Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Δευτέρα 14 Δεκεμβρίου 2015

Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes

Background. The Ryan White HIV/AIDS Program (RWHAP) provides persons infected with human immunodeficiency virus (HIV) with services not covered by other healthcare payer types. Limited data exist to inform policy decisions about the most appropriate role for RWHAP under the Patient Protection and Affordable Care Act (ACA).

Methods. We assessed associations between RWHAP assistance and antiretroviral therapy (ART) prescription and viral suppression. We used data from the Medical Monitoring Project, a surveillance system assessing characteristics of HIV-infected adults receiving medical care in the United States. Interview and medical record data were collected in 2009–2013 from 18 095 patients.

Results. Nearly 41% of patients had RWHAP assistance; 15% relied solely on RWHAP assistance for HIV care. Overall, 91% were prescribed ART, and 75% were virally suppressed. Uninsured patients receiving RWHAP assistance were significantly more likely to be prescribed ART (52% vs 94%; P < .01) and virally suppressed (39% vs 77%; P < .01) than uninsured patients without RWHAP assistance. Patients with private insurance and Medicaid were 6% and 7% less likely, respectively, to be prescribed ART than those with RWHAP only (P < .01). Those with private insurance and Medicaid were 5% and 12% less likely, respectively, to be virally suppressed (P ≤ .02) than those with RWHAP only. Patients whose private or Medicaid coverage was supplemented by RWHAP were more likely to be prescribed ART and virally suppressed than those without RWHAP supplementation (P ≤ .01).

Conclusions. Uninsured and underinsured HIV-infected persons receiving RWHAP assistance were more likely to be prescribed ART and virally suppressed than those with other types of healthcare coverage.



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First bite syndrome after bimaxillary osteotomy: case report

We read the recently published paper by Scholey and Suida,1 in which they described a case of first bite syndrome that developed after a bimaxillary osteotomy. They described symptoms consistent with first bite syndrome and diagnosed the condition with no evidence of intraoral or extraoral disease. The syndrome has a specific symptom of facial pain that occurs only with the first bite of a meal. We reproduced this by introducing lemon glycerine swabs into the mouth to stimulate the secretion of saliva, which seems to be a reliable technique for diagnosis.

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Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?

We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14mm (range 10–22mm).Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0–4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significant complications.

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Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials

Non-invasive electroencephalography during peripheral nerve stimulation provides functional information about central stimulus processing. In particular, the clinically established low-frequency EEG (<100Hz) mainly reflects cortical postsynaptic potentials, i.e., the input of neuronal computation (Okada et al., 1997). In contrast, somatosensory evoked potentials (SEPs) contain an additional oscillatory high-frequency EEG burst (≈600Hz), denoted here as 'σ-burst', which is concomitant with the first cortical low-frequency component (the post-synaptically generated 'N20' for median nerve stimulation) and can be isolated by high-pass filtering above 400 Hz (Cracco and Cracco, 1976; Eisen et al., 1984).

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New technique for closure of an oroantral fistula using platelet-rich fibrin

An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a "scaffold" for the epithelial cells to grow from the margins towards the centre of the wound to heal it.

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Evidence of small fiber neuropathy in a patient with Ehlers–Danlos syndrome, hypermobility-type

Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue diseases. Their clinical identity has been recently suggested and many researchers are now considering EDS-HT and JHS as one and the same (i.e. JHS/EDS-HT) (Castori et al., 2013). As the molecular basis of JHS/EDS-HT is largely unknown, the diagnosis remains based exclusively on clinical criteria. Generalized joint hypermobility, joint complications and skin hyperextensibility are the major features of JHS/EDS-HT and chronic pain, fatigue, headache and dysautonomia represent the major causes of patient disability (Castori et al., 2013; De Wandele et al., 2014).

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SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Abstract

Background

Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory. Therefore, we performed this meta-analysis to evaluate the relationship.

Methods

The meta-analyses were conducted to evaluate the effect of SHMT1 C1420T polymorphism on NHL risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the strength of the association.

Results

Eight studies encompassing 3232 cases and 4077 controls were included. A statistically significant association was found between SHMT1 C1420T polymorphism and NHL risk under the allelic comparison (T vs. C: OR = 1.09, 95% CI 1.01–1.17); a borderline association was found between SHMT1 C1420T polymorphism and NHL risk under the homozygote model (TT vs. CC: OR = 1.18, 95% CI 1.00–1.39) and the dominant model (CT+TT vs. CC: OR = 1.10, 95% CI 1.00–1.21).

Conclusion

SHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies.

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