Purpose: Adequate suppression of cardiac glucose metabolism increases the interpretability and diagnostic reliability of 18F-FDG-PET studies performed for cardiac inflammation and infection detection. There are no standardized guidelines, though prolonged fasting (>6 h), carbohydrate-restricted diets, fatty meals and heparin loading have all been proposed. The aim of this study was to compare the three preparatory protocols used in our institution. Methods: A total of 150 18F-FDG-PET scans were selected and grouped according to three preparatory protocols (50 consecutive scans per group): 6 hour fast (group 1), low carbohydrate diet + 12 hour fast (group 2) and low carbohydrate diet + 12 hour fast + 50 IU/kg IV heparin pre-administration (group 3). Consecutive scans were retrospectively included from time-frames during which the particular protocol was used. Group 1 included oncological indications, group 2 and 3 infection or inflammation detection. Cardiac segments with cardiac inflammation or infection foci confirmed on other imaging modalities were excluded from the analysis. FDG uptake in normal myocardium was scored according to a five-point scale ranging from 0 (less than left ventricle blood pool) to 4 (diffuse uptake above liver). Adequate suppression was defined as uptake less than liver without focal uptake (scores 0-2). Results: Adequate suppression differed significantly between groups: 28% in group 1, 54% in group 2 and 88% in group 3 (p<0.0001 for all comparisons). Conclusion: Single dose heparin pre-administration before 18F-FDG-PET in addition to low carbohydrate diet significantly outperforms low carbohydrate diet alone in adequately suppressing cardiac glucose metabolism.
from Medicine via xlomafota13 on Inoreader http://ift.tt/1OV91VU
via IFTTT
from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OV9reO
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου