Penicillium chrysogenum DSOA associated with marine sponge (Tedania anhelans) exhibit antimycobacterial activity

Publication date: Available online 23 November 2015
Source:Microbiological Research
Author(s): Visamsetti Amarendra, Ramachandran Sarojini Santhosh, Kandasamy Dhevendaran
A strain of Penicillium chrysogenum was isolated from Tedania anhelans (marine sponge) collected from Indian Ocean (8° 22′ 30″ N latitude and 76° 59′ 16″ longitude) and deposited in culture collection centers. The strain subjected to different culture conditions for production of extrolites were extracted using ethyl acetate and chloroform. When both extracts were subjected for antibacterial activity, latter had high activity. Minimum inhibitory concentration of chloroform extract ranged from 31.25-1000μg/mL in tested microbes such as, Mycobacterium tuberculosis H37Ra, Mycobacterium avium, Mycobacterium fortuitum, Mycobacterium smegmatis, Mycobacterium vaccae, Staphylococcus aureus, Aeromonas hydrophila, Pseudomonas aeruginosa and Vibrio cholerae. No cytotoxicity was observed in Vero cell line up to 399.10μg/mL. Antibacterial activity previously reported by Parameswaran et al. in 1997 from ethyl acetate extract of T. anhelans might be due to the diketopiperazines, Cyclo-(L-Pro-L-Phe) and Cyclo-(L-Leu-L-Pro) produced by the associated fungi-Penicillium chrysogenum DSOA. It is producing a metabolites having antimycobacterial activity, a first report.



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A lacZ Reporter-Based Strategy for Rapid Expression Analysis and Target Validation of Mycobacterium tuberculosis Latent Infection Genes

Abstract

We report a novel lacZ fusion vector and demonstrate its utility for expression analysis of genes associated with Mycobacterium tuberculosis latent infection. The vector contains E. coli (oriE) and mycobacterial (oriM) origins of replication, a kanamycin resistance gene (Km^r) as selection marker, and a lacZ reporter gene in fusion with MCS for cloning of upstream regulatory sequence of the desired genes. β-galactosidase activity of the vector was standardized for expression analysis under latent mycobacterial conditions using Phsp60, a constitutive mycobacterial promoter, utilizing Mycobacterium smegmatis as model organism. Validation of the vector was done by cloning and expression analysis of PhspX (alpha crystalline) and Picl (isocitrate lyase), promoters from two of the genes shown to be involved in M. tuberculosis persistence. Both genes showed appreciable levels of β-galactosidase expression under hypoxia-induced persistent conditions in comparison to their actively replicating state. Expression analysis of a set of hypothetical genes was also done, of which Rv0628c showed increased expression under persistent conditions. The reported fusion vector and the strategy can be effectively used for short listing and validation of drug targets deduced from various non-conclusive approaches such as bioinformatics and microarray analysis against latent/persistent form of mycobacterial infection.

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Secretome Analysis of Metarhizium anisopliae Under Submerged Conditions Using Bombyx mori Chrysalis to Induce Expression of Virulence-Related Proteins

Abstract

The entomopathogenic fungus Metarhizium anisopliae is used to control insect pests. This species is specialized for the secretion of an enzymatic complex consisting of proteases, lipases, and chitinases related to pathogenicity and virulence. In this context, the secretomes of strains IBCB 167 and IBCB 384 of M. anisopliae var. anisopliae, grown under submerged fermentation in the presence of chrysalis as an inducer, were analyzed. Analysis of two-dimensional gels showed qualitative and quantitative differences between secreted proteins in both isolates. Around 102 protein spots were analyzed, and 76 % of the corresponding proteins identified by mass spectrometry were grouped into different classes (hydrolases, oxidases, reductases, isomerases, kinases, WSC domains, and hypothetical proteins). Thirty-three per cent of all the proteins analyzed were found to be common in both strains. Several virulence-related proteins were identified as proteases and mannosidases. Endo-N-acetyl-β-d-glucosaminidase expression was observed to be 10.14-fold higher for strain IBCB 384 than for strain IBCB 167, which may be an important contributor to the high virulence of IBCB 384 in Diatraea ssaccharalis. These results are important for elucidation of the host-pathogen relationship and the differences in virulence observed between the two strains.

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Muddy clinical waters: a missed betel nut in the bronchus

A toddler presented with a 5-month history of recurrent episodes of cough, wheezing and fever. Before referral, the toddler had been initially diagnosed as having bronchial asthma and later as having pulmonary tuberculosis. On examination, the patient was febrile and had severe respiratory distress. Chest radiograph and high-resolution CT of the chest revealed collapse of the entire left lung with diffuse bronchiectasis along with a grossly hyperinflated right lung. CT virtual bronchoscopy did not reveal any foreign body. The parents denied any history suggestive of foreign body aspiration and refused consent for rigid bronchoscopy. Nine days after admission, chest physiotherapy was inadvertently prescribed to the patient. Within an hour, the patient experienced acute respiratory deterioration and died. Autopsy revealed a piece of betel nut in the right main bronchus; it had got dislodged from its initial site in the left main bronchus following the chest physiotherapy session.

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Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome

10.3109/23744235.2015.1113557<br/>Anu Laulajainen-Hongisto

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Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults.

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There is still time to submit to our ‘Single-Cell Omics’ Special Issue

Submit a Manuscript Editorial Board Author Instructions Article Alerts Dear Colleague, With only a month to go until close of submissions, we would like to remind you that Genome Biology is accepting submissions for a special issue on Single-Cell Omics which is planned for the first half of 2016. The special issue, guest edited by Sten Linnarsson and Sarah Teichmann, will also include commissioned Reviews and Opinions on timely topics, written by leaders in the field. Single-Cell Omics Advances in single-cell approaches are now enabling us to study differences between individual cells, cell types and subpopulations, at the level of the genome, transcriptome and epigenome. Single-cell technologies are being used to study diverse areas of biology and disease, such as development, microbial population composition, and cancer evolution. For more information visit our website. We will consider Research, Method, and Software manuscripts using single-cell approaches or advancing the underlying technologies, including but not limited to: Uses of single-cell approaches to study all areas of biology Disease-related applications of single-cell approaches Advances in single-cell technologies for studying genomes, transcriptomes and epigenomes Methods for analyzing single-cell data Don't miss out - deadline for submissions is 31st December 2015 Please use the online submission system, and indicate in your covering letter that you would like the manuscript to be considered for the 'Single-Cell Omics' special issue. If you would like to inquire about the suitability of a manuscript for consideration, please email a pre-submission inquiry to editorial@genomebiology.com. Kind regards, Barbara Cheifet Special Issue Editor Louisa Flintoft Editor

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A dual injury of the shoulder: acromioclavicular joint dislocation (type IV) coupled with ipsilateral mid-shaft clavicle fracture

A direct blow to the shoulder, as may be sustained in a road traffic accident (RTA), can result in various combinations of fracture dislocations in the shoulder joint complex. Among these, a rare variety is an acromioclavicular joint (ACJ) dislocation coupled with ipsilateral mid-shaft clavicle fracture. Diverse treatment options have been described in the literature, ranging from non-operative and operative, to hybrid management. Treatment for this complex injury is predominantly dictated by the type of dislocation and displacement of the clavicle fracture, as well as age and demand of the patient. Acute high grades of ACJ dislocation require restoration of the coracoclavicular relationship (in place of torn coracoclavicular (CC) ligament) by some form of internal fixation, thereby maintaining the ACJ reduction. An arthroscopic reinstatement of the coracoclavicular relationship using a dog bone button and fibre tape implant for this composite injury pattern has not been previously described. Furthermore, a comprehensive review of the literature associated with this injury pattern is briefly described.

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Bimatoprost (0.03%)-induced accommodative spasm and pseudomyopia

Bimatoprost is a prostaglandin analogue used topically in the treatment of glaucoma. Commonly known side effects include eyelash growth, iris pigmentation and conjunctival hyperemia. While pseudomyopia is reported to be caused by parasympathomimetics, such an effect precipitated by bimatoprost has not yet been reported. We report a case demonstrating pseudomyopia and accommodative spasm caused after starting bimatoprost 0.03% in a young patient with glaucoma.

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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The unexpected benefits of the national piperacillin/tazobactam shortage on antibiotic stewardship

10.3109/23744235.2015.1110859<br/>Burke A. Cunha

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U of T research sheds new light on mysterious fungus that has major health consequences

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

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Penicillium chrysogenum DSOA associated with marine sponge (Tedania anhelans) exhibit antimycobacterial activity

Publication date: Available online 23 November 2015
Source:Microbiological Research
Author(s): Visamsetti Amarendra, Ramachandran Sarojini Santhosh, Kandasamy Dhevendaran
A strain of Penicillium chrysogenum was isolated from Tedania anhelans (marine sponge) collected from Indian Ocean (8° 22′ 30″ N latitude and 76° 59′ 16″ longitude) and deposited in culture collection centers. The strain subjected to different culture conditions for production of extrolites were extracted using ethyl acetate and chloroform. When both extracts were subjected for antibacterial activity, latter had high activity. Minimum inhibitory concentration of chloroform extract ranged from 31.25-1000μg/mL in tested microbes such as, Mycobacterium tuberculosis H37Ra, Mycobacterium avium, Mycobacterium fortuitum, Mycobacterium smegmatis, Mycobacterium vaccae, Staphylococcus aureus, Aeromonas hydrophila, Pseudomonas aeruginosa and Vibrio cholerae. No cytotoxicity was observed in Vero cell line up to 399.10μg/mL. Antibacterial activity previously reported by Parameswaran et al. in 1997 from ethyl acetate extract of T. anhelans might be due to the diketopiperazines, Cyclo-(L-Pro-L-Phe) and Cyclo-(L-Leu-L-Pro) produced by the associated fungi-Penicillium chrysogenum DSOA. It is producing a metabolites having antimycobacterial activity, a first report.



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A lacZ Reporter-Based Strategy for Rapid Expression Analysis and Target Validation of Mycobacterium tuberculosis Latent Infection Genes

Abstract

We report a novel lacZ fusion vector and demonstrate its utility for expression analysis of genes associated with Mycobacterium tuberculosis latent infection. The vector contains E. coli (oriE) and mycobacterial (oriM) origins of replication, a kanamycin resistance gene (Km^r) as selection marker, and a lacZ reporter gene in fusion with MCS for cloning of upstream regulatory sequence of the desired genes. β-galactosidase activity of the vector was standardized for expression analysis under latent mycobacterial conditions using Phsp60, a constitutive mycobacterial promoter, utilizing Mycobacterium smegmatis as model organism. Validation of the vector was done by cloning and expression analysis of PhspX (alpha crystalline) and Picl (isocitrate lyase), promoters from two of the genes shown to be involved in M. tuberculosis persistence. Both genes showed appreciable levels of β-galactosidase expression under hypoxia-induced persistent conditions in comparison to their actively replicating state. Expression analysis of a set of hypothetical genes was also done, of which Rv0628c showed increased expression under persistent conditions. The reported fusion vector and the strategy can be effectively used for short listing and validation of drug targets deduced from various non-conclusive approaches such as bioinformatics and microarray analysis against latent/persistent form of mycobacterial infection.

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Secretome Analysis of Metarhizium anisopliae Under Submerged Conditions Using Bombyx mori Chrysalis to Induce Expression of Virulence-Related Proteins

Abstract

The entomopathogenic fungus Metarhizium anisopliae is used to control insect pests. This species is specialized for the secretion of an enzymatic complex consisting of proteases, lipases, and chitinases related to pathogenicity and virulence. In this context, the secretomes of strains IBCB 167 and IBCB 384 of M. anisopliae var. anisopliae, grown under submerged fermentation in the presence of chrysalis as an inducer, were analyzed. Analysis of two-dimensional gels showed qualitative and quantitative differences between secreted proteins in both isolates. Around 102 protein spots were analyzed, and 76 % of the corresponding proteins identified by mass spectrometry were grouped into different classes (hydrolases, oxidases, reductases, isomerases, kinases, WSC domains, and hypothetical proteins). Thirty-three per cent of all the proteins analyzed were found to be common in both strains. Several virulence-related proteins were identified as proteases and mannosidases. Endo-N-acetyl-β-d-glucosaminidase expression was observed to be 10.14-fold higher for strain IBCB 384 than for strain IBCB 167, which may be an important contributor to the high virulence of IBCB 384 in Diatraea ssaccharalis. These results are important for elucidation of the host-pathogen relationship and the differences in virulence observed between the two strains.

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There is still time to submit to our ‘Single-Cell Omics’ Special Issue

Submit a Manuscript Editorial Board Author Instructions Article Alerts Dear Colleague, With only a month to go until close of submissions, we would like to remind you that Genome Biology is accepting submissions for a special issue on Single-Cell Omics which is planned for the first half of 2016. The special issue, guest edited by Sten Linnarsson and Sarah Teichmann, will also include commissioned Reviews and Opinions on timely topics, written by leaders in the field. Single-Cell Omics Advances in single-cell approaches are now enabling us to study differences between individual cells, cell types and subpopulations, at the level of the genome, transcriptome and epigenome. Single-cell technologies are being used to study diverse areas of biology and disease, such as development, microbial population composition, and cancer evolution. For more information visit our website. We will consider Research, Method, and Software manuscripts using single-cell approaches or advancing the underlying technologies, including but not limited to: Uses of single-cell approaches to study all areas of biology Disease-related applications of single-cell approaches Advances in single-cell technologies for studying genomes, transcriptomes and epigenomes Methods for analyzing single-cell data Don't miss out - deadline for submissions is 31st December 2015 Please use the online submission system, and indicate in your covering letter that you would like the manuscript to be considered for the 'Single-Cell Omics' special issue. If you would like to inquire about the suitability of a manuscript for consideration, please email a pre-submission inquiry to editorial@genomebiology.com. Kind regards, Barbara Cheifet Special Issue Editor Louisa Flintoft Editor

Follow BioMed Central:      How to ensure BioMed Central's emails reach your inbox. You have received this message because you have asked for updates from Genome Biology. Your registered email address is: alsfakia.journals1@blogger.com To change your email preferences please login to: http://ift.tt/1XlWsTC To unsubscribe as a registrant please visit our journal unsubscribe page. For further information or enquiries please contact Customer Services at: info@biomedcentral.com.

BioMed Central Ltd, 236 Gray's Inn Road, London, WC1X 8HB, United Kingdom. Part of Springer Science+Business Media. Privacy Policy. BMC24337

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Bimatoprost (0.03%)-induced accommodative spasm and pseudomyopia

Bimatoprost is a prostaglandin analogue used topically in the treatment of glaucoma. Commonly known side effects include eyelash growth, iris pigmentation and conjunctival hyperemia. While pseudomyopia is reported to be caused by parasympathomimetics, such an effect precipitated by bimatoprost has not yet been reported. We report a case demonstrating pseudomyopia and accommodative spasm caused after starting bimatoprost 0.03% in a young patient with glaucoma.

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The unexpected benefits of the national piperacillin/tazobactam shortage on antibiotic stewardship

10.3109/23744235.2015.1110859<br/>Burke A. Cunha

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Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults.

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A dual injury of the shoulder: acromioclavicular joint dislocation (type IV) coupled with ipsilateral mid-shaft clavicle fracture

A direct blow to the shoulder, as may be sustained in a road traffic accident (RTA), can result in various combinations of fracture dislocations in the shoulder joint complex. Among these, a rare variety is an acromioclavicular joint (ACJ) dislocation coupled with ipsilateral mid-shaft clavicle fracture. Diverse treatment options have been described in the literature, ranging from non-operative and operative, to hybrid management. Treatment for this complex injury is predominantly dictated by the type of dislocation and displacement of the clavicle fracture, as well as age and demand of the patient. Acute high grades of ACJ dislocation require restoration of the coracoclavicular relationship (in place of torn coracoclavicular (CC) ligament) by some form of internal fixation, thereby maintaining the ACJ reduction. An arthroscopic reinstatement of the coracoclavicular relationship using a dog bone button and fibre tape implant for this composite injury pattern has not been previously described. Furthermore, a comprehensive review of the literature associated with this injury pattern is briefly described.

