Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

Αρχειοθήκη ιστολογίου

! # Ola via Alexandros G.Sfakianakis on Inoreader

Η λίστα ιστολογίων μου

Παρασκευή 11 Μαΐου 2018

The potential accumulation of polycyclic aromatic hydrocarbons in phytoplankton and bivalves in Can Gio coastal wetland, Vietnam

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are one of the most important classes of anthropogenic persistent organic contaminants in the marine environment. This review discusses a whole range of findings that address various aspects of the bioaccumulation of PAHs in two common marine biota (phytoplankton and bivalves) globally and especially for Can Gio coastal wetland, Vietnam. The published information and collected data on the bioconcentration and accumulation mechanisms of PAHs as well as implications for Can Gio coastal wetland are compiled for phytoplankton and bivalves. PAHs are still released to Can Gio coastal environments from various sources and then transported to coastal environments through various physical processes; they may enter marine food chains and be highly accumulated in phytoplankton and bivalves. Thus, PAHs' bioaccumulation should be considered as one important criterion to assess the water's quality, directly linked to human health due to seafood consumption. Ecologically, Can Gio coastal wetland plays an important role to the South Vietnam key economic zone. However, it is also an area of potential PAHs inputs. With the abundant phytoplankton and bivalves in Can Gio coastal wetland, the PAHs bioaccumulation in these biota is inevitably detected. Thus, further study on the bioavailability of these contaminants is urgently needed in order to mitigate their negative effects and protect the ecosystems.



https://ift.tt/2G9Q9AI

Acromegaly is associated with high fibroblast growth factor-21 levels

Abstract

Purpose

Fibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition.

Methods

We studied 43 subjects (21 females and 22 males, mean age of 50.0 ± 12.8) with acromegaly. The control group consisted of 40 gender- and age-matched subjects (25 females and 15 males, mean age of 48.8 ± 8.8). Acromegaly patients were classified into two groups; active acromegaly (AA; n = 26) and controlled acromegaly (CA; n = 17). Metabolic, anthropometric and laboratory values of subjects were recorded. FGF-21 level was measured by ELISA assay.

Results

Median FGF-21 levels were significantly higher in acromegaly group compared to control group (85.5 vs. 59.0 pg/mL, p = 0.02, respectively). In the multiple regression model, FPG, A1c, HOMA-IR, glucose intolerance, BMI, visceral fat, hs-CRP, presence of hypertension, dyslipidemia and acromegaly were included as independent variables to explain variability of plasma FGF-21 levels in whole study group. The presence of acromegaly was the only determinant of increased FGF-21 levels in the whole study group (β coefficient = 0.253, p = 0.006).

Conclusion

FGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly. Acromegaly may also be a FGF-21 resistance state independent from insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemia.



https://ift.tt/2wzrO86

Elucidation of contamination sources for poly- and perfluoroalkyl substances (PFASs) on Svalbard (Norwegian Arctic)

Abstract

A combination of local (i.e. firefighting training facilities) and remote sources (i.e. long-range transport) is assumed to be responsible for the occurrence of per- and polyfluoroalkyl substances (PFASs) in Svalbard (Norwegian Arctic). However, no systematic elucidation of local PFASs sources has been conducted yet. Therefore, a survey was performed aiming at identifying local PFAS pollution sources on the island of Spitsbergen (Svalbard, Norway). Soil, freshwater (lake, draining rivers), seawater, meltwater run-off, surface snow and coastal sediment samples were collected from Longyearbyen (Norwegian mining town), Ny-Ålesund (research facility) and the Lake Linnévatnet area (background site) during several campaigns (2014–2016) and analysed for 14 individual target PFASs. For background site (Linnévatnet area, sampling during April to June 2015), ΣPFAS levels ranged from 0.4 to 4 ng/L in surface lake water (n = 20). PFAS in meltwater from the contributing glaciers showed similar concentrations (~ 4 ng/L, n = 2). The short-chain perfluorobutanoate (PFBA) was predominant in lake water (60–80% of the ΣPFASs), meltwater (20–30%) and run-off water (40%). Long-range transport is assumed to be the major PFAS source. In Longyearbyen, five water samples (i.e. 2 seawater, 3 run-off) were collected near the local firefighting training site (FFTS) in November 2014 and June 2015, respectively. The highest PFAS levels were found in FFTS meltwater run-off (118 ng/L). Perfluorooctane sulfonic acid (PFOS) was the most abundant compound in the FFTS meltwater run-off (53–58% PFASs). At the research station Ny-Ålesund, seawater (n = 6), soil (n = 9) and freshwater (n = 10) were collected in June 2016. Low ΣPFAS concentrations were determined for seawater (5–6 ng/L), whereas high ΣPFAS concentrations were found in run-off water (113–119 ng/L) and soil (211–800 ng/g dry weight (dw)) collected close to the local FFTS. In addition, high ΣPFAS levels (127 ng/L) were also found in freshwater from lake Solvatnet close to former sewage treatment facility. Overall, at both FFTS-affected sites (soil, water), PFOS was the most abundant compound (60–69% of ΣPFASs). FFTS and landfill locations were identified as major PFAS sources for Svalbard settlements.



https://ift.tt/2G9Rvvb

Effect of foliar-applied iron complexed with lysine on growth and cadmium (Cd) uptake in rice under Cd stress

Abstract

Contamination of soils with cadmium (Cd) is a serious problem worldwide. Rice (Oryza sativa L.) is reported to accumulate relatively higher Cd contents in consumable parts and is considered a main source of Cd toxicity to humans from rice-derived products. The aim of this pot trial was to investigate the effect of foliar-applied iron (Fe) complexed with lysine on growth, photosynthesis, Cd concentration in plants, oxidative stress, and activities of antioxidants of rice in soil contaminated with Cd. Rice seedlings (30-day-old) were transferred to the soil, and after 2 weeks, different concentrations of Fe-lysine (0, 1.5, 3.0, 4.5, 6.0, and 7.5 mg L−1) were applied as a foliar spray once in a week for 4 weeks and plant samples were taken after 10 weeks of growth in the soil under ambient conditions. Foliar supply of Fe-lysine complex significantly enhanced the plant height, dry weights of plants, concentration of chlorophyll, and gas exchange attributes in Cd-stressed rice. Fe-lysine decreased the Cd concentrations in plants while increasing the Fe concentrations in rice seedlings being maximum with Fe-lysine of 6.0 mg L−1. Electrolyte leakage decreased while activities of key antioxidant enzymes increased with Fe-lysine compared to the control. According to the present results, Fe-lysine complex can effectively be used to reduce Cd concentrations in rice and probably in other crop species.



https://ift.tt/2jPomwJ

“White Thyroid” on Unenhanced Computed Tomography in Amiodarone-Induced Thyrotoxicosis Type 2

Thyroid, Ahead of Print.


https://ift.tt/2wB3tid

Possible impact of environmental policies in the recovery of a Ramsar wetland from trace metal contamination

Publication date: 1 October 2018
Source:Science of The Total Environment, Volumes 637–638
Author(s): Miguel Ángel Álvarez-Vázquez, Serafín Jesús González-Prieto, Ricardo Prego
The Umia-Grove Intertidal Complex is located within the Ria of Arousa (NW Iberian Peninsula). Out of its significance for wintering shorebirds it has been included in the Ramsar List of Wetlands of International Importance as well as in international protection networks such as the European Natura 2000 and Important Bird and Biodiversity Areas-BirdLife International. In a sediment analysis conducted in the year 1999, the wetland was found to have been contaminated by potentially toxic trace metals, to wit: Cr, Cu, Ni, and Pb. Sediment samples retrieved in 2014 to make an updated assessment of the condition of the ecosystem showed evidence of the presence of selected trace elements, namely, Cd, Co, Cr, Cu, Ni, Pb, and Zn, within or slightly above the background ranges of local, regional, and general references. In the 15-year time frame between the two samplings there has been noticeable change in the relationship between nature and society as a consequence of the entry into force of a number of regulations aimed at avoiding the emission of contaminants; among others, the ban of Pb in gasoline, the deployment of wastewater treatment plants according to the European Water Framework Directive, and the limitation of the use of Cu pesticides. With the ensuing drop of human pressure, the self-purifying capacity of the ecosystem has effectively contributed to the wetland's recovery. Nevertheless, the application of a normalized enrichment factor to the more recent set of samples suggests the presence of relict low contamination by Cd, Cu, and Ni in localized areas. The compared analysis of the wetland condition in the two years is a sign of the success of the policies and regulations for environmental protection, but further work and more effectiveness are necessary in order to preserve threatened ecosystems of such importance as the Umia-Grove wetland.

Graphical abstract

image


https://ift.tt/2wDb7so

Novel magnetic nanobeads-based fluoroimmunoassays for zearalenone detection in cereals using protein G as the recognition linker

Publication date: 1 October 2018
Source:Sensors and Actuators B: Chemical, Volume 270
Author(s): Fuyuan Zhang, Bing Liu, Guozhen Liu, Wei Sheng, Yan Zhang, Qi Liu, Shuo Wang
Zearalenone (ZEN) is a type of estrogenic mycotoxin commonly found in cereals. In order to satisfy the need for ultrasensitive detection of ZEN, we developed two novel magnetic nanobeads (MNBs)-based fluoroimmunoassays using protein G (PG) as recognition binder on the sensing interface. One proposed facile strategy is based on a first capture last react (FCLR) procedure while the other is a first react last capture (FRLC) format. Specifically, CdTe/CdS/ZnS quantum dots were synthesized and modified to antigen (OVA-ZEN) as the signal probes. The PG modified MNBs specifically captured the fragment crystallizable region of immunoglobulin G (IgG) with a level of orientation while avoiding the destruction of antibody's binding sites caused by chemical coupling. Under the optimized conditions, the detection limits of 0.019 ng mL−1 and 0.049 ng mL−1 in the extract solution were obtained for the FCLR and FRLC, respectively. Furthermore, the established methods proved to be successful in detecting ZEN in real cereal samples with the detection limits being 0.6 μg kg−1 and 1.5 μg kg−1 in the FCLR and FRLC, respectively. The performance of the proposed assays was evaluated utilizing commercial ELISA kits with satisfactory results.



https://ift.tt/2rzZJsq

Interference of three herbicides on iron acquisition in maize plants

Publication date: September 2018
Source:Chemosphere, Volume 206
Author(s): Maria Luce Bartucca, Alessandro Di Michele, Daniele Del Buono
The use of herbicides to control weed species could lead to environmental threats due to their persistence and accumulation in the ecosystems and cultivated fields. Nonetheless, the effect of these compounds on plant mineral nutrition in crops has been barely investigated. This study aimed at ascertaining the effect of three herbicides (S-metolachlor, metribuzin and terbuthylazine) on the capacity of maize to acquire iron (Fe). Interferences on plant growth and reductions on the Fe contents were found in the plants treated. Furthermore, root cell viability and functionality losses were ascertained following the treatments, which, in turn, decreased the amount of phytosiderophores (PSs) released by the roots. An investigation carried out in greater depth on root apices of treated plants using an FE-SEM (Scanning Electron Microscope) coupled with EDX (Energy Dispersive X-ray) indicated that the reductions on Fe content started in this part of the roots. Lastly, decreases were found also in copper (Cu+2), zinc (Zn+2) and manganese (Mn+2) content in root apices.

