Recombinant bone morphogenetic protein in patients under 18 years of age
[image: alertIcon.gif] Publication date: Available online 25 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): K. Kumar, M. Nagarjuna, R. Raut, H. Pipalia from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1WVjqWo from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22pVxpn via IFTTT
Primer Part 1—The building blocks of epilepsy genetics
[image: cover.gif?v=1&s=353a143970dce8336631be13] Summary This is the first of a two-part primer on the genetics of the epilepsies within the Genetic Literacy Series of the Genetics Commission of the International League Against Epilepsy. In Part 1, we cover the foundations of epilepsy genetics including genetic epidemiology and the range of genetic variants that can affect the risk for developing epilepsy. We discuss various epidemiologic study designs that have been applied to the genetics of the epilepsies including population studies, which provide compelling evidence for a st...περισσότερα »
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Allergy to fish collagen
: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish via Allergology International Publication date: Available online 25 May 2016 *Source:*Allergology International Author(s): Yukihiro Kobayashi, Takuma Kuriyama, Ryoko Nakagawara, Michiko Aihara, Naoko Hamada-Sato BackgroundParvalbumin was identified as a major fish allergen, and has been well investigated. Collagen was identified as a second allergen; however, its allergenic properties remain uncharacterized. Although fish is an important staple in coastal count...περισσότερα »
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Intramuscular botulinum toxin injection
additional to arthrocentesis in the management of temporomandibular joint pain via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Oksana Ivask, Edvitar Leibur, Stephanie Akermann, Tiia Tamme, Ülle Voog-Oras ObjectiveThe aim of this study was to compare the effect of intramuscular injection of botulinum toxin (BTX-A) as an adjunct to arthrocentesis between BTX-A injection only in the treatment of temporomandibular joint disorders (TMD-s) with masticatory muscles tension.Study DesignThe cl...περισσότερα »
Cyst Like Lesion in Mandibular Coronoid Process
: an Unusual Location via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Elif Keriş Yıldızer, Kahraman Gungor, Sevil Altundag Kahraman [image: Panoramic radiograph of the lesion.] [image: The patient's CBCT images showing a unilocular, well-defined radiolucent lesion ...] [image: Giant cell granuloma with multinucleated giant cells (haematoxylin and eosin ...] [image: Three-year postoperative radiograph.] from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inorea... περισσότερα »
Neural and neurochemical basis of reinforcement-guided decision making
Decision making is an adaptive behavior that takes into account several internal and external input variables and leads to the choice of a course of action over other available and often competing alternatives. While it has been studied in diverse fields ranging from mathematics, economics, ecology and ethology, to psychology and neuroscience, recent cross-talk among perspectives from different fields have yielded novel descriptions of decision processes. Reinforcement guided decision making models are based on economic and reinforcement learning theories and their focus is on the ... περισσότερα »
Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome
The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e the mechanism by which brain PCO2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (TASK-2, GPR4) as well as synaptic input from peripheral chemoreceptors and other brain regions. Murine models of Congenital Central Hypoventilation Syndrome designed with PHOX2B mutations have...περισσότερα »
A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex
Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) enables non-invasive neurophysiological investigation of the human cortex. A TMS paradigm of short-latency afferent inhibition (SAI) is characterised by attenuation of the motor evoked potential (MEP) and modulation of N100 of the TMS-evoked potential (TEP) when TMS is delivered to motor cortex (M1) following median nerve stimulation. SAI is a marker of cholinergic activity in the motor cortex, however, the SAI has not been tested from the prefrontal cortex. We aimed to explore the effect of SAI in dor... περισσότερα »
Short-latency afferent inhibition determined by the sensory afferent volley
Short-latency afferent inhibition (SAI) is characterized by the suppression of the Transcranial magnetic stimulation (TMS) motor evoked potential (MEP) by the cortical arrival of a somatosensory afferent volley. It remains unknown whether the magnitude of SAI reflects changes in the sensory afferent volley, similar to that observed for somatosensory evoked potentials (SEPs). The present study investigated stimulus-response relationships between sensory nerve action potentials (SNAPs), SAI and SEPs, and their interrelatedness. Experiment 1 (n=23, aged 23 ± 1.5) investigated the sti... περισσότερα »
Synaptic integration of transplanted interneuron progenitor cells into native cortical networks
Interneuron-based cell transplantation is a powerful method to modify network function in a variety of neurological disorders, including epilepsy. Whether new interneurons integrate into native neural networks in a subtype-specific manner is not well understood and the therapeutic mechanisms underlying interneuron-based cell therapy, including the role of synaptic inhibition, are debated. Here, we tested subtype-specific integration of transplanted interneurons using acute cortical brain slices and visualized patch clamp recordings to measure excitatory synaptic inputs, intrinsic ... περισσότερα »
Does gravity influence the visual line bisection task?