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Muddy clinical waters: a missed betel nut in the bronchus

A toddler presented with a 5-month history of recurrent episodes of cough, wheezing and fever. Before referral, the toddler had been initially diagnosed as having bronchial asthma and later as having pulmonary tuberculosis. On examination, the patient was febrile and had severe respiratory distress. Chest radiograph and high-resolution CT of the chest revealed collapse of the entire left lung with diffuse bronchiectasis along with a grossly hyperinflated right lung. CT virtual bronchoscopy did not reveal any foreign body. The parents denied any history suggestive of foreign body aspiration and refused consent for rigid bronchoscopy. Nine days after admission, chest physiotherapy was inadvertently prescribed to the patient. Within an hour, the patient experienced acute respiratory deterioration and died. Autopsy revealed a piece of betel nut in the right main bronchus; it had got dislodged from its initial site in the left main bronchus following the chest physiotherapy session.

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome

10.3109/23744235.2015.1113557<br/>Anu Laulajainen-Hongisto

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U of T research sheds new light on mysterious fungus that has major health consequences

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

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There is still time to submit to our ‘Single-Cell Omics’ Special Issue

Submit a Manuscript Editorial Board Author Instructions Article Alerts Dear Colleague, With only a month to go until close of submissions, we would like to remind you that Genome Biology is accepting submissions for a special issue on Single-Cell Omics which is planned for the first half of 2016. The special issue, guest edited by Sten Linnarsson and Sarah Teichmann, will also include commissioned Reviews and Opinions on timely topics, written by leaders in the field. Single-Cell Omics Advances in single-cell approaches are now enabling us to study differences between individual cells, cell types and subpopulations, at the level of the genome, transcriptome and epigenome. Single-cell technologies are being used to study diverse areas of biology and disease, such as development, microbial population composition, and cancer evolution. For more information visit our website. We will consider Research, Method, and Software manuscripts using single-cell approaches or advancing the underlying technologies, including but not limited to: Uses of single-cell approaches to study all areas of biology Disease-related applications of single-cell approaches Advances in single-cell technologies for studying genomes, transcriptomes and epigenomes Methods for analyzing single-cell data Don't miss out - deadline for submissions is 31st December 2015 Please use the online submission system, and indicate in your covering letter that you would like the manuscript to be considered for the 'Single-Cell Omics' special issue. If you would like to inquire about the suitability of a manuscript for consideration, please email a pre-submission inquiry to editorial@genomebiology.com. Kind regards, Barbara Cheifet Special Issue Editor Louisa Flintoft Editor

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Bimatoprost (0.03%)-induced accommodative spasm and pseudomyopia

Bimatoprost is a prostaglandin analogue used topically in the treatment of glaucoma. Commonly known side effects include eyelash growth, iris pigmentation and conjunctival hyperemia. While pseudomyopia is reported to be caused by parasympathomimetics, such an effect precipitated by bimatoprost has not yet been reported. We report a case demonstrating pseudomyopia and accommodative spasm caused after starting bimatoprost 0.03% in a young patient with glaucoma.

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The unexpected benefits of the national piperacillin/tazobactam shortage on antibiotic stewardship

10.3109/23744235.2015.1110859<br/>Burke A. Cunha

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Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome

10.3109/23744235.2015.1113557<br/>Anu Laulajainen-Hongisto

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A dual injury of the shoulder: acromioclavicular joint dislocation (type IV) coupled with ipsilateral mid-shaft clavicle fracture

A direct blow to the shoulder, as may be sustained in a road traffic accident (RTA), can result in various combinations of fracture dislocations in the shoulder joint complex. Among these, a rare variety is an acromioclavicular joint (ACJ) dislocation coupled with ipsilateral mid-shaft clavicle fracture. Diverse treatment options have been described in the literature, ranging from non-operative and operative, to hybrid management. Treatment for this complex injury is predominantly dictated by the type of dislocation and displacement of the clavicle fracture, as well as age and demand of the patient. Acute high grades of ACJ dislocation require restoration of the coracoclavicular relationship (in place of torn coracoclavicular (CC) ligament) by some form of internal fixation, thereby maintaining the ACJ reduction. An arthroscopic reinstatement of the coracoclavicular relationship using a dog bone button and fibre tape implant for this composite injury pattern has not been previously described. Furthermore, a comprehensive review of the literature associated with this injury pattern is briefly described.

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Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults.

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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U of T research sheds new light on mysterious fungus that has major health consequences

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

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Muddy clinical waters: a missed betel nut in the bronchus

A toddler presented with a 5-month history of recurrent episodes of cough, wheezing and fever. Before referral, the toddler had been initially diagnosed as having bronchial asthma and later as having pulmonary tuberculosis. On examination, the patient was febrile and had severe respiratory distress. Chest radiograph and high-resolution CT of the chest revealed collapse of the entire left lung with diffuse bronchiectasis along with a grossly hyperinflated right lung. CT virtual bronchoscopy did not reveal any foreign body. The parents denied any history suggestive of foreign body aspiration and refused consent for rigid bronchoscopy. Nine days after admission, chest physiotherapy was inadvertently prescribed to the patient. Within an hour, the patient experienced acute respiratory deterioration and died. Autopsy revealed a piece of betel nut in the right main bronchus; it had got dislodged from its initial site in the left main bronchus following the chest physiotherapy session.

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Bimatoprost (0.03%)-induced accommodative spasm and pseudomyopia

Bimatoprost is a prostaglandin analogue used topically in the treatment of glaucoma. Commonly known side effects include eyelash growth, iris pigmentation and conjunctival hyperemia. While pseudomyopia is reported to be caused by parasympathomimetics, such an effect precipitated by bimatoprost has not yet been reported. We report a case demonstrating pseudomyopia and accommodative spasm caused after starting bimatoprost 0.03% in a young patient with glaucoma.

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Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome

10.3109/23744235.2015.1113557<br/>Anu Laulajainen-Hongisto

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Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults.

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U of T research sheds new light on mysterious fungus that has major health consequences

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

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The unexpected benefits of the national piperacillin/tazobactam shortage on antibiotic stewardship

10.3109/23744235.2015.1110859<br/>Burke A. Cunha

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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Muddy clinical waters: a missed betel nut in the bronchus

A toddler presented with a 5-month history of recurrent episodes of cough, wheezing and fever. Before referral, the toddler had been initially diagnosed as having bronchial asthma and later as having pulmonary tuberculosis. On examination, the patient was febrile and had severe respiratory distress. Chest radiograph and high-resolution CT of the chest revealed collapse of the entire left lung with diffuse bronchiectasis along with a grossly hyperinflated right lung. CT virtual bronchoscopy did not reveal any foreign body. The parents denied any history suggestive of foreign body aspiration and refused consent for rigid bronchoscopy. Nine days after admission, chest physiotherapy was inadvertently prescribed to the patient. Within an hour, the patient experienced acute respiratory deterioration and died. Autopsy revealed a piece of betel nut in the right main bronchus; it had got dislodged from its initial site in the left main bronchus following the chest physiotherapy session.

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A dual injury of the shoulder: acromioclavicular joint dislocation (type IV) coupled with ipsilateral mid-shaft clavicle fracture

A direct blow to the shoulder, as may be sustained in a road traffic accident (RTA), can result in various combinations of fracture dislocations in the shoulder joint complex. Among these, a rare variety is an acromioclavicular joint (ACJ) dislocation coupled with ipsilateral mid-shaft clavicle fracture. Diverse treatment options have been described in the literature, ranging from non-operative and operative, to hybrid management. Treatment for this complex injury is predominantly dictated by the type of dislocation and displacement of the clavicle fracture, as well as age and demand of the patient. Acute high grades of ACJ dislocation require restoration of the coracoclavicular relationship (in place of torn coracoclavicular (CC) ligament) by some form of internal fixation, thereby maintaining the ACJ reduction. An arthroscopic reinstatement of the coracoclavicular relationship using a dog bone button and fibre tape implant for this composite injury pattern has not been previously described. Furthermore, a comprehensive review of the literature associated with this injury pattern is briefly described.

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The unexpected benefits of the national piperacillin/tazobactam shortage on antibiotic stewardship

10.3109/23744235.2015.1110859<br/>Burke A. Cunha

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Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome

10.3109/23744235.2015.1113557<br/>Anu Laulajainen-Hongisto

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Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults.

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U of T research sheds new light on mysterious fungus that has major health consequences

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

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Muddy clinical waters: a missed betel nut in the bronchus

A toddler presented with a 5-month history of recurrent episodes of cough, wheezing and fever. Before referral, the toddler had been initially diagnosed as having bronchial asthma and later as having pulmonary tuberculosis. On examination, the patient was febrile and had severe respiratory distress. Chest radiograph and high-resolution CT of the chest revealed collapse of the entire left lung with diffuse bronchiectasis along with a grossly hyperinflated right lung. CT virtual bronchoscopy did not reveal any foreign body. The parents denied any history suggestive of foreign body aspiration and refused consent for rigid bronchoscopy. Nine days after admission, chest physiotherapy was inadvertently prescribed to the patient. Within an hour, the patient experienced acute respiratory deterioration and died. Autopsy revealed a piece of betel nut in the right main bronchus; it had got dislodged from its initial site in the left main bronchus following the chest physiotherapy session.

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A dual injury of the shoulder: acromioclavicular joint dislocation (type IV) coupled with ipsilateral mid-shaft clavicle fracture

A direct blow to the shoulder, as may be sustained in a road traffic accident (RTA), can result in various combinations of fracture dislocations in the shoulder joint complex. Among these, a rare variety is an acromioclavicular joint (ACJ) dislocation coupled with ipsilateral mid-shaft clavicle fracture. Diverse treatment options have been described in the literature, ranging from non-operative and operative, to hybrid management. Treatment for this complex injury is predominantly dictated by the type of dislocation and displacement of the clavicle fracture, as well as age and demand of the patient. Acute high grades of ACJ dislocation require restoration of the coracoclavicular relationship (in place of torn coracoclavicular (CC) ligament) by some form of internal fixation, thereby maintaining the ACJ reduction. An arthroscopic reinstatement of the coracoclavicular relationship using a dog bone button and fibre tape implant for this composite injury pattern has not been previously described. Furthermore, a comprehensive review of the literature associated with this injury pattern is briefly described.

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive Protein Concentrations With Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis

High-sensitivity C-reactive protein (hs-CRP) has been associated with coronary heart disease (CHD) in numerous but not all observational studies, and whether low levels of low-density lipoprotein cholesterol (LDL-C) alter this association is unknown. In the Multi-Ethnic Study of Atherosclerosis (2000–2012), we prospectively assessed the association of hs-CRP concentrations with incident CHD in participants who did not receive lipid-lowering therapy, as well as in those with LDL-C concentrations less than 130 mg/dL (n = 3,106) and those with LDL-C concentrations of 130 mg/dL or greater (n = 1,716) at baseline (2000–2002). Cox proportional hazard analyses were used to assess the associations after adjustment for socioeconomic status, traditional risk factors, body mass index, diabetes, aspirin use, kidney function, and coronary artery calcium score. Log_e hs-CRP was associated with incident CHD in participants with LDL-C concentrations of 130 mg/dL or higher (hazard ratio (HR) = 1.29, 95% confidence interval (CI): 1.05, 1.60) but not in those with LDL-C concentrations less than 130 mg/dL (HR = 0.88, 95% CI: 0.74, 1.05; P for interaction = 0.003). As a whole, log_e hs-CRP was not associated with incident CHD in participants who had not received lipid-lowering therapy at baseline (HR = 1.05, 95% CI: 0.92, 1.20) and who had mean LDL-C concentrations less than 130 mg/dL. These findings suggest that LDL-C concentrations might be a moderator of the contribution of hs-CRP to CHD.

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OtoRhinoLaryngology & Medicine,New Articles,November 23rd,2015,a

Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 2 ώρες

Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia: This study suggested that sluggish rather than decreased hyolaryngeal movements during swallowing are a remarkable feature of post-stroke dysphagia. The association of reduced epiglottic movement with the risk of aspiration in patients with post-stroke dysphagia was supported by the quantitative analysis. (Source: Dysphagia)

Targeting the DNA Damage Response in Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες

*Targeting the DNA Damage Response in Cancer.* Mol Cell. 2015 Nov 19;60(4):547-560 Authors: O'Connor MJ Abstract An underlying hallmark of cancers is their genomic instability, which is associated with a greater propensity to accumulate DNA damage. Historical treatment of cancer by radiotherapy and DNA-damaging chemotherapy is based on this principle, yet it is accompanied by significant collateral damage to normal tissue and unwanted side effects. Targeted therapy based on inhibiting the DNA damage response (DDR) in cancers offers the potential for a greater therapeutic window ... περισσότερα »

Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες

*Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.* Lancet Oncol. 2015 Nov 13; Authors: Bois AD, Kristensen G, Ray-Coquard I, Reuss A, Pignata S, Colombo N, Denison U, Vergote I, Del Campo JM, Ottevanger P, Heubner M, Minarik T, Sevin E, de Gregorio N, Bidziński M, Pfisterer J, Malander S, Hilpert F, Mirza MR, Scambia G, Meier W, Nicoletto MO, Bjørge L, Lortholary A, Sailer MO, Merger M, Harter P, AGO Study Group led Gynecologic Cancer Intergroup (GCIG)/European Net...περισσότερα »

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες

*Designing a broad-spectrum integrative approach for cancer prevention and treatment.* Semin Cancer Biol. 2015 Dec;35S:S276-S304 Authors: Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker ... περισσότερα »

Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

*Swallowing Kinematics and Factors Associated with Laryngeal Penetration and Aspiration in Stroke Survivors with Dysphagia.* Dysphagia. 2015 Nov 21; Authors: Seo HG, Oh BM, Han TR Abstract The purpose of this study was to investigate swallowing kinematics and explore kinematic factors related with penetration-aspiration in patients with post-stroke dysphagia. Videofluoroscopic images of 68 patients with post-stroke dysphagia and 34 sex- and age-matched healthy controls swallowing a thin liquid were quantitatively analyzed using two-dimensional motion digitization. The measuremen... περισσότερα »

Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula.

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

*Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula.* Dysphagia. 2015 Nov 21; Authors: Leder SB, Siner JM, Bizzarro MJ, McGinley BM, Lefton-Greif MA Abstract Use of high-flow oxygen via nasal cannula (HFO2-NC) is increasingly common in intensive care unit (ICU) settings. Despite the critical interface between respiration and swallowing, and the high acuity of patients in ICUs, the impact of HFO2-NC on feeding and swallowing is unknown. The present prospective, single-center, cohort study investigated the impact of HFO2-NC use on oral...περισσότερα »

Changes in coagulation during therapeutic hypothermia in cardiac arrest patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3KqIG via IFTTT

Prevalence of Chest Injury With the Presence of NEXUS Chest Criteria: Data to Inform Shared Decisionmaking About Imaging Use

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJyrqx via IFTTT

Imaging in blunt cardiac injury: computed tomographic findings in cardiac contusion and associated injuries

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Kqsf via IFTTT

Manual cardiopulmonary resuscitation versus CPR including a mechanical chest compression device in out-of-hospital cardiac arrest: a comprehensive meta-analysis from randomized and observational studies

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJytyA via IFTTT

Temperature measurements in trauma patients: is the ear the key to the core?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3KqZn via IFTTT

Prospective validation of the Ottawa 3DY Scale by geriatric emergency management nurses to identify impaired cognition in older emergency department patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJyr9L via IFTTT

Post-traumatic neuroma due to closed nerve injury. Is recovery after peripheral nerve trauma related to ultrasonographic neuroma size?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Clinical Neurology and Neurosurgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Ko3A via IFTTT

Comparison of complications secondary to cardiopulmonary resuscitation between out-of-hospital cardiac arrest and in-hospital cardiac arrest

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJyqmq via IFTTT

Unhealthy alcohol use in older adults: Association with readmissions and emergency department use in the 30 days after hospital discharge

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Drug and Alcohol Dependence from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3KpEG via IFTTT

An asthma protocol improved adherence to evidence-based guidelines for pediatric subjects with status asthmaticus in the emergency department

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Respiratory Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJyqCL via IFTTT

Severe cranial neuropathies caused by falls from heights in children

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Graefe's Archive for Clinical and Experimental Ophthalmology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3KnN8 via IFTTT

A three-year follow-up on injuries sustained by cruise ship passengers and crew treated at the Orthopaedic and Traumatology Department at Dubrovnik County Hospital

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJynqO via IFTTT

Does lidocaine as an adjuvant to morphine improve pain relief in patients presenting to the emergency department with acute renal colic? A double-blind, randomized controlled trial

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Kpoa via IFTTT

Prenatal versus postnatal tobacco smoke exposure and intensive care use in children hospitalized with bronchiolitis

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Academic Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJypyR via IFTTT

The influence of different operating conditions on the blood damage of a pulsatile ventricular assist device

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

ASAIO Journal from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Kp7C via IFTTT

Analgesic access for acute abdominal pain in the emergency department among racial/ethnic minority patients: A nationwide examination

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Medical Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJypin via IFTTT

Giant Intrahepatic Biloma Following Blunt Hepatic Injury

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 ώρες

Miscellaneous Chien-Ze Peng, Chien-Ying Wang Canadian Journal of Emergency Medicine, FirstView Article(s), 2 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from C via ola Kala on Inoreader http://ift.tt/1jfIh56 via IFTTT

Vincent Di Marino and Hubert Lepidi: Anatomic study of the clitoris and the bulbo-clitoral organ : Springer Heidelberg Dordrecht London New York (2014) 152 p, 108 illustrations, format 21.5 × 28.5 cm. ISBN 978-3-319-04893-2, ISBN 978-3-319-04894-9 (e-Book), doi: 10.1007/978-3-319-04894-9.

