Head and Neck Diseases by Alexandros G.Sfakianakis: 02/23/16

Τρίτη 23 Φεβρουαρίου 2016

Independent data agree on ctenophore misplacement Biological Sciences

In their letter, Halanych et al. (1) criticize our recent assertion (2) that the phylogenetic placement of ctenophores as the sister group to all other animals (the Ctenophora-sister hypothesis) in three previous studies (3–5) was an artifact caused by undetected systematic error. Halanych et al. (1) claim we used no…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWBnxR
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HpnX
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLAuE
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TE4Q3l
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQWQb
via IFTTT

Sensitive cytometry based system for enumeration, capture and analysis of gene mutations of circulating tumor cells

Methods for the enumeration and molecular characterization of circulating tumor cells (CTC) have been actively investigated. However, such methods are still technically challenging. We have developed a novel epithelial cell adhesion molecule independent CTC enumeration system integrated with a sorting system using a microfluidics chip. We compared the number of CTC detected using our system with those detected using the CellSearch system in 46 patients with various cancers. We also evaluated epidermal growth factor receptor (EGFR) and PIK3CA mutations of captured CTC in a study of 4 lung cancer and 4 breast cancer patients. The percentage of samples with detected CTC was significantly higher with our system (65.2%) than with CellSearch (28.3%). The number of detected CTC per patient using …

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QaB6VV
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQWPX
via IFTTT

Lenalidomide and low‐dose dexamethasone in Japanese patients with newly diagnosed multiple myeloma: a phase II study

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QC3FBf
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQXU7
via IFTTT

Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis

cover.gif?v=1&s=c4bfdba1ede08299c7b428b7

BACKGROUND

Hepatocellular carcinoma (HCC)-associated mortality is increasing at an alarming rate, and there is a readily identifiable cohort of at-risk patients with cirrhosis, viral hepatitis, nonalcoholic fatty liver disease, and diabetes. These patients are candidates for chemoprevention. Metformin is an attractive agent for chemoprevention because it is inexpensive, has a favorable safety profile, and is well tolerated over long time periods.

METHODS

The authors studied the efficacy of metformin as a prevention agent in a clinically relevant rat model of HCC, in which tumors develop in the setting of chronic inflammation and cirrhosis. Repeated injections of diethylnitrosamine were used to induce sequential cirrhosis and HCC, and metformin was administered at the first signs of either fibrosis or cirrhosis.

RESULTS

Prolonged metformin exposure was safe and was associated with decreases in fibrotic and inflammatory markers, especially when administered early at the first signs of fibrosis. In addition, early metformin treatment led to a 44% decrease in HCC incidence, whereas tumor burden was unchanged when metformin was administered at the first signs of cirrhosis. It is noteworthy that activation of the hepatic progenitor/stem cell compartment was first observed at the onset of cirrhosis; therefore, only early metformin treatment suppressed receptor for advanced glycation end products and inhibited the activation of hepatic progenitor cells.

CONCLUSIONS

The current results are the first to demonstrate an effect on progenitor/stem cells in the setting of chemoprevention and provide further rationale to explore metformin as an early intervention in clinical trials of patients with chronic liver disease at high risk for HCC. Cancer 2016. © 2016 American Cancer Society.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1KHtcqd
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1ysv2
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HpEC
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLALo
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TDXnRZ
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwIni6
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQWj7
via IFTTT

Étude anatomique des rapports de l’artère sous-mentonnière pour le prélèvement du lambeau sous-mentonnier

