Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer

Patients with HPV positive oropharyngeal squamous cell carcinoma (OPSCC) are known to have a significantly more favorable prognosis than their HPV negative counterparts [1]. The substantially better prognosis of these patients has created new challenges in determining the optimal treatment approach. While concurrent chemoradiotherapy to 70Gy is presently the standard of care for OPSCC, this recommendation is based on randomized clinical trials which were dominated by HPV negative patients. As a result, it is difficult to extrapolate from historical trials to determine the optimal treatment strategy for the HPV positive patient.

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