl.2015.09.006* *Publication stage: In Press Corrected Proof* AbstractObjective *The occurrence of persistent inf... περισσότερα »
Auris Nasus Larynx
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
*Article in Press* Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis *Received: May 15, 2015; Accepted: September 8, 2015; Published Online: October 20, 2015* *Masafumi Yonezaki, Kosuke Akiyama[image: correspondence][image: email], Masayuki Karaki, Rieko Goto, Rhyuhei Inamoto, Yasushi Samukawa, Ryuichi Kobayashi, Eiji Kobayashi, Hiroshi Hoshikawa* *Auris Nasus Larynx* *DOI: http://dx.doi.org/10.1016/j.anl.2015.09.003* *Publication stage: In Press Corrected Proof* AbstractObjective *Intranasal cort...περισσότερα »
Auris Nasus Larynx
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
- Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitisMasafumi Yonezaki, Kosuke Akiyama, Masayuki Karaki, Rieko Goto, Rhyuhei Inamoto, Yasushi Samukawa, Ryuichi Kobayashi, Eiji Kobayashi, Hiroshi Hoshikawa, 2015-10-21 07:56:46 AM Intranasal corticosteroid sprays (INCSs) are commonly used for therapy of allergic rhinitis (AR). Adherence to regular use of INCSs is influenced by patient perception and preferences of products. The study objective was to compare perceived sensory at... περισσότερα »
Fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Preference evaluation and perceived sensory comparison of by Masafumi Yonezaki, Kosuke Akiyama, Masayuki Karaki, Rieko Goto, Rhyuhei Inamoto, Yasushi Samukawa, Ryuichi Kobayashi, Eiji Kobayashi, Hiroshi Hoshikawa via Auris Nasus Larynx AbstractObjective Intranasal corticosteroid sprays (INCSs) are commonly used for therapy of allergic rhinitis (AR). Adherence to regular use of INCSs is influenced by patient perception and preferences of products. The study objective was to compare perceived sensory attributes of fluticasone furoate nasal spray (FFNS) and mometasone furoate nasal spra...περισσότερα »
Self-Reported Smell and Taste Alterations
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES) by Rawal, S., Hoffman, H. J., Bainbridge, K. E., Huedo-Medina, T. B., Duffy, V. B. via Chemical Senses Chemosensory problems challenge health through diminished ability to detect warning odors, consume a healthy diet, and maintain quality of life. We examined the prevalence and associated risk factors of self-reported chemosensory alterations in 3603 community-dwelling adults (aged 40+ years), from the nationally representat...περισσότερα »
Double Lateral Flap: A New Technique for Lower Eyelid Reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Alternative to the Tenzel Procedure via Latest Results for Aesthetic Plastic Surgery AbstractBackgroundThe final esthetic result is a common concern of patients with eyelid tumors, especially young patients and those with tumors affecting the medial edge of the lower eyelid. MethodsThe procedure herein described combines two lateral flaps: one tarsoconjunctival and the other from the periosteum. The first step is removal of the tumor lesion. Preseptal dissection is then performed through a subciliary incision on both the lateral and medial halves of the eyelid up to the orbital rim. ... περισσότερα »
The Public Perception of the Scope of Plastic Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Aesthetic Surgery Reality Television Shows: Do they Influence Public Perception of the Scope of Plastic Surgery? via Latest Results for Aesthetic Plastic Surgery AbstractBackgroundThe purpose of this survey was to assess the influence of aesthetic surgery “reality television” shows viewing on the public’s perception of the scope of plastic surgery practice. MethodsPerceptions of the scope of plastic surgery (33 scenarios), aesthetic surgery “reality television” viewing patterns (“high,” “moderate,” or “low” familiarity, similarity, confidence, and influence viewers), sociodemographic ... περισσότερα »
A modified distal onlay dorsal graft, a modified columella strut, and bilateral caudal septal sliver grafts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
The Multi-Lock System for Rhinoplasty via Latest Results for Aesthetic Plastic Surgery AbstractBackgroundAmong the greatest challenges in rhinoplasty are setting the nasal tip contour and projection, and avoiding excessive upward rotation of the nose. Many suture and graft fixation techniques have attempted to achieve this result but may still produce results lacking in refinement. This study aims to describe in detail a new approach to stabilize the nasal tip for a durable and more predictable result. MethodsTwenty-eight surgeries were performed by the author, following a standardize... περισσότερα »
Sexuality in Aesthetic Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Sexuality in Aesthetic Breast Surgery via Latest Results for Aesthetic Plastic Surgery AbstractBackgroundThe breasts are important for a woman’s psychological well-being, which may be negatively affected by distortions of breast size and shape. Improvements in self-esteem and sexuality are important psychological factors associated with motivation for cosmetic surgery. Mammaplasty is among the most sought-after and performed cosmetic procedures. The aim of this study was to evaluate the impact of aesthetic breast surgery on a woman’s sexuality. MethodsThis study was conducted in a pla...περισσότερα »
Blepharoplasty Combined with Fat Grafting.Polyacrylamide hydrogel (PAAG) can cause serious complications during facial augmentation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
: A Treatment of Complications Following Polyacrylamide Hydrogel Injections in Tear Troughs via Latest Results for Aesthetic Plastic Surgery AbstractBackgroundPolyacrylamide hydrogel (PAAG) can cause serious complications during facial augmentation. Previous studies have reported complications following PAAG injections to correct tear troughs. MethodsWe report a rare case of tear trough deformity following PAAG injections. We developed a comprehensive treatment plan including transcutaneous blepharoplasty and fat grafting to address the presenting complications. ResultsThe patient sho... περισσότερα »
Flap Failure and Wound Complications