Publication date: Available online 23 February 2016
Source:Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
Author(s): C. Ricour, J. Ferri, G. Thiery, C. Fontaine, G. Raoul
IntroductionLe lambeau sous-mentonnier est utile pour les reconstructions intra-orales et des deux tiers inférieurs de la face. La dissection est délicate à cause d'une exposition difficile sous le bord basilaire mandibulaire, de nombreuses collatérales dans une couche cellulo-graisseuse et de la proximité du rameau marginal de la mandibule. Le but de notre travail était de proposer des repères anatomiques pour faciliter le prélèvement du lambeau sous-mentonnier.Matériel et méthodeDix cadavres traités par liquide de conservation Biomet ont été disséqués de façon bilatérale. Les rapports anatomiques du rameau marginal du nerf facial avec la mandibule, les rapports de l'artère sous-mentonnière, le nombre de ses collatérales et leurs positions ont été mesurés à l'aide d'un pied à coulisse.RésultatsLa position la plus haute du rameau marginal était située 0,5cm au-dessus du bord basilaire alors que la plus basse était située 0,6cm au-dessous. La longueur mesurée entre le passage de l'artère facial sur le bord basilaire au niveau de l'encoche pré-angulaire et l'origine de l'artère sous-mentonnière a été en moyenne de 1,5cm. Le nombre moyen de collatérales était de 3,6.DiscussionL'incision cutanée réalisée directement sous le bord basilaire, comme décrite par certains auteurs, entraîne un risque de lésion du rameau marginal mandibulaire. Trois positions de l'artère sous-mentonnière par rapport à la glande sub-mandibulaire sont décrites. Les collatérales sont à destinée glandulaire, musculaire, cutanée et osseuse. Il faut accorder un intérêt particulier à l'artère sublinguale, artère de diamètre important qui naît en moyenne à 2,8cm de son origine et plonge distalement vers le plancher buccal. Il ne faut pas la suivre sous peine de risquer de clamper le grêle pédicule destiné au muscle digastrique. Il est indispensable de respecter l'ambiance cellulo-graisseuse superficielle satellite de l'artère sous-mentonnière pour limiter la congestion veineuse du lambeau.IntroductionSubmental flap is useful for intra-oral reconstructions and reconstructions of the lower two thirds of the face. Dissection is delicate because of a difficult exposure under the lower rim of the mandible, numerous collateral arterial branches and the proximity of the marginal branch of the facial nerve. The aim of our work was to propose anatomical landmarks in order to facilitate the submental flap raising.Material and methodTen bodies preserved in Biomet liquid were dissected bilaterally. The anatomic relationships between the marginal branch of the facial nerve and the mandible, the relationships of the submental artery, the amount and the location of its collateral branches were measured by means of a caliper.ResultsThe highest marginal branch observed was located 0.5 cm above the mandibular lower rim, while the lower one was located 0.6cm below this rim. The mean length measured between the facial artery at its crossing over the mandibular rim at the level of the pre-angular notch and the origin of the submental artery was 1.5cm. The average number of collateral branches was 3.6.DiscussionA skin incision made directly under the mandibular lower rim, as mentioned by some authors, may endanger the mandibular marginal branch of the facial nerve. Three positions of the submental artery in relation to the sub-maxillary gland are reported. The collateral branches are intended for gland, muscle, skin and bone. It is necessary to pay particular attention to the sub-lingual artery, an artery of big diameter that arises at 2.8cm on average from its origin and plunges towards the mouth's floor. It must not be followed at risk of clamping the thin pedicle destined to the digastric muscle. It is important to preserve the fat tissue around the submental pedicle in order to avoid venous congestion of the flap.

from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1SRkYyo
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PWXnZm
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQXnd
via IFTTT

A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

Authors: J Cai, Y Zuo, T Wang, Y Cao, R Cai, F-L Chen, J Cheng & J Mu (Source: Oncogene)

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QaB8NJ
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQXn1
via IFTTT

Voies d’abords des tumeurs du cône postérieur de l’orbite

Publication date: Available online 23 February 2016
Source:Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
Author(s): J.T. Bachelet, H. Shipkov, P. Breton, M. Berhouma, E. Jouanneau, A. Gleizal
La chirurgie des tumeurs du cône postérieur de l'orbite est complexe car il s'agit d'une zone anatomique située aux confins du crâne et de la face. L'objectif des gestes chirurgicaux réalisés dans cette zone est d'effectuer l'exérèse de la tumeur tout en préservant la fonction visuelle grâce à la voie d'abord présentant la plus faible morbidité possible. Le but de ce travail était, à travers notre expérience et une analyse de la littérature, de déterminer les avantages et les inconvénients des nombreuses voies d'abord décrites.The surgical management of posterior orbital tumors is complex because it is an anatomical area located at the borders between the face and the skull base. The goal of the procedures carried-out in this area is to resect the tumor while preserving vision by using the safest possible approach. The aim of our work was to determine, in the light of our experience and of a review of the literature, the advantages and drawbacks of the numerous approaches described.

from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1XL0fvA
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TE08mf
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQW2n
via IFTTT

