Melanoma

Ειδοποίηση Μελετητή:[ Melanoma ]

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

SE Boyle, CG Fedele, V Corbin, E Wybacz, P Szeto… - Cancer Research, 2016

Abstract The stability of markers that identify cancer cells that propagate disease is important
to the outcomes of targeted therapy strategies. In human melanoma, conflicting data exist as
to whether hierarchical expression of CD271/p75/NGFR (nerve growth factor receptor) ...

A Small Molecule Inhibitor of PDK1/PLC? 1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.

C Raimondi, V Calleja, R Ferro, A Fantin, A Riley… - 2016

Abstract Strong evidence suggests that phospholipase C? 1 (PLC? 1) is a suitable target to
counteract tumourigenesis and metastasis dissemination. We recently identified a novel
signalling pathway required for PLC? 1 activation which involves formation of a protein ...

Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo.

C Posch, H Moslehi, M Sanlorenzo, G Green, I Vujic… - Oncotarget, 2016

Mutations in the receptor tyrosine kinase c-KIT (KIT) are frequent oncogenic alterations in
melanoma and are predominantly detected in tumors of acral, mucosal, and chronically sun-
damaged skin. Research indicates that melanocytes with aberrant KIT signaling can be ...

Integrated analysis of multidimensional omics data on cutaneous melanoma prognosis

Y Jiang, X Shi, Q Zhao, M Krauthammer, BEG Rothberg… - Genomics, 2016

Multiple types of genetic, epigenetic, and genomic changes have been implicated in
cutaneous melanoma prognosis. Many of the existing studies are limited in analyzing a
single type of omics measurement and cannot comprehensively describe the biological ...

Dendritic cell vaccination in melanoma patients: from promising results to future perspectives

S Boudewijns, M Bloemendal, WR Gerritsen… - Human Vaccines & …, 2016

Abstract Dendritic cells (DCs) play an important role in the induction of antitumor immunity.
Therefore, they are used as anti-cancer vaccines in clinical studies in various types of
cancer. DC vaccines are generally well tolerated and able to induce antigen-specific T cell ...

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

L Strizzi, NV Margaryan, P Gerami, Z Haghighat… - Oncology Letters, 2016

... Published online on: Tuesday, June 21, 2016. This article is mentioned in: Abstract.
The TGF-β associated growth factor Nodal is highly expressed in aggressive metastatic
melanoma. Determining the risk for melanomagenesis ...

Inherited susceptibility to melanoma: insights from a high‐risk Austrian cohort

I Stefanaki, AJ Stratigos - British Journal of Dermatology, 2016

Melanoma is a complex disease with environmental, phenotypic and genetic risk factors
contributing to disease susceptibility. Inherited germline alterations may predispose to
melanoma by increasing the baseline individual risk and by enhancing key molecular ...

Glycoprotein non-metastatic melanoma protein B promotes glioma motility and angiogenesis through the Wnt/β-catenin signaling pathway

G Bao, N Wang, R Li, G Xu, P Liu, B He - Experimental Biology and Medicine, 2016

Abstract Glioma is a common tumor with high mortality and poor overall survival. However,
the regulatory mechanisms of glioma tumorigenesis and glioma cell motility are completely
unknown. Here, we investigated the role of glycoprotein non-metastatic melanoma protein ...

Beneficial roles of melanoma cell adhesion molecule in spinal cord transection recovery in adult zebrafish

CJ Liu, L Xie, C Cui, M Chu, H De Zhao, L Yao, YH Li… - Journal of Neurochemistry, 2016

Abstract Melanoma cell adhesion molecule (MCAM) is a multifunctional protein involved in
miscellaneous processes, including development and tumor angiogenesis. Here, spinal
cord transection in adult zebrafish was used to investigate the effects of MCAM on spinal ...

The melanoma field with dendritic roots

AE Aplin - Pigment Cell & Melanoma Research, 2016

... Editorial. The melanoma field with dendritic roots. Andrew E. Aplin Associate Editor. Version of
Record online: 20 JUN 2016. ... 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Issue. Pigment Cell & Melanoma Research. Volume 29, Issue 4, page 397, July 2016. ...

