When anti-TNF fails, anti-IL12-23 is an alternate option in psoriasis and psoriatic arthritis.

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When anti-TNF fails, anti-IL12-23 is an alternate option in psoriasis and psoriatic arthritis.

Rev Bras Reumatol. 2014 May-Jun;54(3):247-9

Authors: Golmia RP, Martins AH, Scheinberg M

Abstract
Patients with psoriasis and psoriatic arthritis respond to anti-TNF therapy, but not all patients maintain effective response, and some do not respond. In this article, we demonstrate the role of a new pathogenetic pathway to some extent TNF-independent in these patients. Anti-IL12-23 is a new and alternate mode of therapy for patients with recalcitrant response to anti-TNF.

PMID: 25054605 [PubMed - indexed for MEDLINE]

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