Prevention of osteoradionecrosis of the jaws by low-intensity ultrasound in the dog model

Publication date: Available online 23 February 2016
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): Z. Zhou, M. Lang, W. Fan, X. Dong, L. Zhu, J. Xiao, Y. Wang
The prevention of osteoradionecrosis of the jaws (ORNJ) is very important because of the current absence of effective therapies for this disease. The aim of this study was to determine whether low-intensity ultrasound has a preventive effect on ORNJ. Sixty healthy adult dogs were divided randomly into three groups: group A (radiotherapy alone), group B (radiotherapy followed by low-intensity ultrasound treatment), and a control group. The development of ORNJ was assessed and the rate of occurrence of ORNJ was compared between groups A and B. Micro-computed tomography, haematoxylin–eosin staining, and immunofluorescence were used to evaluate the microstructure of the mandible and changes in microvascular density in all groups. All animals in group A and group B (ultrasound applied for 30 days) developed ORNJ. Alveolar bone density was 609.48±53.77HU in group A and 829.65±81.46HU in group B (P=0.008). The trabecular bone volume fraction, bone surface area/bone volume ratio, trabecular thickness, and trabecular number were all lower in group A than in group B (P=0.037, P=0.022, P=0.017, and P=0.034, respectively). Haematoxylin–eosin staining showed that the Haversian canals in the osteons had expanded significantly in group A, with collagen fibres losing their circular orientation; group B tended to show typical osteons. The microvascular density in group A was decreased. In conclusion, the use of low-intensity ultrasound in the dog appears not to prevent the incidence of ORNJ, however it does somewhat improve vascularity and bone quality at the microscopic level, which contribute to ORNJ healing.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWABAP
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1Hrwj
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLCTo
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5UbF
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TDXrkH
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RlQVLV
via IFTTT

Reply

Publication date: Available online 23 February 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Essam Ahmed Al-Moraissi, Edward Ellis

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1La8b7I
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WHrNAH
via IFTTT

Does Unilateral Temporomandibular Total Joint Reconstruction Result in Contralateral Joint Pain and Dysfunction?

Publication date: Available online 23 February 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Daniel Perez, Larry M. Wolford, Emet Schneiderman, Reza Movahed, Campbell Bourland, Enrique Perez
PurposeThe purpose of this study was to evaluate patients requiring unilateral TMJ total joint reconstruction and the risk for development of post-surgical contralateral TMJ pain and dysfunction over time requiring subsequent contralateral total joint reconstruction. Long-term subjective and objective outcomes of unilateral TMJ reconstruction were also evaluated.Methods and MaterialsSeventy patients had unilateral total joint reconstruction using a patient-fitted total joint prosthesis from a single private practice from 1990 through 2012. The inclusion criteria were: 1) Unilateral TMJ reconstruction with TMJ Concepts/Techmedica patient-fitted total joint prosthesis; 2) Operated by one surgeon (LMW); 3) Minimum of 12 month follow-up; and 4) Adequate records. There were no specific exclusion criteria. The primary outcome variable was to evaluate the effects of unilateral TMJ reconstruction with a total joint prosthesis on the contralateral TMJs relative to development of pain and dysfunction requiring subsequent contralateral reconstruction with a total joint prosthesis. Secondary outcome variables for all patients included; TMJ pain, facial pain, headaches, diet, disability, quality of life, maximum incisal opening, and lateral excursion movements following unilateral TMJ reconstruction with the patient-fitted total joint prosthesis. Student's-t tests and Wilcoxon tests were used for statistical analyses with a p-value of <0.01 for statistical significance.ResultsThere were 61 of 70 patients (87%) that met the inclusion criteria; 47 females (77%) and 14 males (23%); average age 38 years (range 11 to 69 years); and average follow-up 44 months (range 12 to 215 months). Eight of 61 patients (13%) required contralateral TMJ reconstruction with a total joint prosthesis at a later time related to contralateral pain, dysfunction, and arthritis, but all 8 (8 of 27 or 29.6%) had previous contralateral TMJ disc repositioning surgery. Relative to the secondary outcomes; TMJ pain decreased 63% and jaw function improved 61%, facial pain decreased 59% and headaches 57%, diet improved 52%, disability 58.5% and maximal incisal opening increased a mean 7.4 mm, from 31.4 to 38.8 mm. All subjective factors and MIO had statistically significant improvements at longest follow-up (p<0.01)ConclusionsPatients requiring unilateral TMJ reconstruction with a patient-fitted total joint prosthesis have a high probability of improving their clinical condition and do not require bilateral reconstruction if the contralateral TMJ is healthy. Patients with previous or concomitant contralateral TMJ surgery (articular disc repositioning) have about a 30% chance of requiring a total joint prosthesis in the future.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1WHgyZa
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TEolsH
via IFTTT

