In patients with acute intracerebral hemorrhage, higher neutrophils, lower lymphocytes, and higher NLRs predicted worse 3-month outcome.

Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage:

1. Simona Lattanzi, MD;
   
2. Claudia Cagnetti, MD;
   
3. Leandro Provinciali, MD;
   
4. Mauro Silvestrini, MD

1. From the Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.

1. Correspondence to Simona Lattanzi, MD, Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic
   University, Via Conca 71, 60020 Ancona, Italy. E-mail alfierelattanzisimona{at}gmail.com

Abstract

Background and Purpose—Increasing evidence suggests that inflammatory mechanisms are involved in the intracerebral hemorrhage–induced brain injury.
We evaluated the prognostic role of the peripheral leukocyte counts and neutrophil-to-lymphocyte ratio (NLR) in patients with
intracerebral hemorrhage.

Methods—Patients with acute spontaneous intracerebral hemorrhage were retrospectively identified. Total white blood cells, absolute
neutrophil count, and absolute lymphocyte count were obtained and the NLR computed from the admission blood work. The study
end point was the occurrence of death or major disability at 3 months.

Results—One hundred seventy-seven subjects were enrolled. Ninety-four (53.1%) had unfavorable outcome. The absolute neutrophil count,
absolute lymphocyte count, and NLR were independently associated with the 3-month status. The NLR resulted the best discriminating
variable and the best predictive cut-off value was 4.58.

Conclusions—In patients with acute intracerebral hemorrhage, higher neutrophils, lower lymphocytes, and higher NLRs predicted worse 3-month
outcome.

Key Words:

• Received March 31, 2016.
  
• Revision received March 31, 2016.
  
• Accepted April 12, 2016.
  

• © 2016 American Heart Association, Inc.

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