[Renovascular effects of antiangiogenic drugs].

[Renovascular effects of antiangiogenic drugs].

Bull Cancer. 2016 Jun 15;

Authors: Deray G, Janus N, Aloy B, Launay-Vacher V

Abstract
During the last decade, inhibitors of the vascular endothelial growth factor (VEGF) were developed for the treatment of cancer. Many anti-VEGF are available but the issue is still the same: to inhibit the effect of the VEGF on their receptors. There are two main classes, depending on the mechanism of action by blocking the binding of the ligand on the receptor (VEGF trap or monoclonal antibody) or by affecting directly the receptor (tyrosine kinase inhibitor [TKI], monoclonal antibody directed against the VEGF receptor). These selective agents are safe. Nevertheless, side effects were described, in particular renal and vascular effects. In this article, we analyze the frequency of these renovascular complications, their clinical aspects and the interest of these indexes as a marker of treatment efficacy.

PMID: 27318610 [PubMed - as supplied by publisher]

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