Favoring inhibitory synaptic drive mediated by GABAA receptors in the basolateral nucleus of the amygdala efficiently reduces pain symptoms in neuropathic mice

Abstract

Pain is an emotion and neuropathic pain symptoms are modulated by supraspinal structures such as the amygdala. If the central nucleus of the amygdala is often named as the "nociceptive amygdala", little is known on the role of the basolateral amygdala. Here, we monitored the mechanical nociceptive thresholds in a mouse model of neuropathic pain and infused modulators of the glutamate/GABAergic transmission in the BLA via chronically-implanted cannulas. First, we found that NMDA-type glutamate receptor antagonist (MK-801) exerted a potent anti-allodynic effect whereas a transient allodynia was induced after perfusion of bicuculline, a GABAA receptor antagonist. Potentiating GABAA receptor function using diazepam (DZP) or etifoxine (EFX, a nonbenzodiazepine anxiolytic) fully but transiently alleviated mechanical allodynia. Interestingly, the anti-allodynic effect of EFX disappeared in animals incapable of producing 3alpha-steroids. DZP had a similar effect but of shorter duration. As indicated by patch-clamp recordings of BLA neurons, these effects were mediated by a potentiation of GABAAR-mediated synaptic transmission. Together with a presynaptic elevation of miniature IPSC frequency, the duration and amplitude of GABAA mIPSCs was also increased (postsynaptic effect). The analgesic contribution of endogenous neurosteroid seemed to be exclusively postsynaptic. This study highlights the importance of BLA and of the local inhibitory/excitatory neuronal network activity while setting the mechanical nociceptive threshold. Furthermore, it appears that promoting inhibition in this specific nucleus could fully alleviate pain symptoms. Therefore BLA could be a novel interesting target to develop pharmacological or non pharmacological therapies

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1VCJVvg
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WHrPsj
via IFTTT

Overexpression of DJ-1/PARK7, Parkinson’s disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells

Abstract

DJ-1/PARK7, the Parkinson's disease-related protein, plays an important role in mitochondrial function. However, the mechanisms by which DJ-1 affects the mitochondrial function are not fully understood. Akt is a promoter of neuron survival has partly involved in the neurodegenerative process. This research aimed at investigating a possible relationship between DJ-1 and Akt signaling in regulating mitochondrial function in dopaminergic neuron-like cells SH-SY5Y and PC-12. Overexpression of DJ-1 was firstly validated at both the transcriptional and translational levels after transit transfection with plasmid pcDNA3-Flag-DJ-1. Confocal fluorescence microscopy manifested that overexpression of DJ-1 increased the mitochondrial mass, but did not disrupt the mitochondrial morphology. In addition, mitochondrial complex I activity was raised in DJ-1 overexpressed cells, and this rise has occurred with an increase in cellular ATP content. Moreover, immunoblotting demonstrated that the levels of phosphoinositide 3-kinase and the total Akt were not altered in DJ-1 overexpressed cells, nor was the Akt phosphorylation on serine 473 changed. By contrast, Akt phosphorylation on threonine 308 was significantly augmented by overexpression of DJ-1, and the expression of glycogen synthase kinase-3beta, a downstream effector of Akt, was suppressed. In summary, these results suggest that overexpression of DJ-1 improves the mitochondrial function, at least in part, through a mechanism involving Akt phosphorylation on threonine 308.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1VCH59K
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TEon3u
via IFTTT

Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of m…

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1QwO0g6
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WHrPsg
via IFTTT

Prevention of osteoradionecrosis of the jaws by low-intensity ultrasound in the dog model

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWABAP
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1Hrwj
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLCTo
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5UbF
via IFTTT