The visual line bisection task (LBT) is sensitive to perceptual biases of visuospatial attention, showing slight leftward (for horizontal lines) and upward (for vertical lines) errors in healthy subjects. It may be solved in an egocentric or allocentric reference frame and there is no obvious need for graviceptive input. However, for other visual line adjustments, such as the subjective visual vertical, otolith input is integrated. We hypothesized that graviceptive input is incorporated when performing the LBT and predicted reduced accuracy and precision when roll-tilted. Twenty h... περισσότερα »
Differences in Chloride Gradients Allow for Three Distinct Types of Synaptic Modulation by Endocannabinoids
Endocannabinoids can elicit persistent depression of excitatory and inhibitory synapses, reducing or enhancing (disinhibiting) neural circuit output, respectively. In this study, we examined whether differences in Cl- gradients can regulate which synapses undergo endocannabinoid-mediated synaptic depression vs. disinhibition using the well-characterized central nervous system (CNS) of the medicinal leech, Hirudo verbana. Exogenous application of endocannabinoids or capsaicin elicits potentiation of pressure (P) cell synapses and depression of both polymodal (Npoly) and mechanical ...περισσότερα »
PREFERENTIAL DISTRIBUTION OF NOCICEPTIVE INPUT TO MOTOR NEURONS WITH MUSCLE UNITS IN THE CRANIAL PORTION OF THE UPPER TRAPEZIUS MUSCLE
Pain is associated with changes in the neural drive to muscles. For the upper trapezius muscle, surface EMG recordings have indicated that acute noxious stimulation in either the cranial or the caudal region of the muscle leads to a relative decrease in muscle activity in the cranial region. It is however not known if this adaption reflects different recruitment thresholds of the upper trapezius motor units in the cranial and caudal region or a non-uniform nociceptive input to the motor units of both regions. This study investigated these potential mechanisms by direct motor unit ... περισσότερα »
Heat pulse excitability of vestibular hair cells and afferent neurons
In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells and afferent neurons. We recorded whole-cell currents in mammalian type II vestibular hair cells using an excised preparation (mouse), and action potentials (APs) in afferent neurons in vivo (chinchilla) in response to optical heat pulses applied to the crista (T0.25°C pulse -1). Afferent spike trains evoked by heat pulse stimuli were diverse and included asynchronous inhibition, asynchronous excitation,... περισσότερα »
Superficial Mucocele of the Ventral Tongue
: Presentation of a Rare Case and Literature Review via Oral and Maxillofacial Surgery Publication date: June 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 6 Author(s): John K. Brooks, Kevin G. Schwartz, John R. Basile [image: Superficial mucocele on the ventral tongue.] [image: Photomicrographs of superficial mucocele. A, Flattened overlying epithelium and ...] [image: Positive mucin staining with mucicarmine (original magnification, ×10; ...] The superficial mucocele is a rare variant of the common mucocele and noted microscopically by subepithelial pools o...περισσότερα »
A new technique to open an airway in emergencies with partial resection of the cricoid cartilage
Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage: Cricotracheostomy is suitable for use in high-risk situations when urgent endotracheal intubation and conventional open tracheostomy cannot be achieved. We successfully removed the anterior portion of the cricoid cartilage to establish access to the airways in seven patients with cancer of the head and neck without complications, and the stomas were closed in three patients who had no stenosis of the larynx. from #Med Blogs by Alexandros G.Sfakianakis via Alexandros ...περισσότερα »
The binaural transfer function on perceived externalization in a reverberant environment
The role of spectral detail in [image: cm_sbs_024_plain.png] Individual binaural room impulse responses (BRIRs) were recorded at a distance of 1.5 m for azimuth angles of 0° and 50° in a reverberant room. Spectral details were reduced in either the direct or the reverberant part of the BRIRs by averaging the magnitude responses with band-pass filters. For various filter bandwidths, the modified BRIRs were convolved with broadband noise and listeners judged the perceived position of the noise when virtualized over headphones. Only reductions in spectral details of the direct part ob...περισσότερα »
Indexing head movement during speech production using optical markers
Indexing head movement during speech production using optical markers: Optical marker tracking integrated with electromagnetic articulometry was used to assess the movement extent of various points on (a) forehead skin and (b) points on a head-mounted apparatus, relative to a fixed point just above the upper incisors, and to compare the accuracy of the two different approaches to indexing head position during speech production. Both methods can provide a satisfactory index of head position. If skin-affixed markers are used, a minimum of 4 is recommended. Locations for optimal marker ...περισσότερα »
Hearing Impairment : Spectrum and Frequency of the GJB2 Gene Pathogenic Variants
Spectrum and Frequency of the GJB2 Gene Pathogenic Variants in a Large Cohort of Patients with Hearing Impairment Living in a Subarctic Region of Russia (the Sakha Republic): by Nikolay A. Barashkov, Vera G. Pshennikova, Olga L. Posukh, Fedor M. Teryutin, Aisen V. Solovyev, Leonid A. Klarov, Georgii P. Romanov, Nyurgun N. Gotovtsev, Andrey A. Kozhevnikov, Elena V. Kirillina, Oksana G. Sidorova, Lena M. Vasilyevа, Elvira E. Fedotova, Igor V. Morozov, Alexander A. Bondar, Natalya A. Solovyevа, Sardana K. Kononova, Adyum M. Rafailov, Nikolay N. Sazonov, Anatoliy N. Alekseev, Mikhail I.... περισσότερα »
Temporal Change in Voice Quality After Thyroidectomy
Analysis of Temporal Change in Voice Quality After Thyroidectomy: Single-institution Prospective Study via Voice Publication date: Available online 25 May 2016 *Source:*Journal of Voice Author(s): Doh Young Lee, Ki Jeong Lee, Soo Min Hwang, Kyoung Ho Oh, Jae-Gu Cho, Seung-Kuk Baek, Soon-Young Kwon, Jeong-Soo Woo, Kwang-Yoon Jung ObjectivesThis study analyzed the temporal changes of voice quality after thyroidectomy and assessed the predictive perioperative parameters of postthyroidectomy voice disorder (PTVD).Study designThis is a prospective cohort study.MethodsFrom March 2011 to July... περισσότερα »
Cancer
2m Comparison of Eligibility Criteria Between Protocols, Registries, and Publications of Cancer Clinical Trials Trial registration and public accessibility of appended or published protocols of phase III randomized clinical trials (RCTs) allow comparison of reported research with essential aspects of trial design. We determined how eligibility criteria of participants specified in protocols were described in trial... 2m PD-1 Pathway Blockade in EGFR-mutant and ALK-positive NSCLC Purpose: PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NSC... περισσότερα »
Uranium removal by novel graphene oxide-immobilized Saccharomyces cerevisiae gel beads
[image: S0265931X.gif] Publication date: October 2016 *Source:*Journal of Environmental Radioactivity, Volumes 162–163 Author(s): Can Chen, Jianlong Wang To evaluate its ability to absorb dissolved uranium (VI), the waste biomass of Saccharomyces cerevisiae was immobilized using different agents, including Ca-alginate (Ca-SA), Ca-alginate with graphene oxide (GO), polyvinyl alcohol (PVA, 5% or 10%, w/v)-SA-GO in CaCl2-boric acid solution. The experimental results showed that graphene oxide at 0.01% (w/v) could enhance the performance of the immobilized cells. The yeast gel beads pre... περισσότερα »
The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain.
Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments... περισσότερα »
Publication date: Available online 26 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Richard L. Wasserman, Mark R. Stein, M. Elizabeth M. Younger, Shahnaz Fatteh, Elie Haddad from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/20ENQKr
Adoptive transfer of food allergy via unrelated allogeneic bone marrow transplant
Publication date: Available online 26 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Bhagirathbhai Dholaria, Arveen Bhasin, Murli Krishna, Laura Finn from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1XyCEzz
Association of FEF25%–75% and bronchodilator reversibility with asthma control and asthma morbidity in inner-city children with asthma
Publication date: Available online 26 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Watcharoot Kanchongkittiphon, Jonathan M. Gaffin, Lianne Kopel, Carter R. Petty, Mary E. Bollinger, Rachel L. Miller, Matthew Perzanowski, Elizabeth C. Matsui, Wanda Phipatanakul from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/20EMZJD
Occupational allergic respiratory disease due to royal jelly
Publication date: Available online 26 May 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Elisa Gómez Torrijos, Yesica Méndez Diaz, Jesús M. Borja Segade, J. Francisco Feo Brito, Teresa Alfaya Arias, Pedro A. Galindo Bonilla, Amalia Ledesma Fernandez, Rosa García Rodríguez from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1XyD09s
Clinical implication of the serum periostin level for differentiating phenotypes of NSAID hypersensitivity
Publication date: Available online 25 May 2016 *Source:*Allergology International Author(s): Mi-Ae Kim, Moon Kyung Yoon, Young-Soo Lee, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Ji-Hye Kim, Ga Young Ban, Young-Min Ye, Hae-Sim Park from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/20EkMTe
Allergy to fish collagen: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish
Publication date: Available online 25 May 2016 *Source:*Allergology International Author(s): Yukihiro Kobayashi, Takuma Kuriyama, Ryoko Nakagawara, Michiko Aihara, Naoko Hamada-Sato BackgroundParvalbumin was identified as a major fish allergen, and has been well investigated. Collagen was identified as a second allergen; however, its allergenic properties remain uncharacterized. Although fish is an important staple in coastal countries, its thermostability is unknown. Therefore, we aimed to determine the thermostability of fish collagen as an allergen.MethodsMeat of seven bony and f... περισσότερα »
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
*Actinobacillus pleuropneumoniae* (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of APP biofilm in immune evasion and infection persistence. This study was undertaken to (i) investigate biofilm-associated LPS modifications occurring during the switch to biofilm mode of growth; and (ii) characterize pro-inflammatory cytokines expression in porcine pulmonary alveolar macrophages (PAMs) and proliferation in porcine PBMCs challenged...περισσότερα »
Allergy to fish collagen
: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish via Allergology International Publication date: Available online 25 May 2016 *Source:*Allergology International Author(s): Yukihiro Kobayashi, Takuma Kuriyama, Ryoko Nakagawara, Michiko Aihara, Naoko Hamada-Sato BackgroundParvalbumin was identified as a major fish allergen, and has been well investigated. Collagen was identified as a second allergen; however, its allergenic properties remain uncharacterized. Although fish is an important staple in coastal count...περισσότερα »
Intramuscular botulinum toxin injection
additional to arthrocentesis in the management of temporomandibular joint pain via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Oksana Ivask, Edvitar Leibur, Stephanie Akermann, Tiia Tamme, Ülle Voog-Oras ObjectiveThe aim of this study was to compare the effect of intramuscular injection of botulinum toxin (BTX-A) as an adjunct to arthrocentesis between BTX-A injection only in the treatment of temporomandibular joint disorders (TMD-s) with masticatory muscles tension.Study DesignThe cl...περισσότερα »
Cyst Like Lesion in Mandibular Coronoid Process
: an Unusual Location via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Elif Keriş Yıldızer, Kahraman Gungor, Sevil Altundag Kahraman [image: Panoramic radiograph of the lesion.] [image: The patient's CBCT images showing a unilocular, well-defined radiolucent lesion ...] [image: Giant cell granuloma with multinucleated giant cells (haematoxylin and eosin ...] [image: Three-year postoperative radiograph.]
Superficial Mucocele of the Ventral Tongue
: Presentation of a Rare Case and Literature Review via Oral and Maxillofacial Surgery Publication date: June 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 6 Author(s): John K. Brooks, Kevin G. Schwartz, John R. Basile [image: Superficial mucocele on the ventral tongue.] [image: Photomicrographs of superficial mucocele. A, Flattened overlying epithelium and ...] [image: Positive mucin staining with mucicarmine (original magnification, ×10; ...] The superficial mucocele is a rare variant of the common mucocele and noted microscopically by subepithelial pools o...περισσότερα »
A new technique to open an airway in emergencies with partial resection of the cricoid cartilage
Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage: Cricotracheostomy is suitable for use in high-risk situations when urgent endotracheal intubation and conventional open tracheostomy cannot be achieved. We successfully removed the anterior portion of the cricoid cartilage to establish access to the airways in seven patients with cancer of the head and neck without complications, and the stomas were closed in three patients who had no stenosis of the larynx.
Individuals with Non-Syndromic Oral Clefts
Psychiatric Diagnoses in Individuals with Non-Syndromic Oral Clefts: A Danish Population-Based Cohort Study: by Dorthe Almind Pedersen, George L. Wehby, Jeffrey C. Murray, Kaare Christensen Background The aim of this study was to investigate the risk of psychiatric diagnoses in individuals with non-syndromic oral clefts (OC) compared with individuals without OC, including ages from 1 to 76 years. Methods Linking four Danish nationwide registers, we investigated the risk of psychiatric diagnoses at Danish psychiatric hospitals during the period 1969–2012 for individuals born wi... περισσότερα »
Recombinant bone morphogenetic protein
in patients under 18 years of age: In January 2015, the US Food and Drug Administration (FDA) issued a drug safety communication warning related to the use of bone graft substitutes containing recombinant proteins or synthetic peptides in patients under 18 years of age. The safety communication cited reports of serious injuries such as excess bone growth, fluid accumulation, inhibited bone healing, swelling, and pressure on the adjacent vital organs following the use of bone graft substitutes containing proteins or synthetic peptides.