Alexandros G. SfakianakisστοHead and NeckΠριν από 3 ώρες

*Vincent Di Marino and Hubert Lepidi: Anatomic study of the clitoris and the bulbo-clitoral organ : Springer Heidelberg Dordrecht London New York (2014) 152 p, 108 illustrations, format 21.5 × 28.5 cm. ISBN 978-3-319-04893-2, ISBN 978-3-319-04894-9 (e-Book), doi: 10.1007/978-3-319-04894-9.* Surg Radiol Anat. 2015 Dec;37(10):1291 Authors: Grignon B PMID: 26590932 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1QZQfwZ via IFTTT

Targeting the DNA Damage Response in Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 3 ώρες

*Targeting the DNA Damage Response in Cancer.* Mol Cell. 2015 Nov 19;60(4):547-560 Authors: O'Connor MJ Abstract An underlying hallmark of cancers is their genomic instability, which is associated with a greater propensity to accumulate DNA damage. Historical treatment of cancer by radiotherapy and DNA-damaging chemotherapy is based on this principle, yet it is accompanied by significant collateral damage to normal tissue and unwanted side effects. Targeted therapy based on inhibiting the DNA damage response (DDR) in cancers offers the potential for a greater therapeutic window ... περισσότερα »

Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.

Alexandros G. SfakianakisστοHead and NeckΠριν από 3 ώρες

*Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.* Lancet Oncol. 2015 Nov 13; Authors: Bois AD, Kristensen G, Ray-Coquard I, Reuss A, Pignata S, Colombo N, Denison U, Vergote I, Del Campo JM, Ottevanger P, Heubner M, Minarik T, Sevin E, de Gregorio N, Bidziński M, Pfisterer J, Malander S, Hilpert F, Mirza MR, Scambia G, Meier W, Nicoletto MO, Bjørge L, Lortholary A, Sailer MO, Merger M, Harter P, AGO Study Group led Gynecologic Cancer Intergroup (GCIG)/European Net...περισσότερα »

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 3 ώρες

*Designing a broad-spectrum integrative approach for cancer prevention and treatment.* Semin Cancer Biol. 2015 Dec;35S:S276-S304 Authors: Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker ... περισσότερα »

Stomatology

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 3 ώρες

. Year *2015*Issue *10* is now available on CAOD. *In this issue:* The effect of polyhexamethylene guanidine hydrochloride loaded on TiO2 nanotubes on promoting the osteogenic differentiation of the modified titanium surface (TiO2纳米管负载聚六亚甲基胍促进种植体钛表面成骨分化性能的研究) WANG Guifang, LI Jinhua, CHEN Liping, JIANG Xinquan, Department of Prosthodontics, The Ninth People’ s Hospital, Shanghai Jiao Tong University , School of Medicine ...... page:801-805 Study on the expression of TLR3 and TLR4 with the stimulation of hypoxia in OSCC cell lines (低氧促进口腔鳞癌细胞TLR3及TLR4表达的相关研究) JIANG Linlin, HAN Wei, WANG... περισσότερα »

Chinese Journal of Prosthodontics

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 3 ώρες

. Year *2015* Issue *05* is now available on CAOD. *In this issue:* Investigation on bacteria adhesion conditions on dental curing light-guide rods (光固化灯光导棒细菌粘附状况的调查) TANG Xiao-jun, SHI Sheng-gen, LU Yi, LIU Gen-lan, ZHANG Jian-bo, LU Lin-jie,Stomotological center of Chinese PLA, 306 hospital ...... page:257-261 Effects of siRNA-mediated β-catenin silence on proliferation in human periodontal ligament stem cells (SiRNA沉默β-catenin对人牙周膜干细胞增殖能力的影响) LIU Na, LI Hua, LI Xiao-guang, LIU Hong-chen, Department of Stomatology, Chinese PLA General Hospital ...... page:262-266 In vivo biocompatibi... περισσότερα »

Blood gas measurements in DKA: Are we searching for a unicorn?

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 3 ώρες

[image: bloodletting.gif?resize=400%2C178] Routinely obtaining an ABG or VBG is widely recommended, for example in both American and British guidelines. Why? Is this helping our patients, or is it something that we do out of a sense of habit or obligation? EMCrit by Josh Farkas. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1NmZI1B via IFTTT

Mediators of Inflammation in Myeloproliferative Neoplasms: State of the Art

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

from Infection via ola Kala on Inoreader http://ift.tt/1I9XlHR via IFTTT

Adverse drug reactions in pediatric emergency medicine

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 3 ώρες

Annals of Pharmacotherapy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Kng9 via IFTTT

Derivation and validation of a clinical decision rule to identify young children with skull fracture following isolated head trauma

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 3 ώρες

Canadian Medical Association Journal from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJypia via IFTTT

Co-transplantation of autologous bone marrow mesenchymal stem cells and Schwann cells through cerebral spinal fluid for the treatment of patients with chronic spinal cord injury: safety and possible outcome

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 3 ώρες

Spinal Cord from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PJyp1S via IFTTT

Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: are the new P2Y12 inhibitors really more effective than clopidogrel?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 3 ώρες

Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1N3Kng4 via IFTTT

Adult cutaneous Langerhans cell histiocytosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

A case report of adult cutaneous Langerhans cell histiocytosis *Author(s):* ZHOU Qin-tian, LEI Song, WANG Lin, Department of Dermatovenereology, West China Hospital, Sichuan University *Pages:* 625-627 *Year:* 2015 *Issue:* 10 *Journal:* *Journal of Clinical Dermatology* *Keyword:* Langerhans cell histiocytosis; cutaneous; adult; *Abstract:* A case of adult cutaneous Langerhans cell histiocytosis is reported. A 23-year-old female presented with numerous asymptomatic papules and nodules on her limbs and face for about two years. Histopathological examination showed many mononuclear ce... περισσότερα »

Progress of Triptolide in inhibition of angiogenesis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

in cancer *Author(s):* Naila Ahmed, WANG Geng, ZHANG Ya-fang, Department of Anatomy, School of Basic Medical Sciences, Harbin Medical University *Pages:* 556-559 *Year:* 2015 *Issue:* 5 *Journal:* *Progress of Anatomical Sciences* *Keyword:* 雷公藤甲素; 肿瘤血管; triptolide; 系统性红斑狼疮; 肾病综合征; 类风湿性关节炎; 活性物质; 作用机制; angiogenesis; 抗肿瘤活性; *Abstract:* Triptolide(TPL) is an active ingredient of chinese herb Tripterygium wilfordii F.(Celastraceae). Triptolide has been used to treat various diseases, including lupus, rheumatoid arthritis and nephritic syndrome, also has a strong anti-tumor activity. T...περισσότερα »

Autophagy and neurogenic diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 ώρες

Autophagy signal pathway and the relationship between autophagy and neurogenic diseases *Author(s):* JIN Ming-shun, WANG Rui, REN Yan-hua, ZHANG Jun-ming, LIAO Min , XU Zhao-jin, Department of Histology and Embryology,Institute of Neurobiology, Wenzhou Medical University, Department of Histology and Embryology, Qiqihaer Medical College *Pages:* 539-542+546 *Year:* 2015 *Issue:* 5 *Journal:* *Progress of Anatomical Sciences* *Keyword:* 自噬; 信号通路; 神经性疾病; α-突触核蛋白; 分子伴侣; 细胞骨架; 溶酶体酶; 神经变性; 氧化应激; 神经退行性疾病; *Abstract:* Autophagy is a selective degradation process, divided into three forms: ma... περισσότερα »

NPC : Cytochrome b5 reductase 2 suppresses tumor formation by attenuating angiogenesis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 ώρες

Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis *Author(s):* Huixin Ming, Ying Lan, Feng He, Xue Xiao, Xiaoying Zhou, Zhe Zhang, Ping Li, Guangwu Huang, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Medical Research Centre, Guangxi Medical University *Pages:* 459-467 *Year:* 2015 *Issue:* 10 *Journal:* *Chinese Journal of Cancer* *Keyword:* Cytochrome b5 reductase 2; Nasopharyngea... περισσότερα »

Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 ώρες

:time to expand the M categorization system *Author(s):* Lu-Jun Shen, Si-Yang Wang, Guo-Feng Xie, Qi Zeng, Chen Chen, An-Nan Dong, Zhi-Mei Huang, Chang-Chuan Pan, Yun-Fei Xia, Pei-Hong Wu, Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Radiation Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Department of Radiation Oncology, Cancer Center of Guangzhou Medical University,Department of Radiation Oncolo... περισσότερα »

An improved RT-IPCR for detection of pyrene and related polycyclic aromatic hydrocarbons

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 4 ώρες

[image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): X.Y. Meng, Y.S. Li, Y. Zhou, Y. Sun, B. Qiao, C.C. Si, P. Hu, S.Y. Lu, H.L. Ren, Z.S. Liu, H.J. Qiu, J.Q. Liu Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous homogeneous chemicals which are well known by carcinogens, mutagens and endocrine disorder. Here, an improved real-time immuno-PCR (RT-IPCR) was developed for detection of pyrene and its homologs in water samples. The PAHs in sample compete with pyrene-modified DNA to bind with monoclonal antibody (McAb) co... περισσότερα »

Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 4 ώρες

[image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): Linling Zhu, Junying Zhang, Fengyang Wang, Ya Wang, Linlin Lu, Chongchong Feng, Zhiai Xu, Wen Zhang Amyloid-beta (Aβ) oligomers are highly toxic species in the process of Aβ aggregation and are regarded as potent therapeutic targets and diagnostic markers for Alzheimer's disease (AD). Herein, a label-free molecular beacon (MB) system integrated with enzyme-free amplification strategy was developed for simple and highly selective assay of Aβ oligomers. The MB system was... περισσότερα »

Detecting trypsin at liquid crystal/aqueous interface by using surface-immobilized bovine serum albumin

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 4 ώρες

[image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): Cheng-Hao Chuang, Yi-Cheng Lin, Wei-Long Chen, Yu-Hsuan Chen, Yu-Xun Chen, Chieh-Ming Chen, Hung Wei Shiu, Lo-Yueh Chang, Chia-Hao Chen, Chih-Hsin Chen We report a new mechanism for liquid crystal (LC)-based sensor system for trypsin detection. In this system, bovine serum albumin (BSA) was immobilized on gold grids as the enzymatic substrate. When the BSA-modified grid was filled with LC and immersed in the solution containing trypsin, the peptide bonds of BSA were hy... περισσότερα »

Aptamer-based colorimetric detection of proteins using a branched DNA cascade amplification strategy and unmodified gold nanoparticles

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 4 ώρες

[image: S09565663.gif] Publication date: 15 April 2016 *Source:*Biosensors and Bioelectronics, Volume 78 Author(s): Chia-Chen Chang, Chen-Yu Chen, Tsung-Liang Chuang, Tzu-Heng Wu, Shu-Chen Wei, Hongen Liao, Chii-Wann Lin A branched DNA amplification strategy was employed to design a colorimetric aptameric biosensor using unmodified gold nanoparticles (AuNPs). First, a programmed DNA dendritic nanostructure was formed using two double-stranded substrate DNAs and two single-stranded auxiliary DNAs as assembly components via a target-assisted cascade amplification reaction, and it was ...περισσότερα »

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Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 4 ώρες

Jetzt Springer Shop besuchen und Rabatt sichern. Lesen Sie diese E-Mail hier online. | Fügen Sie " springer@news.springer.com" Ihrem Adressbuch hinzu. Das Springer Shop Angebot Follow us ( #SpringerSpecial ) : [image: Follow us on Facebook] [image: Find us on Twitter] [image: Follow us on Google+] Letzte Chance: 50% Rabatt auf englische Bücher in Medizin *Sichern Sie sich Ihren Rabatt und profitieren Sie von allen Vorteilen:* Das Springer Shop Angebot endet heute - Sparen Sie jetzt! Ausgewählte englische Bestseller in Medizin um 50% reduziert* Kostenloser Versand weltweit Deuts... περισσότερα »

Molbank, Vol. 2015, Article M875: (8R,10aS)-Methyl 2,4-diamino-8-(tert-butyl)-6-oxo-6,8,10,10a-tetrahydrooxazolo[3′′,4′′:1′,5′]-pyrrolo[3′,4′:5,6]pyrido[2,3-d]pyrimidine-10a-carboxylate

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 4 ώρες

A fused polyheterocyclic derivative is available by annulation of a tetramate scaffold, and has been shown to have some Gram-negative, but not Gram-positive, antibacterial activity. from #Medicine via ola Kala on Inoreader http://ift.tt/1NmTmPU via IFTTT

Remote Sensing, Vol. 7, Pages 15702-15728: On the Use of Global Flood Forecasts and Satellite-Derived Inundation Maps for Flood Monitoring in Data-Sparse Regions

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 4 ώρες

Early flood warning and real-time monitoring systems play a key role in flood risk reduction and disaster response decisions. Global-scale flood forecasting and satellite-based flood detection systems are currently operating, however their reliability for decision-making applications needs to be assessed. In this study, we performed comparative evaluations of several operational global flood forecasting and flood detection systems, using 10 major flood events recorded over 2012–2014. Specifically, we evaluated the spatial extent and temporal characteristics of flood detections fro... περισσότερα »

Energies, Vol. 8, Pages 13265-13283: Feasibility Study of a Solar-Powered Electric Vehicle Charging Station Model

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

In China, the power sector is currently the largest carbon emitter and the transportation sector is the fastest-growing carbon emitter. This paper proposes a model of solar-powered charging stations for electric vehicles to mitigate problems encountered in China's renewable energy utilization processes and to cope with the increasing power demand by electric vehicles for the near future. This study applies the proposed model to Shenzhen City to verify its technical and economic feasibility. Modeling results showed that the total net present value of a photovoltaic power charging st... περισσότερα »

Materials, Vol. 8, Pages 7926-7937: Compressive Behavior and Microstructural Characteristics of Iron Hollow Sphere Filled Aluminum Matrix Syntactic Foams

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

Iron hollow sphere filled aluminum matrix syntactic foams (AMSFs) were produced by low pressure, inert gas assisted infiltration. The microstructure of the produced AMSFs was investigated by light and electron microscopy, extended by energy dispersive X-ray spectroscopy and electron back-scattered diffraction. The investigations revealed almost perfect infiltration and a slight gradient in the grain size of the matrix. A very thin interface layer that ensures good bonding between the hollow spheres and the matrix was also observed. Compression tests were performed on cylindrical s... περισσότερα »

Energies, Vol. 8, Pages 13255-13264: Governing China’s Clean Energy Transition: Policy Reforms, Flexible Implementation and the Need for Empirical Investigation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

In the ten years since committing to clean energy transition, China has formulated a large number of policies and programs to achieve some very ambitious targets. This paper argues that the dearth of empirical studies concerning the implementation of these new policies and programs has created a knowledge gap between official policy documents, which are vague and lacking in specifics, and official policy outcomes, which are unreliable. In particular, the merits and limitations of flexible implementation with regard to desirable outcomes need to be debated and clarified. This paper... περισσότερα »

Materials, Vol. 8, Pages 7913-7925: Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

Calcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption in vivo. This allows for the space to be created for the new bone tissue to form and infiltrate within the implanted graft material. Several factors affect the biodegradation and resorption of calcium phosphate materials after implantation. Various cell types are involved in the degradation process... περισσότερα »

Materials, Vol. 8, Pages 7900-7912: Ultrasound-Assist Extrusion Methods for the Fabrication of Polymer Nanocomposites Based on Polypropylene/Multi-Wall Carbon Nanotubes