Brainwide imaging Neuroscience

We present an imaging system for pan-neuronal recording in crawling Caenorhabditis elegans. A spinning disk confocal microscope, modified for automated tracking of the C. elegans head ganglia, simultaneously records the activity and position of ∼80 neurons that coexpress cytoplasmic calcium indicator GCaMP6s and nuclear localized red fluorescent protein at 10…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oFr88C
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1Hrwd
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLAL6
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6Ih6
via IFTTT

Irradiation and immunotherapy: From concept to the clinic

In recent years, an increased understanding of T-cell–regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies—even those that historically were not believed to be sensitive to immune therapy. With this, there has been renewed interest in the potential for synergy with more traditional forms of anticancer therapy like radiation therapy (RT). The role of RT in palliation or as definitive treatment for certain malignancies has been well established. Yet, in recent years, the concept has come to light that RT could be an attractive partner for use in combination with other immunotherapies. The effects of RT include not only control of an irradiated tumor but also multiple immunomodulatory effects on both the tumor and the microenvironment, priming tumors for an immune-mediated response. Herein, the authors summarize relevant preclinical data and rationale supporting the synergy of combined RT and immunotherapy and highlight recent clinical work on promising combination strategies. Cancer 2015. © 2016 American Cancer Society.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1WGBEXx
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q9PspJ
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBw8q
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa1245
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5WAh
via IFTTT

Miscues misplace sponges Biological Sciences

In contrast to several recent publications (1–5), Pisani et al. (6) claim that (i) genomic data do not support ctenophores as the sister group to other animals and (ii) independent evolution of complex features (e.g., neurons, muscles) in ctenophores is not supported. These claims are based on selective interpretation, subjective…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWBo4O
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBw8m
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa1241
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6JBG
via IFTTT

Rate-limiting processes of bacterial cytokinesis Microbiology

Bacterial cytokinesis is accomplished by the essential 'divisome' machinery. The most widely conserved divisome component, FtsZ, is a tubulin homolog that polymerizes into the 'FtsZ-ring' ('Z-ring'). Previous in vitro studies suggest that Z-ring contraction serves as a major constrictive force generator to limit the progression of cytokinesis. Here, we applied…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1p1x2AD
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1Hrw5
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLCTk
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5TVj
via IFTTT

Aspergillosis immunoPET/MR imaging Medical Sciences

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease caused by the fungus Aspergillus fumigatus, and is a leading cause of invasive fungal infection-related mortality and morbidity in patients with hematological malignancies and bone marrow transplants. We developed and tested a novel probe for noninvasive detection of A. fumigatus lung…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1p1wZ7S
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HrfP
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLAuO
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6JBB
via IFTTT

Maize neocentromeres Evolution

Functional centromeres, the chromosomal sites of spindle attachment during cell division, are marked epigenetically by the centromere-specific histone H3 variant cenH3 and typically contain long stretches of centromere-specific tandem DNA repeats (∼1.8 Mb in maize). In 23 inbreds of domesticated maize chosen to represent the genetic diversity of maize germplasm,…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1p1x23K
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBvRQ
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa12B7
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5Wk3
via IFTTT

New directions in human evolution Biological Sciences

We welcome Almécija's critique (1), but his claims of "bias" in our conclusions are unfounded. All available evidence continues to support an African ape-like shoulder and pattern of forelimb use in our last common ancestor (LCA) with chimpanzees and bonobos (Pan). First, controlling for within-group size variation is uncontroversial (2),…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWBlWD
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBvRY
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa12Ru
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6IgV
via IFTTT

Independent data agree on ctenophore misplacement Biological Sciences

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWBnxR
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HpnX
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLAuE
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5WjX
via IFTTT

Synchronous presentation of trigeminal, glossopharyngeal and geniculate neuralgias in a single patient

Publication date: Available online 23 February 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Lujain Homeida, Sophia Elmuradi, Thomas P. Sollecito, Eric T. Stoopler
Orofacial pain disorders can present as a diagnostic and therapeutic challenge for oral health care providers. Odontogenic and non-odontogenic sources of orofacial pain should be considered and cranial neuralgias may be included in the differential diagnosis. Synchronous presentation of multiple cranial neuralgias is a rare occurrence. We report a case of a patient with a synchronous presentation of trigeminal, glossopharyngeal and geniculate neuralgias. To our knowledge, this is the first case of a synchronous presentation of these conditions reported to date.

