A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 8 δευτερόλεπτα
[image: http:--www.bioone.org-userimages-Content] Authors: Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M Abstract Radiation-induced heart disease (RIHD) is a common and sometimes severe late side effect of radiation therapy for intrathoracic and chest wall tumors. We have previously shown that local heart irradiation in a rat model caused prolonged changes in mitochondrial respiration and increased susceptibility to mitochondrial permeability transition pore (mPTP) opening. Because tocotrienols are known to p... περισσότερα »
The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Zhao J, Du F, Luo Y, Shen G, Zheng F, Xu B Abstract The hypoxic condition is a common feature that negatively impacts the efficacy of radio- and chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate the adaptation to hypoxia at the cellular or organismal level. HIF-2 is one of the three known alpha subunits of HIF transcription factors. Previous studies have shown that HIF-1 is associated with chemotherapy failure. Accumulating evidence in recent years suggests that HIF-2 also contri... περισσότερα »
Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Economopoulou P, Mountzios G, Pavlidis N, Pentheroudakis G Abstract Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis of metastatic malignancy in the absence of an identifiable primary site after diagnostic work up. CUP may either resemble a specific primary tumor site sharing common clinicopathological characteristics and prognosis, or present as a distinct disease entity with undifferentiated pathological features, usually bearing dismal prognosis. Diagnosis and management have tradi... περισσότερα »
Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future.
Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S Abstract Hyperthermia, one of the oldest forms of cancer treatment involves selective heating of tumor tissues to temperatures ranging between 39 and 45°C. Recent developments based on the thermoradiobiological rationale of hyperthermia indicate it to be a potent radio- and chemosensitizer. This has been further corroborated through positive clinical outcomes in various tumor sites using thermoradiotherapy or thermoradiochemothe... περισσότερα »
ErbB small molecule tyrosine kinase iDiarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapiesnhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 11 δευτερόλεπτα
ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis.: [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Van Sebille YZ, Gibson RJ, Wardill HR, Bowen JM Abstract Diarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapies. While the mechanisms of diarrhoea induced by traditional chemotherapy have been the focus of much research, the mechanism(s) of diarrhoea induced by small molecule ErbB TKI, have received relatively little attention. Given the increasing use of sm... περισσότερα »
The treatment of advanced melanoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 11 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] *Gaining momentum: New options and opportunities for the treatment of advanced melanoma.* Authors: Michielin O, Hoeller C Abstract Before 2011, patients with advanced or metastatic melanoma had a particularly poor long-term prognosis. Since traditional treatments failed to confer a survival benefit, patients were preferentially entered into clinical trials of investigational agents. A greater understanding of the epidemiology and biology of disease has underpinned the development of newer therapies, including six agents that h... περισσότερα »
Targeted therapies in advanced differentiated thyroid cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 12 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Carneiro RM, Carneiro BA, Agulnik M, Kopp PA, Giles FJ Abstract Differentiated thyroid cancer is the most common endocrine malignancy, and its incidence has been rising rapidly over the past 10years. Although most patients with this disease have an excellent prognosis, a subset develops a more aggressive disease phenotype refractory to conventional therapies. Until recently, there was no effective therapy for these patients. With increasing knowledge of the molecular pathogenesis of thyroid cancer, novel targeted therapie... περισσότερα »
PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 13 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Petrulea MS, Plantinga TS, Smit JW, Georgescu CE, Netea-Maier RT Abstract Thyroid carcinoma (TC) is the most common endocrine malignancy. The pathogenesis of TC is complex and involves multiple genetic events that lead to activation of oncogenic pathways such as the MAP kinase (MAPK) pathway and the PI3K/Akt/mTOR pathway. The PI3K/Akt pathway has emerged as an important player in the pathogenesis of TC, particularly in follicular and advanced anaplastic or poorly differentiated TC. Because these patients have a poor progn... περισσότερα »
Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives.
Alexandros G. SfakianakisστοHead and NeckΠριν από 24 δευτερόλεπτα
Cancer Treat Rev. 2015 Oct 13; Authors: Mirghani H, Amen F, Tao Y, Deutsch E, Levy A Abstract Human papillomavirus driven head and neck squamous cell carcinoma (HNSCC), particularly oropharyngeal squamous cell carcinoma (OPSCC), are characterized by a significant survival advantage over their HPV-negative counterparts. Although the reasons behind this are still not fully elucidated, it is widely accepted that these tumors have a higher response to ionizing radiation that might explain their favorable outcomes. Potential underlying intrinsic mechanisms include impaired DNA repair a... περισσότερα »
Tongue cancer during pregnancy: Surgery and more, a multidisciplinary challenge.
Alexandros G. SfakianakisστοHead and NeckΠριν από 24 δευτερόλεπτα
Crit Rev Oncol Hematol. 2015 Oct 9; Authors: Tagliabue M, Elrefaey SH, Peccatori F, Favia G, Navach V, Pignataro L, Capaccio P, Venturino M, Tredici S, Alterio D, Mosca F, Pugni L, Scarfone G, Cossu Rocca M, Calabrese L Abstract No international guidelines are available for the treatment of oral tongue cancer during pregnancy. Six patients with tongue cancer during pregnancy were identified by a retrospective chart review. In three of the cases we did not follow the standard treatment, the women had disease progression, and two of them died after a short time. A multidisciplinary d... περισσότερα »
Set-up errors and planning margins in planar and CBCT image-guided radiotherapy using three different imaging systems: A clinical study for prostate and head-and-neck cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 24 δευτερόλεπτα
Phys Med. 2015 Oct 14; Authors: Dzierma Y, Beyhs M, Palm J, Niewald M, Bell K, Nuesken F, Licht N, Rübe C Abstract PURPOSE: The purpose of this work is to compare the positioning accuracy achieved by three different imaging techniques and planar vs. CBCT imaging for two common IGRT indications. METHODS: A collective of prostate cancer and head-and-neck cancer patients treated at our institution during the year 2013 was retrospectively analyzed. For all treatment fractions (3078 in total), the kind of acquired set-up image and the performed couch shift before treatment were assesse...περισσότερα »
BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.
Alexandros G. SfakianakisστοHead and NeckΠριν από 24 δευτερόλεπτα
Mol Neurobiol. 2015 Oct 17; Authors: Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, Panford-Walsh R, Hu J, Schimmang T, Zimmermann U, Syka J, Knipper M Abstract For all sensory organs, the establishment of spatial and temporal cortical resolution is assumed to be initiated by the first sensory experience and a BDNF-dependent increase in intracortical inhibition. To address the potential of cortical BDNF for sound processing, we used mice with a conditional deletion of BDNF in which Cre expression was under...περισσότερα »
Cross-activation and Detraining Effects of Tongue Exercise in Aged Rats.
Alexandros G. SfakianakisστοHead and NeckΠριν από 26 δευτερόλεπτα
Behav Brain Res. 2015 Oct 15; Authors: Schaser AJ, Ciucci MR, Connor NP Abstract Voice and swallowing deficits can occur with aging. Tongue exercise paired with a swallow may be used to treat swallowing disorders, but may also benefit vocal function due to cross-system activation effects. It is unknown how exercise-based neuroplasticity contributes to behavior and maintenance following treatment. PMID: 26477376 [PubMed - as supplied by publisher]
Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial.
Alexandros G. SfakianakisστοHead and NeckΠριν από 26 δευτερόλεπτα
Radiother Oncol. 2015 Oct 15; Authors: de Bree R, van der Putten L, van Tinteren H, Wedman J, Oyen WJ, Janssen LM, van den Brekel MW, Comans EF, Pruim J, Takes RP, Hobbelink MG, Valdés Olmos R, van der Laan BF, Boers M, Hoekstra OS, Leemans CR Abstract PURPOSE: The purpose of this study is to evaluate the efficacy of (18)F-FDG-PET as first-line diagnostic investigation, prior to performing a direct laryngoscopy with biopsy under general anesthesia, in patients suspected of recurrent laryngeal carcinoma after radiotherapy. PATIENTS AND METHODS: 150 patients suspected of recurrent T2... περισσότερα »
Validation of the total dysphagia risk score (TDRS) in HNC
Alexandros G. SfakianakisστοHead and NeckΠριν από 26 δευτερόλεπτα
*Validation of the total dysphagia risk score (TDRS) in head and neck cancer patients in a conventional and a partially accelerated radiotherapy scheme.* Radiother Oncol. 2015 Oct 15; Authors: Nevens D, Deschuymer S, Langendijk JA, Daisne JF, Duprez F, De Neve W, Nuyts S Abstract BACKGROUND AND PURPOSE: A risk model, the total dysphagia risk score (TDRS), was developed to predict which patients are most at risk to develop grade ⩾2 dysphagia at 6months following radiotherapy (RT) for head and neck cancer. The purpose of this study was to validate this model at 6months and to inves... περισσότερα »
Pituitary Glioblastoma
Alexandros G. SfakianakisστοHead and NeckΠριν από 26 δευτερόλεπτα
Iran J Cancer Prev. 2015 Authors: Anvari K, Samini F, Faraji M, Khooei A, Ghiasi T, Dehghan P Abstract INTRODUCTION: Pituitary adenomas have been the most common sellaturcica tumors. There have been many unusual types of pituitary tumors that might neglect by radiologists and clinicians. One of these tumors would be the malignant glioma. CASE PRESENTATION: A 62-year-old male has complained from sudden frontal headache, nausea, vomiting, decreased vision, blurred vision and double vision. In skull radiographic, there was an expansion of sellaturcica and a lesion with clear border o... περισσότερα »
Association of Systemic Anaplastic Large Cell Lymphoma and Active Toxoplasmosis in a Child.
Alexandros G. SfakianakisστοHead and NeckΠριν από 28 δευτερόλεπτα
Iran J Cancer Prev. 2015 Authors: Sayyahfar S, Karimi A, Gharib A, Fahimzad A Abstract INTRODUCTION: Anaplastic large cell lymphoma is a subset of non-Hodgkin lymphoma and an unusual disease in children. CASE PRESENTATION: Herein we have reported a 7- year- old girl with a large necrotic skin ulcer on the chest caused by systemic form of anaplastic large-cell lymphoma and simultaneous active toxoplasmosis diagnosed by PCR on lymph node specimen. There were few reports showing a role for toxoplasma infection to cause some malignancies such as lymphoma in adults. CONCLUSIONS: Based ... περισσότερα »
Erectile Dysfunction in Patients with Obstructive Sleep Apnea
Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα
*Low Quality of Life and Depressive Symptoms as an Independent Risk Factor for Erectile Dysfunction in Patients with Obstructive Sleep Apnea.* J Sex Med. 2015 Oct 19; Authors: Jeon YJ, Yoon DW, Han DH, Won TB, Kim DY, Shin HW Abstract INTRODUCTION: Accumulating evidence indicates that obstructive sleep apnea (OSA) is associated with a high prevalence of erectile dysfunction (ED), but the factors that predict the risk of ED in OSA patients have yet to be defined clearly. AIMS: The aims of the present study were to investigate the clinical characteristics of OSA patients with ED and...περισσότερα »
Epidemiological Evaluation of Head and Neck Sarcomas
Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα
*Epidemiological Evaluation of Head and Neck Sarcomas in Iran (the Study of 105 Cases Over 13 Years).* Iran J Cancer Prev. 2015 Authors: Alishahi B, Kargahi N, Homayouni S Abstract BACKGROUND: Head and neck sarcomas are exceedingly rare and they include 4% - 10% of all sarcomas and less than 1% of all neoplasm of head and neck. OBJECTIVES: The aim of this study is to evaluate the epidemiological characteristics of head and neck sarcomas of patients in Isfahan, Iran. PATIENTS AND METHODS: In this retrospective study, from the 16000 patients whose files were evaluated, the total num... περισσότερα »
Sentinel lymph node biopsy in Merkel cell carcinoma
Alexandros G. SfakianakisστοHead and NeckΠριν από 32 δευτερόλεπτα
*Sentinel lymph node biopsy in Merkel cell carcinoma: a 15 year institutional experience and statistical analysis of 721 reported cases.* Br J Dermatol. 2015 Oct 19; Authors: Gunaratne DA, Howle JR, Veness MJ Abstract Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine malignancy which frequently metastasises to the regional lymphatic basin. Pathological assessment of regional lymph nodes with sentinel lymph node biopsy (SLNB) in patients without clinical involvement has permitted more accurate staging and more appropriate management. Nonetheless, concerns ha... περισσότερα »
An evaluation of olfactory function in adults with gastro-esophageal reflux disease.
Alexandros G. SfakianakisστοHead and NeckΠριν από 32 δευτερόλεπτα
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Günbey E, Gören İ, Ünal R, Yılmaz M Abstract CONCLUSION: To the best of the authors' knowledge, this study is the first to evaluate the olfactory function of adult patients diagnosed with GERD. The results revealed that adults with GERD have diminished olfactory function. OBJECTIVE: This study aimed to evaluate the olfactory abilities of subjects using the 'Sniffin' Sticks' olfactory test. METHODS: A total of 35 men and women aged 18-60 years with a diagnosis of GERD and 45 healthy controls were included in the study. The Sniffin' Stick... περισσότερα »
Audiologic evaluation of vestibular schwannoma and other cerebellopontine angle tumors.
Alexandros G. SfakianakisστοHead and NeckΠριν από 32 δευτερόλεπτα
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Kim SH, Lee SH, Choi SK, Lim YJ, Na SY, Yeo SG Abstract CONCLUSION: Otologic accompanying symptoms, audiogram patterns, and hearing levels according to tumor size differed in patients with CPA tumors classified as VS and non-VS types. OBJECTIVES: The diagnosis of CPA tumors is often delayed. Late-diagnosed tumors can grow until they compress and damage vital structures. This study evaluated the otologic symptoms and results of audiologic tests in patients with vestibular schwannomas (VS) and other types of CPA tumors. METHODS: This study... περισσότερα »
Clinical characteristics and prognosis of low frequency sensorineural hearing loss without vertigo.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Jung AR, Kim MG, Kim SS, Kim SH, Geun SY Abstract CONCLUSION: Factors prognostic of recovery from low frequency sensorineural hearing loss without vertigo are co-occurrence of tinnitus, PTA determined hearing level on the affected side before treatment initiation, and time from onset to treatment initiation. The rate of hearing recovery was higher in the oral steroid than in the intra-tympanic steroid and combined groups. OBJECTIVES: Although many studies have assessed acute sudden hearing loss, few have analyzed low-frequency hearing los... περισσότερα »
Clinical evaluation of the xDP output compression strategy for cochlear implants.