Hyperfractionated Intensity-modulated Radiotherapy (IMRT) Versus Conventional Fraction IMRT for Patients With Loco-regionally Recurrent Nasopharyngeal Carcinoma.
Hyperfractionated Intensity-modulated Radiotherapy (IMRT) Versus Conventional Fraction IMRT for Patients With Loco-regionally Recurrent Nasopharyngeal Carcinoma.: *Conditions*: Nasopharyngeal Neoplasms; Mortality; Quality of Life; Complications *Interventions*: Radiation: Hyperfractionated IMRT; Radiation: Conventional Fraction IMRT *Sponsor*: Sun Yat-sen University ArmsAssigned Interventions Experimental: Hyperfractionated IMRT Group IMRT (total dose of 65Gy, division 54 times, twice a day, once 1.2Gy, irradiation interval of 6-8 hours) Radiation: Hyperfractionated ... περισσότερα »
The Pneupac VR1 Portable Ventilator and Manual Ventilation
A RCT to Compare the Pneupac VR1 Portable Ventilator and Manual Ventilation Via a Mapleson C- Circuit During the Intra-hospital Transfers of Intubated Patients: *Condition*: Cancer *Intervention*: Device: Pneupac VR1 *Sponsors*: Brighton and Sussex University Hospitals NHS Trust; St Thomas' Hospital, London Following major head and neck surgery it may be necessary to keep patients intubated and ventilated for at least 12 hours to allow the swelling associated with the operation to subside. Therefore patients (participants) are transferred to the intensive care unit anaest... περισσότερα »
Endoscopic Zenker's diverticulotomy
The safety and efficacy of endoscopic Zenker's diverticulotomy: A cohort study: Objectives/Hypothesis To determine whether the application of laser-assisted techniques for the treatment of Zenker's diverticulum would reduce the failure rate of endoscopic procedures without compromising safety or durability. Study Design Cohort study with long-term follow-up. Methods We performed a single-institution review of 106 consecutive patients in whom endoscopic laser-assisted diverticulotomy (ELD) or endoscopic stapler-assisted diverticulotomy (ESD) was attempted. The Eating Assessment T...περισσότερα »
Amitriptyline treatment for idiopathic cough
Long-term follow-up of Objectives/Hypothesis To evaluate short- and long-term treatment outcomes of amitriptyline for idiopathic cough. Study Design Retrospective chart review and anonymous survey of a patient cohort. Methods We evaluated a cohort of adults treated for cough at the Duke Voice Care Center with amitriptyline over a 2- to 3-year period. We characterized demographics, symptoms, treatment variability, and treatment effects from chart review and survey responses. We performed univariate analysis comparing cough improvement to age, gender, symptoms of throat irritation, co... περισσότερα »
Type II thyroplasty on phonatory physiology
Evaluation of type II thyroplasty on phonatory physiology in an excised canine larynx model: Objectives/Hypothesis Type II thyroplasty is an alternative treatment for spasmodic dysphonia, addressing hyperadduction by incising and lateralizing the thyroid cartilage. We quantified the effect of lateralization width on phonatory physiology using excised canine larynges. Methods Normal closure, hyperadduction, and type II thyroplasty (lateralized up to 5 mm at 1-mm increments with hyperadducted arytenoids) were simulated in excised larynges (N = 7). Aerodynamic, acoustic, and videok... περισσότερα »
HNCs
Factors that impact health-related quality of life over time for individuals with head and neck cancer: Objectives/Hypothesis To identify sociodemographic, behavioral, and clinical factors associated with health-related quality of life (HRQOL) for head and neck cancer (HNC) patients over time. Study Design A population-based longitudinal cohort study. Methods Newly diagnosed HNC patients (N = 587) were administered the Functional Assessment of Cancer Therapy–Head and Neck questionnaire at baseline (median 3 months postdiagnosis) and two follow-up assessments (median 22 and 42 mo...περισσότερα »
Aesthetic rhinoplasty :, The Body Dysmorphic Disorder Questionnaire–Aesthetic Surgery (BDDQ-AS)
Body Dysmorphic Disorder in aesthetic rhinoplasty: Validating a new screening tool: Objectives/Hypothesis To validate a new screening tool for body dysmorphic disorder (BDD) in patients seeking aesthetic rhinoplasty. Study Design We performed a prospective instrument validation study in an academic rhinology clinic. Methods The Body Dysmorphic Disorder Questionnaire–Aesthetic Surgery (BDDQ-AS) is a seven-item short questionnaire validated in 116 patients undergoing aesthetic rhinoplasty. Screening was positive if the patient acknowledged on the BDDQ-AS that he/she was concerned ... περισσότερα »
Long-term Macrolide therapy in Chronic Rhinosinusitis
The value of a Feasibility Study into long-term Macrolide therapy in Chronic Rhinosinusitis: Abstract Objectives There is currently conflicting level 1 evidence in the use of long-term antibiotics for chronic rhinosinusitis without nasal polyps. The primary aim of this feasibility study was to optimise future randomised trial design by assessing recruitment and retention of patients alongside providing preliminary data on symptomatic control. Design Prospective, multi-centre feasibility (cohort) study with all patients receiving macrolide therapy for 12-weeks and a further subse... περισσότερα »
Focus Harmonic scalpel and other hemostatic techniques in open thyroidectomy
