Méningiomes et acétate de cyprotérone : mise au point

Publication date: Available online 25 April 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): J.-L. Schmutz




https://ift.tt/2HY0jHa

Hydratation cutanée et produits hydratants

Publication date: Available online 25 April 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): H. Duplan, T. Nocera
Une des fonctions majeures de la peau est de fournir à l'organisme une protection vis-à-vis de son environnement en maintenant une barrière épidermique efficace, non seulement vis-à-vis de l'extérieur, mais aussi vis-à-vis de la perte en eau corporelle. En effet, l'homéostasie hydrique est une condition requise pour un fonctionnement physiologique normal de la peau. Le taux d'hydratation influence non seulement les paramètres macroscopiques apparents, tels que souplesse et douceur cutanée, mais aussi des paramètres moléculaires, les activités enzymatiques et la signalisation cellulaire au sein de l'épiderme. Une part de l'eau corporelle est continuellement perdue, mais ce phénomène ainsi que le maintien d'un gradient hydrique optimal dans la peau est garanti par un ensemble de régulations fines, s'appuyant sur les propriétés fonctionnelles et dynamiques de la couche la plus superficielle de la peau constituée par le stratum corneum. Cet article rassemble les données récemment acquises dans le domaine de l'hydratation cutanée et de la caractérisation de la peau déshydratée ou sèche, que ce soit dans la compréhension des phénomènes de régulation mis en jeu ou dans l'évolution des principales techniques de mesure in situ, et par conséquent dans l'optimisation de la prise en charge.One of the skin's principal functions is to protect the body against its environment by maintaining an effective epidermal barrier, not only against external factors, but also to prevent water loss from the body. Indeed, water homeostasis is vital for the normal physiological functioning of skin. Hydration levels affect not only visible microscopic parameters such as the suppleness and softness of skin, but also molecular parameters, enzyme activities and cellular signalling within the epidermis. The body is continually losing some of its water, but this phenomenon is limited and the optimal hydration gradient in skin is ensured via a set of sophisticated regulatory processes that rely on the functional and dynamic properties of the uppermost level of the skin consisting of the stratum corneum. The present article brings together data recently acquired in the fields of skin hydration and the characterisation of dehydrated or dry skin, whether through study of the regulatory processes involved or as a result of changes in the techniques used for in situ measurement, and thus in optimisation of management.



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Angiosarcomes cutanés de la tête et du cou inopérables traités par bevacizumab et paclitaxel

Publication date: Available online 24 April 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): O. Becquart, C. Girard, C. Lesage, B. Guillot




https://ift.tt/2HXsqq1

Traitements des patients atteints de mélanome de stade III inopérable ou de stade IV. Société française de dermatologie

Publication date: Available online 25 April 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): B. Guillot, J. Charles, G. Jeudy, D. Cupissol, A. Dupuy, C. Dutriaux, D. Gangloff, N. Magne, X. Mirabel, A. M'Sadek, M. Pracht, C. Sichel, G. Do Outeiro




https://ift.tt/2FfpVMS

Xerostomia, salivary characteristics and gland volumes following intensity‐modulated radiotherapy for nasopharyngeal carcinoma: a two‐year follow up

Australian Dental Journal, EarlyView.


https://ift.tt/2HNb8y0

MHC class I presented antigens from malignancies: A perspective on analytical characterization & immunogenicity

Publication date: Available online 24 April 2018
Source:Journal of Proteomics
Author(s): Maike Schmidt, Jennie R. Lill
The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors. Several of these clinical approaches involve the exploitation of a CD8 + T cell response against MHC I presented tumor antigens. Here, we describe the types of tumor antigens which are considered as targets in the design of T cell based therapeutic approaches, the rationale for targeting MHC I antigens and the analytical tools commonly employed for the discovery of MHC I presented peptides. The advantages and disadvantages of each approach are discussed and a perspective on the future directions of the MHC I peptide exploration field and biotherapeutic strategies is given.SignificanceThis work is the first review time an article has been written to show summarize all the various types of tumor antigens, and the analytical tools employed to discover and characterize them.



https://ift.tt/2Hp97c6

Incidence and Risk Factors for Intraoperative Seizures During Elective Craniotomy

Background: Perioperative seizures may affect 1% to 50% of patients undergoing craniotomy and adversely impact outcomes. However, data on intraoperative seizures are limited. This retrospective case-control study investigated the incidence and risk factors for intraoperative seizures during elective supratentorial craniotomy involving evoked potential monitoring. Materials and Methods: Patients aged 18 years or above undergoing elective supratentorial craniotomy with evoked potential monitoring who experienced intraoperative seizures at our institution between December 2008 and March 2014 were compared with a control group generated using a random number generator. Six controls were used for each case from among the patients who underwent elective supratentorial craniotomy during the same calendar year. Multivariate analysis was conducted using logistic regression to identify the risk factors for intraoperative seizures. Results: Among the 1916 patients who met the inclusion criteria, 45 (2.3%) had intraoperative seizures. The majority of seizures occurred during burr-hole placement or craniotomy, before lesion manipulation. Timing of seizures relative to motor evoked potential runs and stimulus intensity was variable. Significant risk factors for intraoperative seizures were seizure history (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.07-4.46; P=0.03), diagnosis of brain tumor (OR, 2.41; 95% CI, 1.16-4.19; P=0.02), and temporal craniotomy (OR, 5.18; 95% CI, 2.03-13.25; P=0.001). Intraoperative prophylactic use of phenytoin/fosphenytoin and levetiracetam was protective against seizure (phenytoin/fosphenytoin: OR, 0.12; 95% CI, 0.04-0.35; P

https://ift.tt/2HWLTab