Graphical abstract

image


https://ift.tt/2KeVkBQ

Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Fernanda Weber Mello, Fernanda Marcello Scotti, Gilberto Melo, Saman Warnakulasuriya, Eliete Neves Silva Guerra, Elena Riet Correa Rivero
Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté consumption and occurrence of the UADT cancer?". Studies investigating any association between maté consumption and occurrence of UADT cancer were included. Out of the 569 studies, 18 met the inclusion criteria for qualitative and 15 for quantitative analysis. An increased odds was observed regarding maté consumption and overall occurrence of UADT cancer (OR = 2.24; 95%CI = 1.74–2.87). Consistent evidence of a positive association was found for all UADT subsites, oral, pharynx, esophagus and larynx. No differences in effect were found between consumption of cold/warm and hot/very hot mate (OR = 1.08; 95%CI = 0.83–1.41). Consumption of more than one liter of maté per day was associated with increased odds of having UADT cancer compared to an intake of less than one liter per day (OR = 1.72; 95%CI = 1.47–2.01). According to published data, regardless of the temperature, maté consumption significantly increased the odds of occurrence of UADT cancer.



https://ift.tt/2jRpTCA

Effect of Pseudomonas fluorescens and pyoverdine on the phytoextraction of cesium by red clover in soil pots and hydroponics

Abstract

With the aim of improving the phytoextraction rate of cesium (Cs), the effect of Pseudomonas fluorescens ATCC 17400 and its siderophore pyoverdine (PVD) on the uptake of Cs by red clover was studied in soil pots. This work also provides a mechanistic understanding of the Cs-bacteria (or PVD)-illite-plant interactions by using a simplified experimental design, i.e., hydroponics with either Cs in solution or Cs-spiked illite in suspension. For soil spiked with 11.2 mmol kg−1 (1480 mg kg−1) of Cs, 0.43% of total Cs was taken up by red clover in 12 days (119 μmol g−1 (16 mg g−1) of Cs dry matter in roots and 40 μmol g−1 (5 mg g−1) in shoots). In hydroponics with Cs in solution (0.1 mmol L−1 or 13 mg L−1), 75% of Cs was taken up vs. only 0.86% with Cs-spiked illite suspension. P. fluorescens and PVD did not increase Cs concentrations in aboveground parts and roots of red clover and even decreased them. The damaging effect of PVD on red clover growth was demonstrated with the biomass yielding 66% of the control in soil pots (and 100% mortality after 12 days of exposition) and only 56% in hydroponics (78% with illite in suspension). Nonetheless, PVD and, to a lesser extent, P. fluorescens increased the translocation factor up to a factor of 2.8. This study clearly showed a direct damaging effect of PVD and to a lower extent the retention of Cs by biofilm covering both the roots and illite, both resulting in the lower phytoextraction efficiency.



https://ift.tt/2G8DyxC

The Glycoscience of Immunity

Publication date: Available online 11 May 2018
Source:Trends in Immunology
Author(s): Julie Y. Zhou, Douglas M. Oswald, Kelsey D. Oliva, Lori S.C. Kreisman, Brian A. Cobb
Carbohydrates, or glycans, are as integral to biology as nucleic acids and proteins. In immunology, glycans are well known to drive diverse functions ranging from glycosaminoglycan-mediated chemokine presentation and selectin-dependent leukocyte trafficking to the discrimination of self and non-self through the recognition of sialic acids by Siglec (sialic acid-binding Ig-like lectin) receptors. In recent years, a number of key immunological discoveries are driving a renewed and burgeoning appreciation for the importance of glycans. In this review, we highlight these findings which collectively help to define and refine our knowledge of the function and impact of glycans within the immune response.



https://ift.tt/2Kib875

Learned Suppression for Multiple Distractors in Visual Search.

Author: Won, Bo-Yeong; Geng, Joy J.
DOI: 10.1037/xhp0000521
Publication Date: POST AUTHOR CORRECTIONS, 7 May 2018


https://ift.tt/2KgNaJg

Visual Working Memory is More Tolerant Than Visual Long-Term Memory.

Author: Schurgin, Mark W.; Flombaum, Jonathan I.
DOI: 10.1037/xhp0000528
Publication Date: POST AUTHOR CORRECTIONS, 7 May 2018


https://ift.tt/2rByfm5

Exploring the Contribution of Motivation and Experience in the Postpubescent Own-Gender Bias in Face Recognition.

Author: Hills, Peter J.; Pake, J. Michael; Dempsey, Jack R.; Lewis, Michael B.
DOI: 10.1037/xhp0000533
Publication Date: POST AUTHOR CORRECTIONS, 7 May 2018


https://ift.tt/2KiPtvd

Correlation of Individual Differences in Audiovisual Asynchrony Across Stimuli and Tasks: New Constraints on Temporal Renormalization Theory.

Author: Ipser, Alberta; Karlinski, Maayan; Freeman, Elliot D.
DOI: 10.1037/xhp0000535
Publication Date: POST AUTHOR CORRECTIONS, 7 May 2018


https://ift.tt/2rByf5z

Lead exposure is associated with risk of impaired coagulation in preschool children from an e-waste recycling area

Abstract

Environmental lead exposure leads to various deleterious effects on multiple organs and systems, including the hematopoietic system. To explore the effects of lead exposure on platelet indices in preschool children from an informal, lead-contaminated electronic waste (e-waste) recycling area, we collected venous blood samples from 466 preschool children (331 from an e-waste area (Guiyu) and 135 from a non-e-waste area (Haojiang)). Child blood lead levels (BLLs) were determined by graphite furnace atomic absorption spectrophotometry, while platelet indices were quantified using a Sysmex XT-1800i hematology analyzer. Higher blood lead levels are observed in e-waste lead-exposed preschool children. Significant relationships between high blood lead levels (exceeding current health limits) and elevated platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) were also uncovered. Furthermore, the median PLT and PCT levels of children from the exposed group both exceeded the respective recommended maximum reference range value, whereas the reference group did not. Location of child residence in Guiyu and BLLs were both risk factors related to platelet indices. These results suggest that high blood lead exposure from e-waste recycling may increase the risk of an amplified coagulation process through the activation of platelets in preschool children.



https://ift.tt/2KfdYtf

The cognitive treatment components and therapies of cognitive behavioral therapy for insomnia: A systematic review

Since the beginning of the twenty-first century, there has been an increased focus on developing and testing cognitive components and therapies for insomnia disorder. The aim of the current review was thus to describe and review the efficacy of cognitive components and therapies for insomnia. A systematic review was conducted on 32 studies (N=1455 subjects) identified through database searches. Criteria for inclusion required that each study constituted a report of outcome from a cognitive component or therapy, that the study had a group protocol, adult participants with diagnosed insomnia or undiagnosed insomnia symptoms or reported poor sleep, and that the study was published until and including 2016 in English.

https://ift.tt/2It6HZV

The importance of allergic disease in public health: an iCAALL statement.

https:--s3-service-broker-live-ddda94b7- Related Articles

The importance of allergic disease in public health: an iCAALL statement.

World Allergy Organ J. 2018;11(1):8

Authors: Sánchez-Borges M, Martin BL, Muraro AM, Wood RA, Agache IO, Ansotegui IJ, Casale TB, Fleisher TA, Hellings PW, Papadopoulos NG, Peden DB, Sublett JL, Tilles SA, Rosenwasser L

PMID: 29743965 [PubMed]



https://ift.tt/2rBaKcC

Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis.

https:--s3-service-broker-live-ddda94b7- Related Articles

Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis.

World Allergy Organ J. 2018;11(1):7

Authors: Heffler E, Puggioni F, Peveri S, Montagni M, Canonica GW, Melioli G

Abstract
Background: Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the introduction of recombinant components in the test. More recently, microarrays of allergen components have significantly improved the ability to describe the IgE profile. Aim of this study was to evaluate the characteristics of the newly developed Allergy Explorer (ALEX), a macroarray containing both extracted "whole" allergens and molecular components. This method allows the acquisition of an IgE profile comprising 282 reagents (157 allergen extracts and 125 components), resulting in the widest screening of potential allergens available.
Methods: Sera from 43 patients with allergies were assayed with ALEX and then with ImmunoCAP ISAC. The results of the two tests were compared, and the consistency of the molecular results with the presence of IgE in the relevant extract was also evaluated.
Results: A good correlation between ISAC and ALEX was observed. The ALEX results for second-level tests (i.e., specific IgE to complete extracted allergens) were consistent with the results obtained for the relevant components.
Discussion: Despite differences in the methodology, the IgE profiles detected for molecular allergens by ALEX and ISAC were very similar. The differences were mainly related to the lower dynamic range of ALEX and to the use of a CCD inhibitor in the first incubation phase, which reduced the binding of IgE to CCD, as represented in the extracted allergens and components.
Conclusion: Based on our findings, ALEX is a novel tool for describing the IgE profile in a PM setting, where the IgE assay must be performed on many allergens and components. In particular, polysensitized patients and patients with pollen-food syndrome will have a real advantage due the combination of the second and third levels of allergy diagnostics in the same chip.