Alexandros G. SfakianakisστοHead and NeckΠριν από 34 δευτερόλεπτα
Eur Arch Otorhinolaryngol. 2015 Oct 17; Authors: Bozorg-Grayeli A, Guevara N, Bebear JP, Ardoint M, Saaï S, Hoen M, Gnansia D, Romanet P, Lavieille JP Abstract Technological advances in the domain of digital signal processing adapted to cochlear implants (CI) are partially responsible for the ever-improving outcomes observed with this neural prosthesis. The goal of the present study was to evaluate audiometric outcomes with a new signal processing strategy implemented in Oticon Medical-Neurelec cochlear implant systems, the xDP strategy. The core of this approach is a preset-based ...περισσότερα »
Human papilloma virus detection and typing
Alexandros G. SfakianakisστοHead and NeckΠριν από 35 δευτερόλεπτα
[image: http:--www.tandfonline.com-templates-jsp] *Human papilloma virus detection and typing in 334 lung cancer patients.* Authors: Sagerup CM, Nymoen DA, Halvorsen AR, Lund-Iversen M, Helland A, Brustugun OT Abstract BACKGROUND: Unlike cervical, anogenital and oropharyngeal cancers, where high-risk human papillomavirus (hrHPV) has long been known to play a major role, a causative link between HPV and lung cancer has been investigated for decades with discrepant results. METHODS: Lung cancer patients eligible for surgical treatment were tested for the presence of HPV-DNA in exc... περισσότερα »
European reference values for the quality of life questionnaire EORTC QLQ-C30: Results of a German investigation and a summarizing analysis of six European general population normative studies.
Alexandros G. SfakianakisστοHead and NeckΠριν από 36 δευτερόλεπτα
[image: http:--www.tandfonline.com-templates-jsp] Authors: Hinz A, Singer S, Brähler E Abstract BACKGROUND: The aims of this study are to present the results of a new general population normative study of the quality of life questionnaire EORTC QLQ-C30 and to give European reference values averaged across six studies. METHODS: The empirical study was based on a representative sample of the German adult population (N = 2448). The subjects were asked to fill in several questionnaires, one of them being the EORTC QLQ-C30. RESULTS: EORTC QLQ-C30 mean scores of this sample indicate... περισσότερα »
The validity and reliability of the 'Cancer Caregiving Tasks, Consequences and Needs Questionnaire' (CaTCoN).
Alexandros G. SfakianakisστοHead and NeckΠριν από 37 δευτερόλεπτα
[image: http:--www.tandfonline.com-templates-jsp] Acta Oncol. Authors: Lund L, Ross L, Petersen MA, Groenvold M Abstract BACKGROUND: Caregivers are often involved in and affected by the patient's disease. The questionnaire 'Cancer Caregiving Tasks, Consequences and Needs Questionnaire' (CaTCoN) was developed to measure caregivers' experiences. The aim of this study is to evaluate the construct validity and reliability of the multi-item scales in the CaTCoN using psychometric analyses as well as tests of convergent and discriminant validity with the existing instruments FAMCARE a... περισσότερα »
Patient selection for whole brain radiotherapy (WBRT)
Alexandros G. SfakianakisστοHead and NeckΠριν από 37 δευτερόλεπτα
[image: http:--www.tandfonline.com-templates-jsp] *Patient selection for whole brain radiotherapy (WBRT) in a large lung cancer cohort: Impact of a new Dutch guideline on brain metastases.* Acta Oncol. Authors: Hendriks LE, Troost EG, Steward A, Bootsma GP, De Jaeger K, van den Borne BE, Dingemans AM Abstract BACKGROUND: Median survival after diagnosis of brain metastases is, depending on the Recursive Partitioning Analysis (RPA) classes, 7.1 (class I) to 2.3 months (class III). In 2011 the Dutch guideline on brain metastases was revised, advising to withhold whole brain radioth... περισσότερα »
CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity.
Alexandros G. SfakianakisστοHead and NeckΠριν από 37 δευτερόλεπτα
Cancer Biol Ther. 2015 Oct 19;:0 Authors: Zhang Y, Gao J, Wang X, Deng S, Ye H, Guan W, Wu M, Zhu S, Yu Y, Han W Abstract The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality. We propose that elucidating the mechanisms of tumor regrowth after chemotherapy in tumor-bearing mice may provide new insights into tumor relapse in cancer patients. We firstly report the identification of a chemokine, CXCL4, that plays an important role in the molecular mechanism of cancer regrowth after chemotherapy. A syngenic transplantation tumor model was es...περισσότερα »
The accuracy of locating the cricothyroid membrane by palpation
Alexandros G. SfakianakisστοHead and NeckΠριν από 38 δευτερόλεπτα
[image: http:--www.biomedcentral.com-graphics-pu] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *The accuracy of locating the cricothyroid membrane by palpation - an intergender study.* BMC Anesthesiol. Authors: Campbell M, Shanahan H, Ash S, Royds J, Husarova V, McCaul C Abstract BACKGROUND: The cricothyroid membrane (CTM) is the recommended site of access to the airway during cricothyrotomy to provide emergency oxygenation. We sought to compare the ability of physicians to correctly identify the CTM in male and female patients. METHODS: In a prospective observational study... περισσότερα »
Radionuclide (131)I-labeled multifunctional dendrimers for targeted SPECT imaging and radiotherapy of tumors.
Alexandros G. SfakianakisστοHead and NeckΠριν από 38 δευτερόλεπτα
Nanoscale. 2015 Oct 19; Authors: Zhu J, Zhao L, Cheng Y, Xiong Z, Tang Y, Shen M, Zhao J, Shi X Abstract We report the synthesis, characterization, and utilization of radioactive (131)I-labeled multifunctional dendrimers for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of tumors. In this study, amine-terminated poly(amidoamine) dendrimers of generation 5 (G5·NH2) were sequentially modified with 3-(4'-hydroxyphenyl)propionic acid-OSu (HPAO) and folic acid (FA) linked with polyethylene glycol (PEG), followed by acetylation modification of the d...περισσότερα »
Surgical management of ventrally based lower cervical (subaxial) meningiomas through the lateral approach: Report on 16 cases.
Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα
Clin Neurol Neurosurg. 2015 Oct 13;139:152-158 Authors: Aboul-Enein HA, Khidr WM, Abdeen KM, Madawi AA Abstract OBJECTIVES: Spinal meningiomas are benign and relatively rare tumors. These tumors present about only 25% of primary spinal tumors. Although spinal meningiomas are considered as slowly growing benign tumors, yet they may cause devastating neurological deficits rendering patients crippled. This study describes performing a posterolateral approach to surgically treat anterior based cervical meningioma. We hereby report on 16 cases operated upon using this approach, and we p... περισσότερα »
Sinonasal paraganglioma with a different morphology
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
*A case of sinonasal paraganglioma with a different morphology: nine-year follow-up.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Aydın S, Karabulut B, Orhan KS, Kılıçaslan I, Değer K Abstract Paragangliomas are very occasionally located in the nasal cavity. In this article, we present a 32-year-old female case with a sinonasal paraganglioma with atypical histopathological morphology. In our case, sinonasal paraganglioma consisted of lipoblast-like vacuolated cells instead of the typical Zellballan histological pattern. The prognosis of a nasal paraganglioma is not very clear. The... περισσότερα »
Atypical presentation in Kimura's disease
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Bayır Ö, Karagöz T, Tatar EÇ, Özdek A, Han Ü, Saylam G, Korkmaz MH Abstract Kimura's disease is a rare chronic inflammatory disorder with an unknown etiology which presents with the involvements of salivary glands and subdermal tissue in the head or neck region, in particular. Besides the most common manifestations of the disease; as the involvements of preauricular region, submandibular region, cervical lymph nodes and major salivary glands, nephrotic syndrome, as an additional systemic pathology, may be also seen due to glomerulonephrit... περισσότερα »
Giant osteoma with intracranial extension filling sinonasal cavity
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Gürsoy M, Karaca Erdoğan N, Dağ F, Başoğlu MS, Rezanko Atasever T Abstract Osteomas are the most frequently observed benign bone tumors of paranasal sinuses. Although they are generally detected by chance during radiological analyses, they may create severe complications after intracranial extension. While computed tomography findings play a key role to differentiate osteoma from other osseous lesions of paranasal sinus, magnetic resonance imaging identifies extension to surrounding structures and possible complications. Osteoma was detec... περισσότερα »
[Subjective assessment of olfactory function].
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Evren C, Yiğit VB, Çınar F Abstract Of the five senses, the sense of smell is the most complex and unique in structure and organization. As diagnostic and therapeutic modalities are often underdeveloped, the sense of smell has been inadequately studied. Olfactory disorders may result from benign pathologies such as sinusitis as well as several diseases including Parkinson's disease, temporal lobe epilepsy, schizophrenia and Alzheimer disease. In this article, we aim to instruct the otorhinolaryngology specialists and residents regarding t...περισσότερα »
Investigation of myringosclerosis development in different grafting materials after myringo-/tympanoplasty.
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Çatlı T, Çelik Ç, Demir E, Gür H, Tokat T, Olgun L Abstract OBJECTIVES: This study aims to investigate the prevalence of myringosclerosis in tragal perichondrium (TP) and temporalis fascia (TF) grafts after myringo-/tympanoplasty. PATIENTS AND METHODS: Thirty patients, who were diagnosed with non-suppurative chronic otitis media and administered myringo-/tympanoplasty under general anesthesia using TP or TF as grafting material in our clinic between January 2012 and May 2013, were recruited in this retrospective case-control study. Patie...περισσότερα »
Is the time from the onset to the treatment a prognostic indicator for hearing recovery in idiopathic sudden sensorineural hearing loss?
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Uysal İÖ, Müderris T, Polat K, Yüce S, Gültürk S Abstract OBJECTIVES: This study aims to investigate whether the time from the onset of symptoms to the start of treatment is a prognostic indicator in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). PATIENTS AND METHODS: In this study, 96 patients (58 males, 38 females; mean age 37.8±2.5 years; range 16 to 67 years) who were diagnosed with ISSNHL in our clinic between January 1992 and April 2010 were retrospectively analyzed. All patients were treated with dextran 40 (...περισσότερα »
Efficacy of multimodality approach to sudden hearing loss.
Alexandros G. SfakianakisστοHead and NeckΠριν από 40 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Naiboğllu B, Külekçi S, Sürmeli M, Verim A, Kalaycık Ertugay Ç, İhvan Ö, Şeneldir L, Zer Toros S Abstract OBJECTIVES: This study aims to investigate whether addition of intratympanic steroid (ITS) to systemic steroid and hyperbaric oxygen (HBO) is effective in the treatment of sudden hearing loss (SHL). PATIENTS AND METHODS: Between January 2008 and October 2011, 58 patients diagnosed with SHL were enrolled in the study. Twenty patients (11 males, 9 females; mean age 45.3±21 years; range 24 to 66 years) who received systemic steroid and ... περισσότερα »
Does Onodi cell limit the exposure of sella during transsphenoidal pituitary surgery?
Alexandros G. SfakianakisστοHead and NeckΠριν από 42 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: İmre A, Pınar E, Yüceer N, Songu M, Olgun Y, Aladağ İ Abstract OBJECTIVES: This study aims to evaluate the association between the presence of Onodi cell and sella exposure during endonasal endoscopic transsphenoidal pituitary surgery (EETPS). PATIENTS AND METHODS: Forty-two patients who underwent EETPS for a pituitary adenoma with the collaboration of Neurosurgery and Otorhinolaryngology Departments at Katip Çelebi University Atatürk Training and Research Hospital between February 2011 and March 2014 were retrospectively analyzed. Preop... περισσότερα »
The incidence of facial canal dehiscence in Bell's palsy patients
Alexandros G. SfakianakisστοHead and NeckΠριν από 42 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Demirci Ş, Kurt A, Tüzüner A, Samim EE, Çaylan R Abstract OBJECTIVES: In this study, we compared the incidence of facial canal dehiscence in patients with idiopathic peripheral facial paralysis (Bell's palsy) with a healthy population. PATIENTS AND METHODS: Forty-five patients who were defined as idiopathic peripheral facial paralysis between May 2011 and June 2012 were enrolled the study. The clinical and demographic characteristics of the patients were noted. Spiral computed tomography (CT) was used for the study with a slice thickness...περισσότερα »
Smell function changes in pregnancy
Alexandros G. SfakianakisστοHead and NeckΠριν από 43 δευτερόλεπτα
*[Evaluation of smell function changes in pregnancy].* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Gül A, Yılmaz B, Karababa S, Tuna SF, Özkurt FE, Yaman Yörük N, Topçu İ Abstract OBJECTIVES: This study aims to compare the olfactory function changes among pregnant women in varying trimesters and non-pregnant women. PATIENTS AND METHODS: Thirty-five healthy pregnant women and 14 non-pregnant women were included in the study. Volunteer pregnant women were divided into three subgroups including the first trimester, second trimester, and third trimester. All volunteers were tested wit... περισσότερα »
Nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio
Alexandros G. SfakianakisστοHead and NeckΠριν από 44 δευτερόλεπτα
*[New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio].* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Atan D, Özcan KM, Köseoğlu S, İkincioğulları A, Çetin MA, Ensari S, Dere H Abstract OBJECTIVES: This study aims to investigate the correlations between nasal polyposis (NP) and NP density with neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). PATIENTS AND METHODS: The study included 105 patients (72 males, 33 females; mean age 41.33±12.85 years; range 16 to 63 years) diagnosed as NP (NP group) and... περισσότερα »
Deep neck infection
Alexandros G. SfakianakisστοHead and NeckΠριν από 44 δευτερόλεπτα
*Clinical features of deep neck infection: analysis of 77 patients.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Sakarya EU, Kulduk E, Gündoğan O, Soy FK, Dündar R, Kılavuz AE, Özbay C, Eren E, İmre A Abstract OBJECTIVES: This retrospective study aims to detect the prognostic factors which affect the duration of hospital stay and evaluate the complications which develop in patients with deep neck infection. PATIENTS AND METHODS: The study included 77 patients (40 males, 37 females; mean age 42.4±20.1 years; range 11 to 88 years) treated with a diagnosis of deep neck infection in o... περισσότερα »
Nasal foreign bodies
Alexandros G. SfakianakisστοHead and NeckΠριν από 45 δευτερόλεπτα
*[Nasal foreign bodies: an analysis of 130 patients].* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Memiş M, İlhan E, Ulucanlı S, Yaman H, Güçlü E Abstract OBJECTIVES: This study aims to investigate clinical manifestations and treatment protocols in patients with a diagnosis of nasal foreign bodies. PATIENTS AND METHODS: We retrospectively evaluated 130 patients (72 males, 58 females; mean age 3.65±2.31 years; range 15 month to 72 years) who were diagnosed with nasal foreign bodies and received treatment between November 2008 and July 2013. Age and sex of the patients, type of forei...περισσότερα »
Laryngeal leiomyosarcoma with coexistent tuberculous mediastinal lymphadenopathy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 45 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Yüksel Aslıer NG, Doğan E, Sarıoğlu S, İkiz AÖ Abstract Laryngeal leiomyosarcoma is an extremely rare malignancy originating from the smooth muscles of blood vessels. Herein, we present the first case of leiomyosarcoma arising from the glottic area of the larynx with coexistent tuberculous mediastinal lymphadenopathy. The patient was treated with vertical laryngectomy and anti-tuberculous medication. He has been disease-free for 24 months since initial treatment. PMID: 25935064 [PubMed - in process]
Bilateral hypopharyngeal perforations caused by penetrating trauma to the neck.