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

Isotactic polypropylenes (iPP) with different melt flow indexes (MFI) were used to fabricate nanocomposites (NCs) with 10 wt % loadings of multi-wall carbon nanotubes (MWCNTs) using ultrasound-assisted extrusion methods to determine their effect on the morphology, melt flow, and electrical properties of the NCs. Three different types of iPPs were used with MFIs of 2.5, 34 and 1200 g/10 min. Four different NC fabrication methods based on melt extrusion were used. In the first method melt extrusion fabrication without ultrasound assistance was used. In the second and third methods, a... περισσότερα »

Molecules, Vol. 20, Pages 20823-20831: Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa &amp; Koki Ito

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 5 ώρες

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa &amp; Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). from #Medicine via ola Kala on Inore...περισσότερα »

Small cell neuroendocrine carcinomas arising in the head and neck region

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Small cell neuroendocrine carcinomas arising in the head and neck region: We evaluated the clinical factors associated with outcomes of head and neck small cell neuroendocrine carcinoma (SCNEC-HN). AbstractPurpose We evaluated the clinical factors associated with outcomes of head and neck small cell neuroendocrine carcinoma (SCNEC-HN). Methods A retrospective review of clinical data was performed for 11 patients with SCNEC-HN treated at the Hamamatsu University Hospital. We evaluated the clinical features, treatment methods, and outcomes. The main outcome measures were disease sta... περισσότερα »

Comparison of Groundwater Level Models Based on Artificial Neural Networks and ANFIS

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 5 ώρες

Water table forecasting plays an important role in the management of groundwater resources in agricultural regions where there are drainage systems in river valleys. The results presented in this paper pertain to an area along the left bank of the Danube River, in the Province of Vojvodina, which is the northern part of Serbia. Two soft computing techniques were used in this research: an adaptive neurofuzzy inference system (ANFIS) and an artificial neural network (ANN) model for one-month water table forecasts at several wells located at different distances from the river. The re... περισσότερα »

Breast Cancer Research and Treatment, Vol. 154, Issue 2 - New Issue Alert

Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 5 ώρες

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/23/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Breast Cancer Research and Treatment*. Volume 154 Number 2 is now available online. Important news Make greater discoveries with AdisInsight See the bigger picture of a drug or disease landscape with a unique, joined-up view of drug treatments being developed worldwide - how well they work, how safe they are, who is working on them, and how soon they will... περισσότερα »

Description of the Baudet Surgical Technique and Introduction of a Systematic Method for Training Surgeons to Perform Male-to-Female Sex Reassignment Surgery

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 5 ώρες

Abstract Introduction Male-to-female sex reassignment surgery involves three main procedures, namely, clitoroplasty, new urethral meatoplasty and vaginopoiesis. Herein we describe the key steps of our surgical technique. Methods Male-to-female sex reassignment surgery includes the following 14 key steps which are documented in this article: (1) patient installation and draping, (2) urethral catheter placement, (3) scrotal incision and vaginal cavity formation, (4) bilateral orchidectomy, (5) penile skin inversion, (6) dismembering of the urethra from the corpora, (7) neoclitoris f... περισσότερα »

Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS.: This study suggests that (1)H-HR-MAS-MRS may be a valuable tool for evaluating the role of hypoxia and lactate in tumor metastasis as well as for identification of metastasis-associated metabolic profiles. PMID: 26585232 [PubMed - in process] (Source: Neoplasia) Neoplasia. 2015 Oct;17(10):767-75. doi: 10.1016/j.neo.2015.10.001. Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS. Gorad SS1, Ellingsen C2, Bathen TF3, Mathiesen BS2, Moestue SA1, Rofstad EK... περισσότερα »

Small cell neuroendocrine carcinomas arising in the head and neck region

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Small cell neuroendocrine carcinomas arising in the head and neck region: We evaluated the clinical factors associated with outcomes of head and neck small cell neuroendocrine carcinoma (SCNEC-HN). AbstractPurpose We evaluated the clinical factors associated with outcomes of head and neck small cell neuroendocrine carcinoma (SCNEC-HN). Methods A retrospective review of clinical data was performed for 11 patients with SCNEC-HN treated at the Hamamatsu University Hospital. We evaluated the clinical features, treatment methods, and outcomes. The main outcome measures were disease sta... περισσότερα »

Late Reconstruction of the Orbit With Patient-Specific Implants Using Computer-Aided Planning and Navigation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Late Reconstruction of the Orbit With Patient-Specific Implants Using Computer-Aided Planning and Navigation: Reconstruction of orbital deformities is a challenging task. Virtual 3-dimensional (3D) planning and the use of patient-specific implants (PSIs) could improve anatomic and functional outcomes in the orbital region. Purpose Reconstruction of orbital deformities is a challenging task. Virtual 3-dimensional (3D) planning and the use of patient-specific implants (PSIs) could improve anatomic and functional outcomes in the orbital region. Materials and Methods A retrospective s... περισσότερα »

A Geometric Classification of Jaw Deformities

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

A Geometric Classification of Jaw Deformities: In the United States, the most widely used classification system for jaw deformities is the one provided by the Center for Medicare and Medicaid Services and the National Center for Health Statistics. This classification is part of the International Classification of Diseases, Clinical Modification (ICD-CM), a taxonomy scheme that is based on the World Health Organization's ICD, the world's standard diagnostic tool for epidemiology, health management, and clinical care.1

The Neurobiology of Cancer Pain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

The Neurobiology of Cancer Pain: Oral cancers are often severely painful and clinically difficult to manage. Few researchers have investigated the neurobiologic factors responsible for cancer pain; however, the study of oral cancer pain might inform us about the fundamental biology of cancer. The purpose of the present report was to summarize the clinical challenges inherent in oral cancer pain management, oral cancer pain mechanisms and mediators, and the convergence of the investigation of carcinogenesis and pain.

Regenerative Technologies for Craniomaxillofacial Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Regenerative Technologies for Craniomaxillofacial Surgery: Regenerative medicine has recently enjoyed a tremendous amount of basic and translational research activity. A convergence of technologies is occurring that has afforded opportunities previously not possible with conventional surgical reconstructive techniques. These discoveries are making their way into current surgical practice. Patients requiring complex reconstructive surgery in the craniomaxillofacial region typically benefit from local or regional flaps, nonvascularized grafts, microvascular tissue transfer, and substi... περισσότερα »

Mandibular Tissue Engineering: Past, Present, Future

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Mandibular Tissue Engineering: Past, Present, Future: Almost 2 decades ago, the senior author's (M.T.J.) first article was with our mentor, Dr Leonard B. Kaban, a review article titled “Distraction Osteogenesis: Past, Present, Future.” In 1998, many thought it would be impossible to have a remotely activated, small, curvilinear distractor that could be placed using endoscopic techniques. Currently, a U.S. patent for a curvilinear automated device and endoscopic techniques for minimally invasive access for jaw reconstruction exist. With minimally invasive access for jaw reconstructio... περισσότερα »

Developing an Immunotherapy Strategy for the Effective Treatment of Oral, Head and Neck Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Developing an Immunotherapy Strategy for the Effective Treatment of Oral, Head and Neck Squamous Cell Carcinoma: The recent understanding of the role of tumor-infiltrating lymphocytes in different solid cancers suggests that only patients with evidence of an immune response will have durable responses to therapeutic intervention. Therefore, for more patients to achieve clinical benefit, it is necessary to find effective approaches to prime de novo antitumor immunity. This is particularly true for oral, head and neck squamous cell carcinomas (OHNSCCs), which are known for their immun... περισσότερα »

Nevoid Basal Cell Carcinoma Syndrome and the Keratocystic Odontogenic Tumor

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Nevoid Basal Cell Carcinoma Syndrome and the Keratocystic Odontogenic Tumor: To analyze the clinical and radiographic manifestations of nevoid basal cell carcinoma syndrome (NBCCS) with a particular emphasis on the presence, treatment, and outcomes of keratocystic odontogenic tumors (KOTs) in these patients. Purpose To analyze the clinical and radiographic manifestations of nevoid basal cell carcinoma syndrome (NBCCS) with a particular emphasis on the presence, treatment, and outcomes of keratocystic odontogenic tumors (KOTs) in these patients. Patients and Methods The authors im... περισσότερα »

Upper Airway Length is Predictive of Obstructive Sleep Apnea in Syndromic Craniosynostosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Upper Airway Length is Predictive of Obstructive Sleep Apnea in Syndromic Craniosynostosis: Midfacial hypoplasia is a characteristic feature of the syndromic craniosynostoses and predisposes these patients to developing obstructive sleep apnea (OSA). The purpose of this study was to identify anatomic factors associated with airway obstruction in patients with syndromic craniosynostoses. Purpose Midfacial hypoplasia is a characteristic feature of the syndromic craniosynostoses and predisposes these patients to developing obstructive sleep apnea (OSA). The purpose of this study was... περισσότερα »

Is the Pyriform Ligament Important for Alar Width Maintenance After Le Fort I Osteotomy?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Is the Pyriform Ligament Important for Alar Width Maintenance After Le Fort I Osteotomy?: To determine whether identification and incorporation of the pyriform ligament in the alar cinch results in decreased alar base widening compared with standard alar cinch techniques. Purpose To determine whether identification and incorporation of the pyriform ligament in the alar cinch results in decreased alar base widening compared with standard alar cinch techniques. Materials and Methods This was a retrospective case series and the sample was composed of patients undergoing Le Fort I ost...περισσότερα »

Is It Safe to Re-Harvest the Anterior Iliac Crest to Manage Le Fort I Interpositional Defects in Young Adults With a Repaired Cleft?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Is It Safe to Re-Harvest the Anterior Iliac Crest to Manage Le Fort I Interpositional Defects in Young Adults With a Repaired Cleft?: Re-harvesting the anterior iliac crest to obtain autogenous bone grafts is a controversial practice. The purpose of this study was to assess the feasibility and associated disability of re-harvesting the anterior iliac crest. Purpose Re-harvesting the anterior iliac crest to obtain autogenous bone grafts is a controversial practice. The purpose of this study was to assess the feasibility and associated disability of re-harvesting the anterior iliac... περισσότερα »

Heads, Hands and Jaws: The Role of the Hand Specialist in the Craniofacial Clinic

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Heads, Hands and Jaws: The Role of the Hand Specialist in the Craniofacial Clinic: The association of craniofacial and limb anomalies is well known. The inclusion of the upper limb hand specialist in a multidisciplinary team creates a unique opportunity for patient and surgeon. The experience reported in this article is not what one would initially expect. Within our children's hospital, Dr Joseph Murray created a single division within the department of pediatric surgery and recruited 3 surgeons—a plastic pediatric and cleft specialist, an oral and maxillofacial surgeon, and a plas... περισσότερα »

Evaluating Craniofacial Anomalies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

The Partnership of Medical Genetics and Oral and Maxillofacial Surgery When Evaluating Craniofacial Anomalies: A medical geneticist who has an interest in craniofacial anomalies forms a natural partnership with an oral and maxillofacial surgeon, which facilitates patient care. Using complementary diagnostic and therapeutic skills, the search for a recognizable pattern can lead to a syndrome diagnosis. After the initial examination, there is usually genetic testing to confirm the clinical diagnosis. Once established, care coordination and genetic counseling can be provided for the pa... περισσότερα »

Central Cemento-Ossifying Fibroma: Primary Odontogenic or Osseous Neoplasm?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Central Cemento-Ossifying Fibroma: Primary Odontogenic or Osseous Neoplasm?: Currently, central cemento-ossifying fibroma is classified by the World Health Organization as a primary bone-forming tumor of the jaws. However, histopathologically, it is often indistinguishable from cemento-osseous dysplasias in that it forms osteoid and cementicles (cementum droplets) in varying proportions. It is believed that pluripotent cells within the periodontal membrane can be stimulated to produce either osteoid or woven bone and cementicles when stimulated. If this is true, cemento-ossifying fi...περισσότερα »

A Fascia and The Fascial System

Alexandros G. SfakianakisστοΘεραπείαΠριν από 5 ώρες

Publication date: Available online 23 November 2015 *Source:*Journal of Bodywork and Movement Therapies Author(s): Carla Stecco, Robert Schleip from Pharmacology via ola Kala on Inoreader http://ift.tt/1NmLGx9 via IFTTT

Treatment Outcomes for Medication-Related Osteonecrosis of the Jaw

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Disease Stage and Mode of Therapy Are Important Determinants of Treatment Outcomes for Medication-Related Osteonecrosis of the Jaw: The treatment of patients with medication-related osteonecrosis of the jaw (MRONJ) is challenging. The purpose of the present study was to estimate the frequency and identify the factors associated with clinical improvement during treatment. Purpose The treatment of patients with medication-related osteonecrosis of the jaw (MRONJ) is challenging. The purpose of the present study was to estimate the frequency and identify the factors associated with c...περισσότερα »

Correlation of Airway Volume With Orthognathic Surgical Movement Using Cone-Beam Computed Tomography

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Correlation of Airway Volume With Orthognathic Surgical Movement Using Cone-Beam Computed Tomography: Orthognathic surgery can induce changes in airway volume. The aim of this study was to determine whether there is a correlation of surgical movement of the maxilla or mandible to airway volume changes. Purpose Orthognathic surgery can induce changes in airway volume. The aim of this study was to determine whether there is a correlation of surgical movement of the maxilla or mandible to airway volume changes. Materials and Methods This was a prospective cohort study and the sample ... περισσότερα »

Azathioprine is effective for oral involvement in Crohn's disease but not for orofacial granulomatosis alone

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 ώρες

Azathioprine is effective for oral involvement in Crohn's disease but not for orofacial granulomatosis alone: Background There have been no previous reports assessing the effectiveness of azathioprine (AZA) in the treatment of orofacial granulomatosis (OFG). This report is a review of patients receiving AZA for active OFG with or without concomitant gut Crohn's disease (CD) in a specialist tertiary referral centre. Methods Clinical response was defined by Global Physician Assessment at 4-, 12- and 24-month follow-up and a standardised oral disease activity score (ODAS). Results Sixt... περισσότερα »

Observational Analysis of T Cell Responses to SPIREs for Multiple Allergens in Subjects With Allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Observational Analysis of T Cell Responses to SPIREs for Multiple Allergens in Subjects With Allergy in North America: Condition: AllergyIntervention: Other: Blood SamplingSponsors: Adiga Life Sciences, Inc.; Circassia LimitedRecruiting - verified November 2015 (Source: ClinicalTrials.gov) This is a research study intending to look at the response of a specific type of allergy cells in the blood (called T cells) to a a type of immunotherapy product known as SPIREs (Synthetic Peptide Immuno-Regulatory Epitopes), across a broad range of subjects. This is a non-interventiona... περισσότερα »

Food Allergy Challenge Diagnostic Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Food Allergy Challenge Diagnostic Study: Condition: Food HypersensitivityIntervention: Sponsors: ORA, Inc.; Tufts Medical CenterNot yet recruiting - verified November 2015 (Source: ClinicalTrials.gov) Groups/CohortsChallenge Subjects Male or female subjects aged 5 - 35 with suspected food allergy and an upcoming scheduled clinical food challenge Detailed Description: Patients often discover their food allergies after consuming a given food and experiencing a subsequent allergic reaction. The majority of patients (75%) will then consult a food allergist for formal diagnos... περισσότερα »

Infant Eosinophilic Gastroenteritis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

One Case of Infant Eosinophilic Gastroenteritis and Literature Review *Author(s):* Wang Xin, Zhu Li, Chai Zhongping, Guiyang Maternal and Child Health Care Hospital *Pages:* 33-36 *Year:* 2015 *Issue:* 11 *Journal:* *Journal of Pediatric Pharmacy* *Keyword:* Eosinophil; Gastroenteritis; Literature review; Infants; Infection; Treatment; *Abstract:* Objective: To report a case of infant eosinophilic gastroenteritis and review the literature,provide a reference for clinicians. Methods: The clinical data of infant eosinophilic gastroenteritis was analyzed and reviewed of the literature,... περισσότερα »

Azithromycin to Macrolide-Resistant Mycoplasma Pneumonia in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

The Efficacy and Prognosis of *Author(s):* Yang Huixiang, Zhao Yanfei, Han Li, Zhang Man, People’s Hospital of Xiangtan County, Hunan Province *Pages:* 30-33 *Year:* 2015 *Issue:* 11 *Journal:* *Journal of Pediatric Pharmacy* *Keyword:* Macrolide; Drug resistant; Mycoplasma pneumonia; Azithromycin; *Abstract:* Objective: To evaluate the efficacy of azithromycin to macrolide-resistant( MR) mycoplasma pneumonia in children and to analyze the clinical characteristics. Methods: Ninety-six cases of mycoplasma pneumonia in children were investigated in our hospital.The pneumoniae mycopla... περισσότερα »