PMID: 29743964 [PubMed]



https://ift.tt/2KgzJZW

Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study



https://ift.tt/2IfE52E

Patient injuries in operative rhinology during a ten‐year period: Review of national patient insurance charts



https://ift.tt/2jRNoew

Current studies of immunotherapy in head and neck cancer



https://ift.tt/2IecjDL

Temporal patterns of patient‐reported trismus and associated mouth‐opening distances in radiotherapy for head and neck cancer: A prospective cohort study



https://ift.tt/2I9rja3

A cross‐sectional evaluation of the validity of a smartphone otoscopy device in screening for ear disease in Nepal



https://ift.tt/2IgZrwN

Revisits after adenotonsillectomy in children with sleep‐disordered breathing: A retrospective single‐institution study



https://ift.tt/2jQK9nV

Psychological impact of a genetic diagnosis on hearing impairment—An exploratory study



https://ift.tt/2IfE3I4

The genetics of cholesteatoma. A systematic review using narrative synthesis



https://ift.tt/2jOhfEO

Determining fitting ranges of various bone conduction hearing aids



https://ift.tt/2IgZgS9

A UK community‐based survey on the prevalence of rhinosinusitis



https://ift.tt/2jS7TIk

Health utility reporting in chronic rhinosinusitis patients



https://ift.tt/2If4Wfp

Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in Sjögren's syndrome: Results of a pilot monocentric trial



https://ift.tt/2IbOwIM

Epistaxis in anticoagulated patients: Fewer hospital admissions and shorter hospital stays on rivaroxaban compared to phenprocoumon



https://ift.tt/2IgZ9pH

Effects of comorbidity and medication use on the haemodynamic status during office‐based laryngeal procedures: A prospective cohort study



https://ift.tt/2jPrCIw

Do laryngoscopic findings reflect the characteristics of reflux in patients with laryngopharyngeal reflux?



https://ift.tt/2IbjTD4

The validity of nasal endoscopy in patients with chronic rhinosinusitis—An inter‐rater agreement study



https://ift.tt/2IhojEu

Saliva testing for human papilloma virus in oropharyngeal squamous cell carcinoma: A diagnostic accuracy study



https://ift.tt/2jS7QME

Zika virus vaccines: immune response, current status, and future challenges

Justin M Richner | Michael S Diamond

https://ift.tt/2I9ElEF

Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

Taia T .Wang | Stylianos Bournazos | Jeffrey V Ravetch

https://ift.tt/2KR1Uj3

MR1 antigen presentation to MAIT cells: new ligands, diverse pathways?

Hamish EG McWilliam | Jose A Villadangos

https://ift.tt/2ICGHeI

"J BUON"[jour]; +44 new citations

44 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"J BUON"[jour]

These pubmed results were generated on 2018/05/11

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.



https://ift.tt/2rzQBE8

Editorial Board

alertIcon.gif

Publication date: June 2018
Source:Critical Reviews in Oncology/Hematology, Volume 126





https://ift.tt/2KfUDIJ

Electrophysiological correlates of timbre imagery and perception

Publication date: Available online 11 May 2018
Source:International Journal of Psychophysiology
Author(s): Przemysław Tużnik, Paweł Augustynowicz, Piotr Francuz
The primary objective of the present study was to verify whether the differences in imagined timbre are reflected by the event-related potentials (ERPs). It was verified the hypotheses that imagining of sounds, varying in spectral characteristics of timbre, influence the amplitude of the late positive component (LPC), associated with auditory imagery-related processes. It was also verified whether the manipulation of the perceived timbre corresponds to the amplitude fluctuations of the auditory evoked potentials (AEPs) N1 and P2. Also, it was expected that the amplitudes of the LPC, N1 and P2 components depend on musical expertise.Musicians and non-musicians took part in two experiments, each of which involved timbre manipulation in term of one parameter of the sound spectrum – spectral centroid or spectral irregularity. Each experiment consisted of auditory perception task followed by auditory imagery training and auditory imagery task.The present study showed that differences in perceived timbre associated with spectral centroid and spectral irregularity are reflected by fluctuations in the amplitude of the N1 and P2 potentials. Perceived differences in spectral centroid are sufficiently distinctive that generation of auditory images of sounds differing in this property induces changes in the amplitude of the late positive component (LPC), recorded during auditory imagery. This means that the LPC is sensitive to changes in the timbre of the imagined sound. Musicians are more accurate in performing auditory imagery task related to timbre than non-musicians. However, musical expertise does not affect the amplitude of the N1, P2 and LPC potentials.



https://ift.tt/2IeTrof

Dr. elliot f. ellis: initiating personalized asthma management in children

Elliot F. Ellis is indeed a giant in the field of allergy and immunology. From his leadership role in developing a pediatric allergy and immunology fellowship at National Jewish Health and his seminal work in theophylline pharmacokinetics, he trained many excellent clinicians and researchers. He assumed the role of Chair of Pediatrics at the Children's Hospital of Buffalo in 1974 and transformed that training program in pediatrics to a top-rated program in the country along with his own training program in allergy and immunology.

https://ift.tt/2Ii0KM5

Primary investigation of the antialgal activity of shrimp shell on Microcystis aeruginosa

Abstract

This study aimed to explore the application potential of an eco-friendly waste—shrimp shell in Microcystis aeruginosa (M. aeruginosa) control—for the first time. Four treatments with different doses (0.75, 1.5, 3.0, and 6.0 g/L) were built to investigate the effects of shrimp shell on the growth, cell viability, physiological changes, and microcystins (MCs) release of M. aeruginosa cells. The water quality after shrimp shell treatment was also detected. Results showed that the growth of M. aeruginosa was effectively inhibited by shrimp shell, and the inhibition rates were dose-dependent within 7 days. Though shrimp shells at high doses could inhibit the cell growth greatly, the MC release was accelerated as they led to the cells lysis. While with the low shrimp shell dose (0.75 g/L), both satisfied inhibition effect and low MC release could be achieved simultaneously. For the water quality, we found that the turbidity and TN was not affected obviously with low dosage of shrimp shell, but it resulted in the increasing of CODMn and TP contents. In summary, the shrimp shell can be used as an effective algicide to control algal blooms but its adverse effect on CODMn and TP of water should be further solved.



https://ift.tt/2rDHTE1

Making a Difference in Low-Resource Settings

By Nathan Douthit

In February, 1999, the World Health Organization partnered with more than 20 non-governmental organizations involved in eye care to launch VISION2020: The Right to Sight. The goal of this initiative is to eliminate the main preventable and treatable causes of blindness by the year 2020. The threefold strategy involves disease control, human resource development, and infrastructure and appropriate technology development. Despite major improvements, there is still work to be done.[1]

In "Management of a rhegmatogenous retinal detachment in a low-resource setting: treatment options when there is no vitreoretinal surgeon," Emsley et all highlight the difficulty in management of opthalmological problems in low resource settings, where no subspecialists are present. The patient presented with a treatable retinal detachment and retinal tear, but, "Unfortunately, no access to any vitreoretinal trained personnel or vitrectomy equipment currently exists in Sierra Leone…. [T]he nearest facility in Ghana is 2018 km away and beyond the financial means of the patient." Despite presenting with vision acuity of 20/30 bilaterally, "At review 8 months later, the visual acuity had dropped to 6/36 and the retina had completely detached.

In the discussion, the authors present the incidence of rhegmatogenous retinal detachment in sub-Saharan Africa and Sierra Leone. Despite the growing prevalence of this disease and the "late presentation with advanced disease and secondary complications" in the developing world, only 15 subspecialty trained vitreoretinal surgeons practice in the region of Senegal to Kenya and Ethiopia to Tanzania. The lack of equipment and continued training for opthalmologic specialties is a well documented problem.[2] The need to develop a system for screening, referring and transporting patients to well-equipped tertiary care centers is also well-described.[3]

Despite steps in these directions, however, there are still countless patients suffering with no access to the necessary specialties—in this case, a vitreoretinal surgeon. Rather than forgoing any care, healthcare professionals with appropriate training can optimize the treatment with the resources they have available to them. Emsley et al excellently describe several interventions in there article that would have helped this patient without the need for a vitreoretinal surgeon. They focus on pneumatic retinopexy, "[T]he ideal treatment option for the case described above in this setting."

BMJ Case Reports invites authors to submit global health case reports that describe feasible interventions that could alleviate disease in low-resource settings. These cases could focus on:

  •  Interventions that have been successfully instituted in a low-resource area
  •  Potential interventions to help a vulnerable population
  •  Challenges to instituting an intervention in a low-resource setting
  •  Low-resource interventions that have aided individual patients

Manuscripts may be submitted by students, physicians, nurses and allied health professionals to BMJ Case Reports via the submission system. For more information, review our guidance on how to write a global health case report and look through our online collection.

To read more about interventions in low resource settings at BMJ Case Reports, please review:

To read more about opthalmologic care in the developing world, please review:

[1] World Health Organization. What is VISION 2020? [internet] Prevention of Blindness and Visual Impairment. WHO 2018. Accessed from: http://www.who.int/blindness/partnerships/vision2020/en/ on 3 May 2018

[2] Courtright P, Ndegwa L, Msosa J, Banzi J. Use of our existing eye care human resources: assessment of the productivity of cataract surgeons trained in eastern Africa. Archives of ophthalmology. 2007 May 1;125(5):684-7.

[3] Sommer A, Taylor HR, Ravilla TD, West S, Lietman TM, Keenan JD, Chiang MF, Robin AL, Mills RP. Challenges of ophthalmic care in the developing world. JAMA ophthalmology. 2014 May 1;132(5):640-4.

Competing Interests

None Declared



https://ift.tt/2jHt7bE

Making a Difference with Individual Patients-Health Equity, Power, and Dignity

By Nathan Douthit

   At another session of CUGH's Annual Meeting, Richard Horton, Editor in Chief of the Lancet, debated Cheryl Heaton, director of New York University's Global Institute of Public Health, on the subject: Equity is the defining objective of global health in the 21st century. Heaton argued in favour of the motion, saying that our past neglect has created high reservoirs of need around the world. She made the point that equity creates hope and optimism in vulnerable populations, which turn motivate their ability to bring about change.

   While Horton agreed that equity is a valuable and admirable goal, he argued that global health, as it is currently framed, makes this impossible to achieve. He argued that global health "is not about equity; it is about power", with power held by the privileged. He continued "before there can be equity, individuals must have liberty and power over their lives." Further, liberty requires that all humans be recognized for their dignity. Dignity affirms that every individual is an end unto themselves; not a means to our ends. "Without dignity, there can be no equity." Horton concluded that our obligation is to challenge authorities that deny liberty. We must discharge this obligation if we are to see the dignity of individual patients recognized.

   BMJ Case Reports is committed to recognizing the dignity and worth of individual patients. Our case reports focus on patients at the center of clinical medicine and global health. While our clinical case reports highlight the challenges of dealing with disease, our global health case reports shed light on the determinants of health and disease: the environments in which patients live and work; education and financial well-being; access to healthcare; local and national politics; instability and conflict; the practice of corporations and industry; and, ethnic and cultural histories. Our authors argue for better living conditions and improvements in health at the level of the individual – working towards global health one patient at a time. Each patient is an end unto themselves. We encourage our authors to work with their patients in writing each global health case report and want to be not merely a repository of global health problems and solutions but a repository of patient voices from across the world.

