Immunotherapy

Innovation in Bladder Cancer Immunotherapy.

HB Grossman, DL Lamm, AM Kamat, S Keefe… - Journal of Immunotherapy, 2016

Abstract Bladder cancer is understudied despite its high prevalence and its remarkable
response to immunotherapy. Indeed, funding for studies to explore mechanisms of tumor
immunity and novel new therapeutics is disproportionately lower for bladder cancer in ...

Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting

G Mountzios, H Linardou, P Kosmidis - Annals of Translational Medicine, 2016

Abstract Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related
death worldwide. In recent years, through a better understanding of the interactions between
the immune system and tumor cells (TC), immunotherapy has emerged as a promising ...

Prospecting TCRs for immunotherapy

Z Fehervari - Nature Immunology, 2016

The elimination of tumors through vaccination or the adoptive transfer of tumor-specific T
cells is an attractive option but is technically challenging because of difficulties in raising
robust and appropriate immune responses. In Science, Schumacher and colleagues study ...

[HTML] Cancer immunotherapy trials: leading a paradigm shift in drug development

LA Emens, LH Butterfield, FS Hodi, FM Marincola… - Journal for ImmunoTherapy …, 2016

Background Cancer immunotherapy has a long history in the clinic. William Coley was an
orthopedic surgeon in the late 1800's who noted marked tumor regression in a patient with
severe erysipelas. Based on this observation, he hypothesized that stimulating the ...

[HTML] Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1

HA Watson, G Dolton, J Ohme, K Ladell, M Vigar… - Immunology and Cell …, 2016

Abstract Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in
cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some
patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein ...

CIMT 2016: Mechanisms of efficacy in cancer immunotherapy-Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy

LM Kranz, M Birtel, L Hilscher, C Grunwitz… - Human Vaccines & …, 2016

Cancer immunotherapy at its golden age is now included as a standard of care treatment for
cancer. Its well-established preclinical era has been flourishing in the recent decade with
many patients benefiting from the therapeutic efficacy of cancer immunotherapy through ...

Melanoma immunotherapy dominates the field

P Diamantopoulos, H Gogas - Annals of Translational Medicine, 2016

Abstract The incidence of melanoma is increasing worldwide and despite early detection
and intervention, the number of patients dying from metastatic disease continues to rise. The
prognosis of advanced melanoma remains poor, with median survival between 6 and 9 ...

Human γδ T cells: From a neglected lymphocyte population to cellularimmunotherapy: A personal reflection of 30years of γδ T cell research

D Kabelitz - Clinical Immunology, 2016

Please note that Internet Explorer version 8.x will not be supported as of January
1, 2016. Please refer to this blog post for more information. Close. ScienceDirect.
Sign in Sign in using your ScienceDirect credentials. Username. ...

Cellular immunotherapy for malignant gliomas

Y Lin, H Okada - Expert Opinion on Biological Therapy, 2016

Abstract Introduction: Cancer immunotherapy has made much progress in recent years.
Clinical trials evaluating a variety of immunotherapeutic approaches are underway in
patients with malignant gliomas. Thanks to recent advancements in cell engineering ...

[HTML] A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

C Alvarez-Fernández, L Escribà-Garcia, S Vidal… - Journal of Translational …, 2016

Background Immunotherapy based on the adoptive transfer of gene modified T cells is an
emerging approach for the induction of tumor-specific immune responses. Memory stem T
cells, due to their enhanced antitumor and self-renewal capacity, have become potential ...

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2a85czw
via IFTTT