The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity.

The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity.

Oncoimmunology. 2016;5(1):e1069462

Authors: Hargadon KM

Abstract
We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth.

PMID: 26942090 [PubMed - as supplied by publisher]

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