   BMJ Case Reports invites authors to submit global health case reports that give voice to individual patients and uphold their dignity. These reports should examine the determinants of health:

  • The effects of culture and environment
  • Education and literacy
  • How occupation may exacerbate or cause disease
  • The effects of conflict, disaster, migration and poverty
  • Access to healthcare
  • The interventions and innovations put into place in global health to treat individual patients.
  • The disproportional effect of social determinants of health on vulnerable communities

   Manuscripts may be submitted by students, physicians, nurses and allied health professionals to BMJ Case Reports via the submission system. For more information, review our guidance on how to write a global health case report and look through our online collection.

Competing Interests

None Declared



https://ift.tt/2JFhNZg

What causes a piercing rejection to occur?

Sometimes, the body will reject a piercing. Piercing rejection happens when the immune system sees the jewelry as a foreign object and tries to push it back out. This can cause discomfort and scarring. In this article, we look at how to spot a piercing rejection, prevention tips, and stopping the process of rejection.

https://ift.tt/2KU5VTS

What causes a piercing rejection to occur?

Sometimes, the body will reject a piercing. Piercing rejection happens when the immune system sees the jewelry as a foreign object and tries to push it back out. This can cause discomfort and scarring. In this article, we look at how to spot a piercing rejection, prevention tips, and stopping the process of rejection.

https://ift.tt/2KU5VTS

Hajrul yahood (Lapis judaicus): An important mineral drug of Unani system of medicine for the management of urolithiasis

Publication date: 10 August 2018
Source:Journal of Ethnopharmacology, Volume 222
Author(s): Shaikh Ajij Ahmed Makbul, Nasreen Jahan, Ghufran Ahmad
Ethnopharmacological relevanceHajrul yahood (Lapis judaicus) is a mineral drug used in different dosage forms in Unani system of medicine and claimed to be effective in the management of urolithiasis.Aim of the studyTo explore the role of Hajrul yahood in the management of urolithiasis along with determination of its morphological, ethnomedicinal, physicochemical and pharmacological attributes.Materials and methodsA review of literature on Hajrul yahood was undertaken using the bibliographic database viz. Pub Med, Google Scholar, Science Direct and Scopus. The search was conducted using the terms 'Hajrul yahood', 'Lapis judaicus', 'Majoon Hajrul yahood' and 'Kushta Hajrul yahood'. Further books, monographs and reports on Lapis judaicus published in Urdu and English were used to compile the information.ResultsHajrul yahood as such and as an ingredient in multidrug formulations has been used for the treatment of kidney and bladder stones since ancient times mainly by the practitioners of traditional medicines. Literature of Unani medicine clearly indicated that Hajrul yahood and its different formulations are safe and have antilithiatic effect. Sufficient information in respect of morphological, physicochemical and ethnomedicinal properties of Hajrul yahood are available but very few pharmacological and clinical studies have been conducted. The available reports on Hajrul yahood and its products mainly Cystone® though has shown varying results but on the whole indicated possible antilithiatic effect. The studies conducted so far have been limited by small patient numbers, weak methodology, and poor study design therefore a conclusive result cannot be arrived at.ConclusionHajrul yahood and its formulations have been claimed by Unani medicine to be useful in the management of urolithiasis. Some of the scientific reports also suggest the possibility of such an effect however further elaborate and comprehensive studies are required to validate such a claim.

Graphical abstract

image


https://ift.tt/2G8Ujc4

Both High and Low Maternal Thyroid Function Are Associated with Child Autistic Spectrum Disorders, While Only Hypothyroxinemia Is Associated with Child ADHD

Clinical Thyroidology, Volume 30, Issue 5, Page 220-222, May 2018.


https://ift.tt/2IdzT3v

More Dynamic Diagnostic Criteria Are Needed to Define Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)

Clinical Thyroidology, Volume 30, Issue 5, Page 200-202, May 2018.


https://ift.tt/2I6pPxc

Noninvasive Follicular Thyroid Neoplasms With Papillary-like Nuclear Features (NIFTP) Show Molecular and Clinical Similarity to Follicular Adenomas

Clinical Thyroidology, Volume 30, Issue 5, Page 203-205, May 2018.


https://ift.tt/2Ibv2ju

Using the American College of Radiology Thyroid Imaging Reporting and Data System Will Decrease the Number of Thyroid Nodule Biopsies While Improving Diagnostic Accuracy

Clinical Thyroidology, Volume 30, Issue 5, Page 206-209, May 2018.


https://ift.tt/2Ibv0YU

Neonatal TSH <0.90 mIU/L Increases the Risk for Hyperthyroidism in Infants of Mothers with Graves’ Disease

Clinical Thyroidology, Volume 30, Issue 5, Page 217-219, May 2018.


https://ift.tt/2IaB5sD

Minimal Extrathyroidal Extension Carries a Modest Increase for Recurrence but Not Mortality in Differentiated Thyroid Cancer

Clinical Thyroidology, Volume 30, Issue 5, Page 210-212, May 2018.


https://ift.tt/2IcHqzv

Radioactive Iodine Ablation Decreases Serum Anti-Müllerian Hormone Concentrations (as a Marker of Ovarian Reserve) in Women with Thyroid Cancer

Clinical Thyroidology, Volume 30, Issue 5, Page 223-225, May 2018.


https://ift.tt/2jRi4ws

Management of Thyroid Nodules in Post-Septuagenarians Needs to Consider Coexistent Serious Diseases

Clinical Thyroidology, Volume 30, Issue 5, Page 213-216, May 2018.


https://ift.tt/2IdzSfX

Does the Level of Certain Thyroidal mRNAs Change with Age?

Clinical Thyroidology, Volume 30, Issue 5, Page 230-233, May 2018.


https://ift.tt/2jRRCTN

Human papillomavirus detection in gargles, tonsil brushings, and frozen tissues in cancer-free patients

alertIcon.gif

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): J.D. Combes, C. Clavel, V. Dalstein, T. Gheit, G.M. Clifford, M. Tommasino, S. Franceschi, J. Lacau St Guily




https://ift.tt/2G8x8ia

Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis

S13688375.gif

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Fernanda Weber Mello, Fernanda Marcello Scotti, Gilberto Melo, Saman Warnakulasuriya, Eliete Neves Silva Guerra, Elena Riet Correa Rivero
Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté consumption and occurrence of the UADT cancer?". Studies investigating any association between maté consumption and occurrence of UADT cancer were included. Out of the 569 studies, 18 met the inclusion criteria for qualitative and 15 for quantitative analysis. An increased odds was observed regarding maté consumption and overall occurrence of UADT cancer (OR = 2.24; 95%CI = 1.74–2.87). Consistent evidence of a positive association was found for all UADT subsites, oral, pharynx, esophagus and larynx. No differences in effect were found between consumption of cold/warm and hot/very hot mate (OR = 1.08; 95%CI = 0.83–1.41). Consumption of more than one liter of maté per day was associated with increased odds of having UADT cancer compared to an intake of less than one liter per day (OR = 1.72; 95%CI = 1.47–2.01). According to published data, regardless of the temperature, maté consumption significantly increased the odds of occurrence of UADT cancer.



https://ift.tt/2jRpTCA

Impact of radical treatments on survival in locally advanced T4a and T4b buccal mucosa cancers: Selected surgically treated T4b cancers have similar control rates as T4a

S13688375.gif

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Manish D. Mair, Noopur Sawarkar, Santosh Nikam, Rajiv Sarin, Deepa Nair, Tejpal Gupta, Pankaj Chaturvedi, Anil D'cruz, Sudhir Nair
IntroductionIn the absence of any robust data supporting the TNM classification of T4 buccal mucosa cancers, we did this prospective study to compare the oncologic outcomes of T4a and T4b buccal mucosa cancer patients.Patients and methodsThis is a prospective study of 210 treatment naïve T4 buccal mucosa cancer patients. All patients underwent upfront radical surgery followed by adjuvant radiotherapy (RT)/chemoradiotherapy (CCRT). This is the largest prospective series in the literature on T4 buccal cancers.ResultsT4a disease was seen in 135(64.3%) patients and T4b in 75(35.7%) patients. On comparison between all T4a and T4b cases, a significant difference was observed with regard to 3-year local control (49.6% vs. 41.1%: p-0.025) and disease-free survival (DFS) (65.3% vs. 42%: p-0.035) with a slightly higher incidence of distant metastasis in T4b patients (17.3% vs. 9.6%). Inadequate cut margin (<5 mm) was seen only in 7.4% patients with T4a disease and 12% patients with T4b disease. When patients with adequate cut margins were considered for analysis, local recurrence rate was similar for T4a (26/135; 19.3%) and T4b (15/66; 22.7%) disease suggesting the importance of radical surgery in infra-notch T4b buccal cancers. While the 3-year survival for T4a patients who received adjuvant RT alone was 72.2%, it was only 42.1% for similar T4b patients suggesting a need to intensify adjuvant treatment for these patients.ConclusionSurgery should be considered as the primary modality of treatment for T4b patients, where clear margins are achievable. The benefit of treatment intensification with adjuvant CCRT should be explored in T4b buccal cancers.



https://ift.tt/2G6dqnl

Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): E. Boon, M.H. Valstar, W.T.A. van der Graaf, E. Bloemena, S.M. Willems, C.A. Meeuwis, P.J. Slootweg, L.A. Smit, M.A.W. Merkx, R.P. Takes, J.H.A.M. Kaanders, P.J.T.A. Groenen, U.E. Flucke, C.M.L. van Herpen
ObjectivesIn 2010, a new subtype of salivary gland cancer (SGC), (mammary analogue) secretory carcinoma (SC), was defined, characterized by the ETV6-NTRK3 fusion gene. As clinical behavior and outcome data of this histological subtype tumor are still sparse, we aimed to describe the clinicopathological course and outcome of a series of translocation positive SC patients.Patient and methodsWe re-evaluated the pathological diagnosis of a subset of SGCs, diagnosed in 4 of 8 Dutch head and neck centers. Subsequently, tumors with a morphological resemblance to SC were tested for the ETV6-NTRK3 fusion gene using RT-PCR. Furthermore, patients prospectively diagnosed with SC were included. The clinical characteristics and outcomes were retrieved from the patient files.ResultsThirty-one patients with ETV6-NTRK3 fusion gene positive SC were included. The median age was 49 years, 17 patients (55%) were male. Eighteen tumors (58%) arose in the parotid gland. One patient presented with lymph node metastasis. All patients underwent tumor resection and 4 patients had a neck dissection. Four patients had re-resection and 15 patients (48%) received postoperative radiotherapy. One patient developed a local recurrence, no regional recurrences or distant metastases were observed. After a median follow-up of 49 months the 5- and 10-year overall survival were 95%, the 5- and 10-year disease free survival were 89%.ConclusionThe clinical course of SC is favorable with a low rate of locoregional recurrence and excellent survival. Given the low incidence of nodal metastases, elective neck treatment, i.e. surgery and/or radiotherapy, does not seem to be indicated.



https://ift.tt/2G8itDJ

AJCC 8th Edition oral cavity squamous cell carcinoma staging – Is it an improvement on the AJCC 7th Edition?