Comparison between Focus Harmonic scalpel and other hemostatic techniques in open thyroidectomy: A systematic review and meta-analysis: Abstract Background The purpose of this review was to compare the efficacy and surgical outcomes of total thyroidectomy between the Focus Harmonic scalpel (Ethicon, Cincinnati, OH) and other hemostatic procedures. Methods An extensive search was conducted using the PubMed and Cochrane databases from January 2008 to October 2014. Operating time, blood loss, pain, complications, and hospital stay were evaluated. Results When compared with conventio... περισσότερα »
Radiation dose distribution in the teeth, maxilla, and mandible
of patients with oropharyngeal and nasopharyngeal tumors who were treated with intensity-modulated radiotherapy: Abstract Background The purpose of this study was to evaluate the distribution of the intensity-modulated radiotherapy (IMRT) dose delivered to the teeth, maxilla, and mandible. Methods The mean dose (Dmean) and maximum dose (Dmax) of radiation for the maxilla, mandible, and teeth of 63 patients with oropharyngeal (*n* = 44) or nasopharyngeal (*n* = 19) tumors were retrospectively evaluated. Results The posterior regions of the mandible received the highest doses, and... περισσότερα »
Intestinal-type sinonasal adenocarcinomas
The road to molecular diagnosis and personalized treatment: Abstract Background Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized. Methods Articles on ...περισσότερα »
Children Born to Mothers with Gum Inflammation during Pregnancy
Risk of Allergic Rhinitis, Allergic Conjunctivitis, and Eczema in Children Born to Mothers with Gum Inflammation during Pregnancy: by Vivian Chia-Rong Hsieh, Chin-Chen Liu, Yu-Chen Hsiao, Trong-Neng Wu Purpose Despite links between maternal and child health status, evidence on the association between gum infection in pregnant mothers and childhood allergies is scarce. We aim to evaluate the risk of developing allergy in children born to periodontal mothers in a nationwide study. Methods We conducted a 9-year population-based, retrospective cohort study using Taiwan's National H...περισσότερα »
Risk of Allergic Rhinitis, Allergic Conjunctivitis, and Eczema in Children
Children Born to Mothers with Gum Inflammation during Pregnancy: by Vivian Chia-Rong Hsieh, Chin-Chen Liu, Yu-Chen Hsiao, Trong-Neng Wu Purpose Despite links between maternal and child health status, evidence on the association between gum infection in pregnant mothers and childhood allergies is scarce. We aim to evaluate the risk of developing allergy in children born to periodontal mothers in a nationwide study. Methods We conducted a 9-year population-based, retrospective cohort study using Taiwan's National Health Insurance database. A study cohort of 42,217 newborns born t...περισσότερα »
The GJB2 Gene Pathogenic Variants
Spectrum and Frequency of the GJB2 Gene Pathogenic Variants in a Large Cohort of Patients with Hearing Impairment Living in a Subarctic Region of Russia (the Sakha Republic): by Nikolay A. Barashkov, Vera G. Pshennikova, Olga L. Posukh, Fedor M. Teryutin, Aisen V. Solovyev, Leonid A. Klarov, Georgii P. Romanov, Nyurgun N. Gotovtsev, Andrey A. Kozhevnikov, Elena V. Kirillina, Oksana G. Sidorova, Lena M. Vasilyevа, Elvira E. Fedotova, Igor V. Morozov, Alexander A. Bondar, Natalya A. Solovyevа, Sardana K. Kononova, Adyum M. Rafailov, Nikolay N. Sazonov, Anatoliy N. Alekseev, Mikhail I... περισσότερα »
Die Behandlung von Tränenwegsstenosen aus HNO‑ärztlicher Sicht
Die Behandlung von Tränenwegsstenosen aus HNO‑ärztlicher Sicht: Zusammenfassung HintergrundDie Epiphora ist das klassische Symptom der postsakkalen Tränenwegsstenose und betrifft insbesondere ältere Patienten. Die extranasale Dakryozystorhinostomie (DZR) nach Toti und die endonasale DZR nach West stellen etablierte Therapieverfahren dar. Ziel der ArbeitDie Ursachen der postsakkalen Tränenwegsstenose und deren Diagnostik werden beleuchtet und die Therapiemöglichkeiten anhand aktueller Literatur unter besonderer Berücksichtigung der Sicht des Hals-Nasen-Ohren-Arztes diskutiert. ... περισσότερα »
Medizinpsychologische Aspekte bei der Behandlung kindlicher Tränenabflussstörungen
Medizinpsychologische Aspekte bei der Behandlung kindlicher Tränenabflussstörungen: Zusammenfassung HintergrundDie Sondierung und Überdruckspülung der ableitenden Tränenwege (TNW) bei konnataler Dakryostenose kann in Lokalanästhesie (LA) oder Allgemeinanästhesie (AA) durchgeführt werden. Dabei können durch Schmerzen und Ängste starke Stressempfindungen bei Eltern und behandelten Kindern entstehen. MethodikMittels Fragebögen (*n* = 65) beurteilten die Eltern ihr eigenes Stressempfinden sowie das ihrer Kinder. Untersucht wurden Einfluss der Anästhesieform, Vertrauen in die ärztl... περισσότερα »
Monoscopic photogrammetry to obtain 3D models
by a mobile device: a method for making facial prostheses: Abstract PurposeThe aim of this study is to present the development of a new technique to obtain 3D models using photogrammetry by a mobile device and free software, as a method for making digital facial impressions of patients with maxillofacial defects for the final purpose of 3D printing of facial prostheses. MethodsWith the use of a mobile device, free software and a photo capture protocol, 2D captures of the anatomy of a patient with a facial defect were transformed into a 3D model. The resultant digital models we... περισσότερα »
Staging and follow-up of high-grade malignant salivary gland tumours : Adenoid cystic carcinoma is the most common high-grade malignant tumour. • Imaging: MRI is the best choice for T-staging a malignant salivary tumour. • Combining traditional MRI with functional MRI improves diagnostic accuracy. • US guided FNAC may confirm nature of primary tumour lymph node metastases. • Follow-up: In high-grade malignant tumours FDG PET/CT is not recommended on a routine basis.