Alexandros G. SfakianakisστοHead and NeckΠριν από 45 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Özbilen Acar G, Tekin M, Karataş M, Özdamar Oİ Abstract External laryngeal trauma is a relatively rare-encountered and sometimes life-threatening emergency condition. Recognition of laryngeal injury related to either blunt or penetrating trauma is important for both initial preservation of life as well as long-term airway and vocal function. Treatment options include medical management with observation and open surgical treatment with or without tracheotomy. We, herein, describe a 23-year-old male case who sustained external penetrating t... περισσότερα »
İdiopathic spontaneous tonsillar hemorrhage
Alexandros G. SfakianakisστοHead and NeckΠριν από 45 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Köycü A, Erbek SS, Erbek HS, Boyvat F Abstract Since the advent of antibiotics, major spontaneous tonsillar hemorrhage is extremely rare. The majority of the spontaneous tonsillar hemorrhage events is associated with acute or chronic tonsillitis, coagulopathies, or tonsillar cancer. A 36-year-old female patient was admitted to the otolaryngology department with the complaint of tonsillar hemorrhage. The patient had no history of prior trauma, coagulopathy, malignancy and infection sign. Preoperatively, carotid angiography was performed to... περισσότερα »
Odynophagia: infected tracheal diverticulum.
Alexandros G. SfakianakisστοHead and NeckΠριν από 47 δευτερόλεπτα
*A rare cause of odynophagia: infected tracheal diverticulum.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Şahin N, Solak A, Genç B Abstract Tracheal diverticulum is a relatively rare lesion. Tracheal diverticula are divided into two subgroups as congenital and acquired with different characteristics and etiologies. The majority of these anomalies is asymptomatic and found as incidental findings on radiological imaging. This article presents a case of an infected tracheal diverticulum presenting with odynophagia. It should be noted that infection may obstruct the air-filled lumen ... περισσότερα »
Tualang honey in reducing post-tonsillectomy pain
Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*The effectiveness of Tualang honey in reducing post-tonsillectomy pain.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Abdullah B, Lazim NM, Salim R Abstract OBJECTIVES: This study aims to evaluate the effectiveness of Tualang honey in reducing post-tonsillectomy pain. PATIENTS AND METHODS: The study included 63 patients (31 males, 32 females; mean age 10±4.16 years; range 3 to 18 years) who were planned to undergo tonsillectomy. Patients were randomized into two groups. Treatment group received topical Tualang honey intraoperatively followed by oral consumption of Tualang honey th...περισσότερα »
Surgical treatment of choanal polyps.
Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Retrospective analysis of surgical treatment of choanal polyps.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: İla K, Topdağ M, Öztürk M, İşeri M, Aydın Ö, Keskin G Abstract OBJECTIVES: This study aims to discuss the efficacy of the surgical method performed in patients with choanal polyp in the light of the literature. PATIENTS AND METHODS: The study included 76 patients (42 males, 34 females; mean age 25.36 years; range 7 to 73 years) diagnosed with choanal polyp in the sinonasal region between January 2005 and December 2013 in the otorhinolaryngology clinic of Kocaeli University....περισσότερα »
Necessity of mastoidectomy in patients with chronic otitis media having sclerotic mastoid bone: a retrospective clinical study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Dündar R, Kulduk E, Soy FK, Yazıcı H, Sakarya EU, Özbay C Abstract OBJECTIVES: This study aims to investigate the efficiency of mastoidectomy during tympanoplasty procedures in patients having sclerotic mastoid bone with dry or dried up tympanic cavity. PATIENTS AND METHODS: The study included 146 patients (66 males, 80 females; mean age 28.6 years; range 16 to 52 years) having sclerotic mastoid bone who underwent tympanoplasty between March 2010 and March 2013. Patients were divided into two groups: group A (34 males, 58 females; mean a... περισσότερα »
Study of hearing aid effectiveness and patient satisfaction.
Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Kayabaşoğlu G, Kaymaz R, Erkorkmaz Ü, Güven M Abstract OBJECTIVES: This study aims to investigate hearing aid using rate, patient satisfaction rate and achievements in social communication of patients by assessing the hearing thresholds before and after device use in patients who were determined as suitable for hearing aid use. PATIENTS AND METHODS: Hundred eighty patients who were admitted to Otolaryngology Clinic of Sakarya University Medical Faculty and approved of hearing aid usage between January 2013 and May 2013 were included in th... περισσότερα »
Concurrent medullary and papillary carcinoma of thyroid.
Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Ateşpare A, Çalış AB, Çelik Ö, Yener N, Vural Ç Abstract Simultaneous occurrence of papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) in the same thyroid gland is a rare condition. These tumors derive from different cells; PTC originates from follicular cells whereas MTC originates from parafollicular cells. Because of this, the treatment of these tumors also differs. This article describes two rare cases of the simultaneous occurrence of MTC and PTC in the thyroid gland. PMID: 26050858 [PubMed - in process]
Sinonasal inflammatory myofibroblastic pseudotumor (plasma cell granuloma).
Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Arpacı RB, Kara T, Özyedek E, Serinsöz E, Vayısoğlu Y, Özgür A, Arpacı T, Özcan C Abstract Inflammatory myofibroblastic pseudotumor (plasma cell granuloma) is a soft tissue lesion consisting of myofibroblasts, mature lymphocytes, histiocytes, plasma cells, eosinophils, and extracellular collagen. Various sites in the body may harbor these lesions. Lungs, omentum, intestines, mesentery, and urinary system are the most susceptible areas. It is usually seen in children and young adults. The lesion is rarely detected in the head and neck reg... περισσότερα »
Oncocytoma of the parotid gland complicated by hypercalcemia
Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Evren C, Demirbilek N, Yiğit VB, Kaur AC Abstract Salivary gland tumors are rare head and neck tumors. The majority of these tumors are benign and include pleomorphic adenoma, monomorphic adenoma, oncocytoma, and papillary cystadenoma lymphomatosum. Oncocytoma is a rare benign salivary gland tumor. In this article, we report a 69-year-old female case of oncocytoma of the right parotid gland in whom fine needle aspiration cytology result was reported as a Warthin's tumor. PMID: 26050860 [PubMed - in process]
Congenital vomer agenesis
Alexandros G. SfakianakisστοHead and NeckΠριν από 51 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Uçar S, Aydın Ö, Öztürk M Abstract Congenital vomer agenesis is a very rare condition. Usually, it is discovered incidentally. Nasal and otologic diseases accompany the cases. In this article, we report two cases of isolated congenital vomer agenesis who were admitted to our clinic with complaint of nasal obstruction. On endoscopic examination, deviated septum and inferior turbinate hypertrophy were observed in both patients. One patient was performed septoplasty, inferior turbinate radiofrequency, and functional endoscopic sinus surgery.... περισσότερα »
[Foreign body in the submandibular gland: a tooth extraction complication].
Alexandros G. SfakianakisστοHead and NeckΠριν από 51 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Kara M, Yazıcı İ, Dereköy FS, Güçlü O Abstract The head and neck region includes many vital anatomic structures. So, diseases of this region may have a more morbid and mortal course compared to other anatomic regions. In this article, we report a patient showing various symptoms due to a suture needle which was left in the surgical region during the extraction of the left inferior molar tooth three years ago. PMID: 26050862 [PubMed - in process]
Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio.
Alexandros G. SfakianakisστοHead and NeckΠριν από 51 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Yenigün A Abstract OBJECTIVES: This study aims to investigate the neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to-lymphocyte ratio (ELR) levels in recurrent and non-recurrent nasal polyposis, and identify how the NLR and ELR reflect the inflammatory status in this specific diagnosis preoperatively. PATIENTS AND METHODS: A total of 158 patients (102 males, 56 females; mean age 29.40±5.44 years; range 14 to 48 years) were included in the study. The patients were divided into two groups: group 1 included 80 recurrent nasal polyposis ... περισσότερα »
Prevalence of otitis media with effusion among school age children
Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
*Prevalence of otitis media with effusion among school age children in rural parts of Konya province, Turkey.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Varsak YK, Gül Z, Eryılmaz MA, Arbağ H Abstract OBJECTIVES: This study aims to evaluate the current prevalence of serous otitis media (SOM) among school age children living in rural areas of Konya province located in southern Turkey. PATIENTS AND METHODS: This cross sectional study which was conducted between October 2012 and January 2013 included 2,352 children (1,179 males, 1,173 females; mean age 8.9±2.8 years; range 4 to 15 ... περισσότερα »
Parathyroid scintigraphy and minimal invasive surgery in parathyroid adenomas.
Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Özkul MH, Uyar M, Bayram Ö, Dikmen B Abstract OBJECTIVES: This study aims to identify the diagnostic capacity of the technetium 99m sestamibi scintigraphy with single photon emission computed tomography for localizing parathyroid pathologies. PATIENTS AND METHODS: Data of 13 patients (4 males, 9 females; mean age 49.23 years; range 27 to 63 years) who had minimally invasive parathyroidectomy due to primary hyperparathyroidism at the Haseki Training and Research Hospital Ear-Nose-Throat clinic between January 2013 and December 2013 were r... περισσότερα »
Foreign body impaction in esophagus
Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
*Foreign body impaction in esophagus: experiences at Ear-Nose-Throat Clinic in Tuzla, 2003-2013.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Umihanić Š, Brkić F, Umihanić Š, Hodźić S Abstract OBJECTIVES: This study aims to report our experience in the management of foreign body (FB) impaction in esophagus in the Ear-Nose-Throat Clinic, University Clinical Center of Tuzla, Bosnia and Herzegovina. PATIENTS AND METHODS: Seventy-one patients (44 males, 27 females; mean age 32.99±28.57 years; range 1 to 81 years) who admitted to our clinic between January 2003 and December 2013 with a...περισσότερα »
Tinnitus caused by sleep bruxism and temporomandibular joint issues
Alexandros G. SfakianakisστοHead and NeckΠριν από 53 δευτερόλεπτα
*Effects of sleep bruxism related tinnitus on quality of life.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Saltürk Z, Özçelik E, Kumral TL, Çakır O, Kasımoğlu Ş, Atar Y, Yıldırım G, Berkiten G, Göker AE, Uyar Y Abstract OBJECTIVES: This study aims to analyze the subjective and objective characteristics of tinnitus in sleep bruxism patients. PATIENTS AND METHODS: The study included 57 patients (12 males; 45 females; mean age 33.89±12.50 years; range 19 to 55 years) with sleep bruxism and tinnitus (sleep bruxism group) and 24 patients (6 males, 18 females; mean age 43.75±16.19 year...περισσότερα »
Pediatric cholesteatoma
Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα
*[Our surgical treatment results in pediatric cholesteatoma].* Kulak Burun Bogaz Ihtis Derg. 2015 P Authors: Akdoğan MV, Hızal E, Yılmaz S, Yavuz H, Yılmazer C, Canpolat T, Yılmaz İ, Özlüoğlu LN Abstract OBJECTIVES: This study aims to evaluate surgical techniques and obtained outcomes in pediatric cholesteatoma. PATIENTS AND METHODS: A total of 62 patients (41 males, 21 females; mean age 13 years; range 3 to 17 years) diagnosed as pediatric cholesteatoma between January 1998 and December 2014 were enrolled into the study. Of the patients, canal wall down (CWD) mastoidectomy was pe... περισσότερα »
Schwannoma of external auditory canal
Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα
*A large schwannoma of external auditory canal: an unusual case.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Bakshi SS, Shankar K, Parida PK Abstract A 49-year-old female patient presented with mass occluding her external auditory meatus. Surgical exploration revealed that the mass eroded the bony canal wall and biopsy reported the mass as a schwannoma. Schwannoma should be considered in the differential diagnosis of a soft tissue swelling arising from the external auditory canal. PMID: 26211864 [PubMed - in process]
Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Yetişer S, Ramadan S Abstract Paragangliomas of the head and neck are usually benign tumors. Malignant form is quite rare and criteria for malignancy are not clear. Clinical, biochemical and histological features of malignant forms are not sufficient to reliably distinguish them from benign tumors and malignancy is established only in the presence of distant metastasis. Herein, we report a patient with glomus jugulare on the right, glomus vagale and glomus caroticum tumors on the left side with cervical lymph node metastasis on the right... περισσότερα »
Unusual foreign body in the larynx: a bee.
Alexandros G. SfakianakisστοHead and NeckΠριν από 55 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: İlhan E, Yaman H, Dost B, Köse GA, Yaman H Abstract Foreign body lodgement in the larynx is a rare situation. Our review of the literature revealed no living foreign body in larynx except for laryngeal leeches and anisakiasis. In this article, we report a patient with unusual laryngeal foreign body lodgement: a bee which presented with sudden odynophagia and stinging sensation in throat. The bee was detected on the laryngeal mucosa in indirect laryngoscopic examination and removed immediately under general anesthesia in apneic period. In ...περισσότερα »
Recurrent glomangiopericytoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 56 δευτερόλεπτα
*An unusual mass of nasal cavity: recurrent glomangiopericytoma.* Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Gökdoğan O, Demirhan B, Köybaşıoğlu A, İleri F Abstract Hemangiopericytomas are rare tumors of sinonasal region. In this article, we described a case of recurrent mass in right nasal cavity which presented with nasal obstruction and intermittent epistaxis. Patient had a surgical history on the same nasal region without any histopathological document. Abnormal bleeding was observed during surgery and mass was partially removed for histopathological investigation. The result ... περισσότερα »
Malignant eccrine spiradenoma of the external ear.
Alexandros G. SfakianakisστοHead and NeckΠριν από 56 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Biçer YÖ, Köybaşı S, Tezcan E, Yılmaz F Abstract Eccrine spiradenoma is a benign tumor of sweat gland origin. Malignant eccrine spiradenoma is a rare neoplasm which almost always arises from a pre-existing spiradenoma lesion. In this article, we present a patient with malignant eccrine spiradenoma of the auricula with a prior diagnosis as benign eccrine spiradenoma. Although malignant transformation is usually associated with aggressive behavior, we did not detect recurrence or metastasis in four years of follow-up after performing wide e... περισσότερα »
Atrophic rhinitis caused by Cedecea davisae with accompanying mucocele.
Alexandros G. SfakianakisστοHead and NeckΠριν από 56 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Authors: Bayır Ö, Yıldırım GA, Saylam G, Yüksel E, Özdek A, Korkmaz MH Abstract Atrophic rhinitis is a chronic inflammatory disease characterized by progressive atrophy of nasal mucosa. Cedecea davisae, a rare pathogen, is a new member of Enterobacteriaceae family. In this article, we report a patient with atrophic rhinitis whose culture test revealed Cedecea davisae. The patient was operated due to accompanying posterior ethmoid mucocele. Levofloxacin and nasal irrigation were administered for two months. Significant improvement was observed in p...περισσότερα »
EP-DWI MRI at differentiation of cholesteatoma and granulation tissue in patients with chronic suppurative otitis media].
