A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo

Vitamin E, gamma-tocopherol (γT), possesses unique anti-inflammatory activities. A short course of γT supplementation in healthy adults reduced inflammatory cytokine production and gene expression following ex vivo LPS challenge of PBMCs.

http://ift.tt/2qBKOim

Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells

Follicular helper T cells (Tfh cells) are a CD4 T cell subset essential for germinal center formation and B cell responses, although their role in allergy and allergen-specific immunotherapy (AIT) is unclear. Here, we show that AIT-treated patients have a higher ratio of regulatory Tfh cells (Tfr) to follicular T cells (Tfh) and hypothesize an IL-2 dependent mechanism.

http://ift.tt/2rbqJMT

Inflammatory Marker Analysis in Psoriatic Skin Under topical Phospodiesterase 4 Inhibitor Treatment

Topical formulations of the two PDE4i roflumilast and TAK-084 lead to a reduction of inflammatory markers and infiltrating cells in psoriatic lesional skin.

http://ift.tt/2qC45Ap

Phase 2 to Phase 3 Clinical Trial Transitions: Reasons for Success and Failure in Immunologic Diseases

http://ift.tt/2rbf8xh

ImmunoCAP cellulose displays cross-reactive carbohydrate (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels

Cellulose-based IgE assays may deliver false-positive test results of up to 2 kUa/L with recombinant allergens in strongly CCD-positive patient sera due to the presence of glycoproteins in the cellulose matrix.

http://ift.tt/2rblSLt

Expression of Semaphorin 3E Is Suppressed in Severe Asthma

The level of a previously unknown mediator, Semaphorin 3E, is diminished in the airways of severe allergic asthmatic patients. This study suggests a potential role of Semaphorin3E in the pathogenesis of asthma severity.

http://ift.tt/2qBWSQv

Pulmonary Inflammation in COPD Patients with Higher Blood Eosinophil Counts

The different nature of airway inflammation in COPD patients with higher blood eosinophil counts supports the concept of eosinophilic COPD being a subgroup of patients with distinct characteristics.

http://ift.tt/2qC33UN