Pulmonary Surfactant Combined with Duo Positive Airway Pressure in Neonatal Respiratory Distress Syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Efficacy Observation of *Author(s):* Wang Shuyu, Zhang Ensheng, Wang Jing, Wang Jun, Xuzhou Medical College, Tengzhou Central People’s Hospital, Shandong,The Affiliated Hospital of Xuzhou Medical College *Pages:* 24-27 *Year:* 2015 *Issue:* 11 *Journal:* *Journal of Pediatric Pharmacy* *Keyword:* Noninvasive respiratory support; Respiratory distress syndrome; Duo positive airway pressure; Continuous positive airway pressure; Neonate; *Abstract:* Objective: To discuss the clinical curative effect in the treatment of neonatal respiratory distress syndrome treatment by pulmonary surfa... περισσότερα »

Sublingual Immunotherapy with Dermatophagoides Farinae Drops in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Clinical Efficacy of Sublingual Immunotherapy with Dermatophagoides Farinae Drops in Children with Bronchial Asthma *Author(s):* Huang Juan, Wan Fangrui, Guo Liyuan, The Third Hospital of Nanchang, Jiangxi Province *Pages:* 22-24 *Year:* 2015 *Issue:* 11 *Journal:* *Journal of Pediatric Pharmacy* *Keyword:* Sublingual immunotherapy; Dermatophagoides farinae drops; Children; Bronchial asthma; *Abstract:* Objective: To evaluate the efficacy and safety of dermatophagoides farinae drops in children with bronchial asthma.Methods: Thirty nine bronchial asthmatic children who were allergic... περισσότερα »

Prevention of Different-Dose Dexmedetomidine for Emergence Agitation in Children Undergoing Tosillectomy and Adenoidectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Prevention of Different-Dose Dexmedetomidine for Emergence Agitation in Children Undergoing Tosillectomy and Adenoidectomy *Author(s):* Wang Xiaofang, Chen Weimin, Shengjing Hospital of China Medical University *Pages:* 15-19 *Year:* 2015 *Issue:* 11 *Journal:* *Journal of Pediatric Pharmacy* *Keyword:* Dexmedetomidine; Tonsil; Adenoid; Anesthesia recovery period; Agitation; Children; *Abstract:* Objective: To observe prevention of different dose of dexmedetomidine for emergence agitation in children undergoing tonsillectomy and adenoidectomy. Methods: Sixty children who undergoed ... περισσότερα »

Research of blood circulating DNA in detecting tumor gene mutation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Research of blood circulating DNA in detecting tumor gene mutation *Author(s):* ZENG Qian, SONG Xian-rang, Clinical Laboratory, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medicine Science *Pages:* 1496-1500 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* tumor; cell-free DNA; gene mutation; review literature; *Abstract:* OBJECTIVE To summarize the resent advances in research of cell-free DNA(cfDNA)and its clinical application in detecting tumor gene mutation.METHODS The a... περισσότερα »

Application of hippocampal protection technology to prevent cognitive dysfunction in patients with whole brain radiation therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Application of hippocampal protection technology to prevent cognitive dysfunction in patients with whole brain radiation therapy *Author(s):* WANG Bu-hai, LI Ying, LIU Li-qin, CHEN Yong, YU Jie, Department of Oncology, Northern Jiangsu People’s Hospital *Pages:* 1470-1474 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* whole-brain radiotherapy; hippocampal avoidance; neurocognitive function; cognitive impairment; brain metastasis; *Abstract:* OBJECTIVE To observe the cognitive function of patients after whole brain radiation with hi... περισσότερα »

Leptomeningeal metastases : Prognostic factors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Prognostic factors in 58 patients with leptomeningeal metastases *Author(s):* SUN Ya-fang, SUN Zeng-feng, SHE Chun-hua, LI Peng, PIAO Ying-zhe, LI Wen-liang, Department of Neurosurgery and Neuro-oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy *Pages:* 1461-1465 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* leptomeningeal metastases; clinical features; treatment; prognosic factors; *Abstract:* OBJECTIVE To investigate cl... περισσότερα »

Expression of snail and slug in laryngeal squamous carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Expression of snail and slug in laryngeal squamous carcinoma and its relation to epithelial-mesenchymal transition, tumor invasion and metastasis *Author(s):* PING Jinliang, GU Dongzuo, XU Zuo, GU Yuanxin, ZHANG Jinghua, SONG Pengtao, FANG Zuo, LIU Jin, DAI Licheng *Pages:* 1681-1683 *Journal:* *Zhejiang Medical Journal* *Keyword:* Epithelial- mesenchymal transition; Largneal tumor; Squamous carcinoma; *Abstract:* Objective To investigate the expression of snail and slug in laryngeal squamous carcinoma and its relation to epithelial- mesenchymal transition(EMT), tumor invasion and me... περισσότερα »

Twist protein expression and epithelia-messenchymal transition in laryngeal squamous carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Relationship between Twist protein expression and epithelia-messenchymal transition in laryngeal squamous carcinoma and its clinic significance *Author(s):* PING Jin-liang, GU Dong-hua, XU Wei, GU Yuan-xin, ZHANG Jing-hua, SONG Peng-tao, FANG Wei, LIU Jin, DAI Li-cheng,Huzhou Central Hospital *Pages:* 1451-1455 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* Twist; epithelial-mesenchymal transition; largneal neoplasms; squamous carcinoma; *Abstract:* OBJECTIVE To investigate the expression of Twist in laryngeal squamous carcinoma a... περισσότερα »

Predictive value of EBV and HPV infection for prognosis of oropharyngeal squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

in Tangshan Area *Author(s):* WU Meng, SUN Yu-man, LIU Hong-xia, YANG Jun-quan, Department of Basic Medicine, Pathological Teaching and Researching Section, Tangshan Vocational and Technical College, Department of Pathology, Tangshan Union Hospital, Department of Radio-Chemotherapy Oncology, Tangshan People’s Hospital *Pages:* 1422-1427 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* oropharyngeal neoplasms; squamous cell carcinoma; human papillomavirus; Epstein-Barr virus; in situ hybridization; PCR-reverse dot blot hybridizatio... περισσότερα »

Analysis of incidence of thyroid cancer in the area around Tianwan Nuclear Power Plant

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

from 2001 to 2012 *Author(s):* DONG Jian-mei, LI Wei-wei, QIN Xu-cheng, ZHANG Wei-wei, Department of Chronic Non-communicable Disease Prevention and Control, Lianyungang Center for Disease Prevention and Control *Pages:* 1417-1421 *Year:* 2015 *Issue:* 18 *Journal:* *Chinese Journal of Cancer Prevention and Treatment* *Keyword:* nuclear power plant; radiation; Iodine nutrition; thyroid neoplasms; morbidity; *Abstract:* OBJECTIVE To analyze the incidence of thyroid cancer in the area around Tianwan Nuclear Power Plant from 2001 to 2012.METHODS Diagnosed thyroid cancer cases from 200...περισσότερα »

Viruses, Vol. 7, Pages 5962-5986: Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 6 ώρες

The genomes of RNA viruses are relatively small. To overcome the small-size limitation, RNA viruses assign distinct functions to the processed viral proteins and their precursors. This is exemplified by poliovirus 3CD protein. 3C protein is a protease and RNA-binding protein. 3D protein is an RNA-dependent RNA polymerase (RdRp). 3CD exhibits unique protease and RNA-binding activities relative to 3C and is devoid of RdRp activity. The origin of these differences is unclear, since crystal structure of 3CD revealed "beads-on-a-string" structure with no significant structural differen... περισσότερα »

Molecules, Vol. 20, Pages 20832-20840: Identification of RNA Oligonucleotides Binding to Several Proteins from Potential G-Quadruplex Forming Regions in Transcribed Pre-mRNA

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 6 ώρες

G-quadruplexes (G4s) are noncanonical DNA/RNA structures formed by guanine-rich sequences. Recently, G4s have been found not only in aptamers but also in the genomic DNA and transcribed RNA. In this study, we identified new RNA oligonucleotides working as aptamers by focusing on G4-forming RNAs located within the pre-mRNA. We showed that the G4 in the 5′ UTR and first intron of VEGFA bound to the protein encoded in VEGFA gene, VEGF165, with high affinity. Moreover, G4-forming RNAs located within the PDGFA and the PDGFB introns bound to PDGF-AA and PDGF-BB, respectively, indicating... περισσότερα »

Molecules, Vol. 20, Pages 20805-20822: A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 6 ώρες

DNA methyltransferases (MTases) catalyze the transfer of the activated methyl group of the cofactor S-adenosyl-l-methionine (AdoMet or SAM) to the exocyclic amino groups of adenine or cytosine or the C5 ring atom of cytosine within specific DNA sequences. The DNA adenine-N6 MTase from Thermus aquaticus (M.TaqI) is also capable of coupling synthetic N-adenosylaziridine cofactor analogues to its target adenine within the double-stranded 5′-TCGA-3′ sequence. This M.TaqI-mediated coupling reaction was exploited to sequence-specifically deliver fluorophores and biotin to DNA using N-ad... περισσότερα »

Viruses, Vol. 7, Pages 5987-6008: Genetic and Phylogenetic Characterization of Tataguine and Witwatersrand Viruses and Other Orthobunyaviruses of the Anopheles A, Capim, Guamá, Koongol, Mapputta, Tete, and Turlock Serogroups

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 6 ώρες

The family Bunyaviridae has more than 530 members that are distributed among five genera or remain to be classified. The genus Orthobunyavirus is the most diverse bunyaviral genus with more than 220 viruses that have been assigned to more than 18 serogroups based on serological cross-reactions and limited molecular-biological characterization. Sequence information for all three orthobunyaviral genome segments is only available for viruses belonging to the Bunyamwera, Bwamba/Pongola, California encephalitis, Gamboa, Group C, Mapputta, Nyando, and Simbu serogroups. Here we present c... περισσότερα »

Laryngeal metastasis from bile duct adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Metástasis de adenocarcinoma de colédoco en laringe via ScienceDirect Publication Acta Otorrinolaringológica Española Publication date: Available online 21 November 2015 *Source:*Acta Otorrinolaringológica Española Author(s): Patricia Varela-Vázquez, Anselmo Padín-Seara, Ignacio Galed-Placed Figures and tables 1. [image: Corte axial de la TC donde se observa una lesión única que destruye el cartílago ...] 2. [image: Pieza quirúrgica.] 3. [image: Corte histológico donde se aprecia invasión del cartílago tiroideo, con ...]

Endotracheal tube cuff pressures and tube position in critically injured patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

on arrival at a referral centre: Avoidable harm? via Emergency Medicine Publication date: Available online 21 November 2015 *Source:*African Journal of Emergency Medicine Author(s): Timothy C. Hardcastle, Michael Faurie, David J.J. Muckart IntroductionThe consequences of excessive endotracheal tube (ETT) cuff pressure are known and have long-term effects; however less attention is placed upon cuff pressure and tube position pre-hospital and in emergency centre. The aim of this study was to evaluate the ETT cuff pressure and tube position on arrival of all patients admitted to the Traum... περισσότερα »

HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile: Abstract BackgroundWe previously conducted a population-based screening trial of high-risk human papillomavirus (hrHPV) testing and conventional cytology, demonstrating higher sensitivity (92.7 % vs 22.1 % for CIN2+) but lower positive predictive value (10.5 % vs 23.9 %) of hrHPV testing. Here we report the performance of HPV16/18 genotyping to triage the hrHPV positive participants. MethodsWomen aged 25 years and older received hrHPV (Hybrid Capture 2) and Papanicolaou test...περισσότερα »

Stereotactic radiation therapy for skull base recurrences

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

: Is a salvage approach still possible? by Reports of Practical Oncology and Radiotherapy via MedWorm Palliative Care Research Conclusions In conclusion, it emerges that SRS and FSRT are effective and safe radiation modalities of realize real salvage treatment for recurrent skull base tumours. (Source: Reports of Practical Oncology and Radiotherapy) [image: Recurrent benign meningioma in a 47 years old male previously treated with ...] [image: Pituitary adenoma in a 61 years old, male already treated with partial surgery. ...] Abstract Aim A literature review was performed to analyse ... περισσότερα »

Von Hippel-Lindau: Current Evidence in Diagnosis, Treatment, and Nursing Implications.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Von Hippel-Lindau: Current Evidence in Diagnosis, Treatment, and Nursing Implications.: Authors: Zhao K, Barkley TW Abstract BACKGROUND: Von Hippel-Lindau (VHL) is a rare autosomal dominant hereditary disorder that predisposes individuals to benign and malignant tumors in the brain, eyes, kidneys, pancreas, genital tract, or other body parts. The VHL gene, which is located on the short arm of chromosome 3, prevents cells from dividing too rapidly. Mutations in the VHL gene result in uncontrollable cell growth and tumor formation. OBJECTIVES: The purpose of this article is to summarize...περισσότερα »

Analysis of the trace element chemistry of otoliths via Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

LA-ICP-MS chemical analysis of archaeological otoliths as a tool for seasonality and site catchment studies via ScienceDirect Publication: Journal of Archaeological Science Publication date: January 2016 *Source:*Journal of Archaeological Science, Volume 65 Author(s): Evan Peacock, Rinat Gabitov, Jonathan R. Frisch, Carla S. Hadden, Bradley Carlock, Kate L. Henderson Analysis of the trace element chemistry of otoliths via Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) has become common in fisheries-related work, allowing biologists to trace connectivity between... περισσότερα »

IgG4-assoziierten Erkrankungen : Multifokale Tumoren bei einem 56-jährigen Patienten

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Multifokale Tumoren bei einem 56-jährigen Patienten: Kasuistik IgG4-assoziierten Erkrankungen sind eine neu beschriebene Entität. Sie kann vorliegen, wenn scheinbar nicht zusammenhängende fokale und/oder diffuse Organvergrößerungen gemeinsam auftreten. Original enclosures:

ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq I)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

GSE72146 ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq I): *Contributors* : Hanseul Yang ; Elaine Fuchs *Series Type* : Expression profiling by high throughput sequencing *Organism* : Mus musculus After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenance.

ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq II)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

GSE74868 ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq II): *Contributors* : Hanseul Yang ; Elaine Fuchs *Series Type* : Expression profiling by high throughput sequencing *Organism* : Mus musculus After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenance.

Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders: Aims Our studies investigated the location of oxytocin receptors in the peripheral trigeminal sensory system and determined their role in trigeminal pain. Methods Oxytocin receptor expression and co-localization with calcitonin gene-related peptide was investigated in rat trigeminal ganglion using immunohistochemistry. Enzyme-linked immunosorbent assay was used to determine the effects of facial electrocutaneous stimulation and adjuvant-induced inflammation...περισσότερα »

Tumor Microenvironment Confers De Novo Therapy Resistance

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Tumor Microenvironment Confers De Novo Therapy Resistance: Resistance to currently available targeted therapies significantly hampers the survival of patients with prostate cancer with bone metastasis. Here we demonstrate an important resistance mechanism initiated from tumor-induced bone. Studies using an osteogenic patient-derived xenograft, MDA-PCa-118b, revealed that tumor cells resistant to cabozantinib, a Met and VEGFR-2 inhibitor, reside in a “resistance niche” adjacent to prostate cancer-induced bone. We performed secretome analysis of the conditioned medium from tumor-induc...περισσότερα »

Networks dynamics and opposite effects of Wnt5a on motility in melanomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Abstract B2-32: Networks dynamics and opposite effects of Wnt5a on motility in melanomas: Melanoma is an aggressive cancer whose incidence continues to rise worldwide; furthermore, metastatic melanoma is associated with poor prognosis. Wnt signaling may lead to conflicting effects on the biology of melanoma as it may either decrease or increase the incidence of metastasis. Here, we show that Wnt5a enhances motility in 3/5 cell lines and represses motility in the other two. We measured the effects of perturbations of the levels of Wnt5a, HADHB, Pirin, and Mart1 on the levels of the se...περισσότερα »

Evolution and Cancer Treatment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Evolution and Cancer Treatment: The dynamic cancer ecosystem, with its rich temporal and spatial diversity in environmental conditions and heritable cell phenotypes, is remarkably robust to therapeutic perturbations. Even when response to therapy is clinically complete, adaptive tumor strategies almost inevitably emerge and the tumor returns. Although evolution of resistance remains the proximate cause of death in most cancer patients, a recent analysis found that evolutionary terms were included in less than 1% of articles on the cancer treatment outcomes, and this has not changed i... περισσότερα »

Phospho-proteomic analysis of MEK inhibition in mutant NRAS melanoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Abstract A2-60: Phospho-proteomic analysis of MEK inhibition in mutant NRAS melanoma: Melanoma is a devastating form of skin cancer with limited therapeutic options. Fifteen to twenty percent of melanoma patients have an activating mutation in NRAS, a small GTPase. NRAS has several downstream effectors, the most well-characterized is RAF leading to activation of MEK/ERK. While there are no FDA-approved targeted therapies for melanoma patients with a primary mutation in NRAS, one form of targeted therapy that has been explored is MEK inhibition. Phase I to III studies of MEK inhibito...περισσότερα »

Airway gene-coexpression network rewiring in the presence of bronchial dysplasia and lung cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Abstract A2-63: Airway gene-coexpression network rewiring in the presence of bronchial dysplasia and lung cancer: In this study, we have expanded upon this work by leveraging gene expression from airway epithelial cells collected in the presence of bronchial premalignant lesions. Specifically, we conducted network-based analyses to further explore alterations in bronchial gene coexpression (GCE) patterns in the uninvolved large airway of patients with tobacco-induced premalignancy and those with lung cancer. By studying airway GCE patterns present in patients with lung cancer and pr...περισσότερα »

Soft-tissue sarcomas (STS) account for 1% of adult and 7% of pediatric malignancies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Epidemiological study of soft-tissue sarcomas in Ireland: Abstract Soft-tissue sarcomas (STS) account for 1% of adult and 7% of pediatric malignancies. Histopathology and classification of these rare tumors requires further refinements. The aim of this paper is to describe the current incidence and survival of STS from 1994 to 2012 in Ireland and compare these with comparably coded international published reports. This is a retrospective, population study based on the data from the National Cancer Registry of Ireland (NCRI). Incidence and relative survival rates for STS in Ireland ... περισσότερα »

Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 ώρες

Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer: • Increased glycolysis and PDK2 overexpression in head and neck cancer (HNC) cells were correlated with decreased sensitivity to cisplatin.• Dichloroacetate (DCA) shifted cellular bioenergetics from glycolysis to mitochondrial oxidative phosphorylation.• DCA induced ROS accumulation and activated downstream mitochondrial apoptotic signaling in HNC cells.• DCA significantly reversed cisplatin resistance in HNC cells in vitro and in vivo. (Source: Cancer Letters) Highligh... περισσότερα »

BacterioFiles 239 - Familial Pheromones Fight faecalis

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 7 ώρες

Just to let you know, I'm trying to finish up my dissertation and graduate in the next few months, so after episode 240, I will be putting the show on hold, at least for a few weeks (but not forever). I'll be sure to bring back some good content after I am done feeling so crunched for time thoug... from Infection via ola Kala on Inoreader http://ift.tt/1NKM3vr via IFTTT

Tariquidar (XR9576) in combination with doxorubicin, vinorelbine, or docetaxel in children and adolescents with refractory solid tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Pharmacokinetic and pharmacodynamic study of tariquidar (XR9576), a P-glycoprotein inhibitor, in combination with doxorubicin, vinorelbine, or docetaxel in children and adolescents with refractory solid tumors: Conclusion A tolerable and biologically active dose of tariquidar was established in children and adolescents. This trial demonstrates that modulators of resistance can be evaluated in combination with chemotherapy, and pharmacokinetic and pharmacodynamic endpoints can be useful in determination of recommended dose in children and adolescents. (Source: Cancer Chemotherapy an...περισσότερα »

Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.: Authors: Bellissimo T, Russo E, Ganci F, Vico C, Sacconi A, Longo F, Vitolo D, Anile M, Disio D, Marino M, Blandino G, Venuta F, Fazi F Abstract Thymic epithelial cells give rise to both thymoma and thymic carcinoma. A crucial advance in thymic epithelial tumors (TET) management may derive from the identification of novel molecular biomarkers able to improve diagnosis, prognosis and treatment planning. In a previous study, we identified microRNAs that were differentially expressed ... περισσότερα »

E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer.: CONCLUSION: Our data suggest that the use of HPV 16 spliced transcripts may help to predict for poorer outcomes in patients with HPV positive OSCC. PMID: 26575468 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy) Cancer Biol Ther. 2015 Nov 17:0. [Epub ahead of print] E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer. Hong A1,2, Zhang X3, Jones D3, Zhang M1,2, Lee CS4, Lyons JG1, Veillard AS5, Rose B3. Au...περισσότερα »

Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy: BACKGROUND An accurate staging system is crucial for cancer management. Evaluations for continual suitability and improvement are needed as staging and treatment methods evolve. METHODS This was a retrospective study of 1609 patients with nasopharyngeal carcinoma investigated by magnetic resonance imaging, staged with the 7th edition of the American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) staging system, and irradia...περισσότερα »

[Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma].

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

[Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma].: Authors: Ben Chaaben A, Abaza H, Douik H, Chaouch L, Ayari F, Ouni N, Mamoghli T, Ben Guezella D, Mejri R, Harzallah L, Guemira F Abstract Cytochrome P450 2E1 (CYP2E1) is a detoxifying enzyme that belongs to the phase I metabolism of xenobiotics. This enzyme is encoded by a highly polymorphic gene whose common polymorphism corresponds to the substitution of cytosine (C) and thymine (T) at position -1019 (rs2031920). This polymorphism has been identified in several cancers including nasopharyngeal... περισσότερα »

Numb chin syndrome as initial manifestation of bisphosphonate-related osteomyelitis of the jaw and methotrexate-associated lymphoproliferative disorders: a rare case

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Numb chin syndrome as initial manifestation of bisphosphonate-related osteomyelitis of the jaw and methotrexate-associated lymphoproliferative disorders: a rare case: Recently, there has been a preference for prescribing antirheumatic drugs such as methotrexate for rheumatoid arthritis,1 but there have been serious side effects, such as methotrexate-associated lymphoproliferative disorders.

Raised Schneiderian membrane compared with peeled bony walls in the formation of bone

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Raised Schneiderian membrane compared with peeled bony walls in the formation of bone: We read with interest the experimental study on dogs by Rong et al,1 in which they used a biocompatible, non-absorbable, ultrathin, titanium membrane with no osteoinductive or osteogenic properties. The membrane was shaped and implanted as a barrier to shield against migration of osteoprogenitor cells from the raised Schneiderian membrane and from the surrounding bony walls towards the implanted graft material. This distinguished between the roles of the two in the formation of new bone.

The Glasgow splint: modification of occlusal splint for cleft osteotomies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

The Glasgow splint: modification of occlusal splint for cleft osteotomies: In patients with cleft lip and palate, orthognathic operations commonly involve Le Fort I osteotomy,1–3 but the cleft, together with the corrective operations often lead to scarring and distortion of the soft tissue,1–3 which cause the maxilla to be hypoplastic. The presence of scar tissue creates additional surgical challenges as it makes mobilisation of the maxilla more difficult and affects long-term stability.1–3

Psychiatrist Tinnitus

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Psychiatrist Tinnitus: Tinnitus is a medical condition that is usually describing as a “ringing” sensation in the ears. Many patients report that the experience can range from a mild sort of buzzing to a constant static or ringing sound. The aspect that makes the condition so difficult is the fact that there is no sure medical cure for it, and once a person suffers from tinnitus, it can be a constant presence that never shuts off. The constant sound and the inability to really sit and experience silence can be seriously debilitating, stressful and very depressing. There are many c... περισσότερα »

Simulation study of high-dose-rate brachytherapy for early glottic cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Simulation study of high-dose-rate brachytherapy for early glottic cancer: External beam radiation therapy (EBRT) is effective for early glottic cancers, with cure rates of ∼90% for T1 tumors. EBRT has strengths but also disadvantages including radiation to healthy tissues and duration of 5–7 weeks. With advances in laryngeal framework surgery, new devices can provide reliable, minimally invasive access to the larynx. Such devices could be modified to insert brachytherapy catheters. Brachytherapy could provide focused radiation while limiting dose to normal structures in the larynx ... περισσότερα »

Primary glottic malignant melanoma of the larynx (PGMML)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Primary glottic malignant melanoma of the larynx (PGMML): a very rare entity: Primary glottic malignant melanoma of the larynx (PGMML) is a very rare clinical entity with less than 20 cases reported in the literature so far. The most frequently reported subsite in primary malignant melanomas of the larynx is the supraglottic larynx. The vocal cord as a subsite for primary malignant melanoma is very rare. The present case is a primary glottic malignant melanoma involving both vocal cords. PGMML may present early due to associated hoarseness of voice, unlike other non-cutaneous melan... περισσότερα »

Giant prolactinomas are rare pituitary tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Ten-year follow-up of a giant prolactinoma: Giant prolactinomas are rare pituitary tumours of which management can be a challenge. A 28-year-old man presented with headaches, visual impairment and behavioural changes. Clinically, the patient was found to have hypogonadism and bitemporal hemianopsia. A MRI demonstrated a pituitary tumour 76 mm in diameter and blood tests revealed a serum prolactin of 158 700 µU/mL (reference range 58–254). Initially, a craniotomy was performed. Immunohistochemistry of the tumour identified a prolactinoma with a high proliferative index and the patie...περισσότερα »

Mastoiditis and Gradenigo's Syndrome with anaerobic bacteria

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Mastoiditis and Gradenigo's Syndrome with anaerobic bacteria: Background: Gradenigo’s syndrome is a rare disease, which is characterized by the triad of the following conditions: suppurative otitis media, pain in the distribution of the first and the second division of trigeminal nerve, and abducens nerve palsy. The full triad may often not be present, but can develop if the condition is not treated correctly.Case presentationWe report a case of a 3-year-old girl, who presented with fever and left-sided acute otitis media. She developed acute mastoiditis, which was initially treated ... περισσότερα »

Thyroid cancer cytologic diagnosis : KIT, TC1, miR-222, miR-146b

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

The combination of four molecular markers improves thyroid cancer cytologic diagnosis and patient management: Background: Papillary thyroid cancer is the most common endocrine malignancy. The most sensitive and specific diagnostic tool for thyroid nodule diagnosis is fine-needle aspiration (FNA) biopsy with cytological evaluation. Nevertheless, FNA biopsy is not always decisive leading to “indeterminate” or “suspicious” diagnoses in 10 %–30 % of cases. BRAF V600E detection is currently used as molecular test to improve the diagnosis of thyroid nodules, yet it lacks sensitivity. The a... περισσότερα »

The combination of four molecular markers improves thyroid cancer cytologic diagnosis and patient management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

The combination of four molecular markers improves thyroid cancer cytologic diagnosis and patient management: Conclusions: The four genes model proposed in this study proved to be highly discriminative of the malignant status compared with BRAF assessment alone. Its implementation in clinical practice can help in identifying malignant/benign nodules that would otherwise remain suspicious. (Source: BMC Cancer) *Federica Panebianco*12*†, *Chiara Mazzanti*13†, *Sara Tomei*4, *Paolo Aretini*3, *Sara Franceschi*3, *Francesca Lessi*3, *Giancarlo Di Coscio*5, *Generoso Bevilacqua*15 a... περισσότερα »

Sensors, Vol. 15, Pages 29478-29510: TF4SM: A Framework for Developing Traceability Solutions in Small Manufacturing Companies

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 7 ώρες

Nowadays, manufacturing processes have become highly complex. Besides, more and more, governmental institutions require companies to implement systems to trace a product's life (especially for foods, clinical materials or similar items). In this paper, we propose a new framework, based on cyber-physical systems, for developing traceability systems in small manufacturing companies (which because of their size cannot implement other commercial products). We propose a general theoretical framework, study the requirements of these companies in relation to traceability systems, propose...περισσότερα »

Children with oral clefts are at greater risk for persistent low achievement in school than classmates

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Children with oral clefts are at greater risk for persistent low achievement in school than classmates: Objectives To examine trajectories in academic achievement for children with oral clefts versus unaffected classmates and explore predictors of persistently low achievement among children with oral clefts. Design Longitudinal cohort study of academic achievement in a population-based sample. Setting and participants Children born from 1983 through 2003 with oral clefts were identified from the Iowa Registry for Congenital and Inherited Disorders and matched to unaffected classm... περισσότερα »

Childhood head injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Trends in admission and death rates due to paediatric head injury in England, 2000-2011: Background The number of children admitted to hospital is increasing year on year, with very short-stay admissions doubling in the last decade. Childhood head injury accounts for half a million emergency department attendances in the UK every year. The National Institute for Health and Care Excellence (NICE) has issued three iterations of evidence-based national guidance for head injury since 2003. Objectives To assess if any changes in the rates of admission, death or causes of head injury co...περισσότερα »

Abusive head trauma and accidental head injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Abusive head trauma and accidental head injury: a 20-year comparative study of referrals to a hospital child protection team: Aim To describe children referred for suspected abusive head trauma (AHT) to a hospital child protection team in Auckland, New Zealand. Methods Comparative review of demographics, histories, injuries, investigations and diagnostic outcomes for referrals under 15 years old from 1991 to 2010. Results Records were available for 345 children. Referrals increased markedly (88 in the first decade, 257 in the second), but the diagnostic ratio was stable: AHT 60%, ... περισσότερα »

Pattern of symptoms and signs of primary intracranial tumours in children and young adults: a record linkage study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Pattern of symptoms and signs of primary intracranial tumours in children and young adults: a record linkage study: Objective To describe the age pattern and temporal evolution of symptoms and signs of intracranial tumours in children and young adults before diagnosis. Design and setting A record linkage study using population-based data from the National Cancer Registry, linked to Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES). Patient cohort Patients aged 0–24 years when diagnosed with a primary intracranial tumour between 1989 and 2006 in Engla...περισσότερα »

Self-asphyxial behaviours ('choking game') in young people

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Prevalence and associated harm of engagement in self-asphyxial behaviours ('choking game') in young people: a systematic review: Objective To assess the prevalence of engagement in self-asphyxial (risk-taking) behaviour (SAB) (‘choking game’) and associated morbidity and mortality in children and young people up to age 20. Design Systematic literature review. Search strategy Electronic database search of MEDLINE, Embase, PsycINFO, CINAHL, PubMed, Web of Science Core Collection, BIOSIS citation index and the Cochrane register with no language or date limits applied. References of k...περισσότερα »

Hypertonic saline for bronchiolitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Hypertonic saline for bronchiolitis: a case of less is more: Acute bronchiolitis is the most common cause for hospitalisation in infancy with 2–3% of all UK infants admitted in their first winter.12 It has a substantial health economic burden with annual costs in the USA of over $0.5 billion for hospital care alone.3 In addition to short-term morbidity, there are also associated long-term consequences with 40–50% of those admitted subsequently enduring recurrent wheeze.45 The significant impact of bronchiolitis has led to an extensive search for effective therapies over the last ha... περισσότερα »

Respiratory distress including wheeze

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Variations in the diagnosis and management of bronchiolitis in older infants: a UK survey: When older infants present with symptoms of respiratory distress including wheeze, diagnosing bronchiolitis can be challenging. This is because other causes of wheeze, such as asthma and viral wheeze (VW) also feature in this age group. In my own practice, I consistently come across wide practice variations, which may indicate confusion on the subject. This study aimed to survey the diagnostic parameters employed by paediatric medical staff for bronchiolitis and the management of wheeze for c...περισσότερα »

Flu vaccine and egg allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Flu vaccine and egg allergy: Atopic children with asthma are at increased risk from influenza, but are also more likely to be egg allergic. Egg allergy reportedly affects up to 2% of all under-5s. It's important, therefore, to remove obstacles to getting them immunised. All ‘flu vaccines licensed for children are manufactured using hen's eggs, and until now live attenuated influenza vaccine (LAIV; ‘Fluenz’) – an intranasal vaccine which families understandably find more acceptable than injections – was contraindicated in egg allergy. A UK group recently completed the SNIFFLE study... περισσότερα »

Human Papillomavirus (HPV) Detection in Cytologic Specimens: Similarities and Differences of Available Methodology.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Human Papillomavirus (HPV) Detection in Cytologic Specimens: Similarities and Differences of Available Methodology.: Accumulating evidence regarding the causative role of human papillomavirus (HPV) in a wide range of malignant and nonmalignant diseases highlights the importance of HPV testing. This study describes and discusses the efficacy and characteristics of 4 well-established and commercially available tests. Here, 181 cytologic specimens from cervical smears were analyzed using the HPV SIGN PQ (Diatech) and the Linear Array (Roche) method. Discrepant results were further stud... περισσότερα »