: The role of traditional versus functional imaging approaches – A review via ScienceDirect Publication: Oral Oncology [image: M, 56yrs, pre-auricular swelling, slowly increasing in size over months. ...] [image: Highly malignant parotid tumour on the left in 72yrs female, who had been ...] [image: (A and B) Axial SET1 post Gadolinium with fat saturation. Patient operated for ...] [image: (A and B) Low-grade mucoepidermoid carcinoma of left parotid gland. The tumour ...] [image: (A–H). (A and B) Recurrent adenoid cystic carcinoma of minor salivary gland ...] [image: (A–D) 18FDG-PET CT... περισσότερα »
Synaptic integration of transplanted interneuron progenitor cells into native cortical networks
Interneuron-based cell transplantation is a powerful method to modify network function in a variety of neurological disorders, including epilepsy. Whether new interneurons integrate into native neural networks in a subtype-specific manner is not well understood and the therapeutic mechanisms underlying interneuron-based cell therapy, including the role of synaptic inhibition, are debated. Here, we tested subtype-specific integration of transplanted interneurons using acute cortical brain slices and visualized patch clamp recordings to measure excitatory synaptic inputs, intrinsic ... περισσότερα »
Does gravity influence the visual line bisection task?
The visual line bisection task (LBT) is sensitive to perceptual biases of visuospatial attention, showing slight leftward (for horizontal lines) and upward (for vertical lines) errors in healthy subjects. It may be solved in an egocentric or allocentric reference frame and there is no obvious need for graviceptive input. However, for other visual line adjustments, such as the subjective visual vertical, otolith input is integrated. We hypothesized that graviceptive input is incorporated when performing the LBT and predicted reduced accuracy and precision when roll-tilted. Twenty h... περισσότερα »
Differences in Chloride Gradients Allow for Three Distinct Types of Synaptic Modulation by Endocannabinoids
Endocannabinoids can elicit persistent depression of excitatory and inhibitory synapses, reducing or enhancing (disinhibiting) neural circuit output, respectively. In this study, we examined whether differences in Cl- gradients can regulate which synapses undergo endocannabinoid-mediated synaptic depression vs. disinhibition using the well-characterized central nervous system (CNS) of the medicinal leech, Hirudo verbana. Exogenous application of endocannabinoids or capsaicin elicits potentiation of pressure (P) cell synapses and depression of both polymodal (Npoly) and mechanical ...περισσότερα »
PREFERENTIAL DISTRIBUTION OF NOCICEPTIVE INPUT TO MOTOR NEURONS WITH MUSCLE UNITS IN THE CRANIAL PORTION OF THE UPPER TRAPEZIUS MUSCLE
Pain is associated with changes in the neural drive to muscles. For the upper trapezius muscle, surface EMG recordings have indicated that acute noxious stimulation in either the cranial or the caudal region of the muscle leads to a relative decrease in muscle activity in the cranial region. It is however not known if this adaption reflects different recruitment thresholds of the upper trapezius motor units in the cranial and caudal region or a non-uniform nociceptive input to the motor units of both regions. This study investigated these potential mechanisms by direct motor unit ... περισσότερα »
Heat pulse excitability of vestibular hair cells and afferent neurons
In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells and afferent neurons. We recorded whole-cell currents in mammalian type II vestibular hair cells using an excised preparation (mouse), and action potentials (APs) in afferent neurons in vivo (chinchilla) in response to optical heat pulses applied to the crista (T0.25°C pulse -1). Afferent spike trains evoked by heat pulse stimuli were diverse and included asynchronous inhibition, asynchronous excitation,... περισσότερα »
Superficial Mucocele of the Ventral Tongue
: Presentation of a Rare Case and Literature Review via Oral and Maxillofacial Surgery Publication date: June 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 6 Author(s): John K. Brooks, Kevin G. Schwartz, John R. Basile [image: Superficial mucocele on the ventral tongue.] [image: Photomicrographs of superficial mucocele. A, Flattened overlying epithelium and ...] [image: Positive mucin staining with mucicarmine (original magnification, ×10; ...] The superficial mucocele is a rare variant of the common mucocele and noted microscopically by subepithelial pools ...περισσότερα »
A new technique to open an airway in emergencies with partial resection of the cricoid cartilage
Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage: Cricotracheostomy is suitable for use in high-risk situations when urgent endotracheal intubation and conventional open tracheostomy cannot be achieved. We successfully removed the anterior portion of the cricoid cartilage to establish access to the airways in seven patients with cancer of the head and neck without complications, and the stomas were closed in three patients who had no stenosis of the larynx. from #Med Blogs by Alexandros G.Sfakianakis via Alexandros ...περισσότερα »
The binaural transfer function on perceived externalization in a reverberant environment
The role of spectral detail in [image: cm_sbs_024_plain.png] Individual binaural room impulse responses (BRIRs) were recorded at a distance of 1.5 m for azimuth angles of 0° and 50° in a reverberant room. Spectral details were reduced in either the direct or the reverberant part of the BRIRs by averaging the magnitude responses with band-pass filters. For various filter bandwidths, the modified BRIRs were convolved with broadband noise and listeners judged the perceived position of the noise when virtualized over headphones. Only reductions in spectral details of the direct part ob...περισσότερα »
Indexing head movement during speech production using optical markers
Indexing head movement during speech production using optical markers: Optical marker tracking integrated with electromagnetic articulometry was used to assess the movement extent of various points on (a) forehead skin and (b) points on a head-mounted apparatus, relative to a fixed point just above the upper incisors, and to compare the accuracy of the two different approaches to indexing head position during speech production. Both methods can provide a satisfactory index of head position. If skin-affixed markers are used, a minimum of 4 is recommended. Locations for optimal marker ...περισσότερα »
Hearing Impairment : Spectrum and Frequency of the GJB2 Gene Pathogenic Variants
