BioEssays 52016

Revival of trade - exchange of goods - heralded the end of the Dark Ages in Europe, bringing upon the intellectual awaking of the Renaissance. Likewise, global and local histone turnover is shaping cell-type specific functions in the nervous system, critical for neurological plasticity and cognition, disruptions of which result in disease and intellectual decline, as described by Wenderski and Maze on page 410. Original artwork based on illumination from the 15th century Trattato de Arithmetica, depicting two merchants engaged in (histone) barter transaction, with histone H3/H4 dimer and nucleosome structures depicted (PDB structures 2HUE and AOI1, respectively).

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