S13688375.gif

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Katherine Pollaers, Anton Hinton-Bayre, Peter L. Friedland, Camile S. Farah
ObjectivesTo explore the prognostic and discriminatory ability of the AJCC 8th Edition Oral Cavity cancer staging in a non-North American population, and compare it to the previously used AJCC 7th Edition.Materials and methodsRetrospective chart review was performed at a tertiary referral Otolaryngology, Head Neck and Skull Base Department in Australia, from June 2002 to June 2017. Oral cavity squamous cell carcinoma cases were staged according to AJCC 8th Edition, which was compared to AJCC 7th Edition staging, for disease-free survival (DFS) and overall survival (OS). DFS and OS were analysed using Kaplan-Meier curves.ResultsThere were 118 patients treated for OSCC, with an average age of 61 years, 63% were male. Overall survival grouped by stage demonstrated statistically significant discrimination between cancer stages using both the AJCC 7th and AJCC 8th Editions. AJCC 7th Edition did not discriminate between stages for DFS. Conversely, AJCC 8th Edition did statistically significantly discriminate for DFS (p = 0.0002). The DFS for both Stage 4a and 4b was significantly worse than cases in Stage 1. AJCC 8th Edition T stage was statistically significantly related to DFS (p = 0.0199), while the AJCC 7th Edition T stage was not.ConclusionThe AJCC Cancer Staging Manual 8th Edition includes both the depth of primary tumour invasion and extracapsular extension of lymph node metastases. The AJCC 8th Edition OSCC staging system showed improved disease-free survival discrimination between overall stages and between T categories, while AJCC 7th Edition did not.



https://ift.tt/2G760Ah

Establishment of prognostic factors in recurrent nasopharyngeal carcinoma patients who received salvage intensity-modulated radiotherapy: A meta-analysis

S13688375.gif

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Qiuyuan Yue, Mingwei Zhang, Yunbin Chen, Dechun Zheng, Ying Chen, Meimei Feng
Local recurrence remains a major cause of therapeutic failure in patients with nasopharyngeal carcinoma (NPC) and the effective treatment of recurrent NPC (r-NPC) is still a challenge. Intensity-modulated radiotherapy (IMRT) is considered as a favorable technique in the management of r-NPC, especially for extensive lesions. However, local r-NPC is a highly heterogeneous disease and the survival outcome following salvage IMRT varies. Furthermore, due to varied samples and therapeutic protocols, no consensus has been reached in the establishment of prognostic values. Hence, we used Medline and Embase electronic databases to conducted a meta-analysis to generate the best estimation of the prognostic factors in local r-NPC following salvage IMRT. Finally, a total of 783 patients in seven studies were enrolled. Overall, the pooled HR for OS of recurrent T stage and recurrent tumor volume was 1.77 (95% CI = 1.15–2.39) and 2.12 (95% CI = 1.42–2.82), without any heterogeneity. In addition, despite a significant association was observed in the pooled HR of significant compliance for OS, however, significant heterogeneity was also observed (I2 = 76.6%, p = 0.039). Furthermore, no significant association was observed among the pooled HRs for OS in terms of age, gender, recurrent time interval, synchronous nodal recurrence, chemotherapy and total re-irradiation dose. Therefore, the present meta-analysis demonstrated that recurrent T stage and tumor volume may serve as the prognostic factors for OS in patients with r-NPC who received salvage IMRT. The other factors such as age, gender, and optimal re-irradiation dose warranted further investigation.



https://ift.tt/2G8LiQg

The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Vassiliki Saloura, Theodore Vougiouklakis, Cem Sievers, Kyunghee Burkitt, Yusuke Nakamura, Gordon Hager, Carter van Waes
Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal survival outcomes and standard therapies with significant comorbidities. Whole exome sequencing data recently revealed an abundance of genetic and expression alterations in a family of enzymes known as protein methyltransferases in a variety of cancer types, including squamous cell carcinoma of the head and neck. These enzymes are mostly known for their chromatin-modifying functions through methylation of various histone substrates, though evidence supports their function also through methylation of non-histone substrates. This review summarizes the current knowledge on the function of protein methyltransferases in squamous cell carcinoma of the head and neck and highlights their promising potential as the next generation of therapeutic targets in this disease.



https://ift.tt/2KTf7Id

Assessing the carcinogenic potential of E-cigarette

elsevier-non-solus.png

Publication date: Available online 24 April 2018
Source:Oral Oncology
Author(s): A. Thirumal Raj, Shankargouda Patil, Kamran Habib Awan, Shivaranjhany Sivakumar




https://ift.tt/2G9dWRh

Nivolumab vs investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression

elsevier-non-solus.png

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Robert L. Ferris, George Blumenschein, Jerome Fayette, Joel Guigay, A. Dimitrios Colevas, Lisa Licitra, Kevin J. Harrington, Stefan Kasper, Everett E. Vokes, Caroline Even, Francis Worden, Nabil F. Saba, Lara Carmen Iglesias Docampo, Robert Haddad, Tamara Rordorf, Naomi Kiyota, Makoto Tahara, Mark Lynch, Vijayvel Jayaprakash, Li Li, Maura L. Gillison
ObjectivesWe report 2-year results from CheckMate 141 to establish the long-term efficacy and safety profile of nivolumab and outcomes by tumor PD-L1 expression in patients with recurrent or metastatic (R/M),platinum-refractory squamous cell carcinoma of the head and neck (SCCHN).MethodsPatients with R/M SCCHN with tumor progression/recurrence within 6 months of platinum therapy were randomized 2:1 to nivolumab 3 mg/kg every 2 weeks or investigator's choice (IC). Primary endpoint: overall survival (OS). Data cutoff: September 2017.ResultsWith 24.2 months' minimum follow-up, nivolumab (n = 240) continued to improve OS vs IC (n = 121), hazard ratio (HR) = 0.68 (95% CI 0.54–0.86). Nivolumab nearly tripled the estimated 24-month OS rate (16.9%) vs IC (6.0%), and demonstrated OS benefit across patients with tumor PD-L1 expression ≥1% (HR [95% CI] = 0.55 [0.39–0.78]) and  < 1% (HR [95% CI] = 0.73 [0.49–1.09]), and regardless of tumor HPV status. Estimated OS rates at 18, 24, and 30 months with nivolumab were consistent irrespective of PD-L1 expression (<1%/≥1%). In the nivolumab arm, there were no observed differences in baseline characteristics or safety profile between long-term survivors and the overall population. Grade 3–4 treatment-related adverse event rates were 15.3% and 36.9% for nivolumab and IC, respectively.ConclusionNivolumab significantly improved OS at the primary analysis and demonstrated prolonged OS benefit vs IC and maintenance of a manageable and consistent safety profile with 2-year follow-up. OS benefit was observed with nivolumab irrespective of PD-L1 expression and HPV status. (Clinicaltrials.gov: NCT02105636)



https://ift.tt/2jOvgSQ

Depth of invasion, size and number of metastatic nodes predicts extracapsular spread in early oral cancers with occult metastases

S13688375.gif

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Manish D. Mair, Rathan Shetty, Deepa Nair, Yash Mathur, Sudhir Nair, Anuja Deshmukh, Shiva Thiagarajan, Gouri Pantvaidya, Sarbani Lashkar, Kumar Prabhash, Devendra Chaukar, Prathmesh Pai, Anil D. Cruz, Pankaj Chaturvedi
ObjectivePresence of extracapsular spread (ECS) significantly decreases survival in oral cancer patients. Considering its prognostic impact, we have studied the incidence and factors predicting ECS in clinically node negative early oral cancers.Materials and MethodsWe performed a retrospective chart review of 354 treatment naïve clinically node negative early oral cancer patients operated between 2012 and 2014. Chi-square test and logistic regression were used for identifying predictors of ECS, while cox-regression test was used for survival analysis.ResultsThe incidence of occult nodal metastasis was 28.5% (101/354). Among them, ECS was seen in 15.3%(54/354) patients. The incidence of ECS in T1 and T2 lesion was 13.4% (21/157) and 16.8% (33/197), respectively. The overall incidence of ECS was 48% and 29% in lymph nodes smaller than 10 mm and 5 mm respectively. We found that tumor depth of invasion (>5 mm; p-0.027) and node (metastatic) size >15 mm (p-0.018) were significant predictors of ECS. p N2b disease was seen in 41/354 (11.6%) of which 31/354 (8.7%) had ECS, i.e. 75.6% of pN2b patients been ECS positive (p-0.000). The 3-year OS of patients without nodal metastasis, nodal metastasis without ECS and nodal metastasis with ECS was 88.4%, 66.9% and 59.2% (p-0.000) respectively.ConclusionA significant number of patients with metastatic nodal size less than 1 cm have ECS which suggests aggressive behavior of the primary tumor. Thus, elective neck dissection is the only way of detecting ECS in these patients which may warrant treatment intensification.



https://ift.tt/2G9dQsT

A clinical prognostic model compared to the newly adopted UICC staging in an independent validation cohort of P16 negative/positive head and neck cancer patients

elsevier-non-solus.png

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Jacob H. Rasmussen, Katrin Håkansson, Gregers B. Rasmussen, Ivan R. Vogelius, Jeppe Friborg, Barbara M. Fischer, Søren M. Bentzen, Lena Specht
ObjectivesA previously published prognostic model in patients with head and neck squamous cell carcinoma (HNSCC) was validated in both a p16-negative and a p16-positive independent patient cohort and the performance was compared with the newly adopted 8th edition of the UICC staging system.Materials and methodsConsecutive patients with HNSCC treated at a single institution from 2005 to 2012 were included. The cohort was divided in three. 1.) Training cohort, patients treated from 2005 to 2009 excluding patients with p16-positive oropharyngeal squamous cell carcinomas (OPSCC); 2.) A p16-negative validation cohort and 3.) A p16-positive validation cohort. A previously published prognostic model (clinical model) with the significant covariates (smoking status, FDG uptake, and tumor volume) was refitted in the training cohort and validated in the two validation cohorts. The clinical model was used to generate four risk groups based on the predicted risk of disease recurrence after 2 years and the performance was compared with UICC staging 8th edition using concordance index.ResultsOverall 568 patients were included. Compared to UICC the clinical model had a significantly better concordance index in the p16-negative validation cohort (AUC = 0.63 for UICC and AUC = 0.73 for the clinical model; p = 0.003) and a borderline significantly better concordance index in the p16-positive cohort (AUC = 0.63 for UICC and 0.72 for the clinical model; p = 0.088).ConclusionThe validated clinical model provided a better prognostication of risk of disease recurrence than UICC stage in the p16-negative validation cohort, and similar prognostication as the newly adopted 8th edition of the UICC staging in the p16-positive patient cohort.