from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1LEHV0b
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLCCW
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6Jlh
via IFTTT

Cone beam computed tomography of plastinated hearts for instruction of radiological anatomy

Abstract

Radiological anatomy education is an important aspect of the medical curriculum. The purpose of this study was to establish and demonstrate the use of plastinated anatomical specimens, specifically human hearts, for use in radiological anatomy education. Four human hearts were processed with routine plastination procedures at room temperature. Specimens were subjected to cone beam computed tomography and a graphics program (ER3D) was applied to generate 3D cardiac models. A comparison was conducted between plastinated hearts and their corresponding computer models based on a list of morphological cardiac features commonly studied in the gross anatomy laboratory. Results showed significant correspondence between plastinations and CBCT-generated 3D models (98 %; p < .01) for external structures and 100 % for internal cardiac features, while 85 % correspondence was achieved between plastinations and 2D CBCT slices. Complete correspondence (100 %) was achieved between key observations on the plastinations and internal radiological findings typically required of medical student. All pathologic features seen on the plastinated hearts were also visualized internally with the CBCT-generated models and 2D slices. These results suggest that CBCT-derived slices and models can be successfully generated from plastinated material and provide accurate representations for radiological anatomy education.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p19FXS
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q9Pu0L
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBxZU
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ul5TVd
via IFTTT

Osteoporosis, osteoporotic fractures, and carotid artery calcification detected on panoramic radiographs in Japanese men and women

Publication date: Available online 23 February 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Yae Iwamoto, Keiichi Uchida, Noriyuki Sugino, Hiroko Kuroiwa, Yutaka Kitamura, Nobuyuki Udagawa, Atsushi Shinohara, Yukihito Higashi, Akira Taguchi
ObjectivesWe investigated the association among diagnosed osteoporosis, osteoporotic fractures, and carotid artery calcification (CAC) detected on panoramic radiographs. Additionally, we assessed whether osteoporosis or fractures could be predicted by an incidental finding of CAC.Study DesignOne thousand and twenty-one subjects participated in this study. Subjects completed a structured questionnaire. Logistic regression analysis adjusted for covariates was used to calculate the odds ratio (95% confidence interval) for diagnosed osteoporosis or fractures according to the presence of CAC. Extended receiver operating characteristic (ROC) curve analysis was used to clarify whether osteoporosis or fractures were predicted by the detection of CAC.ResultsThe odds ratios for diagnosed osteoporosis or fracture associated with CAC were 1.82 (1.02–3.24) and 0.77 (0.33–1.77), respectively. The areas under the ROC curves for identifying subjects with osteoporosis or fractures according to the detection of CAC were 0.54 and 0.50, respectively.ConclusionsCAC may not be useful for identifying Japanese individuals with osteoporosis or those at risk of fracture, although the presence of CAC was significantly associated with a history of diagnosed osteoporosis without osteoporotic fractures.

from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1Txp65q
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa11NC
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QZ6I0A
via IFTTT

Osteoporosis, osteoporotic fractures, and carotid artery calcification detected on panoramic radiographs in Japanese men and women

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Txp65q
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HpV2
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLB1K
via IFTTT

Cancer-causing HPV plummeted in teens since vaccine, study finds

Source: http://www.cnn.com Author: Sarina Storres (CNN)The human papillomavirus vaccine was first recommended for adolescent girls in the United States in 2006. Since that time, the prevalence of the cancer-causing virus has been dropping among young women, according to a new study. Researchers at the Centers for Disease Control and Prevention compared the rates of […]

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WGXf21
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBwFl
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa13oy
via IFTTT

Synchronous presentation of trigeminal, glossopharyngeal and geniculate neuralgias in a single patient

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LEHV0b
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1p1HpEH
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24nLB1C
via IFTTT

Last common ancestor of chimpanzees and humans Biological Sciences

The morphological nature of the last common ancestor (LCA) of chimpanzees/bonobos and humans is a fascinating topic in human evolution. Available evidence suggests that both lineages share a LCA that lived in Africa ∼8–6 Myr. However, the hominoid fossil record of this time period is inadequate, prompting the use of…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1p1x0Zt
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QwBxJz
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qa138c
via IFTTT