Aclaración sobre la evaluación de la obstrucción nasal mediante rinomanometría y escalas subjetivas y medición del éxito terapéutico médico y quirúrgico

Publication date: Available online 14 October 2017
Source:Acta Otorrinolaringológica Española
Author(s): Francisco Larrosa, Isam Alobid




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Migración digestiva y expulsión espontánea de un tubo de derivación salivar de Montgomery

Publication date: Available online 14 October 2017
Source:Acta Otorrinolaringológica Española
Author(s): Pablo Torrico Román




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Myopericytoma of the tongue base: A case report

Publication date: Available online 16 October 2017
Source:Acta Otorrinolaringológica Española
Author(s): Stefano Rubino, Rita De Berardinis, Daniele Colombo, Alessandro De Padova




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Diagnóstico y tratamiento de la otitis media secretora infantil: recomendaciones CODEPEH

Publication date: Available online 13 October 2017
Source:Acta Otorrinolaringológica Española
Author(s): Faustino Núñez-Batalla, Carmen Jáudenes-Casaubón, Jose Miguel Sequí-Canet, Ana Vivanco-Allende, Jose Zubicaray-Ugarteche
La incidencia y prevalencia de la otitis media secretora infantil (OMS) son elevadas, sin embargo, existen evidencias de que solo una minoría de profesionales sigue las recomendaciones de las guías para su manejo clínico. Con objeto de mejorar el diagnóstico y el tratamiento de la OMS, para prevenir y/o reducir sus consecuencias sobre el desarrollo del niño, la Comisión para la Detección Precoz de la Hipoacusia (CODEPEH) ha realizado una amplia revisión de la literatura científica sobre la materia y ha elaborado un documento de recomendaciones para una correcta actitud clínica ante la OMS, abordando métodos diagnósticos y tratamiento médico y quirúrgico. Entre otros, no usar ninguna medicación, especialmente corticoides y antibióticos, siendo la espera vigilada la primera medida a tomar durante 3 meses. Si persiste la OMS, el otorrinolaringólogo valorará el tratamiento quirúrgico. En niños que presentan comorbilidades de diversa entidad, el impacto de la OMS es superior por lo que hay que actuar de forma inmediata, sin espera vigilada.The incidence and the prevalence rates of otitis media with effusion (OME) are high. However, there is evidence that only a minority of professionals follow the recommendations provided in clinical practice guidelines. For the purpose of improving diagnosis and treatment of OME in children to prevent and/or reduce its impact on children's development, the Commission for the Early Detection of Deafness (CODEPEH) has deeply reviewed the scientific literature on this field and has drafted a document of recommendations for a correct clinical reaction to of OME, including diagnosis and medical and surgical treatment methodology. Among others, medication, in particular antibiotics and corticoids, should not be prescribed and 3 months of watchful waiting should be the first adopted measure. If OME persists, an ENT doctor should assess the possibility of sugical treatment. The impact of OME in cases of children with a comorbidity is higher, so it requires immediate reaction, without watchful waiting.



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A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflammatory diseases

Publication date: Available online 16 October 2017
Source:Materials Today
Author(s): Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang
We report the synthesis and characterization of a myeloperoxidase (MPO)-responsive, biodegradable, and luminescent material derived from functionalized cyclodextrin. The nanoparticle based on this functional material shows notably high and sustainable luminescent signals upon triggering by inflammatory conditions with abnormally elevated reactive oxygen species and MPO. Activated neutrophils during inflammatory responses can be selectively imaged using this nanoprobe, with luminescent signals positively correlated to neutrophil counts. This nanoprobe enables in vivo precise quantification and tracking of the number and dynamics of neutrophils in both superficial and deep tissues in various mouse models of inflammatory diseases, including peritonitis, paw edema, colitis, and acute lung injury. In vitro and in vivo evaluations also demonstrate the safety and biocompatibility of this newly engineered material in its native and nanoparticle forms.

Graphical abstract

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Epidermal nevus syndromes: New insights into whorls and swirls

Abstract

Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus comedonicus, congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome, phakomatosis pigmentokeratotica, Becker's nevus, porokeratotic adnexal ostial nevus, inflammatory linear verrucous epidermal nevi, and cutaneous-skeletal hypophosphatemia syndrome. We will discuss how newly defined mutations relate to the biology reflected in the cutaneous patterns seen in these mosaic disorders and how new molecular data has informed our understanding of these diseases and shaped management decisions.

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Alopecic and aseptic nodule of the scalp in a girl

Abstract

Alopecic and aseptic nodule of the scalp is a rare entity characterized by the presence of nodules or cysts with sterile punctured material and negative cultures accompanied by nonscarring alopecia in the scalp of young men. We describe a case in which an 11-year-old girl presented with a nodular, fluctuant, round lesion on the vertex with localized alopecia. High-resolution ultrasound showed a hypoechoic lesion with increased flow on Doppler imaging and culture of the citrine-yellowish material obtained by puncture was negative. The patient showed complete clinical response to treatment with topical indomethacin.

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