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
in Autologous Breast Reconstruction: A National Perspective via Latest Results for Aesthetic Plastic Surgery AbstractPurposeThere are many options for breast reconstruction following a mastectomy, and data on outcomes are greatly needed for both the patient and the care provider. This study aims to identify the prevalence and predictors of adverse outcomes in autologous breast reconstruction in order to better inform patients and surgeons when choosing a surgical technique. MethodsThis study retrospectively reviewed the American College of Surgeons National Surgical Quality Improvemen... περισσότερα »
Lenvatinib in Advanced, Radioactive Iodine-Refractory, DTC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
Lenvatinib in Advanced, Radioactive Iodine-Refractory, Differentiated Thyroid Carcinoma by Yeung, K. T., Cohen, E. E. W. via Clinical Cancer Research Online First Articles Management options are limited for patients with radioactive iodine (RAI) refractory, locally advanced or metastatic differentiated thyroid carcinoma (DTC). Prior to 2015, sorafenib, a multi-targeted tyrosine kinase inhibitor, was the only approved treatment and was associated with a median progression free survival (PFS) of 11 months and overall response rate (ORR) of 12% in a phase 3 trial. Lenvatinib, a multi-ki... περισσότερα »
Microbiology
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 12 ώρες
[image: feedamail.com] Microbiology via ola Kala on Inoreader (Sponsor this newsletter) Biogeographical distribution of Rimicaris exoculata resident gut epibiont communities along the Mid-Atlantic Ridge hydrothermal vent sites *Rimicaris exoculata* is a deep-sea hydrothermal vent shrimp whose enlarged gill chamber houses a complex trophic epibiotic community. Its gut harbours an autochthonous and distinct microbial community. This species dominates hydrothermal ecosystem megafauna along the Mid-Atlantic Ridge, regardless of contrasting geochemical conditions prevailing in them. ... περισσότερα »
Inter-patient variability in docetaxel pharmacokinetics: A review.
Alexandros G. SfakianakisστοHead and NeckΠριν από 15 ώρες
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Nieuweboer AJ, de Morrée ES, de Graan AJ, Sparreboom A, de Wit R, Mathijssen RH Abstract Docetaxel is a frequently used chemotherapeutic agent in the treatment of solid cancers. Because of the large inter-individual variability (IIV) in the pharmacokinetics (PK) of docetaxel, it is challenging to determine the optimal dose in individual patients in order to achieve optimal efficacy and acceptable toxicity. Despite the established correlation between systemic docetaxel exposure and efficacy, the precise factors influencing... περισσότερα »
Head and Neck Diseases
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 15 ώρες
36m Head and Neck Inter-patient variability in docetaxel pharmacokinetics: A review. Authors: Nieuweboer AJ, de Morrée ES, de Graan AJ, Sparreboom A, de Wit R, Mathijssen RHAbstract Docetaxel is a frequently used chemotherapeutic agent in the treatment of solid cancers. Because of the large inter-individual variability (IIV) in the pharmacokinetics (PK) of docetaxel, it is challenging... 36m Head and Neck The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors. Authors: Zhao J, Du F, Luo Y, Shen G, Zheng F, Xu BAbstract The hypoxic condit...περισσότερα »
OtoRhinoLaryngology New Articles,October 20th,2015
Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 16 ώρες
A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. *Alexandros G. SfakianakisστοHead and NeckΠριν από 8 δευτερόλεπτα* *[image: http:--www.bioone.org-userimages-Content] Authors: Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M Abstract Radiation-induced heart disease (RIHD) is a common and sometimes severe late side effect of radiation therapy for intrathoracic and chest wall tumors. We have previously shown that...περισσότερα »
The Use of X Rays in the Treatment of Bronchial Asthma
Alexandros G. SfakianakisστοHead and NeckΠριν από 16 ώρες
*The Use of X Rays in the Treatment of Bronchial Asthma: A Historical Assessment.* Radiat Res. 2015 Authors: Calabrese EJ, Dhawan G, Kapoor R Abstract This article provides a historical assessment of the role of X-ray therapy in the treatment of bronchial asthma. This analysis revealed that X-ray therapy in the treatment of bronchial asthma spanned the first six decades of the 20th century, and involved nearly 6,000 patients in published clinical case studies. Patients selected typically had at least moderate to severe asthma and were refractory to other commonly employed treatmen... περισσότερα »
Acute Effects of Exposure to (56)Fe and (16)O Particles on Learning and Memory.
Alexandros G. SfakianakisστοHead and NeckΠριν από 16 ώρες
Radiat Res. 2015 Authors: Rabin BM, Poulose SM, Carrihill-Knoll KL, Ramirez F, Bielinski DF, Heroux N, Shukitt-Hale B Abstract Although it has been shown that exposure to HZE particles disrupts cognitive performance when tested 2-4 weeks after irradiation, it has not been determined whether exposure to HZE particles acutely affects cognitive performance, i.e., within 4-48 h after exposure. The current experiments were designed to determine the acute effects of exposure to HZE particles ((16)O and (56)Fe) on cognitive performance and whether exposure to HZE particles affected learn... περισσότερα »
A Single Low Dose of Proton Radiation Induces Long-Term Behavioral and Electrophysiological Changes in Mice.
Alexandros G. SfakianakisστοHead and NeckΠριν από 16 ώρες
Radiat Res. 2015 Authors: Bellone JA, Rudobeck E, Hartman RE, Szücs A, Vlkolinský R Abstract Astronauts traveling outside Earth's magnetosphere risk exposure to charged particle radiation that may cause neurophysiological changes and behavioral deficits. Although proton particles comprise a large portion of the space radiation environment, little has been published on the effects of low-dose proton radiation on central nervous system function. In the current study, we irradiated young male mice with 0.5 Gy 150 MeV protons and assessed the effects on behavior and hippocampal neuroph...περισσότερα »