Targeting of Tumor Necrosis Factor Alpha Receptors as a Therapeutic Strategy for Neurodegenerative Disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Antibodies, Vol. 4, Pages 369-408: Targeting of Tumor Necrosis Factor Alpha Receptors as a Therapeutic Strategy for Neurodegenerative Disorders: Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-α), and have linked it with several neurodegenerative disorders. This review describes the signaling pathways induced by TNF-α via its two receptors (TNFR1 and TNFR2), and their functions in neurodegenerative processes as in Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), and ischemic stroke. It has become clear that TNF...περισσότερα »

Impact of Timeliness of Resection and Thyroidectomy Margin Status on Survival for Patients with Anaplastic Thyroid Cancer: An Analysis of 335 Cases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Impact of Timeliness of Resection and Thyroidectomy Margin Status on Survival for Patients with Anaplastic Thyroid Cancer: An Analysis of 335 Cases: Conclusions Timely and aggressive surgical management should be pursued in patients with intrathyroidal disease; however, aggressive resections may not be recommended for patients with stage IVB and IVC disease when morbidity and operative risks outweigh the limited benefits of surgery. (Source: Annals of Surgical Oncology) Abstract Background Controversies regarding anaplastic thyroid cancer (ATC) surround aggressiveness of tumor rese...περισσότερα »

First-Attempt Intubation Success of Video Laryngoscopy in Patients with Anticipated Difficult Direct Laryngoscopy: A Multicenter Randomized Controlled Trial Comparing the C-MAC D-Blade Versus the GlideScope in a Mixed Provider and Diverse Patient Population.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

First-Attempt Intubation Success of Video Laryngoscopy in Patients with Anticipated Difficult Direct Laryngoscopy: A Multicenter Randomized Controlled Trial Comparing the C-MAC D-Blade Versus the GlideScope in a Mixed Provider and Diverse Patient Population.: BACKGROUND: Intubation success in patients with predicted difficult airways is improved by video laryngoscopy. In particular, acute-angle video laryngoscopes are now frequently chosen for endotracheal intubation in these patients. However, there is no evidence concerning whether different acute-angle video laryngoscopes can be ...περισσότερα »

Topic shift impairs pronoun resolution during sentence comprehension: Evidence from event-related potentials

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 7 ώρες

Abstract This study investigated how topic shift and topic continuation influence pronoun interpretation in Chinese. ERPs recorded on pronouns in topic structure showed stronger and earlier late positive responses (P600) for the topic-shift than for the topic-continuation conditions. However, in nontopic structure where the subject (denoting only subjecthood), rather than the topic (denoting both topichood and subjecthood), acted as the antecedent of the pronoun, almost indistinguishable P600 responses were obtained on the pronoun regardless of whether it was referring to the subj... περισσότερα »

Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study.: *Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study.* Otol Neurotol. 2015 Nov ; Authors: Kariya S, Hzl Ö, Kaya S, Hzl P, Nishizaki K, Paparella MM, Cureoglu S Abstract HYPOTHESIS: We hypothesized that a pathologic condition exists in vestibular hair cells in human temporal bones from patients with systemic lupus erythematosus (SLE). BACKGROUND: A significant assoc... περισσότερα »

Hearing Aids Use Reduces Cognitive Decline, Study Says

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Hearing Aids Use Reduces Cognitive Decline, Study Says: By Alissa Katz Those who use hearing aids have relatively the same cognitive level compared with those with no hearing loss, according to a new study published in *Journal of the American Geriatrics Society*. ( http://bit.ly/1MkiNho.) The researchers, led by Hélène Amieva, a professor at the University of Bordeaux, France, followed 3,670 adults 65 and older over a 25-year period. They compared the trajectory of cognitive decline among older adults who were using hearing aids and those who were not, and found no difference in ... περισσότερα »

Bony labyrinth shape variation in extant Carnivora: a case study of Musteloidea.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Bony labyrinth shape variation in extant Carnivora: a case study of Musteloidea.: *Bony labyrinth shape variation in extant Carnivora: a case study of Musteloidea.* J Anat. 2015 Nov 18; Authors: Grohé C, Tseng ZJ, Lebrun R, Boistel R, Flynn JJ Abstract The bony labyrinth provides a proxy for the morphology of the inner ear, a primary cognitive organ involved in hearing, body perception in space, and balance in vertebrates. Bony labyrinth shape variations often are attributed to phylogenetic and ecological factors. Here we use three-dimensional (3D) geometric morphometrics to exa... περισσότερα »

Sound localization measured by eye-tracking.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Sound localization measured by eye-tracking.: *Sound localization measured by eye-tracking.* Int J Audiol. 2015 Nov 18;:1-8 Authors: Volck AC, Laske RD, Litschel R, Probst R, Tasman AJ Abstract OBJECTIVE: To introduce a new method of measuring sound localization ability based on eye-tracking and to test this method by analysing the influence of mild induced conductive hearing loss on sound localization. DESIGN: Sound signals were presented from different angles, and the participant's responses were measured using an eye-tracking device. For validation, a comparison of responses t...περισσότερα »

Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss.: Objective: Listeners with sensorineural hearing loss (SNHL) typically experience reduced speech perception, which is not completely restored with amplification. This likely occurs because cochlear damage, in addition to elevating audiometric thresholds, alters the neural representation of speech transmitted to higher centers along the auditory neuroaxis. While the deleterious effects of SNHL on speech perception in humans...περισσότερα »

Qualities of Single Electrode Stimulation as a Function of Rate and Place of Stimulation with a Cochlear Implant.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Qualities of Single Electrode Stimulation as a Function of Rate and Place of Stimulation with a Cochlear Implant.: Objectives: Although it has been shown previously that changes in temporal coding produce changes in pitch in all cochlear regions, research has suggested that temporal coding might be best encoded in relatively apical locations. The authors hypothesized that although temporal coding may provide useable information at any cochlear location, low rates of stimulation might provide better sound quality in apical regions that are more likely to encode temporal information i...περισσότερα »

Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions.: Objectives: Measurement of changes in transient-evoked otoacoustic emissions (TEOAEs) caused by activation of the medial olivocochlear reflex (MOCR) may have clinical applications, but the clinical utility is dependent in part on the amount of variability across repeated measurements. The purpose of this study was to investigate the within- and across-subject variability of these measurements in a research setting as a step toward determi...περισσότερα »

RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance.: *RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance.* BMC Res Notes. 2015;8(1):691 Authors: Ramírez-Gordillo D, Powers TR, van Velkinburgh JC, Trujillo-Provencio C, Schilkey F, Serrano EE Abstract BACKGROUND: Auditory and vestibular disorders are prevalent sensory disabilities caused by genetic and environmental (noise, tr... περισσότερα »

Effects of Unilateral Cochlear Implantation on Balance Control and Sensory Organization in Adult Patients with Profound Hearing Loss.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Effects of Unilateral Cochlear Implantation on Balance Control and Sensory Organization in Adult Patients with Profound Hearing Loss.: *Effects of Unilateral Cochlear Implantation on Balance Control and Sensory Organization in Adult Patients with Profound Hearing Loss.* Biomed Res Int. 2015;2015:621845 Authors: Parietti-Winkler C, Lion A, Montaut-Verient B, Grosjean R, Gauchard GC Abstract Many studies were interested in the consequence of vestibular dysfunction related to cochlear implantation on balance control. This pilot study aimed to assess the effects of unilateral cochlea... περισσότερα »

Parent Telegraphic Speech Use and Spoken Language in Preschoolers With ASD

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Parent Telegraphic Speech Use and Spoken Language in Preschoolers With ASD: Purpose There is considerable controversy regarding whether to use telegraphic or grammatical input when speaking to young children with language delays, including children with autism spectrum disorder (ASD). This study examined telegraphic speech use in parents of preschoolers with ASD and associations with children's spoken language 1 year later. Method Parent–child dyads (n = 55) participated when children were, on average, 3 (Time 1) and 4 years old (Time 2). The rate at which parents omitted obligato... περισσότερα »

Retrospective Analysis of Decreasing the Use of Anesthesia in Pediatric Audiology: A Preliminary Study

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Retrospective Analysis of Decreasing the Use of Anesthesia in Pediatric Audiology: A Preliminary Study: Purpose The purpose of this article is to analyze outcomes of processes aimed at reducing the need for use of anesthesia in evaluating pediatric hearing loss. Method A retrospective chart review was completed to assess how often a pediatric hearing evaluation was successful/not successful and auditory brainstem response (ABR) testing with anesthesia was avoided/required following review of orders for ABR testing with anesthesia. Results A total of 30% of the patients referred ...περισσότερα »

Influence of Test Condition on Speech Perception With Electric-Acoustic Stimulation

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Influence of Test Condition on Speech Perception With Electric-Acoustic Stimulation: Purpose The goal of this work was to better understand speech perception for cochlear implant (CI) users with bilateral residual hearing, including consideration of effects related to listening conditions and test measures. Of interest was the role of acoustic hearing for speech perception in a complex background, the role of listening experience for CI-alone conditions, and whether performance with electric-acoustic stimulation (EAS) was improved by a contralateral hearing aid (HA). Method Eleve... περισσότερα »

The Effect of Advancing Age on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

The Effect of Advancing Age on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach: Purpose The purpose of the study was to objectively detect age-specific changes that occur in equivalent auditory steady-state responses (ASSRs), corresponding to transient middle- and long-latency auditory evoked potentials as a function of repetition rate and advancing age. Method The study included 48 healthy hearing adults who were equally divided into 3 groups by age: 20–39, 40–59, and 60–79 years. ASSRs were recorded at 7 repetition rates from 40 down to...περισσότερα »

Factors Influencing Hearing Aid Use in the Classroom: A Pilot Study

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Factors Influencing Hearing Aid Use in the Classroom: A Pilot Study: Purpose This pilot study examined factors influencing classroom hearing aid use in school-age children with hearing loss. Method The research team visited classrooms of 38 children with mild-to-moderate hearing loss (Grades 1–7) on 2 typical school days, twice per day, to document hearing aid use. In addition, parents reported the number of hours their children used hearing aids at school. Results Nearly 24% of children were observed not wearing their hearing aids in the classroom on either observation day. Both... περισσότερα »

Addressing Hearing Aid User Needs with Binaural Strategies for Enhanced Hearing

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 7 ώρες

Addressing Hearing Aid User Needs with Binaural Strategies for Enhanced Hearing: Editor’s Note: This text course is an edited transcript of a live webinar. Download supplemental course materials.Dr. Melissa Ruscetta: In this course, I will be specifically reviewing the binaural processing features of our newest produc

Consensus on Dealing with the 5-Minute Oral Appliance Fix

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 7 ώρες

*(Kent Smith, Keith Thornton,* *Les Priemer, Tony Soileau,* *Francesca Milano, Patrick Tessier, Daniel Klauer, Steve Lamberg, Gina Pepitone-Mattiello, John Carollo, Dennis Marangos, Barry Glassman, Steve Carstensen, Christopher Kelly,* *Dan Tache, John Viviano**)* The LinkedIn Discussion Group, *"SleepDisordersDentistry"* has just completed an open discussion on *"Dealing with the 5-Minute Oral Appliance Fix"*. Here is a consensus for all to ponder. *What was asked,* *"We've all been there, you walk into the room, the patient is in the chair, and you have 5 minutes to do someth...περισσότερα »

Review article: the prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 ώρες

Summary Background There is little up-to-date review evidence on the prevalence of *Helicobacter pylori* across Europe. Aim To establish regional and national patterns in *H. pylori* prevalence across Europe. Secondly, to establish trends over time in *H. pylori* prevalence and gastric cancer incidence and, thirdly, to report on the relationship between *H. pylori* prevalence and age group across Europe. Methods A review of *H. pylori* prevalence from unselected surveys of adult or general populations across 35 European countries and four European regions since 1990. Secondly, ... περισσότερα »

Review article: the current treatment of non-cardiac chest pain

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 ώρες

Summary Background Non-cardiac chest pain is one of the most common functional gastrointestinal disorders. By recognising that gastro-oesophageal reflux disease (GERD), oesophageal dysmotility and oesophageal hypersensitivity are the main underlying mechanisms of NCCP, a more directed therapeutic approach has been developed. Aim To determine the value of the current therapeutic modalities for NCCP. Methods Electronic (Pubmed/Medline/Cochrane central) and manual search. Results Double-dose PPI treatment for two months is a reasonable first choice approach in patients with NCCP ... περισσότερα »

Differential effects of antifungal agents on expression of genes related to formation of Candida albicans biofilms

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 7 ώρες

Summary The purpose of this study was to analyse specific molecular mechanisms involved in the intrinsic resistance of *C. albicans* biofilms to antifungals. We investigated the transcriptional profile of three genes (*BGL2, SUN41, ECE1*) involved in *Candida* cell wall formation in response to voriconazole or anidulafungin after the production of intermediate and mature biofilms. *C. albicans* M61, a well-documented biofilm producer strain, was used for the development of intermediate (12 h and 18 h) and completely mature biofilms (48 h). After exposure of cells from each biofilm... περισσότερα »

Antibacterial properties of Biosurfactants against selected gram positive and negative bacteria

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 7 ώρες

The antibacterial properties and ability to disrupt biofilms of biosurfactants (rhamnolipids, sophorolipids) and sodium dodecyl sulphate (SDS) in the presence and absence of selected organic acids were investigated. *Pseudomonas aeruginosa* PAO1 was inhibited by sophorolipids and SDS at concentrations &gt;5% v/v, the growth of *Escherichia coli* NCTC 10418 was also inhibited by sophorolipids and SDS at concentrations &gt;5% and 0.1% v/v respectively. *Bacillus subtilis* NCTC 10400 was inhibited by rhamnolipids, sophorolipids and SDS at concentrations &gt;0.5% v/v of all three; the same eff...περισσότερα »

Awake Craniotomy: A New Airway Approach.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 7 ώρες

Awake Craniotomy: A New Airway Approach.: Awake craniotomies have been performed regularly at the University of Pennsylvania since 2004. Varying approaches to airway management are described for this procedure, including intubation with an endotracheal tube and use of a laryngeal mask airway, simple facemask, or nasal cannula. In this case series, we describe the successful use (i.e., no need for endotracheal intubation related to inadequate gas exchange) of bilateral nasopharyngeal airways in 90 patients undergoing awake craniotomies. The use of nasopharyngeal airways can ease the ...περισσότερα »

Comparison of African American Children's Performances on a Minimal Competence Core for Morphosyntax and the Index of Productive Syntax.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 7 ώρες

Comparison of African American Children's Performances on a Minimal Competence Core for Morphosyntax and the Index of Productive Syntax.: Conclusion: The MCC-MS has convergent criterion validity with the IPSyn. Although more research is warranted, both measures can be potentially used in oral language assessments of African American 3-year-olds. PMID: 26580135 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

Who Receives Speech/Language Services by Five Years of Age in the U.S.?