Alexandros G. SfakianakisστοHead and NeckΠριν από 57 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):255-65 Authors: Tuzcu G, Yardımcı AH, Turna Ö, Göner RE, Acıoğlu E Abstract OBJECTIVES: This study aims to report the significance of echo-planar diffusion-weighted imaging (EP-DWI) in preoperative magnetic resonance imaging of patients with surgically corrected cholesteatoma and granulation tissue according to DWI and apparent diffusion coefficient (ADC) values. PATIENTS AND METHODS: Ninety-one patients (52 males, 39 females; mean age 40.7±15.8 years; range 3 to 77 years) who admitted to radiology clinic of our hospital between Dece... περισσότερα »
Influence of nasal pack removal on patients' anxiety after septoplasty.
Alexandros G. SfakianakisστοHead and NeckΠριν από 57 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):266-70 Authors: Şahin C, İmer Aras H Abstract OBJECTIVES: This study aims to investigate the effects of the removal of Merocel nasal packs on patients' anxiety after septoplasty. PATIENTS AND METHODS: Fifty patients (26 males, 24 females; mean age 30 years; range 18 to 56 years) who underwent septoplasty in the Department of Ear Nose and Throat of our hospital between January 2013 and January 2015 were enrolled in this prospective study. Patients' anxiety was measured using the State-Trait Anxiety Inventory. Anxiety levels were measu... περισσότερα »
Establishment and reliability test of a "Vertigo Council Diagnosis Questionnaire" for patients with chronic vestibular dysfunction: preliminary study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 57 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):271-4 Authors: Karapolat H, Çelebisoy N, Gökçay F, Bilgen C, Özgen G, Göde S, Kirazlı T Abstract OBJECTIVES: This study aims to establish a "Vertigo Council Diagnosis Questionnaire" for patients with chronic vestibular dysfunction and show the reliability of this questionnaire. MATERIALS AND METHODS: A "Vertigo Council Diagnosis Questionnaire" consisting of 10 questions was prepared by 15 specialist physicians and analyzed for reliability using the "translation-back-translation" method. RESULTS: When all the items of our questionnai...περισσότερα »
Pack free septoplasty: functional outcomes and complications.
Alexandros G. SfakianakisστοHead and NeckΠριν από 57 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):275-8 Authors: Eşki E, Yılmaz İ Abstract OBJECTIVES: This study aims to evaluate the functional outcomes and complications of pack free septoplasty in adults. PATIENTS AND METHODS: Forty-nine consecutive patients (35 males, 14 females; mean age 37.7 years; range 18 to 63 years) who underwent septoplasty in our clinic between January 2011 and June 2013 were prospectively included in the study. Preoperative nasal obstruction was scored using the Nasal Obstruction Symptom Evaluation (NOSE). Nasal obstruction was reevaluated in the firs... περισσότερα »
Prevalence of benign paroxysmal positional vertigo among motocross racers: a case-control study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 57 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):279-83 Authors: Hancı D, Altun H Abstract OBJECTIVES: This study aims to investigate the prevalence of benign paroxysmal positional vertigo (BPPV) among motocross racers after cross-country up and downhill activities. PATIENTS AND METHODS: This case-control study included 40 motocross racers (39 males, 1 female; mean age 26 years; range 21 to 43 years) and 40 healthy controls (30 males, 10 females; mean age 28 years; range 22 to 43 years) who had no hearing or balance problems. The Dix-Hallpike maneuver was applied to confirm the di... περισσότερα »
[Impact of markedly nasal septal deviation on 24-hour rhythm Holter findings].
Alexandros G. SfakianakisστοHead and NeckΠριν από 58 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):284-8 Authors: Derin S, Akın F, Şahan M, Altun İ, Şahin C, Eliçora SŞ Abstract OBJECTIVES: This study aims to investigate any impact of nasal septal deviations on cardiac arrhythmias and heart rates by performing 24-hour rhythm Holter analysis before and after septoplasty accompanied by Nasal Obstruction Symptom Evaluation (NOSE) scale. PATIENTS AND METHODS: The study included 21 male patients (mean age 33 years; range 18 to 55 years) who underwent septoplasty between September 2013 and August 2014. Patients were performed 24-hour rh... περισσότερα »
[The relationship between platelet count and mean platelet volume with obstructive sleep apnea syndrome].
Alexandros G. SfakianakisστοHead and NeckΠριν από 58 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):289-94 Authors: Atan D, Sazak Kundi FC, Özcan KM, Dere H Abstract OBJECTIVES: This study aims to investigate the relationship between platelet count and mean platelet volume (MPV) with obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS: This retrospective study included 417 OSAS patients (284 males, 133 females; mean age 47.9±10.0; range 23 to 75 years) who were performed polisomnography (PSG) in our clinic between January 2013 and December 2014. Patients were divided into two groups according to apnea-hipopnea index (AHI... περισσότερα »
Rhino-orbito-cerebral mucormycosis
Alexandros G. SfakianakisστοHead and NeckΠριν από 59 δευτερόλεπτα
*[Rhino-orbito-cerebral mucormycosis: two case reports in the light of the literature].* Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):295-301 Authors: Kara M, Erdoğan H, Toroslu T, Akçalı A, Tatman Okun M, Reşorlu M, Dereköy FS Abstract Rhino-orbito-cerebral mucormycosis is an acute onset and often fatal disease. Risk factors include uncontrolled diabetes mellitus, hematological malignancies, and long-term corticosteroid use. Early diagnosis and treatment are important. The underlying causes should be treated, surgical debridement should be performed and appropriate antifunga... περισσότερα »
Adenoid cystic carcinoma of the accessory parotid gland.
Alexandros G. SfakianakisστοHead and NeckΠριν από 59 δευτερόλεπτα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):302-5 Authors: Baklacı D, Güngör V, Özcan M, Yılmaz YF, Ünal A, Çolak A Abstract Accessory parotid gland is a small salivary gland tissue separated from main part of parotid gland. It is located on the masseter muscle anterior to the Stensen's duct. Tumors of accessory parotid gland are rare. In this article, we report an unusual case of adenoid cystic carcinoma involving accessory parotid gland. The patient presented with a progressively growing mass in the middle portion of her cheek. She underwent a partial parotidectomy including...περισσότερα »
Submandibular hydatid cyst
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*A rare, incidental submandibular hydatid cyst.* Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):306-9 Authors: Doğan M, Polat H, Ayyıldız Ö, Güreli M Abstract Hydatid cyst disease is a parasitic infestation caused by Echinococcus granulosus. It is transmitted via oral ingestion of eggs excreted by dog's stool. Liver and lungs are the most commonly involved organs. Primary involvement of submandibular region by hydatid cyst is extremely rare. In this article, we report a case of a lesion excised from submandibular region with an initial diagnosis of branchial cleft cyst, but shown...περισσότερα »
Hyoid osteoradionecrosis accompanied by candida infection.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):310-4 Authors: Yavaş G, Kara Gedik G, Çolpan B, Ata Ö, Öztürk K, Sarı O Abstract Osteoradionecrosis of the hyoid bone is a rare complication of therapeutic irradiation performed for head and neck cancer. In this article, we present a 52-year-old male patient who admitted with severe odynophagia following chemo-radiotherapy administration for tonsil carcinoma. Fluorine-18-fluorodeoxy-glucose positron emission tomography-computed tomography revealed a metabolic activity in hyoid bone. The pathological findings were consistent with fung... περισσότερα »
[Submucosal lingual schwannoma].
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):315-8 Authors: Ulusoy B, Bozdemir K, Ersoy Çallıoğlu E, Kutluhan A, Korkmaz MH Abstract Schwannoma or neurilemmoma is a slow growing, solitary, and encapsulated benign tumor originating from Schwann cells of the peripheral nerves. Lingual schwannomas are rare. A 46-year-old male patient admitted with a complaint of swelling on the right half of the tongue for one year. An approximately 1x1 cm submucosal mass was detected on the right side of the tongue. The submucosal mass was totally excised under local anesthesia. Pathological exam... περισσότερα »
Prevalence of benign paroxysmal positional vertigo among motocross racers: a case-control study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Kulak Burun Bogaz Ihtis Derg. 2015 Sep-Oct;25(5):279-83 Authors: Hancı D, Altun H Abstract OBJECTIVES: This study aims to investigate the prevalence of benign paroxysmal positional vertigo (BPPV) among motocross racers after cross-country up and downhill activities. PATIENTS AND METHODS: This case-control study included 40 motocross racers (39 males, 1 female; mean age 26 years; range 21 to 43 years) and 40 healthy controls (30 males, 10 females; mean age 28 years; range 22 to 43 years) who had no hearing or balance problems. The Dix-Hallpike maneuver was applied to confirm the di... περισσότερα »
The status of early identification and early intervention in autism spectrum disorders in lower- and middle-income countries.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Int J Speech Lang Pathol. Authors: Samms-Vaughan ME Abstract There is limited information on autism spectrum disorders from lower- and middle-income countries (LMIC). This paper reviews the status of early identification and early intervention for autism spectrum disorders in response to the article by Camarata (2014) . The PubMed database was searched to identify relevant epidemiological studies from LMIC. Seven studies from five countries were identified: Colombia, India, Jamaica, Jordan, and Mexico. The mean age of parental concern, at 21-24 months, and mean age of diagnosis, a...περισσότερα »
Child and setting characteristics affecting the adult talk directed at preschoolers with autism spectrum disorder in the inclusive classroom.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Autism. 2015 Authors: Irvin DW, Boyd BA, Odom SL Abstract Difficulty with social competence is a core deficit of autism spectrum disorder. Research on typically developing children and children with disabilities, in general, suggests the adult talk received in the classroom is related to their social development. The aims of this study were to examine (1) the types and amounts of adult talk children with autism spectrum disorder are exposed to in the preschool classroom and (2) the associations between child characteristics (e.g. language), activity area, and adult talk. Kontos' T... περισσότερα »
How justice can affect jury: training abstract words promotes generalisation to concrete words in patients with aphasia.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Sandberg C, Kiran S Abstract Developing language treatments that not only improve trained items but also promote generalisation to untrained items is a major focus in aphasia research. This study is a replication and extension of previous work which found that training abstract words in a particular context-category promotes generalisation to concrete words but not vice versa (Kiran, Sandberg, & Abbott, 2009 ). Twelve persons with aphasia (five female) with varying types and degrees of severity participated in a generativ... περισσότερα »
Factor analysis of auto-associative neural networks with application in speaker verification.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
IEEE Trans Neural Netw Learn Syst. Authors: Garimella S, Hermansky H Abstract Auto-associative neural network (AANN) is a fully connected feed-forward neural network, trained to reconstruct its input at its output through a hidden compression layer, which has fewer numbers of nodes than the dimensionality of input. AANNs are used to model speakers in speaker verification, where a speaker-specific AANN model is obtained by adapting (or retraining) the universal background model (UBM) AANN, an AANN trained on multiple held out speakers, using corresponding speaker data. When the amo...περισσότερα »
Acquisition of the stop-spirant alternation in bilingual speaking children
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Acquisition of the stop-spirant alternation in bilingual Mexican Spanish-English speaking children: theoretical and clinical implications.: [image: http:--www.tandfonline.com-templates-jsp] Authors: Fabiano-Smith L, Oglivie T, Maiefski O, Schertz J Abstract The purpose of this study was to identify characteristics of typical acquisition of the Mexican Spanish stop-spirant alternation in bilingual Spanish-English speaking children and to shed light on the theoretical debate over which sound is the underlying form in the stop-spirant allophonic relationship. We predicted that biling... περισσότερα »
Enhancing generalisation in biofeedback intervention using the challenge point framework: a case study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.tandfonline.com-templates-jsp] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Hitchcock ER, Byun TM Abstract Biofeedback intervention can help children achieve correct production of a treatment-resistant error sound, but generalisation is often limited. This case study suggests that generalisation can be enhanced when biofeedback intervention is structured in accordance with a "challenge point" framework for speech-motor learning. The participant was an 11-year-old with residual /r/ misarticulation who had previously attained correct /r/ production ... περισσότερα »
Cortical encoding of phonemic context during word production.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--ieeexplore.ieee.org-images-ieee_p] Authors: Mugler EM, Goldrick M, Slutzky MW Abstract Brain-computer interfaces that directly decode speech could restore communication to locked-in individuals. However, decoding speech from brain signals still faces many challenges. We investigated decoding of phonemes - the smallest separable parts of speech - from ECoG signals during word production. We expanded on previous efforts to identify specific phoneme by identifying phonemes by where in the word they were formed. We evaluated how the context of phonemes in words affects... περισσότερα »
Did I say dog or cat? A study of semantic error detection and correction in children.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
J Exp Child Psychol. 2015 Oct 15;142:36-47 Authors: Hanley JR, Cortis C, Budd MJ, Nozari N Abstract Although naturalistic studies of spontaneous speech suggest that young children can monitor their speech, the mechanisms for detection and correction of speech errors in children are not well understood. In particular, there is little research on monitoring semantic errors in this population. This study provides a systematic investigation of detection and correction of semantic errors in children between the ages of 5 and 8years as they produced sentences to describe simple visual ev...περισσότερα »
Social deprivation and hospital admission rates, length of stay and readmissions in emergency medical admissions.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Eur J Intern Med. 2015 Oct 14; Authors: Cournane S, Byrne D, Conway R, O'Riordan D, Coveney S, Silke B Abstract BACKGROUND: Patients from deprived backgrounds have a higher in-patient mortality following an emergency medical admission. How deprivation relates to the admission or readmission incidence rates, episode length of stay (LOS) and ancillary resource utilization is less clear. METHODS: All emergency medical admissions (66,861 episodes in 36,214 patients) between 2002 and 2013, categorized by quintile of Irish National Deprivation Index were assessed against admission or rea... περισσότερα »
Risk factors for the recurrence of post-semicircular canal benign paroxysmal positional vertigo after canalith repositioning.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
J Neurol. 2015 Oct 17; Authors: Su P, Liu YC, Lin HC Abstract This retrospective study was conducted to determine the relationship between variable factors and the recurrence rate of post-semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) after canalith repositioning procedure (CRP). Patients with PSC-BPPV were diagnosed by history and the presence of a positive Dix-Hallpike maneuver between 2008 and 2010. In total, 243 patients (47 males and 196 females, average age = 57.5 years) treated with Epley's maneuver or canalith repositioning procedure (CRP) were included...περισσότερα »
Fiducial markers act as visible surrogates of tumor position during image-guided radiotherapy
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Multimodality guidance for accurate bronchoscopic insertion of fiducial markers.: [image: http:--pt.wkhealth.com-pt-pt-core-templa] Authors: Steinfort DP, Siva S, Kron T, Chee RR, Ruben JD, Ball DL, Irving LB Abstract INTRODUCTION: Fiducial markers act as visible surrogates of tumor position during image-guided radiotherapy. Marker placement has been attempted percutaneously but is associated with high rates of pneumothorax and chest drain placement. METHODS: Patients undergoing radical radiation treatment for non-small-cell lung cancer underwent bronchoscopic implantation of gol... περισσότερα »
Vitamin and carotenoid intake and risk of head-neck cancer subtypes
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study.: [image: http:--highwire.stanford.edu-icons-exter] Authors: de Munter L, Maasland DH, van den Brandt PA, Kremer B, Schouten LJ Abstract BACKGROUND: Head and neck cancer (HNC) is the seventh most-common type of cancer worldwide. Evidence regarding the potential protective effect of vitamins and carotenoids on HNC is limited and mostly based on case-control studies. OBJECTIVE: We evaluated the association of intake of dietary vitamins C and E (including supplementation) and the most... περισσότερα »
