Σφακιανάκης Αλέξανδρος
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Πέμπτη 2 Ιουνίου 2016

Persistent nasal symptoms and mediator release after continuous pollen exposure in an environmental challenge chamber

Publication date: Available online 1 June 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Yusuke Okuma, Yoshitaka Okamoto, Syuji Yonekura, Tomohisa Iinuma, Toshioki Sakurai, Sawako Hamasaki, Yuji Ohki, Heizaburo Yamamoto, Daiju Sakurai
BackgroundImmediate- and late-phase reactions are associated with nasal symptoms of patients with allergic rhinitis.ObjectiveTo examine the symptoms and mediators released after continuous allergen exposure in an environmental challenge chamber (ECC).MethodsFifteen patients with Japanese cedar pollinosis were enrolled in this study and continuously exposed to cedar pollen at a concentration of 8,000 grains/m3 for 3 hours in an ECC. Nasal function tests were performed, and nasal secretions were collected before pollen exposure (0 hour), immediately after exiting the ECC (3 hours), and 6 hours after exiting the ECC (9 hours). Symptom scores were recorded every 30 minutes in the ECC and every 3 hours after exiting the ECC. The frequency of sneezing and nose blowing also was monitored.ResultsThe severity of symptoms in the ECC peaked approximately 2 hours after the beginning of pollen exposure and continued more than 6 hours after leaving the ECC. Concentrations of histamine, tryptase, interleukins 5, 3, 33, and 31, and substance P increased over time, whereas that of nasal fractional exhaled nitric oxide decreased.ConclusionVarious mediators are released during continuous allergen exposure, which subsequently induce persistent nasal symptoms. Effective treatment is required to control the intense inflammation observed after allergen exposure.



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