Association of non-melanoma skin cancer with second non-cutaneous malignancy in the Women's Health Initiative

Abstract

Non-melanoma skin cancer (NMSC), the most prevalent cancer in the US,¹ has been associated with increased risk of non-cutaneous malignancies, including breast cancer, lung cancer, and lymphoma. ^2-7 In the Women's Health Initiative (WHI) Observational Study (OS), women with NMSC history at baseline were more likely to report history of another cancer (Odds ratio [OR] = 2.3, 95% CI = 2.18 –2.44.⁶ Subsequently, Nurses Health Study (NHS) prospective analyses found increased risk of developing breast cancer, lung cancer, and melanoma in women with NMSC.⁷ We sought to replicate these prospective findings in the large WHI cohort, for which important potential confounders, e.g. smoking and body mass index, and rich phenotypic data are available.

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