Cutaneous manifestations in patients with mastocytosis
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology.* J Allergy Clin Immunol. 2015 Oct 15; Authors: Hartmann K, Escribano L, Grattan C, Brockow K, Carter MC, Alvarez-Twose I, Matito A, Broesby-Olsen S, Siebenhaar F, Lange M, Niedoszytko M, Castells M, Oude Elberink JN, Bonadonna P, Zanotti R, Hornick JL, Torrelo A, Grabbe J, Rabenhorst A, Nedoszytko B, Butterfield JH, Gotlib J, Reiter A, Radi... περισσότερα »
Combined Persistent Fetal Vasculature: A Classification Based on High-Resolution B-Mode Ultrasound and Color Doppler Imaging.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Ophthalmology. 2015 Oct 15; Authors: Hu A, Pei X, Ding X, Li J, Li Y, Liu F, Li Z, Zhan Z, Lu L Abstract PURPOSE: The purpose of this study was to classify combined persistent fetal vasculature (PFV) on the basis of the ultrasonographic and Doppler characteristics. The potential clinical significance for both surgery design and prognosis determination was discussed. DESIGN: A cross-sectional case series. PARTICIPANTS: The eyes of 54 children diagnosed with unilateral combined PFV were evaluated using B-mode ultrasound and color Doppler imaging (CDI). METHODS: Each participant's ag... περισσότερα »
The peculiar economics of life-extending therapies: a review of costing methods in health economic evaluations in oncology.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Expert Rev Pharmacoecon Outcomes Res. 2015 Oct 19;:1-10 Authors: Olchanski N, Zhong Y, Cohen JT, Saret C, Bala M, Neumann PJ Abstract Published literature lacks consensus, and most guidelines lack definitive recommendations as to whether cost-effectiveness analyses (CEAs) should include all "future" costs or distinguish between related and unrelated medical costs. This systematic review of oncology CEAs evaluated cost methods used and the impact on the cost-effectiveness of incorporating different cost categories, including costs due to study intervention, related medical costs of ...περισσότερα »
Time, dose and ataxia telangiectasia mutated (ATM) status dependency of coding and noncoding RNA expression after ionizing radiation exposure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Kabacik S, Manning G, Raffy C, Bouffler S, Badie C Abstract Studies of gene expression have proved important in defining the molecular mechanisms of radiation action and identifying biomarkers of ionizing radiation exposure and susceptibility. The full transcriptional response to radiation is very complex since it also involves epigenetic mechanisms triggered by radiation exposure such as modifications of expression of noncoding RNA such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that have not been fully char... περισσότερα »
The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Gerelchuluun A, Manabe E, Ishikawa T, Sun L, Itoh K, Sakae T, Suzuki K, Hirayama R, Asaithamby A, Chen DJ, Tsuboi K Abstract The purpose of this study was to identify the roles of non-homologous end-joining (NHEJ) or homologous recombination (HR) pathways in repairing DNA double-strand breaks (DSBs) induced by exposure to high-energy protons and carbon ions (C ions) versus gamma rays in Chinese hamster cells. Two Chinese hamster cell lines, ovary AA8 and lung fibroblast V79, as well as various mutant sublines lacking DNA-... περισσότερα »
Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM Abstract While radiation therapy is commonly used for treating cancer, radiation resistance can limit long-term control of the disease. In this study, we investigated the reprogramming of the energy metabolism in radiosensitive and radioresistant head and neck squamous cell carcinomas (HNSCC) using a preclinical matched model of radiation resistance. Our investigation found that radioresistant rSCC-61 cells: 1. They display increased glucose uptake an... περισσότερα »
Effect of dose rate on residual γ-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Turner HC, Shuryak I, Taveras M, Bertucci A, Perrier JR, Chen C, Elliston CD, Johnson GW, Smilenov LB, Amundson SA, Brenner DJ Abstract The biological risks associated with low-dose-rate (LDR) radiation exposures are not yet well defined. To assess the risk related to DNA damage, we compared the yields of two established biodosimetry end points, γ-H2AX and micronuclei (MNi), in peripheral mouse blood lymphocytes after prolonged in vivo exposure to LDR X rays (0.31 cGy/min) vs. acute high-dose-rate (HDR) exposure (1.03 Gy/... περισσότερα »
NFκB and Survivin-Mediated Radio-Adaptive Response.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Grdina DJ, Murley JS, Miller RC, Woloschak GE, Li JJ Abstract A survivin-mediated radio-adaptive response was induced in SA-NH murine sarcoma cells following activation of nuclear transcription factor κB (NFκB) by very low doses of ionizing radiation of 5, 20 or 100 mGy. SA-NH cells and a clone stably transfected with a plasmid containing a mutated IκBα gene that prevents the activation of NFκB (SA-NH+mIκBα1) were used to investigate the role of NFκB activation in the development and expression of the survivin-mediated ra... περισσότερα »
Mortality from Circulatory System Diseases among Uranium Miners
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study.: [image: http:--www.bioone.org-userimages-Content] Authors: Drubay D, Caër-Lorho S, Laroche P, Laurier D, Rage E Abstract A significant association has been observed between radon exposure and cerebrovascular disease (CeVD) mortality among French uranium miners, but risk factors for circulatory system diseases (CSD) have not been previously considered. We conducted new analyses in the recently updated (through 2007) French cohort of uranium miners (n = 5,086), which included 442 d... περισσότερα »
Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Deng W, Kimura Y, Gududuru V, Wu W, Balogh A, Szabo E, Thompson KE, Yates CR, Balazs L, Johnson LR, Miller DD, Strobos J, McCool WS, Tigyi GJ Abstract We have previously demonstrated that the small molecule octadecenyl thiophosphate (OTP), a synthetic mimic of the growth factor-like mediator lysophosphatidic acid (LPA), showed radioprotective activity in a mouse model of total-body irradiation (TBI) when given orally or intraperitoneally 30 min before exposure to 9 Gy γ radiation. In the current study, we evaluated the e... περισσότερα »
Ionizing radiation-induced cell death is partly caused by increase of mitochondrial reactive oxygen species in normal human fibroblast cells.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Kobashigawa S, Kashino G, Suzuki K, Yamashita S, Mori H Abstract Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot be repaired. However, in this study we found that a delayed increase of mitochondrial reactive oxygen species (ROS) is responsible for some of the radiation-induced cell death in normal human fibroblast cells. We have previously reported that there is a delayed increase of mitochondrial (·)O2(-), measured using MitoSOX™ Red reagent, due to gamma irradiation. This is depend... περισσότερα »
Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM Abstract One newly recognized consequence of radiation exposure may be the delayed development of diabetes and metabolic disease. We document the development of type 2 diabetes in a unique nonhuman primate cohort of monkeys that were whole-body irradiated with high doses (6.5-8.4 Gy) 5-9 years earlier. We report here a higher prevalence of type 2 diabetes in irradiated monkeys compared to age-matched nonirradiated monkeys. These irradiated diabetic... περισσότερα »
Human Fibroblasts Exposed to Low- and High-LET Radiation
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] *Induction and Repair of DNA DSB as Revealed by H2AX Phosphorylation Foci in Human Fibroblasts Exposed to Low- and High-LET Radiation: Relationship with Early and Delayed Reproductive Cell Death.* Authors: Antonelli F, Campa A, Esposito G, Giardullo P, Belli M, Dini V, Meschini S, Simone G, Sorrentino E, Gerardi S, Cirrone GA, Tabocchini MA Abstract The spatial distribution of radiation-induced DNA breaks within the cell nucleus depends on radiation quality in terms of energy deposition pattern. It is generally assumed that the... περισσότερα »
Analyses of ionizing radiation effects in vitro in peripheral blood lymphocytes with Raman spectroscopy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Maguire A, Vegacarrascal I, White L, McClean B, Howe O, Lyng FM, Meade AD Abstract The use of Raman spectroscopy to measure the biochemical profile of healthy and diseased cells and tissues may be a potential solution to many diagnostic problems in the clinic. Although extensively used to identify changes in the biochemical profiles of cancerous cells and tissue, Raman spectroscopy has been used less often for analyzing changes to the cellular environment by external factors such as ionizing radiation. In tandem with thi... περισσότερα »
Biodosimetry Based on γ-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Zahnreich S, Ebersberger A, Kaina B, Schmidberger H Abstract The aim of this current study was to quantitatively describe radiation-induced DNA damage and its distribution in leukocytes of cancer patients after fractionated partial- or total-body radiotherapy. Specifically, the impact of exposed anatomic region and administered dose was investigated in breast and prostate cancer patients receiving partial-body radiotherapy. DNA double-strand breaks (DSBs) were quantified by γ-H2AX immunostaining. The frequency of unstable... περισσότερα »
Connecting radiation-induced bystander effects and senescence to improve radiation response prediction.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Poleszczuk J, Krzywon A, Forys U, Widel M Abstract For the last two decades radiation-induced bystander effects (RIBEs) have attracted significant attention due to their possible implications for radiotherapy. However, despite extensive research, the molecular pathways associated with RIBEs are still not completely known. In the current study we investigated the role of senescence in the bystander response. Irradiated (2, 4, 6 and 8 Gy) human colorectal carcinoma cells (HCT116) with p53(+/+) (wild-type) or p53(-/-) (knock... περισσότερα »
Hemorrhage trauma increases radiation-induced trabecular bone loss and marrow cell depletion in mice.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Swift JM, Smith JT, Kiang JG Abstract Exposure to high-dose radiation results in deleterious effects on skeletal tissue. However, the effects of combined trauma such as radiation and hemorrhage on skeletal properties have yet to be elucidated. The purpose of this study was to evaluate the effects of radiation injury combined with hemorrhage on trabecular bone properties and biomarkers of bone metabolism, and to determine whether hemorrhage enhances radiation-associated bone loss. Male CD2F1 mice (10 weeks old) were expose... περισσότερα »
What level of accuracy is achievable for preclinical dose painting studies on a clinical irradiation platform?
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Trani D, Reniers B, Persoon L, Podesta M, Nalbantov G, Leijenaar RT, Granzier M, Yaromina A, Dubois L, Verhaegen F, Lambin P Abstract Advancements made over the past decades in both molecular imaging and radiotherapy planning and delivery have enabled studies that explore the efficacy of heterogeneous radiation treatment ("dose painting") of solid cancers based on biological information provided by different imaging modalities. In addition to clinical trials, preclinical studies may help contribute to identifying promisin... περισσότερα »
Spectrum of Radiation-Induced Clustered Non-DSB Damage - A Monte Carlo Track Structure Modeling and Calculations.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Watanabe R, Rahmanian S, Nikjoo H Abstract The aim of this report is to present the spectrum of initial radiation-induced cellular DNA damage [with particular focus on non-double-strand break (DSB) damage] generated by computer simulations. The radiation types modeled in this study were monoenergetic electrons (100 eV-1.5 keV), ultrasoft X-ray photons Ck, AlK and TiK, as well as some selected ions including 3.2 MeV/u proton; 0.74 and 2.4 MeV/u helium ions; 29 MeV/u nitrogen ions and 950 MeV/u iron ions. Monte Carlo track ... περισσότερα »
Pediatric cranial radiation therapy : Treatment age, dose and sex determine neuroanatomical outcome in irradiated juvenile mice.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: de Guzman AE, Gazdzinski LM, Alsop RJ, Stewart JM, Jaffray DA, Wong CS, Nieman BJ Abstract Pediatric cranial radiation therapy can induce long-term neurocognitive deficits, the risk and severity of these deficits are amplified in females and in those individuals exposed at a younger age and/or those irradiated at higher doses. To investigate the developmental consequences of these factors in greater detail, male and female C57Bl/6J mice between infancy and late childhood (16 and 36 days) were irradiated at a single time p... περισσότερα »
Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Liu C, Lin Q, Yun Z Abstract Molecular oxygen has long been recognized as a powerful radiosensitizer that enhances the cell-killing efficiency of ionizing radiation. Radiosensitization by oxygen occurs at very low concentrations with the half-maximum radiosensitization at approximately 3 mmHg. However, robust hypoxia-induced signal transduction can be induced at <15 mmHg and can elicit a wide range of cellular responses that will affect therapy response as well as maligna... περισσότερα »
Radiation-induced sialadenitis : Effect of Phenylephrine Pretreatment on the Expressions of Aquaporin 5 and c-Jun N-Terminal Kinase
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Han L, Wang L, Zhang F, Liu KJ, Xiang B Abstract Radiotherapy for malignant tumors of the head and neck commonly leads to radiation-induced sialadenitis as a result of radiation-induced salivary gland dysfunction. We demonstrated previously that phenylephrine could protect the irradiated submandibular gland against apoptosis, although the mechanism is unclear. In this study, we investigated the influence of phenylephrine pretreatment on the expressions of aquaporin 5 (AQP5) and c-Jun N-terminal kinase (JNK) that were pres... περισσότερα »
Investigation of DNA Damage Dose-Response Kinetics after Ionizing Radiation Schemes Similar to CT Protocols.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Elgart SR, Bostani M, Mok KC, Adibi A, Ruehm S, Enzmann D, McNitt-Gray M, Iwamoto KS Abstract Although there has been extensive research done on the biological response to doses of ionizing radiation relevant to radiodiagnostic procedures, very few studies have examined radiation schemes similar to those frequently utilized in CT exams. Instead of a single exposure, CT exams are often made up of a series of scans separated on the order of minutes. DNA damage dose-response kinetics after radiation doses and schemes similar... περισσότερα »
HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG Abstract Hypoxia is a major cause of radiation resistance, which may predispose to local recurrence after radiation therapy. While hypoxia increases tumor cell survival after radiation exposure because there is less oxygen to oxidize damaged DNA, it remains unclear whether signaling pathways triggered by hypoxia contribute to radiation resistance. F... περισσότερα »
Time and Cell Type Dependency of Survival Responses in Co-cultured Tumor and Fibroblast Cells after Exposure to Modulated Radiation Fields.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Butterworth KT, McMahon SJ, McKee JC, Patel G, Ghita M, Cole AJ, McGarry CK, O'Sullivan JM, Hounsell AR, Prise KM Abstract Advanced radiotherapy techniques such as intensity-modulated radiation therapy (IMRT) achieve high levels of conformity to the target volume through the sequential delivery of highly spatially and temporally modulated radiation fields, which have been shown to impact radiobiological response. This study aimed to characterize the time and cell type dependency of survival responses to modulated fields u... περισσότερα »
The International Nuclear Workers Study (INWORKS)
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Dose Estimation for a Study of Nuclear Workers in France, the United Kingdom and the United States of America: Methods for the International Nuclear Workers Study (INWORKS).: [image: http:--www.bioone.org-userimages-Content] Authors: Thierry-Chef I, Richardson DB, Daniels RD, Gillies M, Hamra GB, Haylock R, Kesminiene A, Laurier D, Leuraud K, Moissonnier M, O'Hagan J, Schubauer-Berigan MK, Cardis E, INWORKS Consortium Abstract In the framework of the International Nuclear Workers Study conducted in France, the UK and the U.S. (INWORKS), updated and expanded methods were developed...περισσότερα »
Local Heart Irradiation : Glutathione S-transferase alpha 4 (GSTA4-4) protection against cardiac function
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model.: [image: http:--www.bioone.org-userimages-Content] Authors: Boerma M, Singh P, Sridharan V, Tripathi P, Sharma S, Singh SP Abstract Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxi... περισσότερα »
Nuclear Workers Exposed to External Ionizing Radiation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Cancer Mortality through 2005 among a Pooled Cohort of U.S. Nuclear Workers Exposed to External Ionizing Radiation.: [image: http:--www.bioone.org-userimages-Content] Authors: Schubauer-Berigan MK, Daniels RD, Bertke SJ, Tseng CY, Richardson DB Abstract UNLABELLED: Nuclear workers worldwide have been studied for decades to estimate associations between their exposure to ionizing radiation and cancer. The low-level exposure of these workers requires pooling of large cohorts studied over many years to obtain risk estimates with appropriate latency and good precision. We assembled a... περισσότερα »
Microbiota-induced intestinal sub-symptomatic inflammationtricted or Conventional Intestinal Microbiota Composition Predisposing to Risk for High-LET Radiation Injury?