High CCL27 immunoreactivity in 'supratumoral'epidermis correlates with better prognosis in patients with cutaneous malignant melanoma

M Martinez-Rodriguez, AK Thompson, C Monteagudo - Journal of Clinical Pathology, 2016

Aims It has been proposed that the expression of chemokines and chemokine receptors by
melanoma cells may have a role in tumour immune escape. Chemokine CCL27 is reported
to be expressed specifically on the epidermal keratinocytes. The implication of CCL27 in ...

[HTML] Melanoma-Derived BRAFV600E Mutation in Peritumoral Stromal Cells: Implications for in Vivo Cell Fusion

Z Kurgyis, LV Kemény, T Buknicz, G Groma, J Oláh… - International Journal of …, 2016

Melanoma often recurs in patients after the removal of the primary tumor, suggesting the
presence of recurrent tumor-initiating cells that are undetectable using standard diagnostic
methods. As cell fusion has been implicated to facilitate the alteration of a cell's phenotype ...

The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care

E van der Meijde, AJM van den Eertwegh, SC Linn… - Cancer Informatics, 2016

Abstract Recently, new but expensive treatments have become available for metastatic
melanoma. These improve survival, but in view of the limited funds available, cost-
effectiveness needs to be evaluated. Most cancer cost-effectiveness models are based on ...

[HTML] Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and …

JJ Luke, Y Zha, K Matijevich, TF Gajewski - Journal for ImmunoTherapy of Cancer, 2016

Background Depletion of CD25+ Tregs improves anti-tumor immunity in preclinical models.
Denileukin diftitox is a recombinant fusion protein of human IL-2 and diptheria toxin fragment
that also can kill CD25+ T cells. Prior clinical trials of denileukin diftitox suggested ...

Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.

J Wu, J Du, X Fu, B Liu, H Cao, T Li, T Su, J Xu, AK Tse… - Oncotarget, 2016

Icaritin (IT) is a flavonoid isolated from Herba Epimedii. In this study, we evaluated the anti-melanoma
activities of IT, and determined its cytotoxic mechanism. We found that IT exerted cytotoxicity
to melanoma cells. Furthermore, IT induced melanoma cell apoptosis, which was ...

The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma

A Kim, MS Cohen - Expert Opinion on Drug Discovery, 2016

Abstract Introduction: In the era of precision medicine and sophisticated modern genetics,
the discovery of the BRAFV600 inhibitor, vemurafenib, quickly became the model for
targeted therapy in melanomas. As early as 2002, the majority of metastatic melanomas ...

Resistant mechanisms to BRAF inhibitors in melanoma

JL Manzano, L Layos, C Bugés, M Llanos Gil, L Vila… - Annals of Translational …, 2016

Abstract Patients with advanced melanoma have traditionally had very poor prognosis.
However, since 2011 better understanding of the biology and epidemiology of this disease
has revolutionized its treatment, with newer therapies becoming available. These newer ...

Risk of individual malignant neoplasms in patients with sickle cell disease: English national record linkage study

OO Seminog, OI Ogunlaja, D Yeates, MJ Goldacre - Journal of the Royal Society of …, 2016

... 10.0, 4.6–21.5). Four solid tumours showed elevated rate ratios: colon cancer (2.8,
1.2–5.5), non-melanoma skin cancer (4.4, 1.3–12.2), kidney cancer (5.4, 2.3–11.5)
and thyroid cancer (5.1, 1.3–15.4). Conclusions The risk ...

[HTML] Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody

MA Bilen, SK Subudhi, J Gao, NM Tannir, SM Tu… - Journal for ImmunoTherapy …, 2016

... Ipilimumab is a monoclonal antibody that directly inhibits the function of the immune checkpoint
cytotoxic T-lymphocyte antigen 4 and it was shown to improve survival, which led to approval
in treatment of patients with melanoma [1, 2]. Nivolumab targets the programmed death ...

[PDF] ICTR-PHE 2016 S39 S40

RJ Barlow, P Low, E Recycling - 2016

... X-rays [1][2]. Beside differences in short-term effects such as DNA repair [3], also some long-term
cellular and tissue properties are differentially affected, such as angiogenesis [4], or metastasis
[5]. We aimed at studying the migratory properties of human melanoma cells after ...

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