https://ift.tt/2KTeWN3

Predictors of oropharyngeal cancer survival in Europe

S13688375.gif

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): D. Anantharaman, A. Billot, T. Waterboer, T. Gheit, B. Abedi-Ardekani, P. Lagiou, A. Lagiou, W. Ahrens, I. Holcátová, F. Merletti, K. Kjaerheim, J. Polesel, L. Simonato, L. Alemany, M. Mena Cervigon, T.V. Macfarlane, A. Znaor, P.J. Thomson, M. Robinson, C. Canova, D.I. Conway, S. Wright, C.M. Healy, M.E. Toner, M. Pawlita, M. Tommasino, P. Brennan
ObjectivesHPV16-positive oropharyngeal cancer (OPC) patients experience better outcomes compared to HPV16-negative patients. Currently, strategies for treatment de-escalation are based on HPV status, smoking history and disease stage. However, the appropriate cut-point for smoking and the role of other non-clinical factors in OPC survival remains uncertain.Materials and MethodsWe examined factors associated with OPC outcome in 321 patients recruited in a large European multi-center study. Seropositivity for HPV16 E6 was used as a marker of HPV16 positive cancer. Hazard ratios (HR) and confidence intervals (CI) were estimated using Cox proportional models adjusted for potential confounders.ResultsOverall 5-year survival following OPC diagnosis was 50%. HPV16-positive OPC cases were at significantly lower risk of death (aHR = 0.51, 95% CI: 0.32–0.80). A significant effect on OPC survival was apparent for female sex (aHR 0.50: 95% CI: 0.29–0.85) and being underweight at diagnosis (aHR: 2.41, 95% CI: 1.38–4.21). A 10 pack year smoking history was not associated with overall survival. Higher stage at diagnosis appeared as the only factor significantly associated with OPC recurrence (aHR: 4.88, 95% CI: 2.12–11.21).ConclusionThis study confirms that HPV16 status is an independent prognostic factor for OPC survival while female sex lowers risk of death and being underweight at diagnosis increases the risk of death. Smoking was not an independent predictor of OPC survival.



https://ift.tt/2G7HS04

Age- and localization-dependent functional and psychosocial impairments and health related quality of life six months after OSCC therapy

elsevier-non-solus.png

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Sabine S. Linsen, Nils-Claudius Gellrich, Gertrud Krüskemper
ObjectivesThe aim of the current study was to evaluate the functional and psychosocial impacts and changes in overall quality of life (QoL) following oral squamous cell carcinoma (OSCC) therapy in different age groups and in different oral locations.Materials and MethodsThe study assessed questionnaire responses from patients with OSCC (n = 1319) after 6 months of oncologic therapy, as collected in the DÖSAK Rehab Study. Oncological variables, dental status, sensory, QoL, psychosocial outcomes and coping strategies in younger (45–60 years) and older (61–100 years) patients were assessed for different OSCC locations including the entire oral cavity, maxilla, mandible and others besides the maxilla and mandible.ResultsYounger patients were generally less satisfied with their dental status and experienced more sensory and QoL impairments, as well as more psychological burden, compared to the older patients. Depending on the age group, different coping strategies were used. Oncologic therapy targeted to the mandible and other locations besides the maxilla and mandible led to the strongest sensory and QoL limitations.ConclusionsRegardless of age, oncologic OSCC therapy leads to profound sensory and psychosocial restrictions and to limitations in QoL. Reasons for the poorer functional and QoL outcomes in younger patients include a more invasive treatment and a lower psychosocial resilience. The identification of patients with depressive and dysfunctional coping strategies should be carried out for all ages, but especially in younger patients, in order to develop functional coping strategies through individualized counseling, treatment and rehabilitation.Registration of clinical trialsObservational study, therefore not required.



https://ift.tt/2jPK4AF

Surgical outreach and microvascular surgery in developing countries

S13688375.gif

Publication date: June 2018
Source:Oral Oncology, Volume 81
Author(s): Chad A. Zender, Kate Clancy, Jason E. Thuener, Kyle Mannion
Due to the discrepancy between surgical demand and resources in Low-Middle Income Countries (LMIC), surgical outreach programs (SOP) have increased in popularity. In these resource-constrained healthcare environments, the resources necessary to perform basic head and neck procedures are often lacking, and offering microvascular reconstruction adds yet another level of complexity. Here we discuss the difficulties and challenges in establishing a SOP abroad and more specifically some of the challenges specific to microvascular reconstruction – including patient selection, burden of cost, lack of infrastructure and equipment, and patient follow up and outcomes. Although challenges certainly exist, we present the feasibility and the benefit for patient care as well as the role it can play in the foundation development of a low-resource region. The goals of the SOP must be well-defined, and incorporating microvascular surgery can be used as an adjunct to enhance the development of many aspects of the LMIC healthcare system. We present a model of care in which the initial focus is centered on providing safe care to these patients undergoing complex procedures, but after the development of a strong foundation, the focus can begin to include program sustainability and education.



https://ift.tt/2G4MrZf

Bisphosphonate-related osteonecrosis of the human jaw: A combined 3D assessment of bone descriptors by histology and synchrotron radiation-based microtomography

alertIcon.gif

Publication date: Available online 8 May 2018
Source:Oral Oncology
Author(s): Alessandra Giuliani, Giovanna Iezzi, Marco Mozzati, Giorgia Gallesio, Serena Mazzoni, Giuliana Tromba, Franco Zanini, Adriano Piattelli, Carmen Mortellaro




https://ift.tt/2KWobfp

Progression beyond nivolumab: Stop or repeat? Dramatic responses with salvage chemotherapy

elsevier-non-solus.png

Publication date: Available online 24 April 2018
Source:Oral Oncology
Author(s): Amaury Daste, Erwan De-Mones, Valérie Cochin, Charles Dupin, Laurence Digue, Alain Ravaud, Charlotte Domblides




https://ift.tt/2G7HRcw

Editorial Board/Aims & Scope

alertIcon.gif

Publication date: May 2018
Source:Oral Oncology, Volume 80





https://ift.tt/2KWo4R1

A novel applicator design for intracavitary brachytherapy of the nasopharynx: Simulated reconstruction, image-guided adaptive brachytherapy planning, and dosimetry

alertIcon.gif

Publication date: Available online 11 May 2018
Source:Brachytherapy
Author(s): Warren R. Bacorro, Ryan Anthony F. Agas, Stellar Marie R. Cabrera, Maureen R. Bojador, Paolo G. Sogono, Michael Benedict A. Mejia, Teresa T. Sy Ortin
PurposeIn nasopharyngeal cancer, brachytherapy is given as boost in primary treatment or as salvage for recurrent or persistent disease. The Rotterdam nasopharyngeal applicator (RNA) allows for suboptimal reduction of soft palate radiation dose, based on image-guided brachytherapy plans. Building on the RNA, we propose a novel design, the Benavides nasopharyngeal applicator (BNA).Methods and MaterialsThe virtual BNA was reconstructed on two cases (one T1, one T2) previously treated with intracavitary brachytherapy using the RNA. Dose was prescribed to the high-risk clinical target volumes (CTVs) and optimization was such that high-risk CTV D90 ≥ 100% of prescribed dose (PD), intermediate-risk-CTV D90 ≥ 75% PD, and soft palate D2cc ≤ 120% PD. The optimized RNA and BNA image-guided brachytherapy plans were compared in terms of CTV coverage and organs-at-risk sparing.ResultsOptimization objectives were more easily met with the BNA. For the T1 case, all three planning objectives were easily achieved in both the RNA and BNA, but with 18–19% lower soft palate doses with the BNA. For the T2 case, the CTV planning objectives were achieved in both the RNA and BNA, but the soft palate constraint was only achieved with the BNA, with 38–41% lower soft palate doses.ConclusionsCompared to the RNA, the BNA permits easier optimization and improves therapeutic ratio by a significant reduction of soft palate doses, based on simulation using a proposed system for CTV/organs-at-risk delineation, prescription, and optimization for image-guided adaptive brachytherapy. Clinical piloting using a prototype is necessary to evaluate its feasibility and utility.



https://ift.tt/2wydTil

Comparison of dosimetric and clinical outcomes between short- and long-channel cylinder applicators for vaginal brachytherapy in intermediate- and high-risk endometrial cancer

alertIcon.gif

Publication date: Available online 11 May 2018
Source:Brachytherapy
Author(s): Michael Z. Kharouta, Nghia Pham, Karina Nieto, Murat Surucu, Michael L. Mysz, Kevin Albuquerque, Abigail Winder, Margaret Liotta, Ronald K. Potkul, William Small, Matthew M. Harkenrider
PurposeVaginal brachytherapy (VBT) using a cylinder applicator is a standard treatment of intermediate- and high-risk endometrial cancer. We conducted a retrospective study of the dosimetric and clinical outcomes at our institution with 2 single-channel applicators in patients receiving VBT.Methods and MaterialsOne hundred thirty-six patients with endometrial cancer treated from 2006 to 2016 receiving VBT after definitive surgery were evaluated. Two cylinders were used with the distal dwell position 7.1–12.8 mm from the apex varying by diameter (short channel), and 3.2 mm from the apex (long channel). We prescribed 18–26 Gy in 3–4 fractions at 0.5 cm depth. Measurements of the distance from the apex to the prescription isodose line were taken from CT imaging. Student's t test and the Wilcoxon rank-sum test were used with corrections for multiple comparisons.ResultsPatients had International Federation of Gynecology and Obstetrics 2009 Stage I-II disease (70 Stage IA, 58 Stage IB, 9 Stage II). Mean cylinder apex dose was 95.2% and 154.7% of prescription (p < 0.001), and mean distance from apex to the prescription isodose line was 0.54 mm and 3.5 mm (p < 0.001) for the short- and long-channel cylinders, respectively. There were no significant differences in any toxicity between cylinders. Four patients (2.9%) had vaginal recurrence, all of whom were treated with the short-channel cylinder. Cylinder type was not associated with vaginal recurrence (p = 0.27).ConclusionsA cylinder applicator with a distal dwell position closer to the apex results in higher doses to the vaginal cuff and increased D2cc to the bladder. All four recurrences were in the short-channel cylinder. Additional investigation into applicator design and impact on patient outcomes in larger cohorts with sufficient followup is warranted.



https://ift.tt/2rx0LVZ

Covering the instrument table decreases bacterial bioburden: An evaluation of environmental quality indicators