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Evidence from Animal Models: Is a Restricted or Conventional Intestinal Microbiota Composition Predisposing to Risk for High-LET Radiation Injury?: [image: http:--www.bioone.org-userimages-Content] Authors: Maier I, Schiestl RH Abstract Intestinal microbiota affect cell responses to ionizing radiation at the molecular level and can be linked to the development of the immune system, controlled cell death or apoptosis. We have developed a microbiota mouse model and report here that high-linear energy transfer (LET) radiation induced the repair of chromosomal DNA lesions more efficie... περισσότερα »
MRI-Tracked Tumor Vascular Changes in the Hours after Single-Fraction Irradiation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Brown SL, Nagaraja TN, Aryal MP, Panda S, Cabral G, Keenan KA, Elmghirbi R, Mikkelsen T, Hearshen D, Knight RA, Wen N, Kim JH, Ewing JR Abstract The purpose of this study was to characterize changes in tumor vascular parameters hours after a single radiation exposure in an orthotopic brain tumor model. U-251 human brain tumors were established intracerebrally in rat brains, and tumor blood flow, forward volume transfer constant (K(trans)) and interstitial volume fraction (v(e)) were measured using magnetic resonance imagi... περισσότερα »
Ciprofloxacin Therapy Results in Mitigation of ATP Loss after Irradiation Combined with Wound Trauma: Preservation of Pyruvate Dehydrogenase and Inhibition of Pyruvate Dehydrogenase Kinase 1.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Swift JM, Smith JT, Kiang JG Abstract Ionizing radiation exposure combined with wound injury increases animal mortalities than ionizing radiation exposure alone. Ciprofloxacin (CIP) is in the fluroquinolone family of synthetic antibiotic that are available from the strategic national stockpile for emergency use and is known to inhibit bacterial sepsis. The purpose of this study was to evaluate the efficacy of ciprofloxacin as a countermeasure to combined injury mortality and determine the signaling proteins involved in en... περισσότερα »
Leukocyte growth factors (LGF),such as Pegfilgrastim Improves Survival of Lethally Irradiated Nonhuman Primates.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Hankey KG, Farese AM, Blaauw EC, Gibbs AM, Smith CP, Katz BP, Tong Y, Prado KL, MacVittie TJ Abstract Leukocyte growth factors (LGF), such as filgrastim, pegfilgrastim and sargramostim, have been used to mitigate the hematologic symptoms of acute radiation syndrome (ARS) after radiation accidents. Although these pharmaceuticals are currently approved for treatment of chemotherapy-induced myelosuppression, such approval has not been granted for myelosuppression resulting from acute radiation exposure. Regulatory approval ...περισσότερα »
Radiation Dose-Rate Effects on Gene Expression
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Radiation Dose-Rate Effects on Gene Expression in a Mouse Biodosimetry Model.: [image: http:--www.bioone.org-userimages-Content] Authors: Paul S, Smilenov LB, Elliston CD, Amundson SA Abstract In the event of a nuclear accident or radiological terrorist attack, there will be a pressing need for biodosimetry to triage a large, potentially exposed population and to assign individuals to appropriate treatment. Exposures from fallout are likely, resulting in protracted dose delivery that would, in turn, impact the extent of injury. Biodosimetry approaches that can distinguish such lo... περισσότερα »
Early-life irradiation may have long-term consequences on the immune system, leading to an altered antiviral response
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A.: [image: http:--www.bioone.org-userimages-Content] Authors: Misra RS, Johnston CJ, Groves AM, DeDiego ML, St Martin J, Reed C, Hernady E, Miller JN, Love T, Finkelstein JN, Williams JP Abstract A number of investigators have suggested that exposure to low-dose radiation may pose a potentially serious health risk. However, the majority of these studies have focused on the short-term rather than long-term effects of exposure to fixed source radiation,... περισσότερα »
Serum Amyloid A as a Biomarker for Radiation Exposure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Sproull M, Kramp T, Tandle A, Shankavaram U, Camphausen K Abstract There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern complicate medical triage for first responders. In this study, we evaluated the efficacy of the acute phase protein serum amyloid A (SAA) as a bi... περισσότερα »
Defining Blood Processing ParamThe direct measurement of radiation-induced γ-H2AX foci in peripheral blood lymphocyteseters for Optimal Detection of γ-H2AX Foci: A Small Blood Volume Method.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Defining Blood Processing Parameters for Optimal Detection of γ-H2AX Foci: A Small Blood Volume Method.: [image: http:--www.bioone.org-userimages-Content] Authors: Wojewodzka M, Sommer S, Kruszewski M, Sikorska K, Lewicki M, Lisowska H, Wegierek-Ciuk A, Kowalska M, Lankoff A Abstract Biodosimetric methods used to measure the effects of radiation are critical for estimating the health risks to irradiated individuals or populations. The direct measurement of radiation-induced γ-H2AX foci in peripheral blood lymphocytes is one approach that provides a useful end point for triage. De... περισσότερα »
High linear energy transfer (LET) α particles are important with respect to the carcinogenic risk associated with human exposure to ionizing radiation
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Variation in RBE for Survival of V79-4 Cells as a Function of Alpha-Particle (Helium Ion) Energy.: [image: http:--www.bioone.org-userimages-Content] Authors: Tracy BL, Stevens DL, Goodhead DT, Hill MA Abstract High linear energy transfer (LET) α particles are important with respect to the carcinogenic risk associated with human exposure to ionizing radiation, most notably to radon and its progeny. Additionally, the potential use of alpha-particle-emitting radionuclides in radiotherapy is increasingly being explored. Within the body the emitted alpha particles slow down, traversing... περισσότερα »
The Techa River Cohort have established associations between radiation dose and the occurrence of solid cancers and leukemia (non-CLL)
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Solid Cancer Incidence in the Techa River Incidence Cohort: 1956-2007.: [image: http:--www.bioone.org-userimages-Content] Authors: Davis FG, Yu KL, Preston D, Epifanova S, Degteva M, Akleyev AV Abstract Previously reported studies of the Techa River Cohort have established associations between radiation dose and the occurrence of solid cancers and leukemia (non-CLL) that appear to be linear in dose response. These analyses include 17,435 cohort members alive and not known to have had cancer prior to January 1, 1956 who lived in areas near the river or Chelyabinsk City at some time... περισσότερα »
Subject-Based versus Population-Based Care after Radiation Exposure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Yu JZ, Lindeblad M, Lyubimov A, Neri F, Smith B, Szilagyi E, Halliday L, MacVittie T, Nanda J, Bartholomew A Abstract In a mass casualty radiation event situation, individualized therapy may overwhelm available resources and feasibility issues suggest a need for the development of population-based strategies. To investigate the efficacy of a population-based strategy, Chinese macaques (n = 46) underwent total-body irradiation and received preemptive antibiotics, IV hydration on predetermined postirradiation days and were ... περισσότερα »
Radiation Effects Investigations Based on Atmospheric Radiation Model (ATMORAD) Considering GEANT4 Simulations of Extensive Air Showers and Solar Modulation Potential.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Hubert G, Cheminet A Abstract The natural radiative atmospheric environment is composed of secondary cosmic rays produced when primary cosmic rays hit the atmosphere. Understanding atmospheric radiations and their dynamics is essential for evaluating single event effects, so that radiation risks in aviation and the space environment (space weather) can be assessed. In this article, we present an atmospheric radiation model, named ATMORAD (Atmospheric Radiation), which is based on GEANT4 simulations of extensive air shower... περισσότερα »
A Case Report: Cytogenetic Dosimetry after Accidental Radiation Exposure during (192)Ir Industrial Radiography Testing.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Radiat Res. 2015 http://www.bioone.org/doi/10.1667/RR14013.1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3Dpubmed Authors: Beinke C, Ben-Shlomo A, Abend M, Port M Abstract The accidental gamma radiation exposure of an industrial radiography worker and the cytogenetic examination of the worker's blood lymphocytes are described here. The exposure of the worker was due to a malfunction at the entrance into the depleted uranium-shielding device of a (192)Ir source during operation. Because the source was sealed no additional beta radiation exposure was assumed. The w... περισσότερα »
A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Radiat Res. 2015 Authors: Buonanno M, Randers-Pehrson G, Smilenov LB, Kleiman NJ, Young E, Ponnayia B, Brenner DJ Abstract Radiation-induced bystander effects have been observed in vitro and in cell and tissue culture models, however, there are few reported studies showing these effects in vivo. To our knowledge, this is the first reported study on bystander effects induced by microbeam irradiation in an intact living mammal. The mouse ear was used to investigate radiation-induced bystander effects in keratinocytes, utilizing a 3 MeV proton microbeam (LET 13.1 keV/μm) with a range...περισσότερα »
X-Band Rapid-Scan Electron Paramagnetic Resonance of Radiation-Induced Defects in Tooth Enamel.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Radiat Res. 2015 Authors: Yu Z, Romanyukha A, Eaton SS, Eaton GR Abstract X-band rapid-scan electron paramagnetic resonance (EPR) spectra from tooth enamel samples irradiated with doses of 0.5, 1 and 10 Gy had substantially improved signal-to-noise relative to conventional continuous wave EPR. The radiation-induced signal in a 60 mg of a tooth enamel sample irradiated with a 0.5 Gy dose was readily characterized in spectra recorded with 34 min data acquisition times. The coefficient of variance of the calculated dose for a 1 Gy irradiated sample, based on simulation of the first-d... περισσότερα »
Thyroid Dose Estimates for a Cohort of Belarusian Children Exposed to (131)I from the Chernobyl Accident: Assessment of Uncertainties.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
Radiat Res. 2015 Authors: Drozdovitch V, Minenko V, Golovanov I, Khrutchinsky A, Kukhta T, Kutsen S, Luckyanov N, Ostroumova E, Trofimik S, Voillequé P, Simon SL, Bouville A Abstract Deterministic thyroid radiation doses due to iodine-131 ((131)I) intake were reconstructed in a previous article for 11,732 participants of the Belarusian-American cohort study of thyroid cancer and other thyroid diseases in individuals exposed during childhood or adolescence to fallout from the Chernobyl accident. The current article describes an assessment of uncertainties in reconstructed thyroid d... περισσότερα »
Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.* Radiat Res. 2015 Authors: Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Abstract Due to concerns surrounding potential large-scale radiological events, there is a need to determine robust radiation signatures for the rapid identification of exposed individuals, which can then be used to guide the development of compact field deployable instruments to assess individual dose. Metabolomics pro... περισσότερα »
Tolerance to Dose Escalation in Minibeam Radiation Therapy Applied to Normal Rat Brain: Long-Term Clinical, Radiological and Histopathological Analysis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
: [image: http:--www.bioone.org-userimages-Content] Authors: Prezado Y, Deman P, Varlet P, Jouvion G, Gil S, Le Clec'H C, Bernard H, Le Duc G, Sarun S Abstract The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT utilizes a combination of spatial fractionation of the dose and submillimetric (600 μm) field sizes with an ... περισσότερα »
Comparison of the Effectiveness of Exposure to Low-LET Helium Particles ((4)He) and Gamma Rays ((137)Cs) on the Disruption of Cognitive Performance.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Rabin BM, Carrihill-Knoll KL, Shukitt-Hale B Abstract In this study, the effects of radiation exposure on cognitive performance were evaluated. Rats were exposed to either helium ((4)He) particles (1,000 MeV/n; 0.1-10 cGy; head only) or cesium (137)Cs gamma rays (50-400 cGy; whole body), after which their cognitive performance was evaluated. The results indicated that exposure to doses of (4)He particles as low as 0.1 cGy disrupted performance in a variety of cognitive tasks, including plus-maze performance (baseline anxi... περισσότερα »
Radioprotectors and Radiomitigators for Improving Radiation Therapy: The Small Business Innovation Research (SBIR) Gateway for Accelerating Clinical Translation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Prasanna PG, Narayanan D, Hallett K, Bernhard EJ, Ahmed MM, Evans G, Vikram B, Weingarten M, Coleman CN Abstract Although radiation therapy is an important cancer treatment modality, patients may experience adverse effects. The use of a radiation-effect modulator may help improve the outcome and health-related quality of life (HRQOL) of patients undergoing radiation therapy either by enhancing tumor cell killing or by protecting normal tissues. Historically, the successful... περισσότερα »
In Vitro Radiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Anbalagan S, Biasoli D, Leszczynska KB, Mukherjee S, Hammond EM Abstract With the increased incidence of esophageal cancer, chemoradiotherapy continues to play an important role in the management of this disease. Developing potent radiosensitizers is therefore critical for improving outcomes. The use of drugs that have already undergone clinical testing is an appealing approach once the side effects and tolerated doses are established. Here, we demonstrate that the aminopeptidase inhibitor, CHR-2797/tosedostat, increases ...περισσότερα »
The Effect of Fermented Papaya Preparation on Radioactive Exposure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Fibach E, Rachmilewitz EA Abstract Exposure to ionizing radiation causes cellular damage, which can lead to premature cell death or accumulation of somatic mutations, resulting in malignancy. The damage is mediated in part by free radicals, particularly reactive oxygen species. Fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, has been shown to act as an antioxidant. In this study, we investigated the potential of FPP to prevent radiation-induced damage. FPP (0-100 μg/ml) was added... περισσότερα »
New Insight into Quantitative Modeling of DNA Double-Strand Break Rejoining.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Herr L, Shuryak I, Friedrich T, Scholz M, Durante M, Brenner DJ Abstract Accurate and mechanistically plausible mathematical models of DNA double-strand break (DSB) rejoining kinetics are needed to correctly estimate the dependence of cell death and transformation on linear energy transfer, radiation dose and time. When integrated into more comprehensive risk estimation approaches, such models are potentially valuable tools in applications such as treatment planning for radiotherapy. In this study, we compared 10 DSB rejo... περισσότερα »
Treating Brain Tumor with Microbeam Radiation Generated by a Compact Carbon-Nanotube-Based Irradiator: Initial Radiation Efficacy Study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Radiat Res. 2015 ;184(3):322-33 Authors: Yuan H, Zhang L, Frank JE, Inscoe CR, Burk LM, Hadsell M, Lee YZ, Lu J, Chang S, Zhou O Abstract Microbeam radiation treatment (MRT) using synchrotron radiation has shown great promise in the treatment of brain tumors, with a demonstrated ability to eradicate the tumor while sparing normal tissue in small animal models. With the goal of expediting the advancement of MRT research beyond the limited number of synchrotron facilities in the world, we recently developed a compact laboratory-sca... περισσότερα »
Captopril Increases Survival after Whole-Body Ionizing Irradiation
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] *Captopril Increases Survival after Whole-Body Ionizing Irradiation but Decreases Survival when Combined with Skin-Burn Trauma in Mice.* Radiat Res. 2015 Sep;184(3):273-9 Authors: Islam A, Bolduc DL, Zhai M, Kiang JG, Swift JM Abstract Past and recent radiation events have involved a high incidence of radiation combined injury where victims often succumb to serious infections as a consequence of bacterial translocation and subsequent sepsis. The risk of infection is exacerbated in radiation combined skin-burn injury (RCI), which i... περισσότερα »
Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP Abstract The acute period after total body irradiation (TBI) is associated with an increased risk of infection, principally resulting from the loss of hematopoietic stem cells, as well as disruption of mucosal epithelial barriers. Although there is a return to baseline infection control coinciding with the apparent progressive recovery of hematopoietic cell populations, late ... περισσότερα »
Microdosimetric and Biological Effects of Photon Irradiation at Different Energies in Bone Marrow.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Authors: Belley MD, Ashcraft KA, Lee CT, Cornwall-Brady MR, Chen JJ, Gunasingha R, Burkhart M, Dewhirst M, Yoshizumi TT, Down JD Abstract To ensure reliability and reproducibility of radiobiological data, it is necessary to standardize dosimetry practices across all research institutions. The photoelectric effect predominates over other interactions at low energy and in high atomic number materials such as bone, which can lead to increased dose deposition in soft tissue adjacent to mineral bone due to secondary radiation particles... περισσότερα »
Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--www.bioone.org-userimages-Content] Radiat Res. 2015 Oct;184(4):341-51 Authors: Fleenor CJ, Higa K, Weil MM, DeGregori J Abstract Human exposure to ionizing radiation is highly associated with adverse health effects, including reduced hematopoietic cell function and increased risk of carcinogenesis. The hematopoietic deficits manifest across blood cell types and persist for years after radiation exposure, suggesting a long-lived and multi-potent cellular reservoir for radiation-induced effects. As such, research has focused on identifying both the immediate and lat... περισσότερα »
Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
[image: http:--www.bioone.org-userimages-Content] Authors: Shimizu N, Ooka M, Takagi T, Takeda S, Hirota K Abstract Ionizing radiation induces more cell death under normoxic conditions than under hypoxic conditions. This phenomenon, which is known as the oxygen enhancement effect, occurs primarily because ionizing radiation causes more DNA lesions in the presence of oxygen than in its absence. However, the roles these lesions play in terms of cell survival and chromosome damage have not been fully characterized. We exposed a panel of chicken DT40 mutant cells to ionizing radiatio... περισσότερα »
Education and Training Needs in the Radiation Sciences: Problems and Potential Solutions.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Radiat Res. 2015 Oct 19; Authors: Dynlacht JR, Zeman EM, Held KD, Deye J, Vikram B, Joiner MC Abstract This article provides a summary of presentations focused on critical education and training issues in radiation oncology, radiobiology and medical physics from a workshop conducted as part of the 60th Annual Meeting of the Radiation Research Society held in Las Vegas, NV (September 21-24, 2014). Also included in this synopsis are pertinent comments and concerns raised by audience members, as well as recommendations for addressing ongoing and future challenges. PMID: 26479274 [Pub...περισσότερα »
Disclosing Secondary Findings from Pediatric Sequencing to Families: Considering the "Benefit to Families".
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
J Law Med Ethics. 2015 Sep;43(3):552-558 Authors: Wilfond BS, Fernandez CV, Green RC Abstract Secondary findings for adult-onset diseases in pediatric clinical sequencing can benefit parents or other family members. In the absence of data showing harm, it is ethically reasonable for parents to request such information, because in other types of medical decision-making, they are often given discretion unless their decisions clearly harm the child. Some parents might not want this information because it could distract them from focusing on the child's underlying condition that prompt... περισσότερα »
Chromobacterium Violaceum Sepsis: Rethinking Conventional Therapy to Improve Outcome.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Am J Case Rep. 2015;16:740-4 Authors: Richard KR, Lovvorn JJ, Oliver SE, Ross SA, Benner KW, Kong MY Abstract BACKGROUND Chromobacterium violaceum (C. violaceum) is a facultative anaerobic gram-negative bacterium found in soil and water, especially in tropical and subtropical areas. Although infection in humans is rare, it is associated with significant morbidity. The bacterium is known for its resistance to multiple antimicrobials, and the possibility of relapse and reinfection. Presence of bacteremia, disseminated infection, and ineffective antimicrobial agents are predictors of ... περισσότερα »
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:218 Authors: Agha-Hosseini F, Mirzaii-Dizgah I Abstract BACKGROUND: Oral lichen planus (OLP) has been classified as a pre-malignant condition. Matrix metalloproteinase-13 (MMP-13) or collagenase-3 may play a key role in cancer development. The aim of this study was to compare serum and saliva MMP-13 between patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). METHODS: This cross sectional study was performed on 30 patients with OLP (8 reticular and 22 erosive forms) and 20 patients with OSCC (6 in low stage and 14 in advan... περισσότερα »
Correlation between CRP and early failure of arteriovenous fistula (AVF).
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:219 Authors: Khavanin Zadeh M, Mohammadipour S, Omrani Z Abstract BACKGROUND: Arteriovenous Fistula (AVF) is the ideal method of vascular access for patients on maintenance hemodialysis (HD). Therefore it is an important part of treatment in HD. There are several observations that indicate the role of inflammation in failure of AVF. The aim of this study was to evaluate the hematologic and inflammatory biomarkers in early AVF failure. METHODS: This case-control study included 110 ESRD patients, whom were undergone AVF creation, divided in two groups... περισσότερα »
Patient education process in teaching hospitals
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Patient education process in teaching hospitals of Tehran University of Medical Sciences.* Med J Islam Repub Iran. 2015;29:220 Authors: Seyedin H, Goharinezhad S, Vatankhah S, Azmal M Abstract BACKGROUND: Patient education is widely recognized as a core component of nursing. Patient education can lead to quality outcomes including adherence, quality of life, patients' knowledge of their illness and self-management. This study aimed to clarify patient education process in teaching hospitals affiliated to Tehran University of Medical Sciences (TUMS) in Iran. METHODS: This cross-se...περισσότερα »
Measuring psychosocial exposures: validation of the Persian of the copenhagen psychosocial questionnaire (COPSOQ).
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:221 Authors: Pournik O, Ghalichi L, TehraniYazdi A, Tabatabaee SM, Ghaffari M, Vingard E Abstract BACKGROUND: The effect of psychosocial work environment on personal and organizational aspects of employees is well-known; and it is of fundamental importance to have valid tools to evaluate them. This study aims to evaluate the reliability and validity of the Persian version of Copenhagen Psychosocial Questionnaire (COPSOQ). METHODS: The questionnaire was translated into Persian and then back translated into English by two translators separately. The w... περισσότερα »
Clinical reasoning assessment through medical expertise theories: past, present and future directions.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:222 Authors: Boushehri E, Soltani Arabshahi K, Monajemi A Abstract Exploration into the concept of "medical expert" dates back to more than 50 years ago, yet yielding three leading theories in the area of clinical reasoning, namely, knowledge structure, hypotheticdeductive, and dual process. Each theory defines "medical expert" in a dissimilar way. Therefore, the methods of assessment through which the experts are identified have been changed during the time. In this paper, we tried to categorize and introduce some widely used tests for identificatio... περισσότερα »
Household food security status
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Household food security status in the Northeast of Iran: a cross-sectional study.* Med J Islam Repub Iran. 2015;29:227 Authors: Gholami A, Foroozanfar Z Abstract BACKGROUND: An important issue the world faces today is ensuring that households living in different countries have access to enough food to maintain a healthy life. Food insecurity is prevalent in both developed and developing countries. The objective of this study was to assess the household food security status and related factors among different rural districts of Neyshabur (A city in northeast of Iran). METHODS: O... περισσότερα »
Organochlorine pesticides residue in breast milk: a systematic review.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:228 Authors: Pirsaheb M, Limoee M, Namdari F, Khamutian R Abstract BACKGROUND: Chlorinated pesticides have been used in pest control for several decades in the world. These compounds are still applied in many regions, and their continuous usage has resulted in their bioaccumulation and residue in the food chain. These residues could transfer to food products and accumulate in fat tissues. Undoubtedly, the breast milk could be a significant biomarker for estimation of these residues in the human body. This study was conducted to review and compile the...περισσότερα »
The association between air pollution and weather conditions with increase in the number of admissions of asthmatic patients in emergency wards: a case study in Kermanshah.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:229 Authors: Khamutian R, Najafi F, Soltanian M, Shokoohizadeh MJ, Poorhaghighat S, Dargahi A, Sharafi K, Afshari A Abstract BACKGROUND: Industrialization and urbanization had a devastating impact on public health and caused an increase in health related morbidity and mortality. In fact, asthma is a chronic condition which is considered as one of the significant challenges of public health. In this study, we investigated the association of air pollution and weather conditions with excess emergency ward admissions of asthmatic patients in Kermanshah ...περισσότερα »
Cyst decreased in size post maxillary sinus floor augmentation surgery in diabetic patient: A case report.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Surg Case Rep. 2015 Oct 16;16:171-173 Authors: Zhang S, Song Y, Wei H, Ren S Abstract INTRODUCTION: Whether mucosal cyst of maxillary sinus is contraindication for sinus floor augmentation surgery has been a controversial hot spot for years. PRESENTATION OF CASE: This case aims to present the surgical procedure of sinus floor augmentation surgery with cyst (18.72mm×24.61mm) in diabetic patient. And 6 months later, the cyst decreased in size. The authors elevated the sinus floor and cyst simultaneously. The surgery was carried out successfully without sinus membrane perforati...περισσότερα »
Pseudo subclavian steal syndrome
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Surg Case Rep. 2015 Authors: Konda S, Dayawansa S, Singel S, Huang JH Abstract INTRODUCTION: Vertebrobasilar insufficiency (VBI) is a condition that results from restricted blood flow to the posterior portions of the brain, which are primarily served by the vertebral and basilar arteries. It is the most common cause of vertigo in the elderly and is usually accompanied by impaired vision and sensation. Congenital abnormalities, atherosclerosis, stroke and/or trauma may all lead to decreased vertebrobasilar circulation. A syndrome called Subclavian Steal Syndrome (SSS), which m...περισσότερα »
Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Am J Clin Nutr. 2015 Aug;102(2):420-32 Authors: de Munter L, Maasland DH, van den Brandt PA, Kremer B, Schouten LJ Abstract BACKGROUND: Head and neck cancer (HNC) is the seventh most-common type of cancer worldwide. Evidence regarding the potential protective effect of vitamins and carotenoids on HNC is limited and mostly based on case-control studies. OBJECTIVE: We evaluated the association of intake of dietary vitamins C and E (including supplementation) and the most-common carotenoids (α-carotene, β-carotene, lutein plus zeaxanthin, lycopene, and β-cryptoxanthin) and risk of HN... περισσότερα »
Resveratrol and Malignancies.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Curr Pharmacol Rep. 2015 Aug;1(4):266-271 Authors: Bunaciu RP, Yen A Abstract Carcinogenesis is a multifactorial process, frequently encompassing 3 stages: initiation, promotion and progression. It is characterized by multiple deviations from normal both at the cell and organism levels. Although most people have a small number of cells that present deviations from normal, most of those cells will not cause cancer. However, some will. What tips the balance between normal and abnormal is the subject of intense scientific research as well as unfounded speculations. Chronic inflammatio...περισσότερα »
Anticancer Potential of Dietary Vitamin D and Ascorbic Acid: A Review.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Crit Rev Food Sci Nutr. 2015 Oct 19;:0 Authors: Sunil Kumar BV, Singh S, Verma R Abstract Cancers have been the leading cause of death worldwide and poor diet and physical inactivity are major risk factors in cancer-related deaths. Micronutrients such as vitamins and minerals appear to have preventive properties against cancer. One important mechanism by which dietary changes can exert preventive effects on cancer is via modulation of micronutrient concentrations in target tissues. Many of these micronutrients are available in the form of dietary supplements, and the intake of thes... περισσότερα »
An evaluation of olfactory function in adults with gastro-esophageal reflux disease.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Günbey E, Gören İ, Ünal R, Yılmaz M Abstract CONCLUSION: To the best of the authors' knowledge, this study is the first to evaluate the olfactory function of adult patients diagnosed with GERD. The results revealed that adults with GERD have diminished olfactory function. OBJECTIVE: This study aimed to evaluate the olfactory abilities of subjects using the 'Sniffin' Sticks' olfactory test. METHODS: A total of 35 men and women aged 18-60 years with a diagnosis of GERD and 45 healthy controls were included in the study. The Sniffin' Stick... περισσότερα »
Audiologic evaluation of vestibular schwannoma and other cerebellopontine angle tumors.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Kim SH, Lee SH, Choi SK, Lim YJ, Na SY, Yeo SG Abstract CONCLUSION: Otologic accompanying symptoms, audiogram patterns, and hearing levels according to tumor size differed in patients with CPA tumors classified as VS and non-VS types. OBJECTIVES: The diagnosis of CPA tumors is often delayed. Late-diagnosed tumors can grow until they compress and damage vital structures. This study evaluated the otologic symptoms and results of audiologic tests in patients with vestibular schwannomas (VS) and other types of CPA tumors. METHODS: This study... περισσότερα »
Clinical characteristics and prognosis of low frequency sensorineural hearing loss without vertigo.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Jung AR, Kim MG, Kim SS, Kim SH, Geun SY Abstract CONCLUSION: Factors prognostic of recovery from low frequency sensorineural hearing loss without vertigo are co-occurrence of tinnitus, PTA determined hearing level on the affected side before treatment initiation, and time from onset to treatment initiation. The rate of hearing recovery was higher in the oral steroid than in the intra-tympanic steroid and combined groups. OBJECTIVES: Although many studies have assessed acute sudden hearing loss, few have analyzed low-frequency hearing los... περισσότερα »
Vestibular evoked myogenic potentials in patients with rheumatoid arthritis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Med J Islam Repub Iran. 2015;29:216 Authors: Heydari N, Hajiabolhassani F, Fatahi J, Movaseghi S, Jalaie S Abstract BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune systemic disease. Most common autoimmune diseases are multisystem disorders that may also present with otological manifestations, and autoimmune inner ear disease accompanied by vestibular dysfunction. This study aimed to compare the vestibular function between RA patients and normal subjects using cervical vestibular evoked myogenic potentials (cVEMPs). METHODS: In this cross- sectional study, 25patients with RA ... περισσότερα »
Recurrence patterns of cervical infections in children.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Pediatr Otorhinolaryngol. 2015 Oct ; Authors: Jakubowski LA, Shariat-Madar B, McCormick ME, Sulman CG, Chun RH Abstract OBJECTIVES: (1) Elucidate the recurrence rate of pediatric cervical cellulitis and abscess (2) Evaluate the impact of pre-procedural imaging, length of stay, culture results, age and gender on readmission rate. METHODS: A retrospective review of all admissions to a tertiary pediatric hospital for cellulitis and abscess of the neck (ICD-9 682.1) from 2007 to 2013 including all readmissions within 91 days. RESULTS: There were a total of 178 admissions (171 pat... περισσότερα »
Salivary botulinum toxin injection may reduce aspiration pneumonia in neurologically impaired children.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Pediatr Otorhinolaryngol. 2015 Oct ; Authors: Faria J, Harb J, Hilton A, Yacobucci D, Pizzuto M Abstract OBJECTIVES: Neurologically impaired children often drool and aspirate saliva leading to recurrent aspiration pneumonia and frequent hospitalizations. Salivary botulinum toxin injection is known to reduce sialorrhea. This study evaluates whether this intervention affects the frequency and duration of respiratory infections including aspiration pneumonia and hospitalizations in neurologically impaired children. METHODS: Retrospective review of patients treated with salivary ... περισσότερα »
Salivary botulinum toxin injection may reduce aspiration pneumonia in neurologically impaired children.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Pediatr Otorhinolaryngol. 2015 Oct ; Authors: Faria J, Harb J, Hilton A, Yacobucci D, Pizzuto M Abstract OBJECTIVES: Neurologically impaired children often drool and aspirate saliva leading to recurrent aspiration pneumonia and frequent hospitalizations. Salivary botulinum toxin injection is known to reduce sialorrhea. This study evaluates whether this intervention affects the frequency and duration of respiratory infections including aspiration pneumonia and hospitalizations in neurologically impaired children. METHODS: Retrospective review of patients treated with salivary ... περισσότερα »
Adenoids and clinical symptoms: Epidemiology of a cohort of 795 pediatric patients.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Pediatr Otorhinolaryngol. 2015 Oct 8; Authors: Pagella F, De Amici M, Pusateri A, Tinelli G, Matti E, Benazzo M, Licari A, Nigrisoli S, Quaglini S, Ciprandi G, Marseglia GL Abstract OBJECTIVE: Adenoid hypertrophy (AH) is very common in children and can cause airway obstruction. The aim of this retrospective study was to investigate the relationship between AH and other factors, including age, possible related symptoms, and allergies. METHODS: Seven hundred and ninety-five patients (460 males, 335 females; mean age=5.9 years; range age: 1-14 years) were seen in an ENT clinic f... περισσότερα »
Day-case adenotonsillectomy for sleep apnoea in children?