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 7 ώρες

Who Receives Speech/Language Services by Five Years of Age in the U.S.?: Authors: Morgan PL, Scheffner Hammer C, Farkas G, Hillemeier MM, Maczuga S, Cook M, Morano S Abstract Purpose: We sought to identify factors predictive of or associated with receipt of speech/language services during early childhood. We did so by analyzing data from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), a nationally representative dataset maintained by the U.S. Department of Education. We addressed two research questions of particular importance to speech-language pathology practice and p...περισσότερα »

Whole-Field Sequential Intensity–Modulated Radiotherapy for Local-Regional Advanced Head-and-Neck Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Whole-Field Sequential Intensity–Modulated Radiotherapy for Local-Regional Advanced Head-and-Neck Squamous Cell Carcinoma: [image: image]Purpose: There is little published data on the technique and results of whole-field (WF) sequential intensity–modulated radiotherapy (S-IMRT) for patients with head-and-neck squamous cell carcinoma (HNSCC). We report the treatment outcomes, adverse events (AEs), and dosimetric parameters in local-regional advanced (LRA) HNSCC patients treated with the WF S-IMRT technique. Methods: The IRB approved this retrospective study. Patients received WF S-IMR... περισσότερα »

ACR Appropriateness Criteria® Diffuse Large B-Cell Lymphoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

ACR Appropriateness Criteria® Diffuse Large B-Cell Lymphoma: [image: image]The management of diffuse large B-cell lymphoma depends on the initial diagnosis including molecular and immunophenotypic characteristics, Ann Arbor staging, and International Prognostic Index (IPI score). Treatment approaches with different chemotherapy regimens used is discussed in detail. The role of radiation as a consolidation is discussed including: (1) the prerituximab randomized trials that challenged the role of radiation, (2) recent prospective studies (UNFOLDER/RICOVER-60), and (3) retrospective st...περισσότερα »

The Development of a Nasogastric Tube Safety Pack.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Discovering Innovation at the Intersection of Undergraduate Medical Education, Human Factors, and Collaboration: The Development of a Nasogastric Tube Safety Pack.: Problem: Significant deficiencies exist in the knowledge and skills of medical students and residents around health care quality and safety. The theory and practice of quality and safety should be embedded into undergraduate medical practice so that health care professionals are capable of developing interventions and innovations to effectively anticipate and mitigate errors. Approach: Since 2011, Leeds Medical School in ... περισσότερα »

The prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Review article: the prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe: Summary Background There is little up-to-date review evidence on the prevalence of *Helicobacter pylori* across Europe. Aim To establish regional and national patterns in *H. pylori* prevalence across Europe. Secondly, to establish trends over time in *H. pylori* prevalence and gastric cancer incidence and, thirdly, to report on the relationship between *H. pylori* prevalence and age group across Europe. Methods A review of *H. pylori* prevalence from unselected surveys of adult o... περισσότερα »

T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients: Background: Chronic rhinosinusitis with nasal polyps is characterized by local inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis, and non-eosinophilic chronic rhinosinusitis. The objective of this study was to investigate the expression of key transcription factors for Treg and Th1/Th2/Th17 cells, in relation to the mRNA expression of representative cytokines in these two subtypes of chronic rhinosinusitis with nasal polyps. Methods: The expression of fork... περισσότερα »

A retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

A retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge: Background: A history of penicillin allergy in patients is common, but only 10–15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done without first carrying out diagnostic skin testing. This is carried out with the major determinant benzylpenicilloyl (PPL) and the minor determinant mixture (MDM), consisting of penilloate, pen... περισσότερα »

Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 ώρες

Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved?: *Background:* Food protein-induced allergic proctocolitis (FPIAP) is mostly a non-immunoglobulin E-mediated disease where a T-cell-mediated reaction to cow's milk protein has been suggested. We determined the expression of transforming growth factor (TGF)-β, TGF-β receptor-1, tumor necrosis factor (TNF)-α, CD86, and CD23 on the colon mucosa to investigate their roles in the pathogenesis of the two subtypes of FPIAP, i.e. infantile FPIAP and FPIAP in older ...περισσότερα »

Fwd: Chinese Journal of Cancer, Year 2015, Issue 10 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Cancer*. Year *2015* Issue *10* is now available on CAOD. *In this issue:* About the Cover ...... page:422 Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling Jari Yli-Hietanen, Antti Ylip??, Olli Yli-Harja, Department of Signal Processing, Tampere University of Technology ...... page:423-426 Effects of subsampling on characteristic... περισσότερα »

Fwd: International Journal of Pharmaceutical Research, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *International Journal of Pharmaceutical Research*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* Phenoconversion of drug-metabolizing enzymes and its mechanism during inflammatory conditions (炎症诱发的药物代谢酶表型变化及其机制研究进展) ZHUANG Xiao-mei, State Key Laboratory of Toxicology and Medical Countermeasures, Laboratory of Drug Metabolism and Pharmacokinetics, Institute of Pharmacology and To... περισσότερα »

Fwd: Progress of Anatomical Sciences, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Progress of Anatomical Sciences*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* The located differences of Akt1 and Akt2 in GV and GVBD stages of mouse oocytes (Akt1和Akt2在小鼠卵母细胞中定位的差别) DENG Xin, LI Sen, LIU Yan-chun, CAO Yu, LI Gen-song, YU Bing-zhi, The Experimental Center of Functional Subjects, China Medical University, Department of Neuryology, the First Affiliated Hospital, ... περισσότερα »

Fwd: Chinese Journal of Prosthodontics, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Prosthodontics*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* Investigation on bacteria adhesion conditions on dental curing light-guide rods (光固化灯光导棒细菌粘附状况的调查) TANG Xiao-jun, SHI Sheng-gen, LU Yi, LIU Gen-lan, ZHANG Jian-bo, LU Lin-jie, Stomotological center of Chinese PLA, 306 hospital ...... page:257-261 Effects of siRNA-mediated β-catenin silence on prolife...περισσότερα »

Fwd: Stomatology, Year 2015, Issue 10 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Stomatology*. Year *2015* Issue *10* is now available on CAOD. *In this issue:* The effect of polyhexamethylene guanidine hydrochloride loaded on TiO2 nanotubes on promoting the osteogenic differentiation of the modified titanium surface (TiO2纳米管负载聚六亚甲基胍促进种植体钛表面成骨分化性能的研究) WANG Guifang, LI Jinhua, CHEN Liping, JIANG Xinquan, Department of Prosthodontics, The Ninth People' s Hospital, Shanghai Jiao To... περισσότερα »

Fwd: Journal of Oral Science Research, Year 2015, Issue 10 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Oral Science Research*. Year *2015* Issue *10* is now available on CAOD. *In this issue:* Study on the Cytoskeleton of Cultured Goat Temporomandibular Joint Disc Cells (山羊颞下颌关节盘细胞肌动蛋白骨架的研究) KONG Nan-nan, ZHANG Wen-xia, KANG Hong, BAO Guang-jie, Key Lab of Stomatology of State Ethnic Affairs Commission, Northwest University for Nationalities, School of Stomatology, Lanzhou University ........ περισσότερα »

Fwd: Journal of Clinical Dermatology, Year 2015, Issue 10 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Dermatology*. Year *2015* Issue *10* is now available on CAOD. *In this issue:* Microvenular hemangioma (微静脉血管瘤) LI Qing-yan, DANG Yan-ling, LIU Yan-ting, GENG Song-mei ...... page:602+601 Roles of dermoscopy in the diagnosis and differential diagnosis of facial seborrheic dermatitis and rosacea (皮肤镜在面部脂溢性皮炎和酒渣鼻诊断和鉴别诊断中的应用) CHEN Dian, XU Chen-chen, LI Jia-ning, LU Jie, LIU Jie, SUN... περισσότερα »

Fwd: Journal of Clinical Neurology, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Neurology*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* lin chuang shen jing bing xue za zhi gao yue (《临床神经病学杂志》稿约) ...... page:320 Study of functional magnetic resonance imaging combined with DTI on the relationship between executive function and struction damage in patients with right temporal lobe epilepsy (联合应用功能磁共振成像和DTI对右侧颞叶癫痫患者执行功能与脑结构损害相关性的研究) JIANG ... περισσότερα »

Fwd: Journal of Biomedical Engineering, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Biomedical Engineering*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* ben kan huo ping di san jie zhong guo jing pin ke ji qi kan he 2013 nian bai zhong zhong guo jie chu xue shu qi kan (本刊获评第三届中国精品科技期刊和2013年百种中国杰出学术期刊) BEN Kanbianjibu ...... page:940 Research of Effective Network of Emotion Electroencephalogram Based on Sparse Bayesian Network (基于稀疏贝叶斯网络的情绪脑电的有效性脑网络研究... περισσότερα »

Fwd: Journal of Evidence-Based Medicine, Year 2015, Issue 04 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Evidence-Based Medicine*. Year *2015* Issue *04* is now available on CAOD. *In this issue:* Targeted Therapy : New Problems, New Exploration (靶向治疗:新问题、新探索) WU Yi-long, SUN Yan, WANG Chang-li, LIAO Mei-lin, ZHOU Qing-hua, LU Shun, CHENG Ying, ZHOU Cai-cun, WANG Jie, ZHANG Li, CHEN Xiao-yuan, MAO Wei-min, JIANG Guo-liang, WANG Jun, WANG Qun, FENG Ji-feng, FU Xiao-long, YU Ding, HUANG Cheng... περισσότερα »

Fwd: Pharmaceutical Care and Research, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Pharmaceutical Care and Research*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* Survey and analysis of the core capabilities of hospital pharmaceutical specialists (医院药学技术人员核心能力调查与分析) All the students of pharmaceutical affairs management advanced 8th issue of Tsinghua University, HU JinHong, Department of Pharmacy, Changhai Hospital, Second Military Medical University ...... pag... περισσότερα »

Fwd: Progress in Pharmaceutical Sciences, Year 2015, Issue 08 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Progress in Pharmaceutical Sciences*. Year *2015* Issue *08* is now available on CAOD. *In this issue:* yi ben zhuan zhu yu yi yao ke ji qian yan yu yan fa dong tai de zhuan ye mei ti yao xue jin zhan (一本专注于医药科技前沿与研发动态的专业媒体《药学进展》) ...... page:557 Expert Interpretations of New Polices on Drug Evaluation Reform ("聚焦医药审评制度改革新政"专家解读) Editorial Board of Progress in Pharmaceutical Sciences ...... page:56... περισσότερα »

Fwd: Pharmaceutical &amp; Engineering Design, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Pharmaceutical &amp; Engineering Design*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* Value of Whole Life Period of Pharmaceutical Engineering Project (医药工程项目全生命周期的价值发现) Wang Yunbao, SINOPHARM Geptech Engineering Co., Ltd ...... page:1-6 huan ying ding yue hua gong yu yi yao gong cheng (欢迎订阅《化工与医药工程》) ...... page:6 Exploration of 4.0 Smart Factories in Pharmaceutical Industry (制药工业... περισσότερα »

Fwd: Journal of Apoplexy and Nervous Diseases, Year 2015, Issue 09 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Apoplexy and Nervous Diseases*. Year *2015* Issue *09* is now available on CAOD. *In this issue:* guan zhu bian yuan xing nao yan (关注边缘性脑炎) RAO Mingli, WU Jiang ...... page:772 bian yuan xing nao yan (边缘性脑炎) SONG Xiaonan ...... page:773-778 Clinical analysis in patients with anti-N-methyl-D-aspartate receptor encephalitis:11 case reports and literature review (抗NMDAR脑炎临床分析(附11例病例报告及文献复习))... περισσότερα »

Fwd: Chinese Journal of Clinical Neurosurgery, Year 2015, Issue 10 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Clinical Neurosurgery*. Year *2015* Issue *10* is now available on CAOD. *In this issue:* 2016 nian tian jin di qi jie shi jie hua ren shen jing wai ke xue shu da hui hui yi tong zhi (2016年天津第七届世界华人神经外科学术大会会议通知) ...... page:574 di shi wu jie shen jing wai ke suo kong wei chuang shou shu guo jia ji ji xu jiao yu xue xi ban tong zhi (第十五届神经外科锁孔微创手术国家级继续教育学习班通知) ...... page:576 zhu... περισσότερα »

Fwd: The Chinese Journal of Clinical Pharmacology, Year 2015, Issue 20 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:13AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *The Chinese Journal of Clinical Pharmacology*. Year *2015* Issue *20* is now available on CAOD. *In this issue:* Clinical efficacy and safety of multiple drug combination in the treatment of children with allergic purpura caused by bacterial infection (多药联合治疗细菌感染致小儿过敏性紫癜的临床疗效与安全性评价) LIN Shi-guang, ZENG Xiao-ming, WU Xue-mei, LIN Shan, ZHANG Zhong-long, GUO Rui-guan, Department of Health Service, Fu... περισσότερα »

Fwd: Chinese Journal of Stereology and Image Analysis, Year 2015, Issue 03 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Stereology and Image Analysis*. Year *2015* Issue *03* is now available on CAOD. *In this issue:* A visual attention model based on supervised learning (一种基于有监督学习的视觉注意力模型) ZOU Xiaochun, ZHAO Xinbo, YANG Yongjia, LI Na, School of Electronics and Information, Northwestern Polytechnical University, School of Computer Science and Engineering, Northwestern Polytechnical University ....... περισσότερα »

Fwd: Chinese Journal of Pharmacology and Toxicology, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Pharmacology and Toxicology*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* re lie zhu he zhong guo yao li xue hui cheng li 30 zhou nian (热烈祝贺中国药理学会成立30周年) ...... page:654 guo ji yao li xue lian he hui (iuphar) he xin ying wen (国际药理学联合会(IUPHAR)贺信（英文）) s.j.enna, MICHAELL Spedding, PETRA Thrmann ...... page:657 ya zhou tai ping yang di qu yao li xue jia lian men...περισσότερα »

Fwd: Chinese Journal of Drug Dependence, Year 2015, Issue 05 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Drug Dependence*. Year *2015* Issue *05* is now available on CAOD. *In this issue:* quan qiu jian shao ben bing an lei xing fen ji shi yong xiang guan wei hai de ce lue he fang fa (全球减少苯丙胺类兴奋剂使用相关危害的策略和方法) LI Jianhua ...... page:321-326 wo guo da ma lan yong de li shi he xian zhuang (我国大麻滥用的历史和现状) ZHOU Limin ...... page:327-331 jin 5 nian zhen ci zhi liao yao wu yi lai de shen jing...περισσότερα »

Fwd: Chinese Pharmaceutical Journal, Year 2015, Issue 20 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Pharmaceutical Journal*. Year *2015* Issue *20* is now available on CAOD. *In this issue:* 2015 nian ban zhong guo yao dian zhuan lan (2015年版《中国药典》专栏) ...... page:1743 Overview on the Chinese Pharmacopoeia 2015 Editon (2015年版《中国药典》编制概况) ZHANG Wei, LAN Fen, HONG Xiao-xu, Chinese Pharmacopeia Commission ...... page:1743-1746 guan yu ju ban zhong guo yao xue hui zhi yao gong cheng zhuan ye wei yu... περισσότερα »

Fwd: China Journal of Chinese Ophthalmology, Year 2015, Issue 04 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 27 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *China Journal of Chinese Ophthalmology*. Year *2015* Issue *04* is now available on CAOD. *In this issue:* Randomized controlled trials of acupuncture for adolescents with mild-to-moderate myopia (针刺治疗青少年轻中度近视的随机对照试验) WANG Yan, ZHANG Yani, GAO Yunxian, Traditional Chinese Medicine Hospital, Affiliated to Xinjiang Medical University ...... page:231-235 Therapeutic effect of intraorbital acupuncture c... περισσότερα »

Fwd: Journal of Otology, Year 2015, Issue 01 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 27 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Otology*. Year *2015* Issue *01* is now available on CAOD. *In this issue:* Advances in microvascular decompression for hemifacial spasm Zhiqiang Cui, Zhipei Ling, Department of Neurosurgery, Chinese PLA General Hospital ...... page:1-6 Advances in diagnosis and non-surgical treatment of Bell's palsy Yang Zhao, Guodong Feng, Zhiqiang Gao, Department of Otolaryngology, Peking Union Medical ...περισσότερα »

Fwd: Journal of Oncology, Year 2015, Issue 11 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 27 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:12AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Oncology*. Year *2015* Issue *11* is now available on CAOD. *In this issue:* Progress on Chemotherapy for Vulvar Cancer (外阴癌化疗进展) JIAO Si-meng, KONG Wei-min, Beijing Obstetrics and Gynecology Hospital, Capital Medical University ...... page:865-869 ben kan qi shi (本刊启事) ...... page:869 Research Progress on Abnormal Glucose Metabolism in the Promotion of Carcinogenesis and Development of O... περισσότερα »

Fwd: Chinese Journal of Cancer Prevention and Treatment, Year 2015, Issue 18 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 27 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:08AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Cancer Prevention and Treatment*. Year *2015* Issue *18* is now available on CAOD. *In this issue:* zhong hua zhong liu fang zhi za zhi she tai li ji you ce yi shu zuo pin zheng ji qi shi (《中华肿瘤防治杂志》社台历及邮册艺术作品征集启事) ...... page:1414 Analysis of incidence of thyroid cancer in the area around Tianwan Nuclear Power Plant from 2001 to 2012 (田湾核电站周围地区2001-2012年甲状腺癌发病分析) DONG Jian-mei, ... περισσότερα »

Fwd: Cancer Frontier, Year 2015, Issue 04 -New Issue Alert.

Alexandros G. SfakianakisστοChina/Asia Medicine on Demand (CAOD) by Alexandros G.SfakianakisΠριν από 27 δευτερόλεπτα

From: order@email.oriprobe.com Date: November 22, 2015 at 08:07AM New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Cancer Frontier*. Year *2015* Issue *04* is now available on CAOD. *In this issue:* wei ai ben pao (为爱奔跑) BEN Kanbianjibu ...... page:1+81+2 zhong liu bing fang li de qi xi jie (肿瘤病房里的七夕节) ZHANG Xiaodan ...... page:5-6 chi jian shi ren ti bian jian zhuan jia zhi chu suan xing ti zhi meng yu hu chun shu yao chuan (吃"碱食"≠人体"变碱"——专家指出酸性体质"猛于虎"纯属谣传) WU Zhi ...... page:7-9 huang lei de 8000 zi jie yan ri j...περισσότερα »