Spectrum and Frequency of the GJB2 Gene Pathogenic Variants in a Large Cohort of Patients with Hearing Impairment Living in a Subarctic Region of Russia (the Sakha Republic): by Nikolay A. Barashkov, Vera G. Pshennikova, Olga L. Posukh, Fedor M. Teryutin, Aisen V. Solovyev, Leonid A. Klarov, Georgii P. Romanov, Nyurgun N. Gotovtsev, Andrey A. Kozhevnikov, Elena V. Kirillina, Oksana G. Sidorova, Lena M. Vasilyevа, Elvira E. Fedotova, Igor V. Morozov, Alexander A. Bondar, Natalya A. Solovyevа, Sardana K. Kononova, Adyum M. Rafailov, Nikolay N. Sazonov, Anatoliy N. Alekseev, Mikhail I.... περισσότερα »
Temporal Change in Voice Quality After Thyroidectomy
Analysis of Temporal Change in Voice Quality After Thyroidectomy: Single-institution Prospective Study via Voice Publication date: Available online 25 May 2016 *Source:*Journal of Voice Author(s): Doh Young Lee, Ki Jeong Lee, Soo Min Hwang, Kyoung Ho Oh, Jae-Gu Cho, Seung-Kuk Baek, Soon-Young Kwon, Jeong-Soo Woo, Kwang-Yoon Jung ObjectivesThis study analyzed the temporal changes of voice quality after thyroidectomy and assessed the predictive perioperative parameters of postthyroidectomy voice disorder (PTVD).Study designThis is a prospective cohort study.MethodsFrom March 2011 to Jul... περισσότερα »
Cancer
2m Comparison of Eligibility Criteria Between Protocols, Registries, and Publications of Cancer Clinical Trials Trial registration and public accessibility of appended or published protocols of phase III randomized clinical trials (RCTs) allow comparison of reported research with essential aspects of trial design. We determined how eligibility criteria of participants specified in protocols were described in trial... 2m PD-1 Pathway Blockade in EGFR-mutant and ALK-positive NSCLC Purpose: PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NS... περισσότερα »
Superficial Mucocele of the Ventral Tongue
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
: Presentation of a Rare Case and Literature Review via Oral and Maxillofacial Surgery Publication date: June 2016 Source:Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 6 Author(s): John K. Brooks, Kevin G. Schwartz, John R. Basile The superficial mucocele is a rare variant of the common mucocele and noted microscopically by subepithelial pools […]
A new technique to open an airway in emergencies with partial resection of the cricoid cartilage
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage: Cricotracheostomy is suitable for use in high-risk situations when urgent endotracheal intubation and conventional open tracheostomy cannot be achieved. We successfully removed the anterior portion of the cricoid cartilage to establish access to the airways in seven patients with […]
Individuals with Non-Syndromic Oral Clefts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
Psychiatric Diagnoses in Individuals with Non-Syndromic Oral Clefts: A Danish Population-Based Cohort Study: by Dorthe Almind Pedersen, George L. Wehby, Jeffrey C. Murray, Kaare Christensen Background The aim of this study was to investigate the risk of psychiatric diagnoses in individuals with non-syndromic oral clefts (OC) compared with individuals without OC, including ages from 1 […]
Recombinant bone morphogenetic protein
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα
in patients under 18 years of age: In January 2015, the US Food and Drug Administration (FDA) issued a drug safety communication warning related to the use of bone graft substitutes containing recombinant proteins or synthetic peptides in patients under 18 years of age. The safety communication cited reports of serious injuries such as excess […]
Recombinant bone morphogenetic protein in patients under 18 years of age
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 25 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): K. Kumar, M. Nagarjuna, R. Raut, H. Pipalia from #ENT via xlomafota13 on Inoreader http://ift.tt/1WVjqWo
Recombinant bone morphogenetic protein in patients under 18 years of age
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 25 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): K. Kumar, M. Nagarjuna, R. Raut, H. Pipalia from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1WVjqWo
Primer Part 1—The building blocks of epilepsy genetics
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
[image: cover.gif?v=1&s=353a143970dce8336631be13] Summary This is the first of a two-part primer on the genetics of the epilepsies within the Genetic Literacy Series of the Genetics Commission of the International League Against Epilepsy. In Part 1, we cover the foundations of epilepsy genetics including genetic epidemiology and the range of genetic variants that can affect the risk for developing epilepsy. We discuss various epidemiologic study designs that have been applied to the genetics of the epilepsies including population studies, which provide compelling evidence for a st...περισσότερα »
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Deformation, decomposition and hardening behavior of nano Al7075 alloy prepared by mechanical milling and hot pressing
Publication date: Available online 25 May 2016 Source:Advanced Powder Technology Author(s): Tuhin Das, R. Karunanithi, Arijit Sinha, K.S. Ghosh, Supriya Bera Al–Zn–Mg–Cu alloy with different crystallite size is prepared by mechanical milling and high temperature consolidation. X-ray line profile analysis and HRTEM image show high temperature consolidation results insignificant grain coarsening. Microhardness of the alloy… Continue reading Deformation, decomposition and hardening behavior of nano Al7075 alloy prepared by mechanical milling and hot pressing
Autophagy Guarantees Stemness of Muscle Stem Cells By Maintaining Quiescence
This article is protected by copyright. All rights reserved. (Source: Oral Diseases) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25iZSfQ via IFTTT
Schmerzreduktion durch Opioide klinisch nicht relevant
Chronische Rückenbeschwerden Erneut hat eine Metaanalyse die mangelnde Effektivität von Opioidanalgetika zur Behandlung chronischer Rückenschmerzen belegt. Jeder zweite Patient bricht die Therapie wegen Nebenwirkungen oder mangelnder Wirksamkeit ab. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Wl02BA via IFTTT
Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage
Cricotracheostomy is suitable for use in high-risk situations when urgent endotracheal intubation and conventional open tracheostomy cannot be achieved. We successfully removed the anterior portion of the cricoid cartilage to establish access to the airways in seven patients with cancer of the head and neck without complications, and the stomas were closed in three patients… Continue reading Cricotracheostomy: new technique to open an airway in emergencies with partial resection of the cricoid cartilage
Human Lymphoid Tissues Harbor a Distinct CD69+CXCR6+ NK Cell Population CLINICAL AND HUMAN IMMUNOLOGY
Knowledge of human NK cells is based primarily on conventional CD56bright and CD56dim NK cells from blood. However, most cellular immune interactions occur in lymphoid organs. Based on the coexpression of CD69 and CXCR6, we identified a third major NK cell subset in lymphoid tissues. This population represents 30–60% of NK cells in marrow, spleen,… Continue reading Human Lymphoid Tissues Harbor a Distinct CD69+CXCR6+ NK Cell Population CLINICAL AND HUMAN IMMUNOLOGY
Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens MUCOSAL IMMUNOLOGY
The liver is the largest gland in the human body and functions as an innate immune organ. Liver macrophages called Kupffer cells (KC) constitute the largest group of macrophages in the human body. Innate immune responses involving KC represent the first line of defense against pathogens in the liver. Human monocyte-derived macrophages have been used… Continue reading Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens MUCOSAL IMMUNOLOGY
CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma INNATE IMMUNITY AND INFLAMMATION
The bronchoconstrictive and proinflammatory properties of cysteinyl leukotrienes (cysLTs) in allergic asthma mediate their effects predominantly through the cysLT1 receptor (cysLT1R). However, the role of cysLTs and cysLT1R in innate immune-triggered asthma is largely unexplored. We explored the synthesis of cysLTs and cysLT1R as determinants of airway responses in an oxidative stress–induced model of irritant… Continue reading CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma INNATE IMMUNITY AND INFLAMMATION
Enhanced Expression of Brutons Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis AUTOIMMUNITY
Upon BCR stimulation, naive B cells increase protein levels of the key downstream signaling molecule Bruton's tyrosine kinase (BTK). Transgenic CD19-hBtk mice with B cell–specific BTK overexpression show spontaneous germinal center formation, anti-nuclear autoantibodies, and systemic autoimmunity resembling lupus and Sjögren syndrome. However, it remains unknown how T cells are engaged in this pathology. In… Continue reading Enhanced Expression of Brutons Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis AUTOIMMUNITY
Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease AUTOIMMUNITY
Type I IFNs play a critical role in the immune response to viral infection and may also drive autoimmunity through modulation of monocyte maturation and promotion of autoreactive lymphocyte survival. Recent demonstrations of type I IFN gene signatures in autoimmune diseases, including scleroderma, led us to investigate the pathological role of IFNs in a preclinical… Continue reading Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease AUTOIMMUNITY
Bioinformatic profiling identifies an immune-related risk signature for glioblastoma
Objective: To investigate the local immune status and its prognostic value in glioma. Methods: A cohort of 297 glioma samples with whole genome microarray expression data from the Chinese Glioma Genome Atlas database were included for discovery. The Cancer Genome Atlas (TCGA) database was used for validation. Principal components analysis and gene set enrichment analysis… Continue reading Bioinformatic profiling identifies an immune-related risk signature for glioblastoma
Recombinant bone morphogenetic protein in patients under 18 years of age
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 25 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): K. Kumar, M. Nagarjuna, R. Raut, H. Pipalia from OroFacial via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WVjqWo via IFTTT
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
Publication date: July 2016 *Source:*Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production...περισσότερα »
Deformation, decomposition and hardening behavior of nano Al7075 alloy prepared by mechanical milling and hot pressing
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: Available online 25 May 2016 Source:Advanced Powder Technology Author(s): Tuhin Das, R. Karunanithi, Arijit Sinha, K.S. Ghosh, Supriya Bera Al–Zn–Mg–Cu alloy with different crystallite size is prepared by mechanical milling and high temperature consolidation. X-ray line profile analysis and HRTEM image show high temperature consolidation results insignificant grain coarsening. Microhardness of the alloy […]
Comparison of Eligibility Criteria Between Protocols, Registries, and Publications of Cancer Clinical Trials
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Trial registration and public accessibility of appended or published protocols of phase III randomized clinical trials (RCTs) allow comparison of reported research with essential aspects of trial design. We determined how eligibility criteria of participants specified in protocols were described in trial registries and articles of 255 cancer RCTs published in leading journals. The mean […]
p110{alpha} inhibition alters PanNETs progression
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Purpose: Mutations in the PI3-kinase (PI3K) pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an exciting setting for PI3K/AKT/mTOR pharmacological intervention. Everolimus, an mTOR inhibitor, is being used to treat patients with advanced PanNETs. However, resistance to mTOR targeted therapy is emerging partially due to the […]
Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: July 2016 Source:Journal of Phonetics, Volume 57 Author(s): Natalia Kartushina, Alexis Hervais-Adelman, Ulrich Hans Frauenfelder, Narly Golestani We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish […]
PD-1 Pathway Blockade in EGFR-mutant and ALK-positive NSCLC
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Purpose: PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NSCLC); however, only a subset of patients derives clinical benefit. To determine the activity of PD-1/PD-L1 inhibitors within clinically-relevant molecular subgroups, we retrospectively evaluated response patterns among EGFR-mutant, ALK-positive, and EGFR wild-type/ALK-negative patients. Experimental Design: We identified 58 patients treated with […]
MELK confers radioresistance in TNBC
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Purpose: While effective targeted therapies exist for estrogen receptor-positive and HER2-positive breast cancer, no such effective therapies exist for triple-negative breast cancer (TNBC), thus it is clear that additional targets for radiosensitization and treatment are critically needed. Experimental Design: Expression microarrays, qRT-PCR, and western blotting were used to assess MELK RNA and protein expression levels. […]
IMA950 Phase I Trial Final Results
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
PURPOSE: To perform a two-cohort, phase 1 safety and immunogenicity study of IMA950 in addition to standard chemo-radiotherapy (CRT) and adjuvant temozolomide in patients with newly diagnosed glioblastoma (GBM). IMA950 is a novel GBM specific therapeutic vaccine containing 11 tumor-associated peptides (TUMAPs), identified on human leukocyte antigen (HLA) surface receptors in primary human GBM tissue. […]
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