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Int J Pediatr Otorhinolaryngol. 2015 Oct 8; Authors: Gan RW, Kamani T, Wilkinson S, Thomas D, Marshall AH, Sudarshan P, Daniel M Abstract OBJECTIVES: Many clinicians are concerned about possible airway or respiratory complications following adenotonsillectomy for sleep related breathing disorder (SRBD), and routinely admit such patients for overnight monitoring. However, published guidelines suggest this is unnecessary in some cases. This study firstly aimed to establish current UK practice, and secondly to investigate whether children with mild/moderate SRBD experience respirator...περισσότερα »
Prolonged auditory brainstem responses in infants with autism.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Autism Res. 2015 Oct 19; Authors: Miron O, Ari-Even Roth D, Gabis LV, Henkin Y, Shefer S, Dinstein I, Geva R Abstract Numerous studies have attempted to identify early physiological abnormalities in infants and toddlers who later develop autism spectrum disorder (ASD). One potential measure of early neurophysiology is the auditory brainstem response (ABR), which has been reported to exhibit prolonged latencies in children with ASD. We examined whether prolonged ABR latencies appear in infancy, before the onset of ASD symptoms, and irrespective of hearing thresholds. To determine h...περισσότερα »
Statistical Learning is Related to Early Literacy-Related Skills.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Read Writ. 2015 ;28(4):467-490 Authors: Spencer M, Kaschak MP, Jones JL, Lonigan CJ Abstract It has been demonstrated that statistical learning, or the ability to use statistical information to learn the structure of one's environment, plays a role in young children's acquisition of linguistic knowledge. Although most research on statistical learning has focused on language acquisition processes, such as the segmentation of words from fluent speech and the learning of syntactic structure, some recent studies have explored the extent to which individual differences in statistical le...περισσότερα »
Practical molecular pathologic diagnosis of infiltrating gliomas.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Pekmezci M, Perry A Abstract Recent advances in molecular diagnostics have led to better understanding of glioma tumorigenesis and biology. Numerous glioma biomarkers with diagnostic, prognostic, and predictive value have been identified. Although some of these markers are already part of the routine clinical management of glioma patients, data regarding others are limited and difficult to apply routinely. In addition, multiple methods for molecular subclassification have been proposed either together with or as an alter... περισσότερα »
Are PrP(C)s involved in some human myelin diseases? Relating experimental studies to human pathology.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
J Neurol Sci. 2015 Oct 15; Authors: Veber D, Scalabrino G Abstract We have experimentally demonstrated that cobalamin (Cbl) deficiency increases normal cellular prion (PrP(C)) levels in rat spinal cord (SC) and cerebrospinal fluid (CSF), and decreases PrP(C)-mRNA levels in rat SC. Repeated intracerebroventricular administrations of anti-octapeptide repeat-PrP(C)-region antibodies to Cbl-deficient (Cbl-D) rats prevent SC myelin lesions, and the administrations of PrP(C)s to otherwise normal rats cause SC white matter lesions similar to those induced by Cbl deficiency. Cbl positivel...περισσότερα »
White matter changes in tinnitus: is it all age and hearing loss?
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Brain Connect. 2015 Oct 19; Authors: Yoo HB, De Ridder D, Vanneste S Abstract Tinnitus is a condition characterized by the perception of auditory phantom sounds. It is known as the result of complex interactions between auditory and non-auditory regions. However, previous structural imaging studies on tinnitus patients showed evidence of significant white matter changes caused by hearing loss that is positively correlated with aging. Current study focused on which aspects of tinnitus pathologies affect the white matter integrity the most. We used diffusion tensor imaging technique ... περισσότερα »
Audiologic evaluation of vestibular schwannoma and other cerebellopontine angle tumors.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Kim SH, Lee SH, Choi SK, Lim YJ, Na SY, Yeo SG Abstract CONCLUSION: Otologic accompanying symptoms, audiogram patterns, and hearing levels according to tumor size differed in patients with CPA tumors classified as VS and non-VS types. OBJECTIVES: The diagnosis of CPA tumors is often delayed. Late-diagnosed tumors can grow until they compress and damage vital structures. This study evaluated the otologic symptoms and results of audiologic tests in patients with vestibular schwannomas (VS) and other types of CPA tumors. METHODS: This study... περισσότερα »
Clinical characteristics and prognosis of low frequency sensorineural hearing loss without vertigo.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
Acta Otolaryngol. 2015 Oct 19;:1-5 Authors: Jung AR, Kim MG, Kim SS, Kim SH, Geun SY Abstract CONCLUSION: Factors prognostic of recovery from low frequency sensorineural hearing loss without vertigo are co-occurrence of tinnitus, PTA determined hearing level on the affected side before treatment initiation, and time from onset to treatment initiation. The rate of hearing recovery was higher in the oral steroid than in the intra-tympanic steroid and combined groups. OBJECTIVES: Although many studies have assessed acute sudden hearing loss, few have analyzed low-frequency hearing los... περισσότερα »
Data analyses and perspectives on laparoscopic surgery for esophageal achalasia.
Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
World J Gastroenterol. 2015 Oct 14;21(38):10830-9 Authors: Tsuboi K, Omura N, Yano F, Hoshino M, Yamamoto SR, Akimoto S, Masuda T, Kashiwagi H, Yanaga K Abstract In general, the treatment methods for esophageal achalasia are largely classified into four groups, including drug therapy using nitrite or a calcium channel blocker, botulinum toxin injection, endoscopic therapy such as endoscopic balloon dilation, and surgery. Various studies have suggested that the most effective treatment of esophageal achalasia is surgical therapy. The basic concept of this surgical therapy has not ch... περισσότερα »
OtoRhinoLaryngology New Articles & Online Journals,October 20th,2015
Αλέξανδρος ΣφακιανάκηςστοOtolaryngology by Alexandros G.SfakianakisΠριν από 4 ώρες
Surgical anatomy and pathology of the middle ear *Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα* *Surgical anatomy and pathology of the middle ear by Jan Christoffer Luers, Karl-Bernd Hüttenbrink via Journal of Anatomy Abstract Middle ear surgery is strongly influenced by anatomical and functional characteristics of the middle ear. The complex anatomy means a challenge for the otosurgeon who moves between preservation or improvement of highly important functions (hearing, balance, facial motion) and eradication of diseases. Of these...περισσότερα »2607174
International Journal of Health & Allied Sciences
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 5 ώρες
- Ranking of higher educational institutions in India – Where did we fail?Prashant Vishwanath, 2015-10-20 00:00:00 AM *Prashant Vishwanath, Sunil D Kumar* International Journal of Health & Allied Sciences 2015 4(4):207-209 Διαβάστε περισσότεραΑρχή - In vitro anti-cancer activity of ethanolic extract of Momordica charantia on cervical and breast cancer cell linesCR Shobha, 2015-10-20 00:00:00 AM *CR Shobha, Prashant Vishwanath, MN Suma, Akila Prashant, Chandini Rangaswamy, Basavana H Gowdappa* International Journal of Health & Allied Scien... περισσότερα »
Indian Journal of Anaesthesia
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 ώρες
- Innovative studies, eloquent peer reviewing and cultured editing: Academic desires and tangible dreams of an editorS Bala Bhaskar, 2015-10-19 00:00:00 AM *S Bala Bhaskar, Sukhminder Jit Singh Bajwa* Indian Journal of Anaesthesia 2015 59(10):627-629 Διαβάστε περισσότεραΑρχή - Evaluation of adjusted central venous blood gases versus arterial blood gases of patients in post-operative paediatric cardiac surgical intensive care unitNaveen G Singh, 2015-10-19 00:00:00 AM *Naveen G Singh, SR Prasad, V Manjunath, PS Nagaraja, Pranav J Adoni, Divya Gopal... περισσότερα »
Journal of Clinical Anesthesia
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 ώρες
- Combination of videolaryngoscope and tracheal tube introducer for difficult infant airway managementFumihiro Ohchi, Nobuyasu Komasawa, Kentaro Imagawa, Toshiaki Minami, 2015-10-20 10:41:38 AM Emergency infant airway management is challenging, especially in difficult airway cases. Here, we report a successful case of difficult infant airway management in which a videolaryngoscope was used in combination with a tracheal tube introducer to perform awake intubation. Διαβάστε περισσότεραΑρχή - Muscular edema presenting as severe neuropathy/CRPSBrooke Anderson, Ala... περισσότερα »
Photodermatology, Photoimmunology & Photomedicine
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 5 ώρες
- Effects of Low-Dose Light-Emitting-Diode Therapy in Combination with Water Bath for Atopic Dermatitis in NC/Nga MiceChang-Hyun Kim, Kyung Ah Cheong, Won Suk Lim, Hyung-Moo Park, Ai-Young Lee, 2015-10-20 11:23:33 AM Abstract Background Light emitting diode (LED) phototherapy and water bath therapy have beneficial effect on atopic dermatitis (AD)-like skin disease. However, not all current treatments work well and alternative therapies are need. The contribution of combination therapy with low-dose 850 nm LED and water bath was investigated on dermatop... περισσότερα »
Journal of Molecular Evolution
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 5 ώρες
- Landscape-Based Biology2015-10-19 02:00:00 AM Διαβάστε περισσότεραΑρχή - Searching for a DNAzyme Version of the Leadzyme2015-10-12 02:00:00 AM Abstract The leadzyme refers to a small ribozyme that cleaves a RNA substrate in the presence of Pb2+. In an optimized form, the enzyme strand contains only two unpaired nucleotides. Most RNA-cleaving DNAzymes are much longer. Two classical Pb2+-dependent DNAzymes, 8–17 and GR5, both contain around 15 nucleotides in the enzyme loop. This is also the size of most RNA-cleaving DNAzymes that use other metal ions fo...περισσότερα »
Indian Journal of Dental Research
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρικήΠριν από 6 ώρες
- Do we have the resources and right ecosystem to channel the Indian work force to accelerate research and innovation?Radhika Chigurupati, 2015-10-20 00:00:00 AM *Radhika Chigurupati* Indian Journal of Dental Research 2015 26(4):337-338 Διαβάστε περισσότεραΑρχή - Self-reporting of improper data interpretationSM Balaji, 2015-10-20 00:00:00 AM *SM Balaji* Indian Journal of Dental Research 2015 26(4):339-339 Διαβάστε περισσότεραΑρχή - Defensins in periodontal healthTaran Bedi, 2015-10-20 00:00:00 AM *Taran Bedi, Jaideep Mahendra, N Ambalavana... περισσότερα »
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