Publication date: Available online 11 May 2018
Source:American Journal of Infection Control
Author(s): Troy A. Markel, Thomas Gormley, Damon Greeley, John Ostojic, Jennifer Wagner
BackgroundCovering the instrument table during surgery may decrease contamination. We hypothesized that (1) covering the instrument table in an operating room (OR) during static periods of nonuse and dynamic periods of active use would dramatically decrease the bacterial bioburden on the table, and (2) the use of sterile plastic table covers would be equivalent to sterile impervious paper covers in reducing the bioburden in a dynamic environment.MethodsBacterial contamination of the instrument table was evaluated by settle plates in static and dynamic ORs. Airborne particulate and bacterial contaminants were sampled throughout the room. Tested groups included instrument tables covered with sterile impervious paper covers, sterile plastic covers, or no covers.ResultsCovering the instrument table during static and dynamic operating room conditions resulted in a significantly decreased bacterial load on the instrument table. No differences were seen between paper and plastic covers.ConclusionsA significant decrease in bacterial bioburden on the instrument table when the table was covered during static and dynamic periods was observed, suggesting the utility for covering the instrument table during periods of nonuse and during active surgeries.



https://ift.tt/2KU9PfB

Impact of antimicrobial wipes compared with hypochlorite solution on environmental surface contamination in a health care setting: A double-crossover study

Publication date: Available online 11 May 2018
Source:American Journal of Infection Control
Author(s): Harsha Siani, Rebecca Wesgate, Jean-Yves Maillard
ObjectiveAntimicrobial wipes are increasingly used in health care settings. This study evaluates, in a clinical setting, the efficacy of sporicidal wipes versus a cloth soaked in a 1,000 ppm chlorine solution.InterventionA double-crossover study was performed on 2 different surgical and cardiovascular wards in a 1,000-bed teaching hospital over 29 weeks. The intervention period that consisted of surface decontamination with the preimpregnated wipe or cloth soaked in chlorine followed a 5-week baseline assessment of microbial bioburden on surfaces. Environmental samples from 11 surfaces were analyzed weekly for their microbial content.ResultsA total of 1,566 environmental samples and 1,591 ATP swabs were analyzed during the trial. Overall, there were significant differences in the recovery of total aerobic bacteria (P < .001), total anaerobic bacteria (P < .001), and ATP measurement (P < .001) between wards and between the different parts of the crossover study. Generally, the use of wipes produced the largest reduction in the total aerobic and anaerobic counts when compared with the baseline data or the use of 1,000 ppm chlorine. Collectively, the introduction of training plus daily wipe disinfection significantly reduced multidrug-resistant organisms recovered from surfaces. Reversion to using 1,000 ppm chlorine resulted in the number of sites positive for multidrug-resistant organisms rising again.ConclusionsThis double-crossover study is the first controlled field trial comparison of using preimpregnated wipes versus cotton cloth dipped into a bucket of hypochlorite to decrease surface microbial bioburden. The results demonstrate the superiority of the preimpregnated wipes in significantly decreasing microbial bioburden from high-touch surfaces.



https://ift.tt/2rDk3bv

Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2IeraOD

Can Posting Be a Catalyst for Dating Violence? Social Media Behaviors and Physical Interactions

Violence and Gender, Ahead of Print.


https://ift.tt/2KWV23U

Durvalumab, Tremelimumab and Stereotactic Body Radiation Therapy in Treating Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Conditions:   Metastatic Head and Neck Squamous Cell Carcinoma;   Recurrent Head and Neck Squamous Cell Carcinoma
Interventions:   Biological: Durvalumab;   Other: Laboratory Biomarker Analysis;   Radiation: Stereotactic Body Radiation Therapy;   Biological: Tremelimumab
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Not yet recruiting

https://ift.tt/2I8tj2k

Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer

Condition:   Recurrent Head and Neck Squamous Cell Carcinoma
Interventions:   Radiation: IMRT;   Biological: Nivolumab
Sponsors:   Emory University;   Bristol-Myers Squibb;   The Cleveland Clinic;   Medical College of Wisconsin
Not yet recruiting

https://ift.tt/2IgguPz

Durvalumab, Tremelimumab and Stereotactic Body Radiation Therapy in Treating Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Conditions:   Metastatic Head and Neck Squamous Cell Carcinoma;   Recurrent Head and Neck Squamous Cell Carcinoma
Interventions:   Biological: Durvalumab;   Other: Laboratory Biomarker Analysis;   Radiation: Stereotactic Body Radiation Therapy;   Biological: Tremelimumab
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Not yet recruiting

https://ift.tt/2I8tj2k

Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer

Condition:   Recurrent Head and Neck Squamous Cell Carcinoma
Interventions:   Radiation: IMRT;   Biological: Nivolumab
Sponsors:   Emory University;   Bristol-Myers Squibb;   The Cleveland Clinic;   Medical College of Wisconsin
Not yet recruiting

https://ift.tt/2IgguPz

Benign thyroid nodule unresponsive to radiofrequency ablation treated with laser ablation: a case report

Radiofrequency ablation and laser ablation are safe and effective techniques for reducing thyroid nodule volume, neck symptoms, and cosmetic complaints. Therapeutic success is defined as a nodule reduction > 5...

https://ift.tt/2rAilaM

Sensibility of the hand in children with conservatively or surgically treated upper neonatal brachial plexus lesion

S08878994.gif

Publication date: Available online 11 May 2018
Source:Pediatric Neurology
Author(s): Sonja M. Buitenhuis, Willem Pondaag, Ron Wolterbeek, Martijn J.A. Malessy
AimThe aim of this study was to assess the sensibility of the hand in children with a neonatal brachial plexus palsy (NBPP) involving the upper nerves C5 and C6, and to correlate the results with dexterity.MethodFifty children with NBPP (mean age 9.8 y) and 25 healthy controls (mean age 9.6 y) were investigated. In the NBPP group, nerve surgery had been performed in 30 children and 20 children had been treated conservatively. Sensibility was assessed with two-point discrimination (2PD) and Semmes-Weinstein (SW) monofilaments. Dexterity was evaluated with a single item from the Movement Assessment Battery for Children-2. We compared the affected side of the NBPP group with the non-dominant hand of the control group.ResultsThe sensibility in the first and second fingers was significantly lower in the NBPP group than in the control group for both the 2PD (p=0.005 and p=0.014 respectively) and the SW monofilament test (p<0.001). Dexterity was significantly lower in the NBPP group than in controls, corrected for age (p=0.023). There was a significant difference toward decreasing hand function with decreasing sensibility according to the SW test for the thumb (Jonckheere-Terpstra non-parametric trend test, p= 0.036)InterpretationThe sensibility of the thumb and index finger in children with an upper plexus lesion (either surgically or conservatively treated) is diminished. The decreased sensibility has a negative impact on hand function. Appreciation of diminished hand function in patients with NBPP involving C5-C6 is important to optimize treatment.



https://ift.tt/2I8yTSj

Antibiotic use in facial plastic surgery

Purpose of review The aim of this study was to review and discuss recent literature regarding perioperative use of antibiotics in the context of facial plastic surgery. Recent findings Despite research efforts, there continues to be insufficient evidence in support of, or against, the use of antimicrobial prophylaxis. Summary Current available evidence regarding antibiotic use in facial plastic surgery procedures fails to demonstrate routine benefit. Therefore, the advantages accompanying administration of preoperative antibiotics should be weighed against any potential complications on a case-by-case basis. Future large-scale prospective studies will be beneficial in developing standardized criteria directing appropriate antibiotic use. Correspondence to Jessyka G. Lighthall, MD, Penn State College of Medicine, The Milton S. Hershey Medical Center, Division of Otolaryngology-Head and Neck Surgery, 500 University Drive, MC H091, Hershey, PA 17033, USA. E-mail: jlighthall@pennstatehealth.psu.edu Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2rCHoKp

Modern postoperative monitoring of free flaps

Purpose of review Flap failure in microvascular reconstruction is a costly complication with total flap loss being the worst-case scenario. With the aim to rapidly identify a postoperative circulatory problem, some susceptible flaps can be saved by careful clinical monitoring or by various technical monitoring methods. In head and neck surgery, where the flaps are often buried and difficult to monitor clinically, a reliable technical monitoring method would be useful. A broad range of different techniques are in use varying according to practical and personal preferences among clinics and surgeons. However, no evidence for any particular technique being superb has emerged. We review reports of some frequently used and modern free flap monitoring techniques. Recent findings Clinical monitoring is still the gold standard to which other techniques are compared to. Laser Doppler flowmetry and near-infrared spectroscopy have been reported to identify early circulatory problems, but both techniques are not well suited for buried flaps. Implantable Doppler, flow coupler, partial tissue oxygen pressure and microdialysis are invasive monitoring methods suitable for buried flaps. Summary More research with practical and clinically relevant parameters, that is flap salvage rate, false positive rate and cost-efficiency are needed before objective comparisons between different monitoring techniques can be made. Correspondence to Jussi Laranne, Department of Otorhinolaryngology - Head and Neck Surgery, Kokkola Central Hospital, Mariankatu 16, 67200 Kokkola, Finland. Tel: +358 50 5271727; e-mail: jussilaranne@me.com Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2KW855A

Management of obstructive sleep apnoea: an update on the role of distraction osteogenesis

Purpose of review This article reviews the current literature on the use of distraction osteogenesis as a treatment for patients with obstructive sleep apnoea (OSA). We reviewed the indications, surgical protocols and outcomes for distraction osteogenesis in paediatric and adult OSA cases described in the literature. Recent findings There is evidence that distraction osteogenesis is effective in treating children with OSA as a result of underdevelopment of jaws such as those with craniofacial syndromes. Distraction osteogenesis appears to be the only available treatment that prevents tracheostomy in some of these cases, or allows decannulation after distraction. For adult OSA patients, distraction osteogenesis is reported to be reserved for challenging cases such as OSA as a consequence of temporomandibular joint ankylosis. It is used where conventional orthognathic surgery is not feasible. The studies reported high success rate/cure rate of OSA after distraction osteogenesis. Technological advances such as three-dimensional printing assist the execution of an accurate distraction process. Summary Distraction osteogenesis appears to be an effective treatment for paediatric OSA patients with craniofacial anomalies, and is used in selected cases of adult with severe OSA. With the improvement in distraction device designs and computer technology, distraction osteogenesis may play a bigger role in the treatment of OSA. Correspondence to Yiu Yan Leung, Oral and Maxillofacial Surgery, Prince Philip Dental Hospital, 34 Hospital Road, Pokfulam, Hong Kong. Tel: +852 28590511; fax: +852 2857 5570; e-mail: mikeyyleung@hku.hk Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2rBdPsC

A Comparative Study of Type-I Underlay Tympanoplasty with Temporalis Fascia Graft Alone and with Conchal Cartilage

Abstract

Tympanoplasty which is the repair of the tympanic membrane using temporalis fascia, has been done worldwide and has stood the test of time. However in cases of reperforation or large/subtotal perforations, we are often left in need of some sturdy material for grafting. To compare the graft uptake and hearing improvement in patients undergoing type I tympanoplasty using temporalis fascia alone and temporalis fascia along with conchal cartilage. The current research is a prospective study of 60 patients with chronic suppurative otitis media (Tubo tympanic type), undergoing type I tympanoplasty, using temporalis fascia alone and temporalis fascia along with conchal cartilage. The graft uptake and hearing improvement was much better using temporalis fascia along with conchal cartilage graft as compared to cartilage alone. The use of temporalis fascia along with conchal cartilage graft is beneficial for patients with chronic suppurative otitis media (tubotympanic type) undergoing type I tympanoplasty than using temporalis fascia alone.



https://ift.tt/2KUjR0n

Exploring the impact of disability on self-determination measurement

S08914222.gif

Publication date: July 2018
Source:Research in Developmental Disabilities, Volume 78
Author(s): Cristina Mumbardó-Adam, Joan Guàrdia-Olmos, Climent Giné
BackgroundSelf-determination is a psychological construct that applies to both the general population and to individuals with disabilities that can be self-determined with adequate accommodations and opportunities. As the relevance of self-determination-related skills in life has been recently acknowledged, researchers have created a measure to assess self-determination in adolescents and young adults with and without disabilities. The Self-Determination Inventory: Student Report (Spanish interim version) is empirically being validated into Spanish.AimsAs this scale is the first assessment addressed to all youth, further exploration of its psychometric properties is required to ensure the reliability of the self-determination measurement and gain further insight into the construct when applied to youth with and without disabilities.MethodsMore than 600 participants were asked to complete the scale. The impact of disability on the item response distributions across the dimensions of self-determination was explored.OutcomesDifferential item functioning (DIF) was found in only 5 of the scale's 45 items. Differences primary favored youth without disabilities.ConclusionsThe weak presence of DIF across the items supports the instrument's psychometrical robustness when measuring self-determination in youth with and without disabilities and provides further understanding of the self-determination construct. Implications and future research directions are also discussed.



https://ift.tt/2rBNQ5b

Implementation of closed-loop-assisted intra-operative goal-directed fluid therapy during major abdominal surgery: A case–control study with propensity matching

BACKGROUND Goal-directed fluid therapy (GDFT) has been associated with improved patient outcomes. However, implementation of GDFT protocols remains low despite growing published evidence and the recommendations of multiple regulatory bodies in Europe. We developed a closed-loop-assisted GDFT management system linked to a pulse contour monitor to assist anaesthesiologists in applying GDFT. OBJECTIVE To assess the impact of our closed-loop system in patients undergoing major abdominal surgery in an academic hospital without a GDFT programme. DESIGN A case–control study with propensity matching. SETTING Operating rooms, Erasme Hospital, Brussels. PATIENTS All patients who underwent elective open major abdominal surgery between January 2013 and December 2016. INTERVENTION Implementation of our closed-loop-assisted GDFT in April 2015. METHODS A total of 104 patients managed with closed-loop-assisted GDFT were paired with a historical cohort of 104 consecutive non-GDFT patients. The historical control group consisted of patients treated before the implementation of the closed-loop-system, and who did not receive GDFT. In the closed-loop group, the system delivered a baseline crystalloid infusion of 3 ml kg−1 h−1 and additional 100 ml fluid boluses of either a crystalloid or colloid for haemodynamic optimisation. MAIN OUTCOME MEASURES The primary outcome was intra-operative net fluid balance. Secondary outcomes were composite major postoperative complications, composite minor postoperative complications and hospital length of stay (LOS). RESULTS Baseline characteristics were similar in both groups. Patients in the closed-loop group had a lower net intra-operative fluid balance compared with the historical group (median interquartile range [IQR] 2.9 [1.6 to 4.4] vs. 6.2 [4.0 to 8.3] ml kg−1 h−1; P 

https://ift.tt/2Kb8Mqv

Peri-operative copeptin concentrations and their association with myocardial injury after vascular surgery: A prospective observational cohort study

BACKGROUND Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury. OBJECTIVES In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels. Second, in an explorative analysis, we sought to examine the association of copeptin in general and at various time points with myocardial injury occurring within the first 48 h. DESIGN Preparatory analysis of a prospective, observational cohort study. SETTING Single university centre from February to July 2016. PATIENTS A total of 30 consecutive adults undergoing vascular surgery. INTERVENTION Serial peri-operative copeptin measurements. MAIN OUTCOME MEASURE We measured copeptin concentrations before and immediately after surgery (0 h), then at 2, 4, 6 and 8 h after surgery and on the first and second postoperative day. Postoperative concentrations were compared with pre-operative levels with a Wilcoxon signed-rank test. Second, we explored an association between postoperative copeptin concentrations and myocardial injury by the second postoperative day. Myocardial injury was defined as a 5 ng l−1 increase between pre-operative and postoperative high-sensitivity cardiac troponin T with an absolute peak of at least 20 ng l−1. RESULTS Immediate postoperative copeptin concentrations (median [interquartile range]) increased nearly eight-fold from pre-operative values (8.5 [3.6 to 13.8] to 64.75 pmol l−1 [29.6 to 258.7]; P 

https://ift.tt/2Iw0bkR

Implementation of closed-loop-assisted intra-operative goal-directed fluid therapy during major abdominal surgery: A case–control study with propensity matching

BACKGROUND Goal-directed fluid therapy (GDFT) has been associated with improved patient outcomes. However, implementation of GDFT protocols remains low despite growing published evidence and the recommendations of multiple regulatory bodies in Europe. We developed a closed-loop-assisted GDFT management system linked to a pulse contour monitor to assist anaesthesiologists in applying GDFT. OBJECTIVE To assess the impact of our closed-loop system in patients undergoing major abdominal surgery in an academic hospital without a GDFT programme. DESIGN A case–control study with propensity matching. SETTING Operating rooms, Erasme Hospital, Brussels. PATIENTS All patients who underwent elective open major abdominal surgery between January 2013 and December 2016. INTERVENTION Implementation of our closed-loop-assisted GDFT in April 2015. METHODS A total of 104 patients managed with closed-loop-assisted GDFT were paired with a historical cohort of 104 consecutive non-GDFT patients. The historical control group consisted of patients treated before the implementation of the closed-loop-system, and who did not receive GDFT. In the closed-loop group, the system delivered a baseline crystalloid infusion of 3 ml kg−1 h−1 and additional 100 ml fluid boluses of either a crystalloid or colloid for haemodynamic optimisation. MAIN OUTCOME MEASURES The primary outcome was intra-operative net fluid balance. Secondary outcomes were composite major postoperative complications, composite minor postoperative complications and hospital length of stay (LOS). RESULTS Baseline characteristics were similar in both groups. Patients in the closed-loop group had a lower net intra-operative fluid balance compared with the historical group (median interquartile range [IQR] 2.9 [1.6 to 4.4] vs. 6.2 [4.0 to 8.3] ml kg−1 h−1; P 

https://ift.tt/2Kb8Mqv

Peri-operative copeptin concentrations and their association with myocardial injury after vascular surgery: A prospective observational cohort study

BACKGROUND Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury. OBJECTIVES In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels. Second, in an explorative analysis, we sought to examine the association of copeptin in general and at various time points with myocardial injury occurring within the first 48 h. DESIGN Preparatory analysis of a prospective, observational cohort study. SETTING Single university centre from February to July 2016. PATIENTS A total of 30 consecutive adults undergoing vascular surgery. INTERVENTION Serial peri-operative copeptin measurements. MAIN OUTCOME MEASURE We measured copeptin concentrations before and immediately after surgery (0 h), then at 2, 4, 6 and 8 h after surgery and on the first and second postoperative day. Postoperative concentrations were compared with pre-operative levels with a Wilcoxon signed-rank test. Second, we explored an association between postoperative copeptin concentrations and myocardial injury by the second postoperative day. Myocardial injury was defined as a 5 ng l−1 increase between pre-operative and postoperative high-sensitivity cardiac troponin T with an absolute peak of at least 20 ng l−1. RESULTS Immediate postoperative copeptin concentrations (median [interquartile range]) increased nearly eight-fold from pre-operative values (8.5 [3.6 to 13.8] to 64.75 pmol l−1 [29.6 to 258.7]; P 

https://ift.tt/2Iw0bkR

A Comparative Study of Type-I Underlay Tympanoplasty with Temporalis Fascia Graft Alone and with Conchal Cartilage

Abstract

Tympanoplasty which is the repair of the tympanic membrane using temporalis fascia, has been done worldwide and has stood the test of time. However in cases of reperforation or large/subtotal perforations, we are often left in need of some sturdy material for grafting. To compare the graft uptake and hearing improvement in patients undergoing type I tympanoplasty using temporalis fascia alone and temporalis fascia along with conchal cartilage. The current research is a prospective study of 60 patients with chronic suppurative otitis media (Tubo tympanic type), undergoing type I tympanoplasty, using temporalis fascia alone and temporalis fascia along with conchal cartilage. The graft uptake and hearing improvement was much better using temporalis fascia along with conchal cartilage graft as compared to cartilage alone. The use of temporalis fascia along with conchal cartilage graft is beneficial for patients with chronic suppurative otitis media (tubotympanic type) undergoing type I tympanoplasty than using temporalis fascia alone.



https://ift.tt/2KUjR0n

Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue

Publication date: June 2018
Source:Neoplasia, Volume 20, Issue 6
Author(s): Elizabeth A. Loughran, Annemarie K. Leonard, Tyvette S. Hilliard, Ryan C. Phan, Madeleine G. Yemc, Elizabeth Harper, Emma Sheedy, Yuliya Klymenko, Marwa Asem, Yueying Liu, Jing Yang, Jeff Johnson, Laura Tarwater, Zonggao Shi, Matthew Leevy, Matthew J. Ravosa, M. Sharon Stack
Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis. Here we report that the aged host is more susceptible to metastatic success using two murine syngeneic allograft models of ovarian cancer metastasis. This age-related increase in metastatic tumor burden corresponds with an increase in tumor infiltrating lymphocytes (TILs) in tumor-bearing mice and alteration of B cell-related pathways in gonadal adipose tissue. Based on this work, further studies elucidating the status of B cell TILs in mouse models of metastasis and human tumors in the context of aging are warranted.



https://ift.tt/2G7Ya9n

Αρχειοθήκη ιστολογίου